Leonard Milstone, MD
Research & Publications
Biography
News
Research Summary
Leonard Milstone's laboratory studies have focused mainly on the structure and function of epidermal keratinocytes in tissue culture, in experimental animals and in patients who have ichthyosis. Past work includes: identification and characterization of keratins 4 and 13; discovery of epican, the CD44 proteoglycan characteristically found on stratified squamous epithelia; production of PTHrP by keratinocytes; seminal observations on interferon gamma.
Clinical studies have focused on effects that systemic retinoids have on bones of patients who have ichthyosis or acne, and on characterization of rare genodermatoses, such as dermatosparaxis and ichthyosis with confetti. We regularly participate in Phase I studies of topical treatments for patients with inherited disorders of keratinization.
Extensive Research Description
Discovery of interferon gamma.In 1968, the only known ways to evoke interferon secretion were by live or dead viruses or by a special class of polynucleotides.Because of the presence of lymphocytes in tissue of brains infected with virus, I hypothesized that those cells were making a virus inhibitor.I further postulated, and then demonstrated, that antigen-sensitized immune cells would respond to an antigen, such as the protein component of the tuberculosis bacillus (PPD), with the production of a virus inhibitor.It turned out to be a distinct interferon, and others subsequently named this inhibitor interferon gamma.The in vitro procedure we used to produce interferon gamma now forms the basis of the widely used blood test for tuberculosis, the quantiferon gold assay.
Milstone LM, Waksman BH.Release of virus inhibitor from tuberculin‑sensitized peritoneal cells stimulated by antigen.J Immunol 105:1068‑1071, 1970
Discovery of K4 and K13 keratins.In 1978 other investigators had begun to characterize keratin proteins that formed intermediate filaments and to show that the unit structure of keratin intermediate filaments was a heteropolymer.The abundance of individual keratins in most tissues left open the question of whether the basic assembly unit was a dimer, trimer or multimer.Unfortunately the complexity of keratin proteins isolated from cutaneous tissues made this difficult to resolve.Fortuitously, I found that esophagus epithelium had only two predominant keratin proteins present in equal stoichiometric amounts.We then isolated and characterized an acidic keratin, later known as keratin 13, and a basic keratin, later known as keratin 4, and showed that purified K4 combined with purified K13 in equal amounts to form intermediate filaments.These data favored a unit structure composed of a dimer of acidic and basic pairs.This structure has been abundantly confirmed by many other investigators and a heterodimer is now accepted as the essential unit of all keratin intermediate filaments. Keratins 4 and 13 are mutated in the mucosal disorder called white sponge nevus.
Milstone LM, McGuire J.Different polypeptides form the intermediate filaments in bovine hoof and esophageal epithelium and in aortic endothelium.J Cell Biol 88:312‑316, 1981.
Milstone LM.Isolation and characterization of two polypeptides that form intermediate filaments in bovine esophageal epithelium.J Cell Biol 88:317‑ 322, 1981.
Discovery of epican and characterization of cell surface proteoglycans on keratinocytes. In 1988, before it was well-established that the cadherins were the most dominant adhesive molecules on keratinocytes, I postulated that cell surface proteoglycans might be important in keratinocyte cell-cell adhesion.We characterized proteoglycans on cultured keratinocytes and made monoclonal antibodies to their core proteins.We then isolated the most abundant proteoglycan on keratinocytes and cloned and characterized the heparin/chondrointin sulfate splice variant of CD44.We called this variant, which is exclusively expressed on stratified squamous epithelia, CD44Epican.We then showed that CD44Epican can mediate weak cell-cell adhesion through a hyaluronate bridge.Additional functions for Epican have been identified since then; no single critical function is known.
Haggerty JG, Bretton RH, Milstone LM.Identification and characterization of a cell surface proteoglycan on keratinocytes. J Invest Dermatol 99:374-380, 1992.
Kugelman LC, Ganguly S, Haggerty JG, Weissman SM, Milstone LM.The core protein of epican, a heparan sulfate proteoglycan on keratinocytes, is an alternative form of CD44.J Invest Dermatol 99:887-891, 1992.
Milstone LM, Hough-Monroe L, Kugelman LC, Bender JR, Haggerty JG. Epican, a heparan/chondroitin sulfate proteoglycan form of CD44, mediates cell-cell adhesion.J Cell Sci 107: 3183-3190, 1994.
Epidermis and systemic mineral metabolism.Stimulated by a difficult patient of mine who had pustular psoriasis, I organized a group to study the relationship between epidermal disease and systemic mineral metabolism.In that patient with pustular psoriasis and subsequently in others, we showed that pustular psoriasis of von Zumbush could be triggered by hypocalcemia caused by hypoparathyroidism (iatrogenic or idiopathic).We later collaborated to utilize cultured keratinocytes to purify, characterize and ultimately sequence PTH-RP, a major cause of humoral hypercalcemia of malignancy.We identified bony effects of systemic retinoids given to treat acne and other epidermal diseases.Finally, my lab developed a transgenic animal model to prove that epidermal desquamation could have a significant impact on iron stores in internal organs.
Stewart AF, Battaglini J, Milstone LM.Hypocalcemia‑induced pustular psoriasis of von Zumbusch: new experience with an old syndrome.Ann Int Med 100:677‑680, 1984.
Merendino JJ, Insogna KL, Milstone LM, Broadus AE, Stewart AF.A parathyroid hormone‑like protein from cultured human keratinocytes.Science 231:388‑390, 1986.
Milstone LM, McGuire J, Ablow RC.Premature epiphyseal closure in a child receiving oral 13‑cis retinoic acid.J Amer Acad Dermatol 7:663‑666, 1982.
Milstone LM, Ellison AF, Insogna KL.Serum parathyroid hormone is elevated in some patients with disorders of keratinization. Arch Dermatol 128:926-930, 1992.
Milstone LM, Hu R-H, Dziura JD, Zhou J.Impact of epidermal desquamation on tissue stores of iron.J Dermatol Sci, 67: 9-13, 2012
Functional delivery of oligonucleotides to epidermis in order to edit or modify expression of mutant genes. For the past 15 years I have worked on mutant RNA and DNA as targets for therapeutic intervention in epidermis.Both in my lab and as part of a large consortium, we have worked to improve methods of oligonucleotide delivery and to quantify their biochemical and biological effects. Notable achievements are the first demonstration of localized gene editing in (mouse) epidermis and a pilot demonstration of localized efficacy of a therapeutic siRNA in a human who has a keratin mutation.
Leachman SA, Hickerson RP, Schwartz ME, Bullough EE, Hutcherson SL, Boucher KM, Hansen CD,Eliason MJ, Srivatsa GS, Kornbrust DJ, Smith FJD, McLean WHI, Milstone LM, Kaspar RL.First-in human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin Disorder.Molec Therapy 18:442-446, 2010
Lara MF, González-González E, Speaker TJ, Hickerson RP, Leake D, Milstone LM, Contag CH, Kaspar RL. Inhibition of CD44 gene expression in human skin models using self-delivery siRNA administered by dissolvable microneedle arrays. Molec Ther, 23:816-823, 2012
Rogers FA, Hu R-H, Milstone LM.Local delivery of gene-modifying triplex-forming molecules to epidermis.J Invest Dermatol, 133:685-691, 2013
Clinical Disorders of Keratinization.As the founder of Yale’s Disorders of Keratinization Clinic and Chair of the Medical and Scientific Advisory Board of F.I.R.S.T. (the Foundation for Ichthyosis and Related Skin Types) I have had many opportunities to contribute to the lay and scientific understanding of those diseases, and to give those patients opportunities to participate in trials of new therapies.Recent projects that I organized include the discovery of a new mechanism for revertant mosaicism in diseased skin and the best available estimate of the incidence of moderate to severe ichthyosis in the United States.The broad collaboration needed to bring new treatments to patients with rare diseases is represented by the 2010 Leachman ref above.
Choate KA, Yu L, Zhou J, Choi M, Elias PM, Farhi A, Nelson-Williams C, Crumrine D, Williams ML, Nopper AJ, Bree A, Milstone LM, Lifton RP.Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10.Science, 330: 94-97, 2010
Milstone LM, Miller K, Haberman M, Dickens J.Incidence of moderate to severe ichthyosis in the United States. Arch Dermatol, 148:1080-1081, 2012
Choate KA, Lu, Y, Zhou J, Elias PM, Zaidi S, Paller AS, Farhi A, Nelson-Williams C, Crumrine D, Milstone LM, Lifton RA. Frequent somatic reversion of KRT1 mutations in ichthyosis with confetti. J Clin Invest, 125:1703-1707, 2015
Coauthors
Research Interests
Ichthyosis
Selected Publications
- 502 The genomic and phenotypic landscape of ichthyosis: An analysis of 1000 kindredsSun Q, Marukian N, Cheraghlou S, Paller A, Larralde M, Bercovitch L, Levinsohn J, Ren I, Hu R, Zhou J, Zaki T, Fan R, Tian C, Saraceni C, Nelson-Williams C, Loring E, Craiglow B, Milstone L, Lifton R, Boyden L, Choate K. 502 The genomic and phenotypic landscape of ichthyosis: An analysis of 1000 kindreds. Journal Of Investigative Dermatology 2022, 142: s85. DOI: 10.1016/j.jid.2022.05.511.
