Soraya Scuderi, PhD
Associate Research Scientist - Child Study Center
Research & Publications
Biography
Research Summary
PsychEncode Project (2015-2018): This project focused on characterizing the transcriptome and noncoding elements, such as enhancers and promoters, in human telencephalic brain organoids. It involved a comprehensive comparison to isogenic fetal cortical human brain tissue. The study made use of cutting-edge stem cell technologies and Next-Generation Sequencing (NGS) techniques, including Bulk RNA-seq, single-cell RNA-seq (scRNA-seq), ChIP-seq, and ATAC-seq, to provide a deep understanding of the molecular landscape of these brain organoids.
Brain Initiative Project (2020-2023): This ongoing project explores the intricate interplay of morphogen gradients in the early stages of neuronal patterning. It involves the development and implementation of a mesofluidic device designed for human induced pluripotent stem cell (iPSC)-derived organoids. This innovative device is employed to recreate gradients of morphogens that play a crucial role in the antero-posterior and dorsal-ventral specification of the human neural tube. The project is conducted in collaboration with the Yale Biomedical Engineering department, specifically with the Levchenko Lab. This interdisciplinary effort promises to shed light on fundamental processes in neural development and patterning.
Coauthors
Research Interests
Nervous System Diseases; Neurons; Organoids; Stem Cells; Neural Tube
Selected Publications
- Early Neuronal Differentiation/patterning of the Human Pallium, Modeling by in Vitro Systems, and Disruption in Developmental DisordersScuderi S, Jourdon A, Vaccarino F. Early Neuronal Differentiation/patterning of the Human Pallium, Modeling by in Vitro Systems, and Disruption in Developmental Disorders. 2023, 423-442. DOI: 10.1002/9781119860914.ch20.
- Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in miceStevens H, Scuderi S, Collica S, Tomasi S, Horvath T, Vaccarino F. Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in mice. Translational Psychiatry 2023, 13: 89. PMID: 36906620, PMCID: PMC10008554, DOI: 10.1038/s41398-023-02372-y.
- 26.1 Biological Action of Ketamine in Developing Neurons: Hope in Treating Maternal Depression to Reduce Children Mood DisordersYuen E, Scuderi S, Vaccarino F. 26.1 Biological Action of Ketamine in Developing Neurons: Hope in Treating Maternal Depression to Reduce Children Mood Disorders. Journal Of The American Academy Of Child & Adolescent Psychiatry 2021, 60: s201. DOI: 10.1016/j.jaac.2021.09.218.
- Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid CulturesScuderi S, Altobelli GG, Cimini V, Coppola G, Vaccarino FM. Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid Cultures. Stem Cell Reports 2021, 16: 264-280. PMID: 33513360, PMCID: PMC7878838, DOI: 10.1016/j.stemcr.2020.12.019.
- Complex mosaic structural variations in human fetal brainsSekar S, Tomasini L, Proukakis C, Bae T, Manlove L, Jang Y, Scuderi S, Zhou B, Kalyva M, Amiri A, Mariani J, Sedlazeck F, Urban AE, Vaccarino F, Abyzov A. Complex mosaic structural variations in human fetal brains. Genome Research 2020, 30: gr.262667.120. PMID: 33122304, PMCID: PMC7706730, DOI: 10.1101/gr.262667.120.
- PsychENCODE and beyond: transcriptomics and epigenomics of brain development and organoidsJourdon A, Scuderi S, Capauto D, Abyzov A, Vaccarino FM. PsychENCODE and beyond: transcriptomics and epigenomics of brain development and organoids. Neuropsychopharmacology 2020, 46: 70-85. PMID: 32659782, PMCID: PMC7689467, DOI: 10.1038/s41386-020-0763-3.
- The role of somatic mosaicism in brain diseaseJourdon A, Fasching L, Scuderi S, Abyzov A, Vaccarino FM. The role of somatic mosaicism in brain disease. Current Opinion In Genetics & Development 2020, 65: 84-90. PMID: 32622340, PMCID: PMC7749073, DOI: 10.1016/j.gde.2020.05.002.
