Chuan-Ju Liu, PhD
Research & Publications
Biography
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Research Summary
In the Liu Lab at Yale School of Medicine, our current research interests include 1) musculoskeletal development and disorders, with particular focuses on osteoarthritis and fracture healing; 2) inflammation and autoimmunity, with a special focus on rheumatoid arthritis; and 3) rare genetic lysosomal storage diseases, including Gaucher disease and Tay-Sachs disease.
Extensive Research Description
Arthritis is a degenerative disease that affects more than 66 million individuals in the United States alone. The destruction of the extracellular matrix of cartilage and bone is thought to be mediated by excessive proteolytic activity and an imbalance between inflammatory cytokines and their antagonists. The discovery of matrix-degrading enzymes and the inhibitors that antagonize the actions of cytokines is therefore important from both a pathophysiological and a therapeutic standpoint.
In the Liu Lab, our studies have led to the identification of ADAMTS-7 and ADAMTS-12 as two metalloproteinases associated with cartilage destabilization and the pathogenesis of arthritis.
In addition to our investigation into the role of ADAMTS, we have turned our attention to progranulin (PGRN), an autocrine growth factor-like molecule with multiple functions, because it was originally isolated as both a chondrogenic and osteoarthritis-related growth factor in our laboratory. Importantly, we also identified PGRN as a binding partner of tumor necrosis factor (TNF) receptors, also known as TNFRs, which are implicated in the regulation of inflammation and autoimmunity.
Our primary focus, accordingly, is to further investigate the roles of PGRN in arthritis and autoimmune diseases, in hopes of using PGRN and its derivatives in the development of new interventions for various degenerative and inflammatory conditions.
In our efforts to determine the role of PGRN in lung inflammation, we unexpectedly identified PGRN as a factor involved in Gaucher disease, one of the most common lysosomal storage diseases. Isolation of PGRN as a Gaucher disease modifier provides a foundation for future discoveries relating to this crucial factor in its disease pathogenesis, as well as in uncovering a unique target for developing novel therapies to combat Gaucher disease and probably other lysosomal storage diseases as well.
Sodium channel Nav1.7, previously believed to be exclusive to neurons, has been identified in chondrocytes. Despite its low density, chondrocyte-expressed Nav1.7 plays a significant role in osteoarthritis progression. Genetic deletion or pharmacological inhibition of Nav1.7 reduced joint damage and alleviated joint pain in various mouse osteoarthritis models. The potential use of existing non-specific Nav blockers or Nav1.7-specific inhibitors represents an unexplored avenue for disease-modifying treatment in osteoarthritis. https://doi.org/10.1038/d41586-023-03845-2
Coauthors
Research Interests
Arthritis, Rheumatoid; Autoimmune Diseases; Bone Regeneration; Cartilage; Inflammation; Musculoskeletal Diseases; Osteoarthritis; Sodium Channels; Lysosomal Storage Diseases; Chondrocytes; Tissue Engineering; Musculoskeletal Development; Fractures, Cartilage; Musculoskeletal Pain
Selected Publications
- Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in miceHasan S, Ghani N, Zhao X, Good J, Huang A, Wrona H, Liu J, Liu C. Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice. Protein & Cell 2024, pwae014. PMID: 38512816, DOI: 10.1093/procel/pwae014.
- Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritisFu W, Vasylyev D, Bi Y, Zhang M, Sun G, Khleborodova A, Huang G, Zhao L, Zhou R, Li Y, Liu S, Cai X, He W, Cui M, Zhao X, Hettinghouse A, Good J, Kim E, Strauss E, Leucht P, Schwarzkopf R, Guo E, Samuels J, Hu W, Attur M, Waxman S, Liu C. Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis. Nature 2024, 625: 557-565. PMID: 38172636, PMCID: PMC10794151, DOI: 10.1038/s41586-023-06888-7.
- Progranulinopathy: A diverse realm of disorders linked to progranulin imbalancesHuang G, Jian J, Liu C. Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances. Cytokine & Growth Factor Reviews 2023, 76: 142-159. PMID: 37981505, PMCID: PMC10978308, DOI: 10.1016/j.cytogfr.2023.11.001.