- The Genomic and Phenotypic Landscape of IchthyosisSun Q, Burgren NM, Cheraghlou S, Paller AS, Larralde M, Bercovitch L, Levinsohn J, Ren I, Hu RH, Zhou J, Zaki T, Fan R, Tian C, Saraceni C, Nelson-Williams CJ, Loring E, Craiglow BG, Milstone LM, Lifton RP, Boyden LM, Choate KA. The Genomic and Phenotypic Landscape of Ichthyosis. JAMA Dermatology 2022, 158: 16-25. PMID: 34851365, PMCID: PMC8637393, DOI: 10.1001/jamadermatol.2021.4242.
- Executive summary: Consensus recommendations for the use of retinoids in ichthyosis and other disorders of cornification in children and adolescentsGroup P, Zaenglein A, Levy M, Stefanko N, Benjamin L, Bruckner A, Choate K, Craiglow B, DiGiovanna J, Eichenfield L, Elias P, Fleckman P, Lawley L, Lewis R, Lucky A, Mathes E, Milstone L, Paller A, Patel S, Siegel D, Teng J, Tanumihardjo S, Thaxton L, Williams M. Executive summary: Consensus recommendations for the use of retinoids in ichthyosis and other disorders of cornification in children and adolescents. Journal Of The American Academy Of Dermatology 2021, 86: 158-161. PMID: 34499997, DOI: 10.1016/j.jaad.2021.08.047.
- Discussion of talks from the symposium: Factor X: From thrombokinase to oral anti-coagulants and beyondMilstone LM, Jackson C, Becker RC, Camire R, Knabb R, Mann K, Ruf W, Wexler RR, Wood J. Discussion of talks from the symposium: Factor X: From thrombokinase to oral anti-coagulants and beyond. Journal Of Thrombosis And Thrombolysis 2021, 52: 408-413. PMID: 34637116, PMCID: PMC8506080, DOI: 10.1007/s11239-021-02545-w.
- Guest editors’ introductionMilstone LM, Jackson CM. Guest editors’ introduction. Journal Of Thrombosis And Thrombolysis 2021, 52: 363-363. PMID: 34264437, DOI: 10.1007/s11239-021-02522-3.
- Factor Xa: Thrombokinase from Paul Morawitz to J Haskell MilstoneMilstone LM. Factor Xa: Thrombokinase from Paul Morawitz to J Haskell Milstone. Journal Of Thrombosis And Thrombolysis 2021, 52: 364-370. PMID: 33484373, DOI: 10.1007/s11239-021-02387-6.
- Use of telemedicine for ichthyosis: Patient advocacy group as conduit to expert physician adviceAsch S, Swink SM, Vivar KL, Pickford J, Breuning L, Wassel C, Hand JL, Milstone L, Castelo‐Soccio L. Use of telemedicine for ichthyosis: Patient advocacy group as conduit to expert physician advice. Pediatric Dermatology 2020, 38: 137-142. PMID: 33230835, DOI: 10.1111/pde.14460.
- Consensus recommendations for the use of retinoids in ichthyosis and other disorders of cornification in children and adolescentsZaenglein AL, Levy ML, Stefanko NS, Benjamin LT, Bruckner AL, Choate K, Craiglow BG, DiGiovanna JJ, Eichenfield LF, Elias P, Fleckman P, Lawley LP, Lewis RA, Lucky AW, Mathes EF, Milstone LM, Paller AS, Patel SS, Siegel DH, Teng J, Tanumihardjo SA, Thaxton L, Williams ML, Group P. Consensus recommendations for the use of retinoids in ichthyosis and other disorders of cornification in children and adolescents. Pediatric Dermatology 2020, 38: 164-180. PMID: 33169909, PMCID: PMC7984068, DOI: 10.1111/pde.14408.
- Development or worsening of sarcoidosis associated with IL‐17 blockade for psoriasisHornick N, Wang A, Lim Y, Gehlhausen J, Siegel J, Wang J, Foss F, Lim I, Zubek A, Milstone L, Galan A, King B, Damsky W. Development or worsening of sarcoidosis associated with IL‐17 blockade for psoriasis. Journal Of The European Academy Of Dermatology And Venereology 2020, 34: e583-e585. PMID: 32277505, DOI: 10.1111/jdv.16451.
- Interleukin‐17 blockade downregulates NOD2 in skin and may promote paradoxical sarcoidosisWang A, Hornick N, Lim Y, Gehlhausen J, Siegel J, Wang J, Foss F, Lim I, Zubek A, Milstone L, Galan A, King B, Damsky W. Interleukin‐17 blockade downregulates NOD2 in skin and may promote paradoxical sarcoidosis. Journal Of The European Academy Of Dermatology And Venereology 2020, 34: e497-e499. PMID: 32249470, DOI: 10.1111/jdv.16416.
- Association of the Severity of Alopecia With the Severity of IchthyosisPutterman E, Zaki T, Milstone L, Choate K, Castelo-Soccio L. Association of the Severity of Alopecia With the Severity of Ichthyosis. JAMA Dermatology 2019, 155: 1077-1078. PMID: 31365037, PMCID: PMC6669775, DOI: 10.1001/jamadermatol.2019.1520.
- Alterations in connexin 26 protein structure from lethal keratitis-ichthyosis-deafness syndrome mutations A88V and G45ELilly E, Strickler M, Milstone LM, Bunick CG. Alterations in connexin 26 protein structure from lethal keratitis-ichthyosis-deafness syndrome mutations A88V and G45E. Journal Of Dermatological Science 2019, 95: 119-122. PMID: 31331740, PMCID: PMC7263394, DOI: 10.1016/j.jdermsci.2019.07.002.
- Mutations in PERP Cause Dominant and Recessive KeratodermaDuchatelet S, Boyden LM, Ishida-Yamamoto A, Zhou J, Guibbal L, Hu R, Lim YH, Bole-Feysot C, Nitschké P, Santos-Simarro F, de Lucas R, Milstone LM, Gildenstern V, Helfrich YR, Attardi LD, Lifton RP, Choate KA, Hovnanian A. Mutations in PERP Cause Dominant and Recessive Keratoderma. Journal Of Investigative Dermatology 2018, 139: 380-390. PMID: 30321533, PMCID: PMC6586468, DOI: 10.1016/j.jid.2018.08.026.
- More than keratitis, ichthyosis, and deafness: Multisystem effects of lethal GJB2 mutationsLilly E, Bunick CG, Maley AM, Zhang S, Spraker MK, Theos AJ, Vivar KL, Seminario-Vidal L, Bennett AE, Sidbury R, Ogawa Y, Akiyama M, Binder B, Hadj-Rabia S, Morotti RA, Glusac EJ, Choate KA, Richard G, Milstone LM. More than keratitis, ichthyosis, and deafness: Multisystem effects of lethal GJB2 mutations. Journal Of The American Academy Of Dermatology 2018, 80: 617-625. PMID: 30287322, PMCID: PMC6372339, DOI: 10.1016/j.jaad.2018.09.042.
- 380 Ichthyosis has a moderate impact on quality of life in adultsRen I, Olamiju B, Li L, Deng Y, Marukian N, Zaki T, Zhou J, Hu R, Milstone L, Choate K. 380 Ichthyosis has a moderate impact on quality of life in adults. Journal Of Investigative Dermatology 2018, 138: s64. DOI: 10.1016/j.jid.2018.03.386.
- CARD14-associated papulosquamous eruption: A spectrum including features of psoriasis and pityriasis rubra pilarisCraiglow BG, Boyden LM, Hu R, Virtanen M, Su J, Rodriguez G, McCarthy C, Luna P, Larralde M, Humphrey S, Holland KE, Hogeling M, Hidalgo-Matlock B, Ferrari B, Fernandez-Faith E, Drolet B, Cordoro KM, Bowcock AM, Antaya RJ, Ashack K, Ashack RJ, Lifton RP, Milstone LM, Paller AS, Choate KA. CARD14-associated papulosquamous eruption: A spectrum including features of psoriasis and pityriasis rubra pilaris. Journal Of The American Academy Of Dermatology 2018, 79: 487-494. PMID: 29477734, PMCID: PMC6098739, DOI: 10.1016/j.jaad.2018.02.034.