- Chapter 5 Induced pluripotent stem cells as models of human neurodevelopmental disordersJourdon A, Mariani J, Scuderi S, Amiri A, Wu F, Yuen E, Abyzov A, Vaccarino F. Chapter 5 Induced pluripotent stem cells as models of human neurodevelopmental disorders. 2020, 99-127. DOI: 10.1016/b978-0-12-814409-1.00005-7.
- Transcriptome and epigenome landscape of human cortical development modeled in organoidsAmiri A, Coppola G, Scuderi S, Wu F, Roychowdhury T, Liu F, Pochareddy S, Shin Y, Safi A, Song L, Zhu Y, Sousa AMM, Gerstein M, Crawford G, Sestan N, Abyzov A, Vaccarino F, Akbarian S, An J, Armoskus C, Ashley-Koch A, Beach T, Belmont J, Bendl J, Borrman T, Brown L, Brown M, Brown M, Brunetti T, Bryois J, Burke E, Camarena A, Carlyle B, Chae Y, Charney A, Chen C, Cheng L, Cherskov A, Choi J, Clarke D, Collado-Torres L, Dai R, De La Torre Ubieta L, DelValle D, Devillers O, Dracheva S, Emani P, Evgrafov O, Farnham P, Fitzgerald D, Flatow E, Francoeur N, Fullard J, Gandal M, Gao T, Garrett M, Geschwind D, Giase G, Girdhar K, Giusti-Rodriguez P, Goes F, Goodman T, Grennan K, Gu M, Gürsoy G, Hadjimichael E, Hahn C, Haroutunian V, Hauberg M, Hoffman G, Huey J, Hyde T, Ivanov N, Jacobov R, Jaffe A, Jiang Y, Jiang Y, Johnson G, Kassim B, Kefi A, Kim Y, Kitchen R, Kleiman J, Knowles J, Kozlenkov A, Li M, Li Z, Lipska B, Liu C, Liu S, Mangravite L, Mariani J, Mattei E, Miller D, Moore J, Nairn A, Navarro F, Park R, Peters M, Pinto D, Pochareddy S, Polioudakis D, Pratt H, Price A, Purcaro M, Ray M, Reddy T, Rhie S, Roussos P, Sanders S, Santpere G, Schreiner S, Sheppard B, Shi X, Shieh A, Shin J, Skarica M, Song L, Sousa A, Spitsyna V, State M, Sullivan P, Swarup V, Szatkiewicz J, Szekely A, Tao R, van Bakel H, Wang Y, Wang D, Warrell J, Webster M, Weissman S, Weng Z, Werling D, White K, Willsey J, Wiseman J, Witt H, Won H, Wray G, Xia Y, Xu M, Yang Y, Yang M, Zandi P, Zhang J, Zharovsky E. Transcriptome and epigenome landscape of human cortical development modeled in organoids. Science 2018, 362 PMID: 30545853, PMCID: PMC6426303, DOI: 10.1126/science.aat6720.
- Heparin-binding EGF-like growth factor in diagnosis of malignant phyllodes tumor of the breast: a case reportMusumeci G, Trovato F, Szychlinska M, Scuderi S, Fidone F, Imbesi R, Castrogiovanni P. Heparin-binding EGF-like growth factor in diagnosis of malignant phyllodes tumor of the breast: a case report. Gazzetta Medica Italiana Archivio Per Le Scienze Mediche 2016, 176 DOI: 10.23736/s0393-3660.16.03300-3.
