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Soraya Scuderi, PhD

Associate Research Scientist - Child Study Center

Contact Information

Soraya Scuderi, PhD

Research Summary

PsychEncode Project (2015-2018): This project focused on characterizing the transcriptome and noncoding elements, such as enhancers and promoters, in human telencephalic brain organoids. It involved a comprehensive comparison to isogenic fetal cortical human brain tissue. The study made use of cutting-edge stem cell technologies and Next-Generation Sequencing (NGS) techniques, including Bulk RNA-seq, single-cell RNA-seq (scRNA-seq), ChIP-seq, and ATAC-seq, to provide a deep understanding of the molecular landscape of these brain organoids.

Brain Initiative Project (2020-2023): This project explored the intricate interplay of morphogen gradients in the early stages of neuronal patterning. It involved the development and implementation of a mesofluidic device called DuoMAPS (Dual Orthogonal-Morphogen Assisted Patterning System), designed for human induced pluripotent stem cell (iPSC)-derived organoids. This innovative device has been employed to recreate gradients of morphogens that play a crucial role in the antero-posterior and dorsal-ventral specification of the human neural tube. Several lineages spanning the entire human brain were modeled in vitro. The project was conducted in collaboration with the Yale Biomedical Engineering department, with the Levchenko Lab and colleagues Tae-Yun Kang and Alexandre Jourdon. This interdisciplinary effort promises to shed light on fundamental processes in neural development and patterning.

SFARI Innovative project (2022-2024) on going study on ASD cohort and DuoMAPS iPSC derived organoids.


Research Interests

Nervous System Diseases; Neurons; Organoids; Stem Cells; Neural Tube

Selected Publications