- Phenotypic spectrum of autosomal recessive congenital ichthyosis due to PNPLA1 mutationBoyden LM, Craiglow BG, Hu RH, Zhou J, Browning J, Eichenfield L, Lim YL, Luu M, Randolph LM, Ginarte M, Fachal L, Rodriguez‐Pazos L, Vega A, Kramer D, Yosipovitch G, Vahidnezhad H, Youssefian L, Uitto J, Lifton RP, Paller AS, Milstone LM, Choate KA. Phenotypic spectrum of autosomal recessive congenital ichthyosis due to PNPLA1 mutation. British Journal Of Dermatology 2017, 177: 319-322. PMID: 28403545, PMCID: PMC5522355, DOI: 10.1111/bjd.15570.
- Establishing and Validating an Ichthyosis Severity IndexMarukian NV, Deng Y, Gan G, Ren I, Thermidor W, Craiglow BG, Milstone LM, Choate KA. Establishing and Validating an Ichthyosis Severity Index. Journal Of Investigative Dermatology 2017, 137: 1834-1841. PMID: 28596001, DOI: 10.1016/j.jid.2017.04.037.
- Expanding the Genotypic Spectrum of Bathing Suit IchthyosisMarukian NV, Hu RH, Craiglow BG, Milstone LM, Zhou J, Theos A, Kaymakcalan H, Akkaya DA, Uitto JJ, Vahidnezhad H, Youssefian L, Bayliss SJ, Paller AS, Boyden LM, Choate KA. Expanding the Genotypic Spectrum of Bathing Suit Ichthyosis. JAMA Dermatology 2017, 153: 537-543. PMID: 28403434, PMCID: PMC5817618, DOI: 10.1001/jamadermatol.2017.0202.
- 452 Alterations to connexin 26 protein structure caused by the lethal keratitis-ichthyosis-deafness syndrome mutations A88V and G45EBunick C, Lilly E, Milstone L. 452 Alterations to connexin 26 protein structure caused by the lethal keratitis-ichthyosis-deafness syndrome mutations A88V and G45E. Journal Of Investigative Dermatology 2017, 137: s78. DOI: 10.1016/j.jid.2017.02.471.
- 291 Establishing and validating an ichthyosis severity indexMarukian N, Deng Y, Gan G, Ren I, Thermidor W, Craiglow B, Milstone L, Choate K. 291 Establishing and validating an ichthyosis severity index. Journal Of Investigative Dermatology 2017, 137: s50. DOI: 10.1016/j.jid.2017.02.307.
- Nail removal in pachyonychia congenita: Patient-reported survey outcomesDeKlotz CMC, Schwartz ME, Milstone LM. Nail removal in pachyonychia congenita: Patient-reported survey outcomes. Journal Of The American Academy Of Dermatology 2017, 76: 990-992. PMID: 28411774, DOI: 10.1016/j.jaad.2016.08.060.
- Palmoplantar Keratoderma in Costello Syndrome Responsive to AcitretinMarukian NV, Levinsohn JL, Craiglow BG, Milstone LM, Choate KA. Palmoplantar Keratoderma in Costello Syndrome Responsive to Acitretin. Pediatric Dermatology 2016, 34: 160-162. PMID: 28008647, DOI: 10.1111/pde.13057.
- The X-Ray Crystal Structure of the Keratin 1-Keratin 10 Helix 2B Heterodimer Reveals Molecular Surface Properties and Biochemical Insights into Human Skin DiseaseBunick CG, Milstone LM. The X-Ray Crystal Structure of the Keratin 1-Keratin 10 Helix 2B Heterodimer Reveals Molecular Surface Properties and Biochemical Insights into Human Skin Disease. Journal Of Investigative Dermatology 2016, 137: 142-150. PMID: 27595935, PMCID: PMC5514376, DOI: 10.1016/j.jid.2016.08.018.
- 383 A novel erythrokeratodermia-cardiomyopathy syndrome is caused by dominant, clustered mutations in desmoplakinBoyden L, Kam C, Hernández-Martín A, Zhou J, Craiglow B, Milstone L, Hu R, Elias P, Green K, Choate K. 383 A novel erythrokeratodermia-cardiomyopathy syndrome is caused by dominant, clustered mutations in desmoplakin. Journal Of Investigative Dermatology 2016, 136: s68. DOI: 10.1016/j.jid.2016.02.416.
- 342 Characterization of the molecular surface properties of keratin 1–keratin 10 intermediate filaments using x-ray crystallographyMilstone L, Bunick C. 342 Characterization of the molecular surface properties of keratin 1–keratin 10 intermediate filaments using x-ray crystallography. Journal Of Investigative Dermatology 2016, 136: s60. DOI: 10.1016/j.jid.2016.02.374.
- Well-Differentiated Syringofibrocarcinoma in a Patient With Clouston SyndromeOdell ID, Lilly E, Reeve K, Bosenberg MW, Milstone LM. Well-Differentiated Syringofibrocarcinoma in a Patient With Clouston Syndrome. JAMA Dermatology 2016, 152: 484. PMID: 26792110, DOI: 10.1001/jamadermatol.2015.4496.
- Recurrent Coxsackievirus Infection in a Patient with Lamellar IchthyosisDamsky WE, Leventhal JS, Khalil D, Vesely MD, Craiglow BG, Milstone LM, Choate KA. Recurrent Coxsackievirus Infection in a Patient with Lamellar Ichthyosis. Pediatric Dermatology 2016, 33: e140-e142. PMID: 26821985, PMCID: PMC7226923, DOI: 10.1111/pde.12769.
- Connexin channels in congenital skin disordersLilly E, Sellitto C, Milstone LM, White TW. Connexin channels in congenital skin disorders. Seminars In Cell And Developmental Biology 2016, 50: 4-12. PMID: 26775130, PMCID: PMC4779425, DOI: 10.1016/j.semcdb.2015.11.018.
- Imaging Functional Nucleic Acid Delivery to SkinKaspar RL, Hickerson RP, González-González E, Flores MA, Speaker TP, Rogers FA, Milstone LM, Contag CH. Imaging Functional Nucleic Acid Delivery to Skin. 2016, 1372: 1-24. PMID: 26530911, DOI: 10.1007/978-1-4939-3148-4_1.
- The Protein Acyl Transferase ZDHHC21 Modulates &agr;1 Adrenergic Receptor Function and Regulates HemodynamicsMarin EP, Jozsef L, Di Lorenzo A, Held KF, Luciano AK, Melendez J, Milstone LM, Velazquez H, Sessa WC. The Protein Acyl Transferase ZDHHC21 Modulates &agr;1 Adrenergic Receptor Function and Regulates Hemodynamics. Arteriosclerosis Thrombosis And Vascular Biology 2015, 36: 370-379. PMID: 26715683, PMCID: PMC4984414, DOI: 10.1161/atvbaha.115.306942.
- Expanding the Phenotypic Spectrum of Olmsted SyndromeWilson NJ, Cole C, Milstone LM, Kiszewski AE, Hansen CD, O'Toole EA, Schwartz ME, McLean WH, Smith FJ. Expanding the Phenotypic Spectrum of Olmsted Syndrome. Journal Of Investigative Dermatology 2015, 135: 2879-2883. PMID: 26067147, PMCID: PMC4652067, DOI: 10.1038/jid.2015.217.
- Frequent somatic reversion of KRT1 mutations in ichthyosis with confettiChoate KA, Lu Y, Zhou J, Elias PM, Zaidi S, Paller AS, Farhi A, Nelson-Williams C, Crumrine D, Milstone LM, Lifton RP. Frequent somatic reversion of KRT1 mutations in ichthyosis with confetti. Journal Of Clinical Investigation 2015, 125: 1703-1707. PMID: 25774499, PMCID: PMC4396494, DOI: 10.1172/jci64415.
- Crystal Structure of Human Profilaggrin S100 Domain and Identification of Target Proteins Annexin II, Stratifin, and HSP27Bunick CG, Presland RB, Lawrence OT, Pearton DJ, Milstone LM, Steitz TA. Crystal Structure of Human Profilaggrin S100 Domain and Identification of Target Proteins Annexin II, Stratifin, and HSP27. Journal Of Investigative Dermatology 2015, 135: 1801-1809. PMID: 25760235, PMCID: PMC4466033, DOI: 10.1038/jid.2015.102.
