Laura Niklason, PhD, MD
Professor AdjunctCards
Appointments
Additional Titles
Division Chief
Vice Chair, Research
Contact Info
Anesthesiology
PO Box 208089, 10 Amistad Street, Room 301D
New Haven, CT 06520-8089
United States
Appointments
Additional Titles
Division Chief
Vice Chair, Research
Contact Info
Anesthesiology
PO Box 208089, 10 Amistad Street, Room 301D
New Haven, CT 06520-8089
United States
Appointments
Additional Titles
Division Chief
Vice Chair, Research
Contact Info
Anesthesiology
PO Box 208089, 10 Amistad Street, Room 301D
New Haven, CT 06520-8089
United States
About
Titles
Professor Adjunct
Division Chief; Vice Chair, Research
Biography
Dr. Niklason is the Nicholas M. Greene Professor at Yale University in Anesthesia and Biomedical Engineering, where she has been on faculty since 2006. Dr. Niklason’s research focuses primarily on regenerative strategies for cardiovascular and lung tissues. Niklason’s engineered blood vessels are currently in clinical trials, and are the first life-sustaining engineered tissue to be studied in any Phase III trial. Niklason’s lab was also one of the first to describe the engineering of whole lung tissue that could exchange gas in vivo, and this work was cited in 2010 as one of the top 50 most important inventions of the year by Time Magazine. She was inducted into the National Academy of Inventors in 2014, and was elected to the National Academy of Medicine in 2015.
Niklason received her PhD in Biophysics from the University of Chicago, and her MD from the University of Michigan. She completed her residency training in anesthesia and intensive care unit medicine at the Massachusetts General Hospital in Boston, and completed post-doctoral scientific training at Massachusetts Institute of Technology.
Appointments
Anesthesiology
Professor AdjunctPrimary
Other Departments & Organizations
- Anesthesiology
- NIH T32 Program
- Niklason Lab
- Yale Stem Cell Center
- Yale Ventures
Education & Training
- Fellow
- Mass General Hospital (1996)
- Resident
- Mass General Hospital (1995)
- Intern
- University of Michigan (1992)
- MD
- University of Michigan/Ann Arbor (1991)
- PhD
- University of Chicago (1988)
Board Certifications
Critical Care Medicine Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 1999
Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 1998
Research
Overview
- Tissue engineered arteries, utilizing decellularization approaches
- Regeneration of whole, functional lung tissue
- Engineering of thoracic conduits, including trachea and esophagus
- Investigation of the molecular basis of cellular aging in various tissues
- Investigation of causes of intimal hyperplasia in vein grafts
Medical Research Interests
ORCID
0000-0002-5156-504X- View Lab Website
Niklason Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Liping Zhao, MS, HT (ASCP)
Micha Sam Brickman Raredon, MD, PhD
Naftali Kaminski, MD
Yifan Yuan
Dianqing (Dan) Wu, PhD
Farida Ahangari, MD
Tissue Engineering
Lung
Blood Vessels
Publications
2025
Adrenomedullin Is Enriched in Human Lung Vascular Niche and Enhances Endothelial Cell Maturation in Bioengineered Lung Models
Yoon Y, Kirk S, Raredon M, Kaminski N, Niklason L, Yuan Y. Adrenomedullin Is Enriched in Human Lung Vascular Niche and Enhances Endothelial Cell Maturation in Bioengineered Lung Models. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7243-a7243. DOI: 10.1164/ajrccm.2025.211.abstracts.a7243.Peer-Reviewed Original ResearchBudget impact model of acellular tissue engineered vessel for the repair of extremity arterial trauma when autologous vein is not feasible