- Injectable hydrogel for sustained delivery of progranulin derivative Atsttrin in treating diabetic fracture healingMoradi L, Witek L, Vivekanand Nayak V, Cabrera Pereira A, Kim E, Good J, Liu C. Injectable hydrogel for sustained delivery of progranulin derivative Atsttrin in treating diabetic fracture healing. Biomaterials 2023, 301: 122289. PMID: 37639975, DOI: 10.1016/j.biomaterials.2023.122289.
- Unraveling the mechanisms behind joint damageFu W, Liu C. Unraveling the mechanisms behind joint damage. ELife 2023, 12: e89778. PMID: 37366155, PMCID: PMC10299819, DOI: 10.7554/elife.89778.
- Pathogenic mechanisms of glucocorticoid-induced osteoporosisChen M, Fu W, Xu H, Liu C. Pathogenic mechanisms of glucocorticoid-induced osteoporosis. Cytokine & Growth Factor Reviews 2023, 70: 54-66. PMID: 36906448, PMCID: PMC10518688, DOI: 10.1016/j.cytogfr.2023.03.002.
- Tau deficiency inhibits classically activated macrophage polarization and protects against collagen-induced arthritis in miceChen M, Fu W, Xu H, Liu C. Tau deficiency inhibits classically activated macrophage polarization and protects against collagen-induced arthritis in mice. Arthritis Research & Therapy 2023, 25: 146. PMID: 37559125, PMCID: PMC10410869, DOI: 10.1186/s13075-023-03133-4.
- PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseasesZhao X, Lin Y, Liou B, Fu W, Jian J, Fannin V, Zhang W, Setchell K, Grabowski G, Sun Y, Liu C. PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseases. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2210442120. PMID: 36574647, PMCID: PMC9910439, DOI: 10.1073/pnas.2210442120.
- Injectable recombinant block polymer gel for sustained delivery of therapeutic protein in post traumatic osteoarthritisKatyal P, Hettinghouse A, Meleties M, Hasan S, Chen C, Cui M, Sun G, Menon R, Lin B, Regatte R, Montclare J, Liu C. Injectable recombinant block polymer gel for sustained delivery of therapeutic protein in post traumatic osteoarthritis. Biomaterials 2022, 281: 121370. PMID: 35032910, PMCID: PMC9055922, DOI: 10.1016/j.biomaterials.2022.121370.
- Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseasesChen Y, Liu R, Cui Y, Hettinghouse A, Fu W, Zhang L, Zhang C, Liu C. Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases. Arthritis Research & Therapy 2022, 24: 27. PMID: 35045889, PMCID: PMC8767691, DOI: 10.1186/s13075-021-02713-6.
- Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritisWang K, Ding X, Jiang N, Zeng C, Wu J, Cai X, Hettinghouse A, Khleborodova A, Lei Z, Chen Z, Lei G, Liu C. Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis. Annals Of The Rheumatic Diseases 2021, 81: 544-555. PMID: 34853001, PMCID: PMC9082564, DOI: 10.1136/annrheumdis-2021-221380.
- Progranulin associates with Rab2 and is involved in autophagosome-lysosome fusion in Gaucher diseaseZhao X, Liberti R, Jian J, Fu W, Hettinghouse A, Sun Y, Liu C. Progranulin associates with Rab2 and is involved in autophagosome-lysosome fusion in Gaucher disease. Journal Of Molecular Medicine 2021, 99: 1639-1654. PMID: 34453183, PMCID: PMC8541919, DOI: 10.1007/s00109-021-02127-6.
- TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunityFu W, Hu W, Yi Y, Hettinghouse A, Sun G, Bi Y, He W, Zhang L, Gao G, Liu J, Toyo-oka K, Xiao G, Solit D, Loke P, Liu C. TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunity. Journal Of Clinical Investigation 2021, 131 PMID: 34185706, PMCID: PMC8363273, DOI: 10.1172/jci144016.
- 14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritisFu W, Hettinghouse A, Chen Y, Hu W, Ding X, Chen M, Ding Y, Mundra J, Song W, Liu R, Yi Y, Attur M, Samuels J, Strauss E, Leucht P, Schwarzkopf R, Liu C. 14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis. Annals Of The Rheumatic Diseases 2021, 80: 1615-1627. PMID: 34226187, PMCID: PMC8595573, DOI: 10.1136/annrheumdis-2021-220000.