- Gene expression profiling in pachyonychia congenita skinCao YA, Hickerson RP, Seegmiller BL, Grapov D, Gross MM, Bessette MR, Phinney BS, Flores MA, Speaker TJ, Vermeulen A, Bravo AA, Bruckner AL, Milstone LM, Schwartz ME, Rice RH, Kaspar RL. Gene expression profiling in pachyonychia congenita skin. Journal Of Dermatological Science 2015, 77: 156-165. PMID: 25656049, PMCID: PMC4374015, DOI: 10.1016/j.jdermsci.2015.01.001.
- Phenotypic Expansion in Ichthyosis With ConfettiChoate KA, Milstone LM. Phenotypic Expansion in Ichthyosis With Confetti. JAMA Dermatology 2015, 151: 15-16. PMID: 25210951, PMCID: PMC6319358, DOI: 10.1001/jamadermatol.2014.2525.
- The molecular genetic analysis of the expanding pachyonychia congenita case collectionWilson N, O'Toole E, Milstone L, Hansen C, Shepherd A, Al‐Asadi E, Schwartz M, McLean W, Sprecher E, Smith F. The molecular genetic analysis of the expanding pachyonychia congenita case collection. British Journal Of Dermatology 2014, 171: 343-355. PMID: 24611874, PMCID: PMC4282083, DOI: 10.1111/bjd.12958.
- Report of the 10th Annual International Pachyonychia Congenita Consortium Meetingvan Steensel MAM, Coulombe PA, Kaspar RL, Milstone LM, McLean IWH, Roop DR, Smith FJD, Sprecher E, Schwartz ME. Report of the 10th Annual International Pachyonychia Congenita Consortium Meeting. Journal Of Investigative Dermatology 2014, 134: 588-591. PMID: 24518109, PMCID: PMC3930927, DOI: 10.1038/jid.2013.392.
- Harlequin Ichthyosis: Neonatal Management and Identification of a New ABCA12 MutationKoochek A, Choate KA, Milstone LM. Harlequin Ichthyosis: Neonatal Management and Identification of a New ABCA12 Mutation. Pediatric Dermatology 2013, 31: e63-e64. PMID: 24274932, DOI: 10.1111/pde.12263.
- Mutations in TGM1 in Ecuadorians with autosomal recessive congenital ichthyosisZambrano H, Montalvan M, Cabezas J, Lu Y, Yang CS, Milstone LM, Choate K. Mutations in TGM1 in Ecuadorians with autosomal recessive congenital ichthyosis. International Journal Of Dermatology 2013, 53: e312-e313. PMID: 24261627, PMCID: PMC4861992, DOI: 10.1111/ijd.12227.
- Improving outcomes for harlequin ichthyosisMilstone LM, Choate KA. Improving outcomes for harlequin ichthyosis. Journal Of The American Academy Of Dermatology 2013, 69: 808-809. PMID: 24124810, DOI: 10.1016/j.jaad.2013.06.017.
- Topical Tazarotene for the Treatment of Ectropion in IchthyosisCraiglow BG, Choate KA, Milstone LM. Topical Tazarotene for the Treatment of Ectropion in Ichthyosis. JAMA Dermatology 2013, 149: 598-600. PMID: 23677086, PMCID: PMC3809825, DOI: 10.1001/jamadermatol.2013.239.
- The molecular genetic analysis of the expanding pachyonychia congenita case collectionWilson N, O’Toole E, Milstone L, Hansen C, Shepherd A, Al-Asadi E, Schwartz M, McLean W, Sprecher E, Smith F. The molecular genetic analysis of the expanding pachyonychia congenita case collection. Journal Of Dermatological Science 2013, 69: e56. DOI: 10.1016/j.jdermsci.2012.11.472.
- Management of ichthyosis and related conditionsRichard G, Choate K, Milstone L, Bale S. Management of ichthyosis and related conditions. Dermatologic Therapy 2013, 26: 55-68. PMID: 23384021, DOI: 10.1111/j.1529-8019.2012.01553.x.
- Management of ichthyoses and related skin typesDiGiovanna JJ, Mauro T, Milstone LM, Schmuth M, Toro JR. Management of ichthyoses and related skin types. Dermatologic Therapy 2013, 26: 26-38. PMID: 23384018, PMCID: PMC3884695, DOI: 10.1111/j.1529-8019.2012.01527.x.
- Local Delivery of Gene-Modifying Triplex-Forming Molecules to the EpidermisRogers FA, Hu RH, Milstone LM. Local Delivery of Gene-Modifying Triplex-Forming Molecules to the Epidermis. Journal Of Investigative Dermatology 2012, 133: 685-691. PMID: 23014335, PMCID: PMC3532560, DOI: 10.1038/jid.2012.351.
- Incidence of Moderate to Severe Ichthyosis in the United StatesMilstone LM, Miller K, Haberman M, Dickens J. Incidence of Moderate to Severe Ichthyosis in the United States. JAMA Dermatology 2012, 148: 1080-1081. PMID: 22986871, DOI: 10.1001/archdermatol.2012.1702.
- Inhibition of CD44 Gene Expression in Human Skin Models, Using Self-Delivery Short Interfering RNA Administered by Dissolvable Microneedle ArraysLara MF, González-González E, Speaker TJ, Hickerson RP, Leake D, Milstone LM, Contag CH, Kaspar RL. Inhibition of CD44 Gene Expression in Human Skin Models, Using Self-Delivery Short Interfering RNA Administered by Dissolvable Microneedle Arrays. Human Gene Therapy 2012, 23: 816-823. PMID: 22480249, PMCID: PMC3413896, DOI: 10.1089/hum.2011.211.
- Impact of epidermal desquamation on tissue stores of ironMilstone LM, Hu RH, Dziura JD, Zhou J. Impact of epidermal desquamation on tissue stores of iron. Journal Of Dermatological Science 2012, 67: 9-14. PMID: 22575277, PMCID: PMC3374011, DOI: 10.1016/j.jdermsci.2012.04.003.
- Interferon- γ Release AssayMilstone LM, Waksman BH. Interferon- γ Release Assay. JAMA Dermatology 2012, 148: 133-134. PMID: 22250255, DOI: 10.1001/archdermatol.2011.2077.
- Pityriasis rubra pilaris: the clinical context of acantholysis and other histologic featuresKo CJ, Milstone LM, Choi J, McNiff JM. Pityriasis rubra pilaris: the clinical context of acantholysis and other histologic features. International Journal Of Dermatology 2011, 50: 1480-1485. PMID: 22097993, DOI: 10.1111/j.1365-4632.2011.04990.x.
- Visualization of plasmid delivery to keratinocytes in mouse and human epidermisGonzález-González E, Kim YC, Speaker TJ, Hickerson RP, Spitler R, Birchall JC, Lara MF, Hu RH, Liang Y, Kirkiles-Smith N, Prausnitz MR, Milstone LM, Contag CH, Kaspar RL. Visualization of plasmid delivery to keratinocytes in mouse and human epidermis. Scientific Reports 2011, 1: 158. PMID: 22355673, PMCID: PMC3240989, DOI: 10.1038/srep00158.
- An appraisal of oral retinoids in the treatment of pachyonychia congenitaGruber R, Edlinger M, Kaspar RL, Hansen CD, Leachman S, Milstone LM, Smith FJ, Sidoroff A, Fritsch PO, Schmuth M. An appraisal of oral retinoids in the treatment of pachyonychia congenita. Journal Of The American Academy Of Dermatology 2011, 66: e193-e199. PMID: 21601946, DOI: 10.1016/j.jaad.2011.02.003.
- A Large Mutational Study in Pachyonychia CongenitaWilson NJ, Leachman SA, Hansen CD, McMullan AC, Milstone LM, Schwartz ME, McLean WH, Hull PR, Smith FJ. A Large Mutational Study in Pachyonychia Congenita. Journal Of Investigative Dermatology 2011, 131: 1018-1024. PMID: 21326300, DOI: 10.1038/jid.2011.20.
- Meeting Report from Frontiers in Ichthyosis ResearchMilstone LM, Rizzo WB, Pickford JR. Meeting Report from Frontiers in Ichthyosis Research. Journal Of Investigative Dermatology 2011, 131: 279-282. PMID: 21228807, PMCID: PMC6028019, DOI: 10.1038/jid.2010.338.
- Development of Quantitative Molecular Clinical End Points for siRNA Clinical TrialsHickerson RP, Leachman SA, Pho LN, Gonzalez-Gonzalez E, Smith FJ, McLean WH, Contag CH, Leake D, Milstone LM, Kaspar RL. Development of Quantitative Molecular Clinical End Points for siRNA Clinical Trials. Journal Of Investigative Dermatology 2010, 131: 1029-1036. PMID: 21191405, DOI: 10.1038/jid.2010.372.
- Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorèze 2009Oji V, Tadini G, Akiyama M, Bardon C, Bodemer C, Bourrat E, Coudiere P, DiGiovanna JJ, Elias P, Fischer J, Fleckman P, Gina M, Harper J, Hashimoto T, Hausser I, Hennies HC, Hohl D, Hovnanian A, Ishida-Yamamoto A, Jacyk WK, Leachman S, Leigh I, Mazereeuw-Hautier J, Milstone L, Morice-Picard F, Paller AS, Richard G, Schmuth M, Shimizu H, Sprecher E, Van Steensel M, Taïeb A, Toro JR, Vabres P, Vahlquist A, Williams M, Traupe H. Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorèze 2009. Journal Of The American Academy Of Dermatology 2010, 63: 607-641. PMID: 20643494, DOI: 10.1016/j.jaad.2009.11.020.
- Mitotic Recombination in Patients with Ichthyosis Causes Reversion of Dominant Mutations in KRT10Choate KA, Lu Y, Zhou J, Choi M, Elias PM, Farhi A, Nelson-Williams C, Crumrine D, Williams ML, Nopper AJ, Bree A, Milstone LM, Lifton RP. Mitotic Recombination in Patients with Ichthyosis Causes Reversion of Dominant Mutations in KRT10. Science 2010, 330: 94-97. PMID: 20798280, PMCID: PMC3085938, DOI: 10.1126/science.1192280.
- Scaly skin and bath pH: Rediscovering baking sodaMilstone LM. Scaly skin and bath pH: Rediscovering baking soda. Journal Of The American Academy Of Dermatology 2010, 62: 885-886. PMID: 20398816, DOI: 10.1016/j.jaad.2009.04.011.
- First-in-human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin DisorderLeachman SA, Hickerson RP, Schwartz ME, Bullough EE, Hutcherson SL, Boucher KM, Hansen CD, Eliason MJ, Srivatsa GS, Kornbrust DJ, Smith FJ, McLean WI, Milstone LM, Kaspar RL. First-in-human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin Disorder. Molecular Therapy 2009, 18: 442-446. PMID: 19935778, PMCID: PMC2839285, DOI: 10.1038/mt.2009.273.
- Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenitaLeachman SA, Hickerson RP, Hull PR, Smith FJ, Milstone LM, Lane EB, Bale SJ, Roop DR, McLean WH, Kaspar RL. Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita. Journal Of Dermatological Science 2008, 51: 151-157. PMID: 18495438, PMCID: PMC2587483, DOI: 10.1016/j.jdermsci.2008.04.003.
- Single-Nucleotide-Specific siRNA Targeting in a Dominant-Negative Skin ModelHickerson RP, Smith FJ, Reeves RE, Contag CH, Leake D, Leachman SA, Milstone LM, McLean WH, Kaspar RL. Single-Nucleotide-Specific siRNA Targeting in a Dominant-Negative Skin Model. Journal Of Investigative Dermatology 2007, 128: 594-605. PMID: 17914454, DOI: 10.1038/sj.jid.5701060.
- Aaron Lerner RememberedMilstone LM, Milstone EB. Aaron Lerner Remembered. Journal Of Investigative Dermatology 2007, 127: 2092-2094. PMID: 17700617, DOI: 10.1038/sj.jid.5701006.
- Obstacles to Translation ConferenceEpstein EH, Gilchrest BA, Milstone LM. Obstacles to Translation Conference. Journal Of Investigative Dermatology 2006, 126: 1434-1437. PMID: 16778808, DOI: 10.1038/sj.jid.5700420.
- Barrier Dysfunction and Pathogenesis of Neutral Lipid Storage Disease with Ichthyosis (Chanarin–Dorfman Syndrome)Demerjian M, Crumrine DA, Milstone LM, Williams ML, Elias PM. Barrier Dysfunction and Pathogenesis of Neutral Lipid Storage Disease with Ichthyosis (Chanarin–Dorfman Syndrome). Journal Of Investigative Dermatology 2006, 126: 2032-2038. PMID: 16741516, DOI: 10.1038/sj.jid.5700332.
- Stratum-Specific Expression of Human Transferrin Receptor Increases Iron in Mouse EpidermisMilstone LM, Adams BD, Zhou J, Sanchez V, Shofner J. Stratum-Specific Expression of Human Transferrin Receptor Increases Iron in Mouse Epidermis. Journal Of Investigative Dermatology 2006, 126: 648-652. PMID: 16424878, PMCID: PMC2243218, DOI: 10.1038/sj.jid.5700127.
- Iron in Skin of Mice with Three Etiologies of Systemic Iron OverloadAdams BD, Lazova R, Andrews NC, Milstone LM. Iron in Skin of Mice with Three Etiologies of Systemic Iron Overload. Journal Of Investigative Dermatology 2005, 125: 1200-1205. PMID: 16354190, PMCID: PMC2243217, DOI: 10.1111/j.0022-202x.2005.23949.x.
- Treatment of Pachyonychia CongenitaMilstone LM, Fleckman P, Leachman SA, Leigh IM, Paller AS, van Steensel MA, Swartling C. Treatment of Pachyonychia Congenita. Journal Of Investigative Dermatology Symposium Proceedings 2005, 10: 18-20. PMID: 16250205, DOI: 10.1111/j.1087-0024.2005.10203.x.
- Gene Therapy for Autosomal Dominant Disorders of KeratinLewin AS, Glazer PM, Milstone LM. Gene Therapy for Autosomal Dominant Disorders of Keratin. Journal Of Investigative Dermatology Symposium Proceedings 2005, 10: 47-61. PMID: 16250209, DOI: 10.1111/j.1087-0024.2005.10207.x.
- Clinical and Pathological Features of Pachyonychia CongenitaLeachman SA, Kaspar RL, Fleckman P, Florell SR, Smith FJ, McLean WH, Lunny DP, Milstone LM, van Steensel MA, Munro CS, O'Toole EA, Celebi JT, Kansky A, Lane E. Clinical and Pathological Features of Pachyonychia Congenita. Journal Of Investigative Dermatology Symposium Proceedings 2005, 10: 3-17. PMID: 16250204, DOI: 10.1111/j.1087-0024.2005.10202.x.
- Isotretinoin does have an adverse effect on bone mineral densityMilstone LM, Insogna KL, Leachman SA. Isotretinoin does have an adverse effect on bone mineral density. Journal Of The American Academy Of Dermatology 2005, 53: 181. PMID: 15965453, DOI: 10.1016/j.jaad.2005.03.025.
- Epidermal desquamationMilstone LM. Epidermal desquamation. Journal Of Dermatological Science 2004, 36: 131-140. PMID: 15541634, DOI: 10.1016/j.jdermsci.2004.05.004.
- Long-Term Murine Keratinocyte Cultures Become Tetraploid, Yet Maintain the Ability to StratifySanchez V, Zhou J, LaCivita D, Milstone L. Long-Term Murine Keratinocyte Cultures Become Tetraploid, Yet Maintain the Ability to Stratify. Journal Of Investigative Dermatology 2004, 123: 403-404. PMID: 15245442, DOI: 10.1111/j.0022-202x.2004.23218.x.
- Is retinoid-induced osteopenia reversible?Milstone AM, Milstone LM. Is retinoid-induced osteopenia reversible? JAMA Dermatology 2002, 138: 1516-7. PMID: 12437467, DOI: 10.1001/archderm.138.11.1516-a.
- Clinical and in vitro responses of bilayered skin construct (graftskin) to meshing.Jansen DA, Asgari MM, Atillasoy ES, Milstone LM. Clinical and in vitro responses of bilayered skin construct (graftskin) to meshing. JAMA Dermatology 2002, 138: 843-4. PMID: 12056981, DOI: 10.1001/archderm.138.6.843.
- Photodegraded Nifedipine Stimulates Uptake and Retention of Iron in Human Epidermal KeratinocytesGruen A, Zhou J, Milstone L, Morton K. Photodegraded Nifedipine Stimulates Uptake and Retention of Iron in Human Epidermal Keratinocytes. Journal Of Investigative Dermatology 2001, 116: 774-777. PMID: 11348469, DOI: 10.1046/j.1523-1747.2001.01318.x.
- Delayed‐onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16Connors J, Rahil A, Smith F, Mclean W, Milstone L. Delayed‐onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16. British Journal Of Dermatology 2001, 144: 1058-1062. PMID: 11359398, DOI: 10.1046/j.1365-2133.2001.04199.x.
- Bone Densities in Patients Receiving Isotretinoin for Cystic AcneLeachman SA, Insogna KL, Katz L, Ellison A, Milstone LM. Bone Densities in Patients Receiving Isotretinoin for Cystic Acne. JAMA Dermatology 1999, 135: 961-965. PMID: 10456346, DOI: 10.1001/archderm.135.8.961.
