Micha Sam Brickman Raredon, MD, PhD
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About
Titles
Assistant Professor of Anesthesiology
Biography
Dr. Micha Sam Brickman Raredon is a research group leader in the Departments of Anesthesiology, Internal Medicine, and Immunobiology studying regenerative lung engineering. Dr. Raredon's laboratory seeks to reverse-engineer tissues for regenerative medicine through the close study of single-cell systems biology.
Dr. Raredon completed his MD/PhD training at Yale in the laboratory of Dr. Laura Niklason (Biomedical Engineering), co-mentored by Dr. Naftali Kaminski (Pulmonary, Critical Care & Sleep Medicine), Dr. Andre Levchenko (Systems Biology) and Dr. Yuval Kluger (Applied Math). He is now affiliated as a research fellow under the mentorship Dr. Kaminski, Dr. Ruslan Medzhitov (Immunobiology), and Dr. Robert Schonberger (Anesthesiology). Dr. Raredon studied Materials Science and Engineering at the Massachusetts Institute of Technology as a Draper Fellow developing tissue micro-fabrication techniques in the laboratories of Dr. Linda Griffith (Bioengineering), Dr. Paula Hammond (Chemical Engineering), and Dr. Jeffrey Borenstein (Draper Labs). He completed his undergraduate work in Biomedical Engineering and the History of Art at Yale University and the University of Cambridge.
Dr. Raredon plays the cello and enjoys finding time to be outdoors and near water as much as possible.
Appointments
Anesthesiology
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- MD
- Yale School of Medicine (2022)
- PhD
- Yale School of Engineering and Applied Science, Biomedical Engineering (2021)
- MS
- Yale School of Engineering and Applied Science, Biomedical Engineering (2020)
- MPhil
- Yale School of Engineering and Applied Science, Biomedical Engineering (2020)
- MS
- Massachusetts Institute of Technology, Materials Science and Engineering (2014)
- BS
- Yale University, Biomedical Engineering & History of Art (2011)
Research
Overview
Dr. Raredon's research group focuses on the mechanisms governing the behavior of complex multicellular systems and in leveraging these principles to engineer living tissues for regenerative medicine. Our work combines systems biology, stem-cell engineering, materials science, surgical fabrication, and biological engineering. The team is particularly invested in engineering, or controlling the self-organization of, cross-length scale perfusable vascular networks and tissue architecture, and in devising principles of microvascular construction and control that can be applied across organ types. We are a clinically-integrated laboratory with two broadly interconnected goals: the modeling of network-level mechanisms of tissue morphogenesis and phenotype regulation, and the application of those models to the design and fabrication of patient-specific tissues for therapeutic use.
ORCID
0000-0003-1441-6122
Research at a Glance
Yale Co-Authors
Publications Timeline
Naftali Kaminski, MD
Jonas Christian Schupp, MD
Taylor Adams
Laura Niklason, PhD, MD
Pavlina Baevova
Farida Ahangari, MD
Publications
2024
Single Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis.
Zhao A, Unterman A, Abu Hussein N, Sharma P, Nekola F, Flint J, Yan X, Adams T, Justet A, Sumida T, Zhao J, Schupp J, Raredon M, Ahangari F, Deluliis G, Zhang Y, Buendia-Roldan I, Adegunsoye A, Sperling A, Prasse A, Ryu C, Herzog E, Selman M, Pardo A, Kaminski N. Single Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis. American Journal Of Respiratory And Critical Care Medicine 2024 PMID: 38924775, DOI: 10.1164/rccm.202401-0078oc.Peer-Reviewed Original ResearchAltmetricConceptsFibrotic hypersensitivity pneumonitisIdiopathic pulmonary fibrosisPeripheral blood mononuclear cellsBronchoalveolar lavage cellsBlood mononuclear cellsClassical monocytesHypersensitivity pneumonitisPulmonary fibrosisT cellsImmune perturbationsLavage cellsMononuclear cellsCD8+ T cellsCytotoxic T cellsInterstitial lung diseaseHypersensitivity pneumonitis patientsCytotoxic CD4Immune aberrationsPneumonic patientsPneumonitisLung diseaseHealthy controlsImmune mechanismsPatient cellsSingle-cell transcriptomicsSingle-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injury
Yuan Y, Sharma L, Tang W, Raredon M, Ahangari F, Khoury J, Wu D, Niklason L, Kaminski N. Single-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injury. Physiology 2024, 39: 1314. DOI: 10.1152/physiol.2024.39.s1.1314.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisAcute lung injuryChronic obstructive pulmonary diseaseAcute respiratory distress syndromeAnalysis of cell-cell communicationVEGF-DMicrovascular nicheSingle-cell RNA-seqLung injury modelSingle-cell RNA-seq analysisLung injuryCell-cell communicationLigand-receptor pairsLPS-induced lung injury modelRNA-seqAdjacent cell typesPulmonary diseaseInjury modelHuman lung endothelial cellsBarrier functionImmune cell infiltrationTumor necrosis factor-aRespiratory distress syndromeLung vascular integrityGene expressionVEGF-D Is Enriched in the Human Lung Microvascular Niche and Improves Vascular Integrity During Acute Lung Injury
Yuan Y, Sharma L, Tang W, Raredon M, Ahangari F, Khoury J, Wu D, Niklason L, Kaminski N. VEGF-D Is Enriched in the Human Lung Microvascular Niche and Improves Vascular Integrity During Acute Lung Injury. 2024, a4694-a4694. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4694.Peer-Reviewed Original ResearchAberrant Alveolar Epithelial Cells Alter the Alveolar Mesenchyme to Promote Fibrosis in a Clinical Sftpc Mutation Model of Lung Fibrosis