- Progranulin promotes bone fracture healing via TNFR pathways in mice with type 2 diabetes mellitusDing Y, Wei J, Hettinghouse A, Li G, Li X, Einhorn T, Liu C. Progranulin promotes bone fracture healing via TNFR pathways in mice with type 2 diabetes mellitus. Annals Of The New York Academy Of Sciences 2021, 1490: 77-89. PMID: 33543485, PMCID: PMC8138780, DOI: 10.1111/nyas.14568.
- Repurposing FDA-approved drugs for SARS-CoV-2 through an ELISA-based screening for the inhibition of RBD/ACE2 interactionFu W, Chen Y, Wang K, Hettinghouse A, Hu W, Wang J, Lei Z, Chen Z, Stapleford K, Liu C. Repurposing FDA-approved drugs for SARS-CoV-2 through an ELISA-based screening for the inhibition of RBD/ACE2 interaction. Protein & Cell 2020, 12: 586-591. PMID: 33210243, PMCID: PMC7673315, DOI: 10.1007/s13238-020-00803-w.
- Monitoring Atsttrin-Mediated Inhibition of TNFα/NF-κβ Activation Through In Vivo Bioluminescence ImagingHettinghouse A, Fu W, Liu C. Monitoring Atsttrin-Mediated Inhibition of TNFα/NF-κβ Activation Through In Vivo Bioluminescence Imaging. 2020, 2248: 201-210. PMID: 33185877, PMCID: PMC8140391, DOI: 10.1007/978-1-0716-1130-2_14.
- In Vitro Physical and Functional Interaction Assays to Examine the Binding of Progranulin Derivative Atsttrin to TNFR2 and Its Anti-TNFα ActivityFu W, Hettinghouse A, Liu C. In Vitro Physical and Functional Interaction Assays to Examine the Binding of Progranulin Derivative Atsttrin to TNFR2 and Its Anti-TNFα Activity. 2020, 2248: 109-119. PMID: 33185871, PMCID: PMC8112733, DOI: 10.1007/978-1-0716-1130-2_8.
- Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in miceWang C, Zhang L, Ndong J, Hettinghouse A, Sun G, Chen C, Zhang C, Liu R, Liu C. Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice. Journal Of Neuroinflammation 2019, 16: 238. PMID: 31775776, PMCID: PMC6882111, DOI: 10.1186/s12974-019-1630-1.
- A novel mechanism of EAE resistance highlights the conflicting roles of progranulin-mediated immunosuppression and antigen processingHettinghouse A, Gao G, Liu C. A novel mechanism of EAE resistance highlights the conflicting roles of progranulin-mediated immunosuppression and antigen processing. Cellular & Molecular Immunology 2019, 18: 506-507. PMID: 31511641, PMCID: PMC8026965, DOI: 10.1038/s41423-019-0292-3.
- Progranulin promotes diabetic fracture healing in mice with type 1 diabetesWei J, Zhang L, Ding Y, Liu R, Guo Y, Hettinghouse A, Buza J, De La Croix J, Li X, Einhorn T, Liu C. Progranulin promotes diabetic fracture healing in mice with type 1 diabetes. Annals Of The New York Academy Of Sciences 2019, 1460: 43-56. PMID: 31423598, PMCID: PMC8138779, DOI: 10.1111/nyas.14208.
- Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritisLiu R, Chen Y, Fu W, Wang S, Cui Y, Zhao X, Lei Z, Hettinghouse A, Liu J, Wang C, Zhang C, Bi Y, Xiao G, Chen Z, Liu C. Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis. Annals Of The Rheumatic Diseases 2019, 78: 1524. PMID: 31302596, PMCID: PMC8157820, DOI: 10.1136/annrheumdis-2019-215543.
- Progranulin: A conductor of receptors orchestra, a chaperone of lysosomal enzymes and a therapeutic target for multiple diseasesCui Y, Hettinghouse A, Liu C. Progranulin: A conductor of receptors orchestra, a chaperone of lysosomal enzymes and a therapeutic target for multiple diseases. Cytokine & Growth Factor Reviews 2019, 45: 53-64. PMID: 30733059, PMCID: PMC6450552, DOI: 10.1016/j.cytogfr.2019.01.002.
- Clinical Application of Teriparatide in Fracture Prevention: A Systematic Review.Chen Y, Liu R, Hettinghouse A, Wang S, Liu G, Liu C. Clinical Application of Teriparatide in Fracture Prevention: A Systematic Review. JBJS Reviews 2019, 7: e10. PMID: 30694878, DOI: 10.2106/jbjs.rvw.18.00052.