- Expression and localization of thymidine phosphorylase/platelet‐derived endothelial cell growth factor in skin and cutaneous tumorsAsgari M, Haggerty J, McNiff J, Milstone L, Schwartz P. Expression and localization of thymidine phosphorylase/platelet‐derived endothelial cell growth factor in skin and cutaneous tumors. Journal Of Cutaneous Pathology 1999, 26: 287-294. PMID: 10472757, DOI: 10.1111/j.1600-0560.1999.tb01846.x.
- Growth and differentiation regulate CD44 expression on human keratinocytesZhou J, Haggerty J, Milstone L. Growth and differentiation regulate CD44 expression on human keratinocytes. In Vitro Cellular & Developmental Biology - Animal 1999, 35: 228-235. PMID: 10478803, DOI: 10.1007/s11626-999-0031-7.
- PURPLE (oops! Atrophie blanche) revisited.Milstone L, Braverman I. PURPLE (oops! Atrophie blanche) revisited. JAMA Dermatology 1998, 134: 1634. PMID: 9875208, DOI: 10.1001/archderm.134.12.1634.
- Pneumocystis carinii pneumonia complicating methotrexate treatment of pityriasis rubra pilarisDuncan K, Imaeda S, Milstone L. Pneumocystis carinii pneumonia complicating methotrexate treatment of pityriasis rubra pilaris. Journal Of The American Academy Of Dermatology 1998, 39: 276-278. PMID: 9704846, DOI: 10.1016/s0190-9622(98)70088-x.
- Use of Apligraf® (graftskin) to study cytokine expression during wound healingAsgari M, Milstone L, Atillasoy E, Schwartz P. Use of Apligraf® (graftskin) to study cytokine expression during wound healing. Journal Of Dermatological Science 1998, 16: s85. DOI: 10.1016/s0923-1811(98)83503-2.
- Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in skin tumorsAsgari M, Madison-McNiff J, Milstone L, Schwartz P. Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in skin tumors. Journal Of Dermatological Science 1998, 16: s156. DOI: 10.1016/s0923-1811(98)83934-0.
- CD44 Expression on Epidermal MelanocytesHerbold K, Zhou J, Haggerty J, Milstone L. CD44 Expression on Epidermal Melanocytes. Journal Of Investigative Dermatology 1996, 106: 1230-1235. PMID: 8752662, DOI: 10.1111/1523-1747.ep12348871.
- Histologic findings in acute HIV exanthemGoldman G, Milstone L, Shapiro P. Histologic findings in acute HIV exanthem. Journal Of Cutaneous Pathology 1995, 22: 371-373. PMID: 7499579, DOI: 10.1111/j.1600-0560.1995.tb01422.x.
- Generalized Linear Porokeratosis Treated With EtretinateGoldman G, Milstone L. Generalized Linear Porokeratosis Treated With Etretinate. JAMA Dermatology 1995, 131: 496-497. DOI: 10.1001/archderm.1995.01690160126029.
- Keratinocytes differentiate in response to inhibitors of deoxyribonucleotide synthesisSchwartz P, Barnett S, Milstone L. Keratinocytes differentiate in response to inhibitors of deoxyribonucleotide synthesis. Journal Of Dermatological Science 1995, 9: 129-135. PMID: 7772575, DOI: 10.1016/0923-1811(94)00370-t.
- Epican, a heparan/chondroitin sulfate proteoglycan form of CD44, mediates cell-cell adhesionMilstone L, Hough-Monroe L, Kugelman L, Bender J, Haggerty J. Epican, a heparan/chondroitin sulfate proteoglycan form of CD44, mediates cell-cell adhesion. Journal Of Cell Science 1994, 107: 3183-3190. PMID: 7699015, DOI: 10.1242/jcs.107.11.3183.
- Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.Wysolmerski JJ, Broadus AE, Zhou J, Fuchs E, Milstone LM, Philbrick WM. Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 1133-1137. PMID: 7508121, PMCID: PMC521468, DOI: 10.1073/pnas.91.3.1133.
- Response of stratified cultures of human keratinocytes to disruption of proteoglycan synthesis by p‐nitrophenyl‐β‐D‐xylopyranosideHaggerty J, Bretton R, Milstone L. Response of stratified cultures of human keratinocytes to disruption of proteoglycan synthesis by p‐nitrophenyl‐β‐D‐xylopyranoside. Journal Of Cellular Physiology 1994, 158: 39-46. PMID: 8263027, DOI: 10.1002/jcp.1041580106.
- Dermatosparaxis in Children: A Case Report and Review of the Newly Recognized PhenotypePetty E, Seashore M, Braverman I, Spiesel S, Smith L, Milstone L. Dermatosparaxis in Children: A Case Report and Review of the Newly Recognized Phenotype. JAMA Dermatology 1993, 129: 1310-1315. DOI: 10.1001/archderm.1993.01680310080014.
- Dermatosparaxis in children. A case report and review of the newly recognized phenotype.Petty EM, Seashore MR, Braverman IM, Spiesel SZ, Smith LT, Milstone LM. Dermatosparaxis in children. A case report and review of the newly recognized phenotype. JAMA Dermatology 1993, 129: 1310-5. PMID: 8215497, DOI: 10.1001/archderm.129.10.1310.
- Epican, a heparan sulfate proteoglycan form of CD44 on keratinocytes, is a cell-cell adhesion moleculeMilstone L, Kugelman L, Haggerty J. Epican, a heparan sulfate proteoglycan form of CD44 on keratinocytes, is a cell-cell adhesion molecule. Journal Of Dermatological Science 1993, 6: 62. DOI: 10.1016/0923-1811(93)91071-2.
- Secondary Hyperparathyroidism in Patients With Ichthyosis Is Not Caused by Vitamin D Deficiency or Ingestion of RetinoidsMilstone L, Bale S, Insogna K. Secondary Hyperparathyroidism in Patients With Ichthyosis Is Not Caused by Vitamin D Deficiency or Ingestion of Retinoids. JAMA Dermatology 1993, 129: 648-648. PMID: 8481031, DOI: 10.1001/archderm.1993.01680260120024.
- The Effects of Isotretinoin on the Axial Skeleton and the Retinoid Effect-ReplyMilstone L, Insogna K. The Effects of Isotretinoin on the Axial Skeleton and the Retinoid Effect-Reply. JAMA Dermatology 1992, 128: 1650-1650. DOI: 10.1001/archderm.1992.04530010086018.
- The Core Protein of Epican, a Heparan Sulfate Proteoglycan on Keratinocytes, Is an Alternative Form of CD44Kugelman L, Ganguly S, Haggerty J, Weissman S, Milstone L. The Core Protein of Epican, a Heparan Sulfate Proteoglycan on Keratinocytes, Is an Alternative Form of CD44. Journal Of Investigative Dermatology 1992, 99: 887-891. PMID: 1281868, DOI: 10.1111/1523-1747.ep12614896.
- The Core Protein of Epican, a Heparan Sulfate Proteoglycan on Keratinocytes, Is an Alternative Form of CD44Kugelman L, Ganguly S, Haggerty J, Weissman S, Milstone L. The Core Protein of Epican, a Heparan Sulfate Proteoglycan on Keratinocytes, Is an Alternative Form of CD44. Journal Of Investigative Dermatology 1992, 99: 381-385. DOI: 10.1111/1523-1747.ep12616092.
- Identification and Characterization of a Cell Surface Proteoglycan on KeratinocytesHaggerty J, Bretton R, Milstone L. Identification and Characterization of a Cell Surface Proteoglycan on Keratinocytes. Journal Of Investigative Dermatology 1992, 99: 374-380. PMID: 1401993, DOI: 10.1111/1523-1747.ep12616087.
- Parathyroid hormone-related protein. Evidence for secretion of a novel mid-region fragment by three different cell types.Soifer NE, Dee KE, Insogna KL, Burtis WJ, Matovcik LM, Wu TL, Milstone LM, Broadus AE, Philbrick WM, Stewart AF. Parathyroid hormone-related protein. Evidence for secretion of a novel mid-region fragment by three different cell types. Journal Of Biological Chemistry 1992, 267: 18236-18243. PMID: 1517251, DOI: 10.1016/s0021-9258(19)37178-9.
- Human dermatosparaxis: a form of Ehlers-Danlos syndrome that results from failure to remove the amino-terminal propeptide of type I procollagen.Smith L, Wertelecki W, Milstone L, Petty E, Seashore M, Braverman I, Jenkins T, Byers P. Human dermatosparaxis: a form of Ehlers-Danlos syndrome that results from failure to remove the amino-terminal propeptide of type I procollagen. American Journal Of Human Genetics 1992, 51: 235-44. PMID: 1642226, PMCID: PMC1682688.
