Research & Publications
PsychEncode Project (2015-2018): This project focused on characterizing the transcriptome and noncoding elements, such as enhancers and promoters, in human telencephalic brain organoids. It involved a comprehensive comparison to isogenic fetal cortical human brain tissue. The study made use of cutting-edge stem cell technologies and Next-Generation Sequencing (NGS) techniques, including Bulk RNA-seq, single-cell RNA-seq (scRNA-seq), ChIP-seq, and ATAC-seq, to provide a deep understanding of the molecular landscape of these brain organoids.
Brain Initiative Project (2020-2023): This ongoing project explores the intricate interplay of morphogen gradients in the early stages of neuronal patterning. It involves the development and implementation of a mesofluidic device designed for human induced pluripotent stem cell (iPSC)-derived organoids. This innovative device is employed to recreate gradients of morphogens that play a crucial role in the antero-posterior and dorsal-ventral specification of the human neural tube. The project is conducted in collaboration with the Yale Biomedical Engineering department, specifically with the Levchenko Lab. This interdisciplinary effort promises to shed light on fundamental processes in neural development and patterning.
Nervous System Diseases; Neurons; Organoids; Stem Cells; Neural Tube