- Brain-penetrant heat shock protein amplifier arimoclomol enhances GCase activity in in vitro Gaucher disease modelsHettinghouse A, Liu C. Brain-penetrant heat shock protein amplifier arimoclomol enhances GCase activity in in vitro Gaucher disease models. EBioMedicine 2018, 38: 7-8. PMID: 30522930, PMCID: PMC6306393, DOI: 10.1016/j.ebiom.2018.11.052.
- Progranulin associates with hexosaminidase A and ameliorates GM2 ganglioside accumulation and lysosomal storage in Tay-Sachs diseaseChen Y, Jian J, Hettinghouse A, Zhao X, Setchell K, Sun Y, Liu C. Progranulin associates with hexosaminidase A and ameliorates GM2 ganglioside accumulation and lysosomal storage in Tay-Sachs disease. Journal Of Molecular Medicine 2018, 96: 1359-1373. PMID: 30341570, PMCID: PMC6240367, DOI: 10.1007/s00109-018-1703-0.
- Role of ADAMTS‐12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth FactorWei J, Fu W, Hettinghouse A, He W, Lipson K, Liu C. Role of ADAMTS‐12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor. Arthritis & Rheumatology 2018, 70: 1745-1756. PMID: 29750395, PMCID: PMC6203634, DOI: 10.1002/art.40552.
- Targeting tumor necrosis factor receptors in ankylosing spondylitisLata M, Hettinghouse A, Liu C. Targeting tumor necrosis factor receptors in ankylosing spondylitis. Annals Of The New York Academy Of Sciences 2018, 1442: 5-16. PMID: 30008173, PMCID: PMC6333510, DOI: 10.1111/nyas.13933.
- Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-inflammatory Activity of Progranulin in Inflammatory ArthritisWei J, Liu C. Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-inflammatory Activity of Progranulin in Inflammatory Arthritis. 2018, 1806: 305-313. PMID: 29956284, DOI: 10.1007/978-1-4939-8559-3_20.
- Molecular regulations and therapeutic targets of Gaucher diseaseChen Y, Sud N, Hettinghouse A, Liu C. Molecular regulations and therapeutic targets of Gaucher disease. Cytokine & Growth Factor Reviews 2018, 41: 65-74. PMID: 29699937, PMCID: PMC8108120, DOI: 10.1016/j.cytogfr.2018.04.003.
- p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in MiceYi Y, Jian J, Gonzalez-Gugel E, Shi Y, Tian Q, Fu W, Hettinghouse A, Song W, Liu R, He M, Qi H, Yang J, Du X, Xiao G, Chen L, Liu C. p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice. EBioMedicine 2018, 29: 78-91. PMID: 29472103, PMCID: PMC5925582, DOI: 10.1016/j.ebiom.2018.02.012.
- Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher DiseaseJian J, Chen Y, Liberti R, Fu W, Hu W, Saunders-Pullman R, Pastores G, Chen Y, Sun Y, Grabowski G, Liu C. Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease. EBioMedicine 2018, 28: 251-260. PMID: 29396296, PMCID: PMC5835567, DOI: 10.1016/j.ebiom.2018.01.022.
- Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat modelsWei J, Fu W, Ding Y, Hettinghouse A, Lendhey M, Schwarzkopf R, Kennedy O, Liu C. Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models. Arthritis Research & Therapy 2017, 19: 280. PMID: 29258611, PMCID: PMC5735869, DOI: 10.1186/s13075-017-1485-8.
- Multifunctional molecule ERp57: From cancer to neurodegenerative diseasesHettinghouse A, Liu R, Liu C. Multifunctional molecule ERp57: From cancer to neurodegenerative diseases. Pharmacology & Therapeutics 2017, 181: 34-48. PMID: 28723413, PMCID: PMC5743601, DOI: 10.1016/j.pharmthera.2017.07.011.
- Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymesJian J, Hettinghouse A, Liu C. Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes. Genes & Diseases 2017, 4: 125-126. PMID: 28944282, PMCID: PMC5609500, DOI: 10.1016/j.gendis.2017.05.001.
- Foxo4‐ and Stat3‐dependent IL‐10 production by progranulin in regulatory T cells restrains inflammatory arthritisFu W, Hu W, Shi L, Mundra J, Xiao G, Dustin M, Liu C. Foxo4‐ and Stat3‐dependent IL‐10 production by progranulin in regulatory T cells restrains inflammatory arthritis. The FASEB Journal 2016, 31: 1354-1367. PMID: 28011648, PMCID: PMC5349791, DOI: 10.1096/fj.201601134r.