- Serum Parathyroid Hormone Level Is Elevated in Some Patients With Disorders of KeratinizationMilstone LM, Ellison AF, Insogna KL. Serum Parathyroid Hormone Level Is Elevated in Some Patients With Disorders of Keratinization. JAMA Dermatology 1992, 128: 926-930. PMID: 1320849, DOI: 10.1001/archderm.1992.01680170058005.
- Analysis of PTHRP binding and signal transduction mechanisms in benign and malignant squamous cellsOrloff J, Ganz M, Ribaudo A, Burtis W, Reiss M, Milstone L, Stewart A. Analysis of PTHRP binding and signal transduction mechanisms in benign and malignant squamous cells. American Journal Of Physiology 1992, 262: e599-e607. PMID: 1590371, DOI: 10.1152/ajpendo.1992.262.5.e599.
- Parathyroid hormone-related protein is a paracrine regulator of prostaglandin E2 and fibronectin production in skinInsogna K, Isales C, Milstone L. Parathyroid hormone-related protein is a paracrine regulator of prostaglandin E2 and fibronectin production in skin. Bone And Mineral 1992, 17: 125. DOI: 10.1016/0169-6009(92)91841-6.
- Hyaluronidase from infective Ancylostoma hookworm larvae and its possible function as a virulence factor in tissue invasion and in cutaneous larva migrans.Hotez P, Narasimhan S, Haggerty J, Milstone L, Bhopale V, Schad G, Richards F. Hyaluronidase from infective Ancylostoma hookworm larvae and its possible function as a virulence factor in tissue invasion and in cutaneous larva migrans. Infection And Immunity 1992, 60: 1018-23. PMID: 1541516, PMCID: PMC257588, DOI: 10.1128/iai.60.3.1018-1023.1992.
- Methotrexate induces differentiation of human keratinocytes.Schwartz P, Barnett S, Atillasoy E, Milstone L. Methotrexate induces differentiation of human keratinocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 594-598. PMID: 1731329, PMCID: PMC48285, DOI: 10.1073/pnas.89.2.594.
- ReplyMilstone L, Atillasoy E, Burtis W. Reply. Journal Of Investigative Dermatology 1991, 97: 1086. DOI: 10.1111/1523-1747.ep12492619.
- Quantitation of cross-linked protein: An alternative to counting cornified envelopes as an index of keratinocyte differentiationHough-Monroe L, Milstone L. Quantitation of cross-linked protein: An alternative to counting cornified envelopes as an index of keratinocyte differentiation. Analytical Biochemistry 1991, 199: 25-28. PMID: 1807158, DOI: 10.1016/0003-2697(91)90264-t.
- Glycosylation of parathyroid hormone-related peptide secreted by human epidermal keratinocytes.Wu T, Soifer N, Burtis W, Milstone L, Stewart A. Glycosylation of parathyroid hormone-related peptide secreted by human epidermal keratinocytes. The Journal Of Clinical Endocrinology & Metabolism 1991, 73: 1002-7. PMID: 1939513, DOI: 10.1210/jcem-73-5-1002.
- Immunoaffinity purification of parathyroid hormone‐related protein from bovine milk and human keratinocyte‐conditioned mediumStewart A, Wu T, Insogna K, Milstone L, Burtis W. Immunoaffinity purification of parathyroid hormone‐related protein from bovine milk and human keratinocyte‐conditioned medium. Journal Of Bone And Mineral Research 1991, 6: 305-311. PMID: 2035357, DOI: 10.1002/jbmr.5650060313.
- Immunohistochemical Localization of Parathyroid Hormone-Related Protein (PTHRP) In Normal Human SkinAtillasoy E, Burtis W, Milstone L. Immunohistochemical Localization of Parathyroid Hormone-Related Protein (PTHRP) In Normal Human Skin. Journal Of Investigative Dermatology 1991, 96: 277-280. PMID: 1991989, DOI: 10.1111/1523-1747.ep12464480.
- Antiviral Activity of 5-Iodo-2’-Deoxyuridine and Related Drugs in Human Keratinocytes Infected in vitro with Herpes simplex Virus Type 1Reuveni H, Bull CO, Landry ML, Milstone LM, Schwartz PM. Antiviral Activity of 5-Iodo-2’-Deoxyuridine and Related Drugs in Human Keratinocytes Infected in vitro with Herpes simplex Virus Type 1. Skin Pharmacology And Physiology 1991, 4: 291-297. PMID: 1665069, DOI: 10.1159/000210964.
- Metalloproteases of infective Ancylostoma hookworm larvae and their possible functions in tissue invasion and ecdysis.Hotez P, Haggerty J, Hawdon J, Milstone L, Gamble H, Schad G, Richards F. Metalloproteases of infective Ancylostoma hookworm larvae and their possible functions in tissue invasion and ecdysis. Infection And Immunity 1990, 58: 3883-92. PMID: 2254016, PMCID: PMC313750, DOI: 10.1128/iai.58.12.3883-3892.1990.
- Measurement of retinoid effects on epidermal renewalMilstone L. Measurement of retinoid effects on epidermal renewal. 1990, 190: 76-81. PMID: 2087197, DOI: 10.1016/0076-6879(90)90011-o.
- Dipyridamole Potentiates the Growth-Inhibitory Action of Methotrexate and 5-Fluorouracil in Human Keratinocytes In VitroSchwartz P, Milstone L. Dipyridamole Potentiates the Growth-Inhibitory Action of Methotrexate and 5-Fluorouracil in Human Keratinocytes In Vitro. Journal Of Investigative Dermatology 1989, 93: 523-527. PMID: 2476512, DOI: 10.1111/1523-1747.ep12284073.
- In Vivo Fluorescence of Human Skin-ReplyLeffell D, Stetz M, Milstone L, Deckelbaum L. In Vivo Fluorescence of Human Skin-Reply. JAMA Dermatology 1989, 125: 999-1000. DOI: 10.1001/archderm.1989.01670190133021.
- Native and a synthetic analogue of the malignancy-associated parathyroid hormone-like protein have in vitro transforming growth factor-like properties.Insogna KL, Stewart AF, Morris CA, Hough LM, Milstone LM, Centrella M. Native and a synthetic analogue of the malignancy-associated parathyroid hormone-like protein have in vitro transforming growth factor-like properties. Journal Of Clinical Investigation 1989, 83: 1057-1060. PMID: 2537846, PMCID: PMC303783, DOI: 10.1172/jci113947.
- PrefaceMilstone L. Preface. Annals Of The New York Academy Of Sciences 1988, 548: ix-ix. DOI: 10.1111/j.1749-6632.1988.tb18786.x.
- Effector Functions of Epidermal KeratinocytesMILSTONE L. Effector Functions of Epidermal Keratinocytes. Annals Of The New York Academy Of Sciences 1988, 548: 1-3. PMID: 2470284, DOI: 10.1111/j.1749-6632.1988.tb18787.x.
- Local and Systemic Implications of Thymidine Catabolism by Human KeratinocytesaSCHWARTZ P, REUVENI H, MILSTONE L. Local and Systemic Implications of Thymidine Catabolism by Human Keratinocytesa. Annals Of The New York Academy Of Sciences 1988, 548: 115-124. PMID: 2470288, DOI: 10.1111/j.1749-6632.1988.tb18798.x.
- Two distinct tumor-derived, parathyroid hormone-like peptides result from alternative ribonucleic acid splicing.Mangin M, Ikeda K, Dreyer B, Milstone L, Broadus A. Two distinct tumor-derived, parathyroid hormone-like peptides result from alternative ribonucleic acid splicing. Endocrinology 1988, 2: 1049-55. PMID: 2464747, DOI: 10.1210/mend-2-11-1049.
- In Vivo Fluorescence of Human Skin: A Potential Marker of PhotoagingLeffell D, Stetz M, Milstone L, Deckelbaum L. In Vivo Fluorescence of Human Skin: A Potential Marker of Photoaging. JAMA Dermatology 1988, 124: 1514-1518. DOI: 10.1001/archderm.1988.01670100016005.
- In vivo fluorescence of human skin. A potential marker of photoaging.Leffell DJ, Stetz ML, Milstone LM, Deckelbaum LI. In vivo fluorescence of human skin. A potential marker of photoaging. JAMA Dermatology 1988, 124: 1514-8. PMID: 3421727, DOI: 10.1001/archderm.124.10.1514.
- Thymidine phosphorylase in human epidermal keratinocytesSchwartz P, Milstone L. Thymidine phosphorylase in human epidermal keratinocytes. Biochemical Pharmacology 1988, 37: 353-355. PMID: 2449215, DOI: 10.1016/0006-2952(88)90740-x.