Hoffman E, Roque Barboza W, Rodriguez L, Murthy A, Dherwani R, Bennett A, Tomer Y, Raredon M, Beers M, Katzen J. Aberrant Alveolar Epithelial Cells Alter the Alveolar Mesenchyme to Promote Fibrosis in a Clinical Sftpc Mutation Model of Lung Fibrosis. 2024, a5197-a5197. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5197.Peer-Reviewed Original Research
2023
Building Epithelial Barrier in Whole-lung Tissue Engineering
Greaney A, Raredon M, Adams T, Langer R, Kaminski N, Niklason L. Building Epithelial Barrier in Whole-lung Tissue Engineering. 2023, a6159-a6159. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6159.Peer-Reviewed Original ResearchRational engineering of lung alveolar epithelium
Leiby K, Yuan Y, Ng R, Raredon M, Adams T, Baevova P, Greaney A, Hirschi K, Campbell S, Kaminski N, Herzog E, Niklason L. Rational engineering of lung alveolar epithelium. Npj Regenerative Medicine 2023, 8: 22. PMID: 37117221, PMCID: PMC10147714, DOI: 10.1038/s41536-023-00295-2.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSARS-CoV-2 leverages airway epithelial protective mechanism for viral infection
Greaney A, Raredon M, Kochugaeva M, Niklason L, Levchenko A. SARS-CoV-2 leverages airway epithelial protective mechanism for viral infection. IScience 2023, 26: 106175. PMID: 36788793, PMCID: PMC9912025, DOI: 10.1016/j.isci.2023.106175.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSingle-cell RNA sequencing datasetsCell-cell communicationRNA sequencing datasetsViral infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infectionEarly SARS-CoV-2 infectionSequencing datasetsSARS-CoV-2 infectionRepair mechanismsEarly viral entryTissue repair mechanismsMature ciliated cellsAlternative therapeutic approachSARS-CoV-2 virusResponse mechanismsFeedforward loopCell precursorsRapid differentiationViral entryBronchial epitheliumTherapeutic approachesBarrier tissuesKey mechanismCiliated cellsInfection
2022
Comprehensive visualization of cell–cell interactions in single-cell and spatial transcriptomics with NICHES
Raredon M, Yang J, Kothapalli N, Lewis W, Kaminski N, Niklason L, Kluger Y. Comprehensive visualization of cell–cell interactions in single-cell and spatial transcriptomics with NICHES. Bioinformatics 2022, 39: btac775. PMID: 36458905, PMCID: PMC9825783, DOI: 10.1093/bioinformatics/btac775.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCell-cell interactionsCell-cell signalingSingle-cell resolutionSingle-cell dataLocal cellular microenvironmentSingle-cell levelSpatial transcriptomics dataCell clustersExtracellular signalingTranscriptomic dataGene expression valuesSpatial transcriptomicsSignaling mechanismCellular microenvironmentNicheExpression valuesSupplementary dataSignalingTranscriptomicsComprehensive visualizationBioinformaticsInteractionFibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer
Sinha S, Sparks H, Labit E, Robbins H, Gowing K, Jaffer A, Kutluberk E, Arora R, Raredon M, Cao L, Swanson S, Jiang P, Hee O, Pope H, Workentine M, Todkar K, Sharma N, Bharadia S, Chockalingam K, de Almeida L, Adam M, Niklason L, Potter S, Seifert A, Dufour A, Gabriel V, Rosin N, Stewart R, Muench G, McCorkell R, Matyas J, Biernaskie J. Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer. Cell 2022, 185: 4717-4736.e25. PMID: 36493752, PMCID: PMC9888357, DOI: 10.1016/j.cell.2022.11.004.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFibrotic scarSite-specific immune responseFull-thickness injurySkin fibroblastsWound healing outcomesInflammatory mediatorsImmunosuppressive phenotypeImmune resolutionLeukocyte recruitmentMyeloid infiltrationImmune responseHuman fetal fibroblastsHealing outcomesFibrotic phenotypeBack skinEctopic transplantationAdult humansSkin woundsScarSkinSkin repairPowerful comparative modelFibroblastsFetal fibroblastsRepairSoluble Signals to Improve Endothelial Integrity in the Lung
Yuan Y, Raredon M, Yuan Q, Obata T, Qian H, Wu D, Kaminski N, Niklason L. Soluble Signals to Improve Endothelial Integrity in the Lung. 2022, a5749-a5749. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5749.Peer-Reviewed Original Research
Academic Achievements and Community Involvement
honor MD/PhD Thesis Prize
Yale School of Medicine AwardYale School of MedicineDetails05/23/2022United Stateshonor Draper Fellowship
Other AwardDraper LaboratoriesDetails09/05/2012United Stateshonor Distinction in Biomedical Engineering
Yale University AwardYale UniversityDetails05/05/2011United Stateshonor Distinction in History of Art
Yale University AwardYale UniversityDetails05/05/2011United Stateshonor Engineering Honors
National AwardTau Beta PiDetails05/01/2011United States
Links & Media
Media
Bronchioalveolar junction
Photo by Micha Sam Brickman RaredonImmunostaining of cellular communities at the bronchioalveolar junction in lung tissue
News
- May 19, 2022
A Celebration of Student Research and Faculty Mentorship
- April 16, 2020
Sharing a Ventilator, Sparing a Life: Two Yale Groups Create Different Ways To Maximize Ventilator Capacity in a Crisis
- April 09, 2020Source: Yale School of Engineering and Applied Sciences
With an Urgent Need, Researchers Develop Multi-Patient Ventilators
- December 03, 2019
With Cellular Blueprint for Lungs, Yale Researchers Look Ahead to Organ Regeneration