Faye Rogers, PhD
Associate Professor of Therapeutic Radiology; Associate Cancer Center Director , Diversity, Equity, and Inclusion; Vice Chair for Diversity, Equity and Inclusion, Therapeutic Radiology; Associate Director, Yale MD-PhD Program; Director, Yale BioMed Amgen Scholars Program
Research & Publications
Biography
News
Locations
Research Summary
Overexpression of HER2, which occurs in ~30% of human breast cancers, correlates with enhanced tumor aggressiveness and decreased patient survival. Although Herceptin has significantly improved the treatment of HER2-positive tumors, drug resistance remains an obstacle in a high fraction of patients. The ability to target these cancers using antitumor agents with mechanisms of action that are independent of HER2 cellular growth function, represents a powerful tool to circumvent this form of resistance. Our lab is interested in the design of novel gene-targeted molecules that can be used in the treatment of both HER2-positive and Hercetin-resistant breast cancers.
Specialized Terms: Breast cancer; Drug design; Altered helical structures; Cancer and genomic instability; DNA repair and apoptosis
Coauthors
Research Interests
Biochemistry; Breast Neoplasms; DNA Repair; Nucleic Acids; Drug Design; Apoptosis; Radiation Oncology; Genomic Instability
Selected Publications
- Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cellsTiwari M, Adaku N, Peart N, Rogers FA. Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cells Nucleic Acids Research 2016, 44: 7742-7754. PMID: 27298253, PMCID: PMC5027492, DOI: 10.1093/nar/gkw515.
- Imaging Functional Nucleic Acid Delivery to SkinKaspar RL, Hickerson RP, González-González E, Flores MA, Speaker TP, Rogers FA, Milstone LM, Contag CH. Imaging Functional Nucleic Acid Delivery to Skin 2016, 1372: 1-24. PMID: 26530911, DOI: 10.1007/978-1-4939-3148-4_1.
- Improved bioactivity of G-rich triplex-forming oligonucleotides containing modified guanine basesRogers FA, Lloyd JA, Tiwari MK. Improved bioactivity of G-rich triplex-forming oligonucleotides containing modified guanine bases Artificial DNA PNA & XNA 2014, 5: e27792. PMID: 25483840, PMCID: PMC4014521, DOI: 10.4161/adna.27792.
- Triplex-induced DNA damage response.Rogers FA, Tiwari MK. Triplex-induced DNA damage response. The Yale Journal Of Biology And Medicine 2013, 86: 471-8. PMID: 24348211, PMCID: PMC3848101.
- XPD-dependent activation of apoptosis in response to triplex-induced DNA damageTiwari M, Rogers FA. XPD-dependent activation of apoptosis in response to triplex-induced DNA damage Nucleic Acids Research 2013, 41: 8979-8994. PMID: 23913414, PMCID: PMC3799437, DOI: 10.1093/nar/gkt670.
- Local Delivery of Gene-Modifying Triplex-Forming Molecules to the EpidermisRogers FA, Hu RH, Milstone LM. Local Delivery of Gene-Modifying Triplex-Forming Molecules to the Epidermis Journal Of Investigative Dermatology 2012, 133: 685-691. PMID: 23014335, PMCID: PMC3532560, DOI: 10.1038/jid.2012.351.
- Targeted Disruption of the CCR5 Gene in Human Hematopoietic Stem Cells Stimulated by Peptide Nucleic AcidsSchleifman EB, Bindra R, Leif J, del Campo J, Rogers FA, Uchil P, Kutsch O, Shultz LD, Kumar P, Greiner DL, Glazer PM. Targeted Disruption of the CCR5 Gene in Human Hematopoietic Stem Cells Stimulated by Peptide Nucleic Acids Cell Chemical Biology 2011, 18: 1189-1198. PMID: 21944757, PMCID: PMC3183429, DOI: 10.1016/j.chembiol.2011.07.010.