- Review: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone RemodelingWilliams A, Wang E, Thurner L, Liu C. Review: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone Remodeling. Arthritis & Rheumatology 2016, 68: 2845-2856. PMID: 27428882, PMCID: PMC5599977, DOI: 10.1002/art.39816.
- Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher DiseaseJian J, Tian Q, Hettinghouse A, Zhao S, Liu H, Wei J, Grunig G, Zhang W, Setchell K, Sun Y, Overkleeft H, Chan G, Liu C. Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease. EBioMedicine 2016, 13: 212-224. PMID: 27789271, PMCID: PMC5264254, DOI: 10.1016/j.ebiom.2016.10.010.
- Association Between Progranulin and Gaucher DiseaseJian J, Zhao S, Tian QY, Liu H, Zhao Y, Chen WC, Grunig G, Torres PA, Wang BC, Zeng B, Pastores G, Tang W, Sun Y, Grabowski GA, Kong MX, Wang G, Chen Y, Liang F, Overkleeft HS, Saunders-Pullman R, Chan GL, Liu CJ. Association Between Progranulin and Gaucher Disease. EBioMedicine 2016, 11: 127-137. PMID: 27515686, PMCID: PMC5049935, DOI: 10.1016/j.ebiom.2016.08.004.
- Chondro-protective effects of low intensity pulsed ultrasoundUddin S, Richbourgh B, Ding Y, Hettinghouse A, Komatsu D, Qin Y, Liu C. Chondro-protective effects of low intensity pulsed ultrasound. Osteoarthritis And Cartilage 2016, 24: 1989-1998. PMID: 27364595, PMCID: PMC5071131, DOI: 10.1016/j.joca.2016.06.014.
- Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone‐related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factorKong L, Zhao Y, Tian Q, Feng J, Kobayashi T, Merregaert J, Liu C. Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone‐related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor. The FASEB Journal 2016, 30: 2741-2754. PMID: 27075243, PMCID: PMC4970607, DOI: 10.1096/fj.201600261r.
- Progranulin inhibits expression and release of chemokines CXCL9 and CXCL10 in a TNFR1 dependent mannerMundra J, Jian J, Bhagat P, Liu C. Progranulin inhibits expression and release of chemokines CXCL9 and CXCL10 in a TNFR1 dependent manner. Scientific Reports 2016, 6: 21115. PMID: 26892362, PMCID: PMC4759551, DOI: 10.1038/srep21115.
- Does progranulin account for the opposite effects of etanercept and infliximab/adalimumab in osteoarthritis?Wei J, Buza J, Liu C. Does progranulin account for the opposite effects of etanercept and infliximab/adalimumab in osteoarthritis? Journal Of Orthopaedic Research® 2015, 34: 12-14. PMID: 26519939, PMCID: PMC4710548, DOI: 10.1002/jor.23091.
- Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanismZanin-Zhorov A, Weiss J, Nyuydzefe M, Chen W, Scher J, Mo R, Depoil D, Rao N, Liu B, Wei J, Lucas S, Koslow M, Roche M, Schueller O, Weiss S, Poyurovsky M, Tonra J, Hippen K, Dustin M, Blazar B, Liu C, Waksal S. Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 16814-16819. PMID: 25385601, PMCID: PMC4250132, DOI: 10.1073/pnas.1414189111.
- Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signallingZhao Y, Liu B, Tian Q, Wei J, Richbourgh B, Liu C. Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling. Annals Of The Rheumatic Diseases 2014, 74: 2244. PMID: 25169730, PMCID: PMC4408266, DOI: 10.1136/annrheumdis-2014-205779.
- Progranulin inhibition of TNFαUddin S, Mundra J, Jian J, Tian Q, Gonzalez‐Gugel E, Richbourgh B, Liu C. Progranulin inhibition of TNFα. Immunology And Cell Biology 2014, 92: 299-300. PMID: 24518982, DOI: 10.1038/icb.2014.7.
- Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domainsJian J, Zhao S, Tian Q, Gonzalez-Gugel E, Mundra J, Uddin S, Liu B, Richbourgh B, Brunetti R, Liu C. Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains. FEBS Letters 2013, 587: 3428-3436. PMID: 24070898, PMCID: PMC3826980, DOI: 10.1016/j.febslet.2013.09.024.
- ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritisLai Y, Bai X, Zhao Y, Tian Q, Liu B, Lin E, Chen Y, Lee B, Appleton C, Beier F, Yu X, Liu C. ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis. Annals Of The Rheumatic Diseases 2013, 73: 1575. PMID: 23928557, PMCID: PMC4418017, DOI: 10.1136/annrheumdis-2013-203561.
- The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signalingZhao Y, Tian Q, Frenkel S, Liu C. The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling. Biomaterials 2013, 34: 6412-6421. PMID: 23746860, PMCID: PMC3713419, DOI: 10.1016/j.biomaterials.2013.05.030.
- Progranulin deficiency exaggerates, whereas progranulin‐derived Atsttrin attenuates, severity of dermatitis in miceZhao Y, Tian Q, Liu C. Progranulin deficiency exaggerates, whereas progranulin‐derived Atsttrin attenuates, severity of dermatitis in mice. FEBS Letters 2013, 587: 1805-1810. PMID: 23669357, PMCID: PMC3683372, DOI: 10.1016/j.febslet.2013.04.037.
- Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISALai Y, Yu X, Zhang Y, Tian Q, Song H, Mucignat M, Perris R, Samuels J, Krasnokutsky S, Attur M, Greenberg J, Abramson S, Di Cesare P, Liu C. Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISA. Osteoarthritis And Cartilage 2012, 20: 854-862. PMID: 22595227, PMCID: PMC3389204, DOI: 10.1016/j.joca.2012.05.003.
- GEP constitutes a negative feedback loop with MyoD and acts as a novel mediator in controlling skeletal muscle differentiationWang D, Bai X, Tian Q, Lai Y, Lin E, Shi Y, Mu X, Feng J, Carlson C, Liu C. GEP constitutes a negative feedback loop with MyoD and acts as a novel mediator in controlling skeletal muscle differentiation. Cellular And Molecular Life Sciences 2011, 69: 1855-1873. PMID: 22179841, PMCID: PMC3319484, DOI: 10.1007/s00018-011-0901-5.
- Progranulin: A growth factor, a novel TNFR ligand and a drug targetLiu C, Bosch X. Progranulin: A growth factor, a novel TNFR ligand and a drug target. Pharmacology & Therapeutics 2011, 133: 124-132. PMID: 22008260, PMCID: PMC4429904, DOI: 10.1016/j.pharmthera.2011.10.003.
- Progranulin: A promising therapeutic target for rheumatoid arthritisLiu C. Progranulin: A promising therapeutic target for rheumatoid arthritis. FEBS Letters 2011, 585: 3675-3680. PMID: 21550343, PMCID: PMC3162080, DOI: 10.1016/j.febslet.2011.04.065.
- Science Signaling Podcast: 26 April 2011Liu C, VanHook A. Science Signaling Podcast: 26 April 2011. Science Signaling 2011, 4 DOI: 10.1126/scisignal.2002099.
- The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in MiceTang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY, Syed NM, Lai Y, Lin EA, Kong L, Su J, Yin F, Ding AH, Zanin-Zhorov A, Dustin ML, Tao J, Craft J, Yin Z, Feng JQ, Abramson SB, Yu XP, Liu CJ. The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice. Science 2011, 332: 478-484. PMID: 21393509, PMCID: PMC3104397, DOI: 10.1126/science.1199214.
- Cartilage Oligomeric Matrix Protein Inhibits Vascular Smooth Muscle Calcification by Interacting With Bone Morphogenetic Protein-2Du Y, Wang Y, Wang L, Liu B, Tian Q, Liu C, Zhang T, Xu Q, Zhu Y, Ake O, Qi Y, Tang C, Kong W, Wang X. Cartilage Oligomeric Matrix Protein Inhibits Vascular Smooth Muscle Calcification by Interacting With Bone Morphogenetic Protein-2. Circulation Research 2011, 108: 917-928. PMID: 21350216, DOI: 10.1161/circresaha.110.234328.
- Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growthKong L, Tian Q, Guo F, Mucignat M, Perris R, Sercu S, Merregaert J, Di Cesare P, Liu C. Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growth. Matrix Biology 2010, 29: 276-286. PMID: 20138147, PMCID: PMC2862898, DOI: 10.1016/j.matbio.2010.01.007.
