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Gianfilippo Coppola, PhD

Assistant Professor of Pathology

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Selected Publications

Sex differences in developmental patterns of neocortical astroglia: A mouse translatome databaseRurak GM, Simard S, Freitas-Andrade M, Lacoste B, Charih F, Van Geel A, Stead J, Woodside B, Green JR, Coppola G, Salmaso N. Sex differences in developmental patterns of neocortical astroglia: A mouse translatome database Cell Reports 2022, 38: 110310. PMID: 35108542, DOI: 10.1016/j.celrep.2022.110310.
Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid CulturesScuderi S, Altobelli GG, Cimini V, Coppola G, Vaccarino FM. Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid Cultures Stem Cell Reports 2021, 16: 264-280. PMID: 33513360, PMCID: PMC7878838, DOI: 10.1016/j.stemcr.2020.12.019.
Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralizationMaulding ND, Kavanagh D, Zimmerman K, Coppola G, Carpenter TO, Jue NK, Braddock DT. Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization Bone 2020, 142: 115656. PMID: 32980560, PMCID: PMC7744330, DOI: 10.1016/j.bone.2020.115656.
Transcriptome and epigenome landscape of human cortical development modeled in organoidsAmiri A, Coppola G, Scuderi S, Wu F, Roychowdhury T, Liu F, Pochareddy S, Shin Y, Safi A, Song L, Zhu Y, Sousa AMM, Gerstein M, Crawford G, Sestan N, Abyzov A, Vaccarino F, Akbarian S, An J, Armoskus C, Ashley-Koch A, Beach T, Belmont J, Bendl J, Borrman T, Brown L, Brown M, Brown M, Brunetti T, Bryois J, Burke E, Camarena A, Carlyle B, Chae Y, Charney A, Chen C, Cheng L, Cherskov A, Choi J, Clarke D, Collado-Torres L, Dai R, De La Torre Ubieta L, DelValle D, Devillers O, Dracheva S, Emani P, Evgrafov O, Farnham P, Fitzgerald D, Flatow E, Francoeur N, Fullard J, Gandal M, Gao T, Garrett M, Geschwind D, Giase G, Girdhar K, Giusti-Rodriguez P, Goes F, Goodman T, Grennan K, Gu M, Gürsoy G, Hadjimichael E, Hahn C, Haroutunian V, Hauberg M, Hoffman G, Huey J, Hyde T, Ivanov N, Jacobov R, Jaffe A, Jiang Y, Jiang Y, Johnson G, Kassim B, Kefi A, Kim Y, Kitchen R, Kleiman J, Knowles J, Kozlenkov A, Li M, Li Z, Lipska B, Liu C, Liu S, Mangravite L, Mariani J, Mattei E, Miller D, Moore J, Nairn A, Navarro F, Park R, Peters M, Pinto D, Pochareddy S, Polioudakis D, Pratt H, Price A, Purcaro M, Ray M, Reddy T, Rhie S, Roussos P, Sanders S, Santpere G, Schreiner S, Sheppard B, Shi X, Shieh A, Shin J, Skarica M, Song L, Sousa A, Spitsyna V, State M, Sullivan P, Swarup V, Szatkiewicz J, Szekely A, Tao R, van Bakel H, Wang Y, Wang D, Warrell J, Webster M, Weissman S, Weng Z, Werling D, White K, Willsey J, Wiseman J, Witt H, Won H, Wray G, Xia Y, Xu M, Yang Y, Yang M, Zandi P, Zhang J, Zharovsky E. Transcriptome and epigenome landscape of human cortical development modeled in organoids Science 2018, 362 PMID: 30545853, PMCID: PMC6426303, DOI: 10.1126/science.aat6720.
Profiling changes in cortical astroglial cells following chronic stressSimard S, Coppola G, Rudyk CA, Hayley S, McQuaid RJ, Salmaso N. Profiling changes in cortical astroglial cells following chronic stress Neuropsychopharmacology 2018, 43: 1961-1971. PMID: 29907879, PMCID: PMC6046043, DOI: 10.1038/s41386-018-0105-x.
T96. Cortical Astroglial-Mediated Plasticity in Chronic StressSimard S, Coppola G, Rudyk C, Hayley S, Salmaso N. T96. Cortical Astroglial-Mediated Plasticity in Chronic Stress Biological Psychiatry 2018, 83: s165-s166. DOI: 10.1016/j.biopsych.2018.02.432.