- Targeted Gene Modification of Hematopoietic Progenitor Cells in Mice Following Systemic Administration of a PNA-peptide ConjugateRogers FA, Lin SS, Hegan DC, Krause DS, Glazer PM. Targeted Gene Modification of Hematopoietic Progenitor Cells in Mice Following Systemic Administration of a PNA-peptide Conjugate Molecular Therapy 2011, 20: 109-118. PMID: 21829173, PMCID: PMC3255600, DOI: 10.1038/mt.2011.163.
- XPD‐Dependent induction of apoptosis in cells with DNA containing triple helical repeatsRogers F, Kaushik M. XPD‐Dependent induction of apoptosis in cells with DNA containing triple helical repeats The FASEB Journal 2011, 25: 310.3-310.3. DOI: 10.1096/fasebj.25.1_supplement.310.3.
- Targeted correction of a thalassemia-associated β-globin mutation induced by pseudo-complementary peptide nucleic acidsLonkar P, Kim KH, Kuan JY, Chin JY, Rogers FA, Knauert MP, Kole R, Nielsen PE, Glazer PM. Targeted correction of a thalassemia-associated β-globin mutation induced by pseudo-complementary peptide nucleic acids Nucleic Acids Research 2009, 37: 3635-3644. PMID: 19364810, PMCID: PMC2699504, DOI: 10.1093/nar/gkp217.
- 1031. Improved Intranuclear Delivery of PNA- Peptide Conjugates Designed for Chromosomal Gene TargetingRogers F, Glazer P. 1031. Improved Intranuclear Delivery of PNA- Peptide Conjugates Designed for Chromosomal Gene Targeting Molecular Therapy 2006, 13: s396. DOI: 10.1016/j.ymthe.2006.08.1126.
- 1030. Pyrazolo[3,4-d]Pyrimidine Guanine Base Substitution in Triplex Forming Oligonucleotides Improves Target Specificity and Chromosomal MutagenesisChin J, Lloyd J, Rogers F, Glazer P. 1030. Pyrazolo[3,4-d]Pyrimidine Guanine Base Substitution in Triplex Forming Oligonucleotides Improves Target Specificity and Chromosomal Mutagenesis Molecular Therapy 2006, 13: s396. DOI: 10.1016/j.ymthe.2006.08.1125.
- Triplex-forming oligonucleotides as potential tools for modulation of gene expression.Rogers FA, Lloyd JA, Glazer PM. Triplex-forming oligonucleotides as potential tools for modulation of gene expression. Anti-Cancer Agents In Medicinal Chemistry 2005, 5: 319-26. PMID: 16101484, DOI: 10.2174/1568011054222300.
- Distance and Affinity Dependence of Triplex-Induced Recombination †Knauert MP, Lloyd JA, Rogers FA, Datta HJ, Bennett ML, Weeks DL, Glazer PM. Distance and Affinity Dependence of Triplex-Induced Recombination † Biochemistry 2005, 44: 3856-3864. PMID: 15751961, DOI: 10.1021/bi0481040.
- Peptide conjugates for chromosomal gene targeting by triplex-forming oligonucleotidesRogers FA, Manoharan M, Rabinovitch P, Ward DC, Glazer PM. Peptide conjugates for chromosomal gene targeting by triplex-forming oligonucleotides Nucleic Acids Research 2004, 32: 6595-6604. PMID: 15602001, PMCID: PMC545466, DOI: 10.1093/nar/gkh998.
- Targeted Genome Modification Via Triple Helix FormationRogers F, Glazer P. Targeted Genome Modification Via Triple Helix Formation 2004, 27-43. DOI: 10.1007/978-1-59259-777-2_3.
- Site-directed recombination via bifunctional PNA–DNA conjugatesRogers FA, Vasquez KM, Egholm M, Glazer PM. Site-directed recombination via bifunctional PNA–DNA conjugates Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 16695-16700. PMID: 12461167, PMCID: PMC139206, DOI: 10.1073/pnas.262556899.