- Effects of Synthetic Anti-Inflammatory Sterol in CB3V-Induced Myocarditis: A Morphological Study on Heart Muscle TissueCastrogiovanni P, Trovato F, Szychlinska M, Loreto C, Giunta S, Scuderi S, Passanisi R, Fidone F, Fagone P, Imbesi R, Nicoletti F, Castorina S. Effects of Synthetic Anti-Inflammatory Sterol in CB3V-Induced Myocarditis: A Morphological Study on Heart Muscle Tissue. Journal Of Functional Morphology And Kinesiology 2016, 1: 69-89. DOI: 10.3390/jfmk1010069.
- The PsychENCODE projectAkbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, Geschwind DH, Mill J, Nairn AC, Abyzov A, Pochareddy S, Prabhakar S, Weissman S, Sullivan PF, State MW, Weng Z, Peters MA, White KP, Gerstein MB, Amiri A, Armoskus C, Ashley-Koch AE, Bae T, Beckel-Mitchener A, Berman BP, Coetzee GA, Coppola G, Francoeur N, Fromer M, Gao R, Grennan K, Herstein J, Kavanagh DH, Ivanov NA, Jiang Y, Kitchen RR, Kozlenkov A, Kundakovic M, Li M, Li Z, Liu S, Mangravite LM, Mattei E, Markenscoff-Papadimitriou E, Navarro FC, North N, Omberg L, Panchision D, Parikshak N, Poschmann J, Price AJ, Purcaro M, Reddy TE, Roussos P, Schreiner S, Scuderi S, Sebra R, Shibata M, Shieh AW, Skarica M, Sun W, Swarup V, Thomas A, Tsuji J, van Bakel H, Wang D, Wang Y, Wang K, Werling DM, Willsey AJ, Witt H, Won H, Wong CC, Wray GA, Wu EY, Xu X, Yao L, Senthil G, Lehner T, Sklar P, Sestan N. The PsychENCODE project. Nature Neuroscience 2015, 18: 1707-1712. PMID: 26605881, PMCID: PMC4675669, DOI: 10.1038/nn.4156.
- Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan dietMusumeci G, Castrogiovanni P, Castorina S, Imbesi R, Szychlinska M, Scuderi S, Loreto C, Giunta S. Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. Brain Research Bulletin 2015, 119: 12-18. PMID: 26444078, DOI: 10.1016/j.brainresbull.2015.09.010.
- Emerging Role of PACAP as a New Potential Therapeutic Target in Major Diabetes ComplicationsMarzagalli R, Scuderi S, Drago F, Waschek J, Castorina A. Emerging Role of PACAP as a New Potential Therapeutic Target in Major Diabetes Complications. International Journal Of Endocrinology 2015, 2015: 160928. PMID: 26074958, PMCID: PMC4446501, DOI: 10.1155/2015/160928.
- Different Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced DiabetesScuderi S, D’amico A, Federico C, Saccone S, Magro G, Bucolo C, Drago F, D’Agata V. Different Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced Diabetes. Journal Of Molecular Neuroscience 2015, 56: 431-439. PMID: 25676032, DOI: 10.1007/s12031-015-0505-x.
- Alternative Splicing Generates Different Parkin Protein Isoforms: Evidences in Human, Rat, and Mouse BrainScuderi S, La Cognata V, Drago F, Cavallaro S, D'Agata V. Alternative Splicing Generates Different Parkin Protein Isoforms: Evidences in Human, Rat, and Mouse Brain. BioMed Research International 2014, 2014: 690796. PMID: 25136611, PMCID: PMC4124806, DOI: 10.1155/2014/690796.
- Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 GeneLa Cognata V, Iemmolo R, D’Agata V, Scuderi S, Drago F, Zappia M, Cavallaro S. Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene. Current Genomics 2014, 15: 203-216. PMID: 24955028, PMCID: PMC4064560, DOI: 10.2174/1389202915666140426003342.
- NAP Reduces Murine Microvascular Endothelial Cells Proliferation Induced by HyperglycemiaD’Amico A, Scuderi S, Maugeri G, Cavallaro S, Drago F, D’Agata V. NAP Reduces Murine Microvascular Endothelial Cells Proliferation Induced by Hyperglycemia. Journal Of Molecular Neuroscience 2014, 54: 405-413. PMID: 24874579, DOI: 10.1007/s12031-014-0335-2.