Human induced pluripotent stem cells for modelling neurodevelopmental disordersArdhanareeswaran K, Mariani J, Coppola G, Abyzov A, Vaccarino FM. Human induced pluripotent stem cells for modelling neurodevelopmental disorders Nature Reviews Neurology 2017, 13: 265-278. PMID: 28418023, PMCID: PMC5782822, DOI: 10.1038/nrneurol.2017.45.
One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative originAbyzov A, Tomasini L, Zhou B, Vasmatzis N, Coppola G, Amenduni M, Pattni R, Wilson M, Gerstein M, Weissman S, Urban AE, Vaccarino FM. One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative origin Genome Research 2017, 27: 512-523. PMID: 28235832, PMCID: PMC5378170, DOI: 10.1101/gr.215517.116.
The PsychENCODE projectAkbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, Geschwind DH, Mill J, Nairn AC, Abyzov A, Pochareddy S, Prabhakar S, Weissman S, Sullivan PF, State MW, Weng Z, Peters MA, White KP, Gerstein MB, Amiri A, Armoskus C, Ashley-Koch AE, Bae T, Beckel-Mitchener A, Berman BP, Coetzee GA, Coppola G, Francoeur N, Fromer M, Gao R, Grennan K, Herstein J, Kavanagh DH, Ivanov NA, Jiang Y, Kitchen RR, Kozlenkov A, Kundakovic M, Li M, Li Z, Liu S, Mangravite LM, Mattei E, Markenscoff-Papadimitriou E, Navarro FC, North N, Omberg L, Panchision D, Parikshak N, Poschmann J, Price AJ, Purcaro M, Reddy TE, Roussos P, Schreiner S, Scuderi S, Sebra R, Shibata M, Shieh AW, Skarica M, Sun W, Swarup V, Thomas A, Tsuji J, van Bakel H, Wang D, Wang Y, Wang K, Werling DM, Willsey AJ, Witt H, Won H, Wong CC, Wray GA, Wu EY, Xu X, Yao L, Senthil G, Lehner T, Sklar P, Sestan N. The PsychENCODE project Nature Neuroscience 2015, 18: 1707-1712. PMID: 26605881, PMCID: PMC4675669, DOI: 10.1038/nn.4156.
FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum DisordersMariani J, Coppola G, Zhang P, Abyzov A, Provini L, Tomasini L, Amenduni M, Szekely A, Palejev D, Wilson M, Gerstein M, Grigorenko EL, Chawarska K, Pelphrey KA, Howe JR, Vaccarino FM. FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders Cell 2015, 162: 375-390. PMID: 26186191, PMCID: PMC4519016, DOI: 10.1016/j.cell.2015.06.034.
The use of stem cells to study autism spectrum disorder.Ardhanareeswaran K, Coppola G, Vaccarino F. The use of stem cells to study autism spectrum disorder. The Yale Journal Of Biology And Medicine 2015, 88: 5-16. PMID: 25745370, PMCID: PMC4345539.
Genetics of Tourette SyndromeLennington J, Coppola G, Fernandez T. Genetics of Tourette Syndrome 2015, 169-189. DOI: 10.1007/978-3-319-17223-1_9.
Transcriptome Analysis of the Human Striatum in Tourette SyndromeLennington JB, Coppola G, Kataoka-Sasaki Y, Fernandez TV, Palejev D, Li Y, Huttner A, Pletikos M, Sestan N, Leckman JF, Vaccarino FM. Transcriptome Analysis of the Human Striatum in Tourette Syndrome Biological Psychiatry 2014, 79: 372-382. PMID: 25199956, PMCID: PMC4305353, DOI: 10.1016/j.biopsych.2014.07.018.
Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flowCaro C, Seneviratne A, Heraty K, Monaco C, Burke M, Krams R, Chang C, Gilson P, Coppola G. Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flow Journal Of The Royal Society Interface 2014, 11: 20131156. PMCID: PMC3899883, DOI: 10.1098/rsif.2013.1156.
Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flow†Caro C, Seneviratne A, Heraty K, Monaco C, Burke M, Krams R, Chang C, Coppola G, Gilson P. Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flow† Journal Of The Royal Society Interface 2013, 10: 20130578. PMID: 24132200, PMCID: PMC3808545, DOI: 10.1098/rsif.2013.0578.
Neurobiology meets genomic science: The promise of human-induced pluripotent stem cellsStevens HE, Mariani J, Coppola G, Vaccarino FM. Neurobiology meets genomic science: The promise of human-induced pluripotent stem cells Development And Psychopathology 2012, 24: 1443-1451. PMID: 23062309, PMCID: PMC3513939, DOI: 10.1017/s095457941200082x.
Systems and synthetic biology of the vessel wall.Frueh J, Maimari N, Lui Y, Kis Z, Mehta V, Pormehr N, Grant C, Chalkias E, Falck-Hansen M, Bovens S, Pedrigi R, Homma T, Coppola G, Krams R. Systems and synthetic biology of the vessel wall. FEBS Letters 2012, 586: 2164-70. PMID: 22710159, DOI: 10.1016/j.febslet.2012.04.031.
Modeling human cortical development in vitro using induced pluripotent stem cellsMariani J, Simonini MV, Palejev D, Tomasini L, Coppola G, Szekely AM, Horvath TL, Vaccarino FM. Modeling human cortical development in vitro using induced pluripotent stem cells Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 12770-12775. PMID: 22761314, PMCID: PMC3411972, DOI: 10.1073/pnas.1202944109.
Index proposal and basic estimator study for quantification of oscillation of the secondary flow pattern in tortuous vesselsMari JM, Khoo M, Riga C, Coppola G, Bicknell C, Caro CG. Index proposal and basic estimator study for quantification of oscillation of the secondary flow pattern in tortuous vessels Ultrasonics 2011, 52: 294-305. PMID: 21982777, DOI: 10.1016/j.ultras.2011.08.015.
Experimental study of highly turbulent isothermal opposed-jet flowsCoppola G, Gomez A. Experimental study of highly turbulent isothermal opposed-jet flows Physics Of Fluids 2010, 22: 105101. DOI: 10.1063/1.3484253.
An experimental and numerical study of the structure and stability of laminar opposed-jet flowsCiani A, Kreutner W, Frouzakis C, Lust K, Coppola G, Boulouchos K. An experimental and numerical study of the structure and stability of laminar opposed-jet flows Computers & Fluids 2010, 39: 114-124. DOI: 10.1016/j.compfluid.2009.07.006.
Experimental investigation on a turbulence generation system with high-blockage platesCoppola G, Gomez A. Experimental investigation on a turbulence generation system with high-blockage plates Experimental Thermal And Fluid Science 2009, 33: 1037-1048. DOI: 10.1016/j.expthermflusci.2009.06.001.
Highly turbulent counterflow flames: A laboratory scale benchmark for practical systemsCoppola G, Coriton B, Gomez A. Highly turbulent counterflow flames: A laboratory scale benchmark for practical systems Combustion And Flame 2009, 156: 1834-1843. DOI: 10.1016/j.combustflame.2009.03.017.
Arterial geometry, flow pattern, wall shear and mass transport: potential physiological significanceCoppola G, Caro C. Arterial geometry, flow pattern, wall shear and mass transport: potential physiological significance Journal Of The Royal Society Interface 2008, 6: 519-528. PMID: 19033138, PMCID: PMC2696143, DOI: 10.1098/rsif.2008.0417.
Oxygen mass transfer in a model three-dimensional arteryCoppola G, Caro C. Oxygen mass transfer in a model three-dimensional artery Journal Of The Royal Society Interface 2008, 5: 1067-1075. PMID: 18252664, PMCID: PMC2607427, DOI: 10.1098/rsif.2007.1338.
Nonlinear Particle Tracking for High-Order ElementsCoppola G, Sherwin S, Peiró J. Nonlinear Particle Tracking for High-Order Elements Journal Of Computational Physics 2001, 172: 356-386. DOI: 10.1006/jcph.2001.6829.
Modeling of biomass devolatilization in a fluidized bed reactorDifelice R, Coppola G, Rapagna S, Jand N. Modeling of biomass devolatilization in a fluidized bed reactor The Canadian Journal Of Chemical Engineering 1999, 77: 325-332. DOI: 10.1002/cjce.5450770219.

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