- Human Keratinocytes Catabolize ThymidineSchwartz P, Kugelman L, Coifman Y, Hough L, Milstone L. Human Keratinocytes Catabolize Thymidine. Journal Of Investigative Dermatology 1988, 90: 8-12. PMID: 3335793, DOI: 10.1111/1523-1747.ep12462412.
- Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy.Mangin M, Webb A, Dreyer B, Posillico J, Ikeda K, Weir E, Stewart A, Bander N, Milstone L, Barton D. Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 597-601. PMID: 2829195, PMCID: PMC279598, DOI: 10.1073/pnas.85.2.597.
- Skin PotionsMilstone L. Skin Potions. JAMA Dermatology 1987, 123: 1087-1088. PMID: 3631990, DOI: 10.1001/archderm.1987.01660320137028.
- Skin-derived fibroblasts respond to human parathyroid hormone-like adenylate cyclase-stimulating proteins.WU T, INSOGNA K, HOUGH L, MILSTONE L, STEWART A. Skin-derived fibroblasts respond to human parathyroid hormone-like adenylate cyclase-stimulating proteins. The Journal Of Clinical Endocrinology & Metabolism 1987, 65: 105-9. PMID: 3034948, DOI: 10.1210/jcem-65-1-105.
- Prescribing Retinoids: The Art and the ScienceMilstone L. Prescribing Retinoids: The Art and the Science. JAMA Dermatology 1986, 122: 761-763. DOI: 10.1001/archderm.1986.01660190039011.
- A Parathyroid Hormone-Like Protein from Cultured Human KeratinocytesMerendino JJ, Insogna KL, Milstone LM, Broadus AE, Stewart AF. A Parathyroid Hormone-Like Protein from Cultured Human Keratinocytes. Science 1986, 231: 388-390. PMID: 2417317, DOI: 10.1126/science.2417317.
- Heterogeneity of Basal Keratinocytes: Nonrandom Distribution of Thymidine-Labeled Basal Cells in Confluent Cultures Is Not a Technical ArtifactMilstone L, LaVigne J. Heterogeneity of Basal Keratinocytes: Nonrandom Distribution of Thymidine-Labeled Basal Cells in Confluent Cultures Is Not a Technical Artifact. Journal Of Investigative Dermatology 1985, 84: 504-507. PMID: 3998498, DOI: 10.1111/1523-1747.ep12273479.
- Epidermal Cell Confluence and Implications for a Two-Step Mechanism of Wound ClosureStenn K, Milstone L. Epidermal Cell Confluence and Implications for a Two-Step Mechanism of Wound Closure. Journal Of Investigative Dermatology 1984, 83: 445-447. PMID: 6209344, DOI: 10.1111/1523-1747.ep12273552.
- LettersClark N, Stillman M, Milstone L, Overman S. Letters. The Physician And Sportsmedicine 1984, 12: 12-17. DOI: 10.1080/00913847.1984.11701863.
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Hyperplasia in Confluent Cultures of Human KeratinocytesMilstone L, LaVigne J. 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Hyperplasia in Confluent Cultures of Human Keratinocytes. Journal Of Investigative Dermatology 1984, 82: 532-534. PMID: 6210328, DOI: 10.1111/1523-1747.ep12261149.
- Classification and Therapy of Atrophie BlancheMilstone L, Braverman I, Lucky P, Fleckman P. Classification and Therapy of Atrophie Blanche. JAMA Dermatology 1983, 119: 963-969. PMID: 6651312, DOI: 10.1001/archderm.1983.01650360009005.
- GABA from putrescine is bound in macromolecular form in keratinocytesCanellakis Z, Milstone L, Marsh L, Young P, Bondy P. GABA from putrescine is bound in macromolecular form in keratinocytes. Life Sciences 1983, 33: 599-603. PMID: 6192309, DOI: 10.1016/0024-3205(83)90247-3.
- Population Dynamics in Cultures of Stratified Squamous EpitheliaMilstone L. Population Dynamics in Cultures of Stratified Squamous Epithelia. Journal Of Investigative Dermatology 1983, 81: s69-s74. PMID: 6863993, DOI: 10.1111/1523-1747.ep12540629.
- Premature epiphyseal closure in a child receiving oral 13-cis-retinoic acidMilstone L, McGuire J, Ablow R. Premature epiphyseal closure in a child receiving oral 13-cis-retinoic acid. Journal Of The American Academy Of Dermatology 1982, 7: 663-666. PMID: 6958690, DOI: 10.1016/s0190-9622(82)70148-3.
- Retinoic Acid Causes Premature Desquamation of Cells from Confluent Cultures of Stratified Squamous EpitheliaMilstone L, McGuire J, Lavigne J. Retinoic Acid Causes Premature Desquamation of Cells from Confluent Cultures of Stratified Squamous Epithelia. Journal Of Investigative Dermatology 1982, 79: 253-260. PMID: 7130743, DOI: 10.1111/1523-1747.ep12500073.
- The influence of retinoids on cultivated human keratinocytesMcGuire J, Fedarko N, Johanssen E, LaVigne J, Lyons G, Milstone L, Osber M. The influence of retinoids on cultivated human keratinocytes. Journal Of The American Academy Of Dermatology 1982, 6: 630-639. PMID: 6175669, DOI: 10.1016/s0190-9622(82)70052-0.
- Progress in Dermatoglyphic ResearchMilstone L. Progress in Dermatoglyphic Research. The Yale Journal Of Biology And Medicine 1982, 55: 542-543. PMCID: PMC2596568.
- Different polypeptides form the intermediate filaments in bovine hoof and esophageal epithelium and in aortic endothelium.Milstone L, McGuire J. Different polypeptides form the intermediate filaments in bovine hoof and esophageal epithelium and in aortic endothelium. Journal Of Cell Biology 1981, 88: 312-316. PMID: 7193680, PMCID: PMC2111748, DOI: 10.1083/jcb.88.2.312.
- Isolation and characterization of two polypeptides that form intermediate filaments in bovine esophageal epithelium.Milstone LM. Isolation and characterization of two polypeptides that form intermediate filaments in bovine esophageal epithelium. The Journal Of Cell Biology 1981, 88: 317-22. PMID: 7193681, PMCID: PMC2111760.
- Changing concepts of keratinMilstone L. Changing concepts of keratin. American Journal Of Dermatopathology 1980, 2: 161-163. PMID: 6166212, DOI: 10.1097/00000372-198000220-00013.
- Keratins in Cultivated Human Keratinocytes Are Stable*McGuire J, Milstone L, Osber M, Ingalls L. Keratins in Cultivated Human Keratinocytes Are Stable*. 1980, 10: 327-342. PMID: 6165526, DOI: 10.1159/000396299.
- δ-Crystallin gene expression in embryonic chick lens epithelia cultured in the presence of insulinMilstone L, Piatigorsky J. δ-Crystallin gene expression in embryonic chick lens epithelia cultured in the presence of insulin. Experimental Cell Research 1977, 105: 9-14. PMID: 837998, DOI: 10.1016/0014-4827(77)90147-1.
- δ-Crystallin mRNA in chick lens cells: mRNA accumulates during differential stimulation of δ-crystallin synthesis in cultured cellsMilstone L, Zelenka P, Piatigorsky J. δ-Crystallin mRNA in chick lens cells: mRNA accumulates during differential stimulation of δ-crystallin synthesis in cultured cells. Developmental Biology 1976, 48: 197-204. PMID: 1254080, DOI: 10.1016/0012-1606(76)90084-1.
- Rates of protein synthesis in explanted embryonic chick lens epithelia: Differential stimulation of δ-crystallin synthesisMilstone L, Piatigorsky J. Rates of protein synthesis in explanted embryonic chick lens epithelia: Differential stimulation of δ-crystallin synthesis. Developmental Biology 1975, 43: 91-100. PMID: 1149925, DOI: 10.1016/0012-1606(75)90133-5.
- Differentiation of lens fibers in explanted embryonic chick lens epitheliaPiatigorsky J, Rothschild S, Milstone L. Differentiation of lens fibers in explanted embryonic chick lens epithelia. Developmental Biology 1973, 34: 334-345. PMID: 4596973, DOI: 10.1016/0012-1606(73)90362-x.
- Release of virus inhibitor from tuberculin-sensitized peritoneal cells stimulated by antigen.Milstone L, Waksman B. Release of virus inhibitor from tuberculin-sensitized peritoneal cells stimulated by antigen. The Journal Of Immunology 1970, 105: 1068-71. PMID: 4321289, DOI: 10.4049/jimmunol.105.5.1068.