- Davunetide (NAP) Protects the Retina Against Early Diabetic Injury by Reducing Apoptotic DeathScuderi S, D’Amico A, Castorina A, Federico C, Marrazzo G, Drago F, Bucolo C, D’Agata V. Davunetide (NAP) Protects the Retina Against Early Diabetic Injury by Reducing Apoptotic Death. Journal Of Molecular Neuroscience 2014, 54: 395-404. PMID: 24488575, DOI: 10.1007/s12031-014-0244-4.
- PACAP and VIP increase the expression of myelin-related proteins in rat schwannoma cells: Involvement of PAC1/VPAC2 receptor-mediated activation of PI3K/Akt signaling pathwaysCastorina A, Scuderi S, D’Amico A, Drago F, D’Agata V. PACAP and VIP increase the expression of myelin-related proteins in rat schwannoma cells: Involvement of PAC1/VPAC2 receptor-mediated activation of PI3K/Akt signaling pathways. Experimental Cell Research 2013, 322: 108-121. PMID: 24246222, DOI: 10.1016/j.yexcr.2013.11.003.
- Increased Hippocampal CREB Phosphorylation in Dopamine D3 Receptor Knockout Mice Following Passive Avoidance ConditioningD’Amico A, Scuderi S, Leggio G, Castorina A, Drago F, D’Agata V. Increased Hippocampal CREB Phosphorylation in Dopamine D3 Receptor Knockout Mice Following Passive Avoidance Conditioning. Neurochemical Research 2013, 38: 2516-2523. PMID: 24100927, DOI: 10.1007/s11064-013-1164-3.
- Antiproliferative Effects of PACAP and VIP in Serum-Starved Glioma CellsD’Amico A, Scuderi S, Saccone S, Castorina A, Drago F, D’Agata V. Antiproliferative Effects of PACAP and VIP in Serum-Starved Glioma Cells. Journal Of Molecular Neuroscience 2013, 51: 503-513. PMID: 23900722, DOI: 10.1007/s12031-013-0076-7.
- Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampusCastorina A, D’Amico A, Scuderi S, Leggio G, Drago F, D’Agata V. Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus. Neuroscience 2013, 250: 546-556. PMID: 23906635, DOI: 10.1016/j.neuroscience.2013.07.053.
- Ameliorative effect of PACAP and VIP against increased permeability in a model of outer blood retinal barrier dysfunctionScuderi S, D’Amico A, Castorina A, Imbesi R, Carnazza M, D’Agata V. Ameliorative effect of PACAP and VIP against increased permeability in a model of outer blood retinal barrier dysfunction. Peptides 2012, 39: 119-124. PMID: 23220033, DOI: 10.1016/j.peptides.2012.11.015.
- Involvement of PACAP/ADNP Signaling in the Resistance to Cell Death in Malignant Peripheral Nerve Sheath Tumor (MPNST) CellsCastorina A, Giunta S, Scuderi S, D’Agata V. Involvement of PACAP/ADNP Signaling in the Resistance to Cell Death in Malignant Peripheral Nerve Sheath Tumor (MPNST) Cells. Journal Of Molecular Neuroscience 2012, 48: 674-683. PMID: 22454142, DOI: 10.1007/s12031-012-9755-z.
- Epidermal growth factor receptor (EGFR) and neuregulin (Neu) activation in human airway epithelial cells exposed to nickel acetateGiunta S, Castorina A, Scuderi S, Patti C, D’Agata V. Epidermal growth factor receptor (EGFR) and neuregulin (Neu) activation in human airway epithelial cells exposed to nickel acetate. Toxicology In Vitro 2011, 26: 280-287. PMID: 22210268, DOI: 10.1016/j.tiv.2011.12.012.