Xiangli Zhao
Associate Research Scientist
Research & Publications
Biography
Research Summary
The therapeutic effect of Progranulin and its derivative on Gaucher Disease
Coauthors
Selected Publications
- Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritisFu W, Vasylyev D, Bi Y, Zhang M, Sun G, Khleborodova A, Huang G, Zhao L, Zhou R, Li Y, Liu S, Cai X, He W, Cui M, Zhao X, Hettinghouse A, Good J, Kim E, Strauss E, Leucht P, Schwarzkopf R, Guo E, Samuels J, Hu W, Attur M, Waxman S, Liu C. Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis. Nature 2024, 625: 557-565. PMID: 38172636, PMCID: PMC10794151, DOI: 10.1038/s41586-023-06888-7.
- Interaction with ERp57 is required for progranulin protection against Type 2 Gaucher disease.Liu Y, Zhao X, Jian J, Hasan S, Liu C. Interaction with ERp57 is required for progranulin protection against Type 2 Gaucher disease. Biosci Trends 2023, 17: 126-135. PMID: 36889696, DOI: 10.5582/bst.2023.01022.
- YQBS Improves Cognitive Dysfunction in Diabetic Rats: Possible Association with Tyrosine and Tryptophan MetabolismLiu Y, Cai J, Wang Y, Zhao X, Qiao Y, Liu C. YQBS Improves Cognitive Dysfunction in Diabetic Rats: Possible Association with Tyrosine and Tryptophan Metabolism. Diabetes Metabolic Syndrome And Obesity 2023, 16: 901-912. PMID: 37021127, PMCID: PMC10069430, DOI: 10.2147/dmso.s401863.
- PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseasesZhao X, Lin Y, Liou B, Fu W, Jian J, Fannin V, Zhang W, Setchell K, Grabowski G, Sun Y, Liu C. PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseases. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2210442120. PMID: 36574647, PMCID: PMC9910439, DOI: 10.1073/pnas.2210442120.
- Analysis of the Biomarkers for Neurodegenerative Diseases in Aged Progranulin Deficient Mice.Zhao X, Hasan S, Liou B, Lin Y, Sun Y, Liu C. Analysis of the Biomarkers for Neurodegenerative Diseases in Aged Progranulin Deficient Mice. Int J Mol Sci 2022, 23 PMID: 35054815, DOI: 10.3390/ijms23020629.
- Cytosolic Phospholipase A2 Is Required for Fexofenadine's Therapeutic Effects against Inflammatory Bowel Disease in Mice.Zhao X, Liu R, Chen Y, Hettinghouse A, Liu C. Cytosolic Phospholipase A2 Is Required for Fexofenadine's Therapeutic Effects against Inflammatory Bowel Disease in Mice. Int J Mol Sci 2021, 22 PMID: 34681815, DOI: 10.3390/ijms222011155.
- Progranulin associates with Rab2 and is involved in autophagosome-lysosome fusion in Gaucher diseaseZhao X, Liberti R, Jian J, Fu W, Hettinghouse A, Sun Y, Liu C. Progranulin associates with Rab2 and is involved in autophagosome-lysosome fusion in Gaucher disease. Journal Of Molecular Medicine 2021, 99: 1639-1654. PMID: 34453183, PMCID: PMC8541919, DOI: 10.1007/s00109-021-02127-6.
- Involvement of CD26 in Differentiation and Functions of Th1 and Th17 Subpopulations of T Lymphocytes.Zhao X, Wang W, Zhang K, Yang J, Fuchs H, Fan H. Involvement of CD26 in Differentiation and Functions of Th1 and Th17 Subpopulations of T Lymphocytes. J Immunol Res 2021, 2021: 6671410. PMID: 33542930, DOI: 10.1155/2021/6671410.
- Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritisLiu R, Chen Y, Fu W, Wang S, Cui Y, Zhao X, Lei Z, Hettinghouse A, Liu J, Wang C, Zhang C, Bi Y, Xiao G, Chen Z, Liu C. Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis. Annals Of The Rheumatic Diseases 2019, 78: 1524. PMID: 31302596, PMCID: PMC8157820, DOI: 10.1136/annrheumdis-2019-215543.
- Delayed allogeneic skin graft rejection in CD26-deficient mice.Zhao X, Zhang K, Daniel P, Wisbrun N, Fuchs H, Fan H. Delayed allogeneic skin graft rejection in CD26-deficient mice. Cell Mol Immunol 2019, 16: 557-567. PMID: 29572550, DOI: 10.1038/s41423-018-0009-z.
- Anti-inflammatory properties of GLPss58, a sulfated polysaccharide from Ganoderma lucidum.Zhang K, Liu Y, Zhao X, Tang Q, Dernedde J, Zhang J, Fan H. Anti-inflammatory properties of GLPss58, a sulfated polysaccharide from Ganoderma lucidum. Int J Biol Macromol 2018, 107: 486-493. PMID: 28890375, DOI: 10.1016/j.ijbiomac.2017.09.015.
- Targeted dianthin is a powerful toxin to treat pancreatic carcinoma when applied in combination with the glycosylated triterpene SO1861.Bhargava C, Dürkop H, Zhao X, Weng A, Melzig MF, Fuchs H. Targeted dianthin is a powerful toxin to treat pancreatic carcinoma when applied in combination with the glycosylated triterpene SO1861. Mol Oncol 2017, 11: 1527-1543. PMID: 28755527, DOI: 10.1002/1878-0261.12115.