- Granulin epithelin precursor: a bone morphogenic protein 2‐inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesisFeng J, Guo F, Jiang B, Zhang Y, Frenkel S, Wang D, Tang W, Xie Y, Liu C. Granulin epithelin precursor: a bone morphogenic protein 2‐inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis. The FASEB Journal 2010, 24: 1879-1892. PMID: 20124436, PMCID: PMC2874481, DOI: 10.1096/fj.09-144659.
- The role of ADAMTSs in arthritisLin E, Liu C. The role of ADAMTSs in arthritis. Protein & Cell 2010, 1: 33-47. PMID: 21203996, PMCID: PMC4418016, DOI: 10.1007/s13238-010-0002-5.
- Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With &agr;7&bgr;1 IntegrinWang L, Zheng J, Du Y, Huang Y, Li J, Liu B, Liu C, Zhu Y, Gao Y, Xu Q, Kong W, Wang X. Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With &agr;7&bgr;1 Integrin. Circulation Research 2009, 106: 514-525. PMID: 20019333, DOI: 10.1161/circresaha.109.202762.
- The p200 family protein p204 as a modulator of cell proliferation and differentiation: a brief surveyLengyel P, Liu CJ. The p200 family protein p204 as a modulator of cell proliferation and differentiation: a brief survey. Cellular And Molecular Life Sciences 2009, 67: 335-340. PMID: 19921484, PMCID: PMC2824682, DOI: 10.1007/s00018-009-0195-z.
- ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth FactorBai X, Wang D, Kong L, Zhang Y, Luan Y, Kobayashi T, Kronenberg H, Yu X, Liu C. ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor. Molecular And Cellular Biology 2009, 29: 4201-4219. PMID: 19487464, PMCID: PMC2715794, DOI: 10.1128/mcb.00056-09.
- miR-199a*, a Bone Morphogenic Protein 2-responsive MicroRNA, Regulates Chondrogenesis via Direct Targeting to Smad1*Lin E, Kong L, Bai X, Luan Y, Liu C. miR-199a*, a Bone Morphogenic Protein 2-responsive MicroRNA, Regulates Chondrogenesis via Direct Targeting to Smad1*. Journal Of Biological Chemistry 2009, 284: 11326-11335. PMID: 19251704, PMCID: PMC2670138, DOI: 10.1074/jbc.m807709200.
- ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-Injured Rat ArteriesWang L, Zheng J, Bai X, Liu B, Liu C, Xu Q, Zhu Y, Wang N, Kong W, Wang X. ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-Injured Rat Arteries. Circulation Research 2009, 104: 688-698. PMID: 19168437, DOI: 10.1161/circresaha.108.188425.
- The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritisLiu C. The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. Nature Reviews Rheumatology 2009, 5: 38-45. PMID: 19098927, PMCID: PMC4433145, DOI: 10.1038/ncprheum0961.
- Regulation of chondrocyte differentiation by ADAMTS-12 metalloproteinase depends on its enzymatic activityBai X, Wang D, Luan Y, Yu X, Liu C. Regulation of chondrocyte differentiation by ADAMTS-12 metalloproteinase depends on its enzymatic activity. Cellular And Molecular Life Sciences 2008, 66: 667. PMID: 19151918, DOI: 10.1007/s00018-008-8633-x.
- p204, a p200 family protein, as a multifunctional regulator of cell proliferation and differentiationLuan Y, Lengyel P, Liu CJ. p204, a p200 family protein, as a multifunctional regulator of cell proliferation and differentiation. Cytokine & Growth Factor Reviews 2008, 19: 357-369. PMID: 19027346, PMCID: PMC4442486, DOI: 10.1016/j.cytogfr.2008.11.002.
- Mediation of Chondrogenic and Osteogenic Differentiation by an Interferon-Inducible p202 ProteinKong L, Liu C. Mediation of Chondrogenic and Osteogenic Differentiation by an Interferon-Inducible p202 Protein. Cellular And Molecular Life Sciences 2008, 65: 3494-3506. PMID: 18791844, DOI: 10.1007/s00018-008-8342-5.
- Cbfa1-dependent expression of an interferon-inducible p204 protein is required for chondrocyte differentiationZhang Y, Kong L, Carlson C, Liu C. Cbfa1-dependent expression of an interferon-inducible p204 protein is required for chondrocyte differentiation. Cell Death & Differentiation 2008, 15: 1760-1771. PMID: 18636074, DOI: 10.1038/cdd.2008.112.
- Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulinLuan Y, Kong L, Howell D, Ilalov K, Fajardo M, Bai X, Di Cesare P, Goldring M, Abramson S, Liu C. Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. Osteoarthritis And Cartilage 2008, 16: 1413-1420. PMID: 18485748, PMCID: PMC2574789, DOI: 10.1016/j.joca.2008.03.017.
- p204 Protein Overcomes the Inhibition of Core Binding Factor α-1–mediated Osteogenic Differentiation by Id Helix-Loop-Helix ProteinsLuan Y, Yu X, Yang N, Frenkel S, Chen L, Liu C. p204 Protein Overcomes the Inhibition of Core Binding Factor α-1–mediated Osteogenic Differentiation by Id Helix-Loop-Helix Proteins. Molecular Biology Of The Cell 2008, 19: 2113-2126. PMID: 18287524, PMCID: PMC2366862, DOI: 10.1091/mbc.e07-10-1057.
- RbAp48 Is a Critical Mediator Controlling the Transforming Activity of Human Papillomavirus Type 16 in Cervical Cancer*Kong L, Yu X, Bai X, Zhang W, Zhang Y, Zhao W, Jia J, Tang W, Zhou Y, Liu C. RbAp48 Is a Critical Mediator Controlling the Transforming Activity of Human Papillomavirus Type 16 in Cervical Cancer*. Journal Of Biological Chemistry 2007, 282: 26381-26391. PMID: 17616526, DOI: 10.1074/jbc.m702195200.
- The Retinoblastoma Protein Is an Essential Mediator of Osteogenesis That Links the p204 Protein to the Cbfa1 Transcription Factor Thereby Increasing Its Activity*Luan Y, Yu XP, Xu K, Ding B, Yu J, Huang Y, Yang N, Lengyel P, Di Cesare PE, Liu CJ. The Retinoblastoma Protein Is an Essential Mediator of Osteogenesis That Links the p204 Protein to the Cbfa1 Transcription Factor Thereby Increasing Its Activity*. Journal Of Biological Chemistry 2007, 282: 16860-16870. PMID: 17439944, DOI: 10.1074/jbc.m610943200.
- Cartilage Oligomeric Matrix Protein Associates with Granulin-Epithelin Precursor (GEP) and Potentiates GEP-stimulated Chondrocyte Proliferation*Xu K, Zhang Y, Ilalov K, Carlson C, Feng J, Di Cesare P, Liu C. Cartilage Oligomeric Matrix Protein Associates with Granulin-Epithelin Precursor (GEP) and Potentiates GEP-stimulated Chondrocyte Proliferation*. Journal Of Biological Chemistry 2007, 282: 11347-11355. PMID: 17307734, DOI: 10.1074/jbc.m608744200.
- ADAMTS-12 Associates with and Degrades Cartilage Oligomeric Matrix Protein*Liu C, Kong W, Xu K, Luan Y, Ilalov K, Sehgal B, Yu S, Howell R, Di Cesare P. ADAMTS-12 Associates with and Degrades Cartilage Oligomeric Matrix Protein*. Journal Of Biological Chemistry 2006, 281: 15800-15808. PMID: 16611630, PMCID: PMC1483932, DOI: 10.1074/jbc.m513433200.
- ADAMTS‐7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix proteinLiu C, Kong W, Ilalov K, Yu S, Xu K, Prazak L, Fajardo M, Sehgal B, Di Cesare P, Liu C, Kong W, Ilalov K, Yu S, Xu K, Prazak L, Fajardo M, Sehgal B, Di Cesare P. ADAMTS‐7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein. The FASEB Journal 2006, 20: 988-990. PMID: 16585064, PMCID: PMC1483927, DOI: 10.1096/fj.05-3877fje.
- Serum Interleukin-6 as a Marker of Periprosthetic Infection Following Total Hip and Knee ArthroplastyDi Cesare P, Chang E, Preston C, Liu C. Serum Interleukin-6 as a Marker of Periprosthetic Infection Following Total Hip and Knee Arthroplasty. Journal Of Bone And Joint Surgery 2005, 87: 1921-1927. PMID: 16140805, DOI: 10.2106/jbjs.d.01803.