Velez F, Rajani R, Malone D, Sun L, Bloudek L, Carter K, Panaccio M, Niklason L. Budget impact model of acellular tissue engineered vessel for the repair of extremity arterial trauma when autologous vein is not feasible. Journal Of Medical Economics 2025, 28: 323-334. PMID: 39964834, DOI: 10.1080/13696998.2025.2469460.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsConduit infectionAutologous veinTissue engineered vesselHarvest site infectionBudget impactTrauma centerSurgical re-interventionOperating roomLevel I trauma centerGraft infectionBudget impact modelRe-interventionComplication rateSite infectionVein repairGraft typeClinical studiesProsthetic graftsParameter uncertaintiesPost-discharge costsArterial traumaPROOVIT registryTrauma repairOR timeInfection
2024
Engineered vascular grafts lend unique insight to pathophysiology of aortic aneurysms
Naegeli K, Niklason L. Engineered vascular grafts lend unique insight to pathophysiology of aortic aneurysms. Cell Stem Cell 2024, 31: 1099-1100. PMID: 39094540, DOI: 10.1016/j.stem.2024.07.002.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis
Kural M, Djakbarova U, Cakir B, Tanaka Y, Chan E, Arteaga Muniz V, Madraki Y, Qian H, Park J, Sewanan L, Park I, Niklason L, Kural C. Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis. Cell Death & Disease 2024, 15: 440. PMID: 38909035, PMCID: PMC11193792, DOI: 10.1038/s41419-024-06822-3.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsFas-induced apoptosisCell surface Fas expressionDeath receptor FasInhibition of endocytosisSurface Fas expressionPlasma membrane tensionCancer cell apoptosisEndocytosis dynamicsApoptotic signalingReceptor FasGlioblastoma cell growthFas expressionPlasma membraneCell growthEndocytosisXenograft mouse modelSoluble FasLCell apoptosisFasApoptosisRho-kinase inhibitorCancer cellsMembrane tensionNonmalignant cellsInduce tumor regression335-OR: Preliminary Results of Islet Survival in a Novel Biovascular Pancreas Implanted in Primates
KURAL M, NASH K, NAEGELI K, QIAN H, WANG J, KIRKTON R, NIKLASON L. 335-OR: Preliminary Results of Islet Survival in a Novel Biovascular Pancreas Implanted in Primates. Diabetes 2024, 73 DOI: 10.2337/db24-335-or.Peer-Reviewed Original ResearchCitationsUse of the Human Acellular Vessel to Repair Iatrogenic Vascular Trauma
Lum Y, Moore E, Morrison J, Shores J, Niklason L, Parikh S. Use of the Human Acellular Vessel to Repair Iatrogenic Vascular Trauma. Journal Of Vascular Surgery 2024, 79: e297. DOI: 10.1016/j.jvs.2024.03.385.Peer-Reviewed Original ResearchCharacteristics of Hemodialysis Patients Experiencing Vascular Access Difficulties
Niklason L, Panaccio M, Willetts J. Characteristics of Hemodialysis Patients Experiencing Vascular Access Difficulties. Journal Of Vascular Surgery 2024, 79: e179. DOI: 10.1016/j.jvs.2024.03.226.Peer-Reviewed Original ResearchResistance to Infection of the Human Acellular Vessel in Extremity Arterial Trauma Repair
Moore E, Fox C, Niklason L, Parikh S. Resistance to Infection of the Human Acellular Vessel in Extremity Arterial Trauma Repair. Journal Of Vascular Surgery 2024, 79: e155. DOI: 10.1016/j.jvs.2024.03.189.Peer-Reviewed Original Research#2598 Risk of vascular access complications in haemodialysis patients initiating dialysis with arteriovenous fistula or arteriovenous graft
Willetts J, Usvyat L, Chaudhuri S, Niklason L, Maddux F. #2598 Risk of vascular access complications in haemodialysis patients initiating dialysis with arteriovenous fistula or arteriovenous graft. Nephrology Dialysis Transplantation 2024, 39: gfae069-1550-2598. DOI: 10.1093/ndt/gfae069.1550.Peer-Reviewed Original ResearchConceptsVascular access complication ratesArteriovenous fistulaEnd-stage kidney diseaseArteriovenous graftsVA complicationsVascular accessIn-center hemodialysisInitial VAComorbid conditionsDuration of follow-upAssociated with increased riskComplication eventsHistory of myocardial infarctionCongestive heart failureVascular access complicationsDiabetic ptsRisk of vascular access complicationsComplication rateDemographic characteristicsIncreased BMIDocumented thrombosisIn-center hemodialysis patientsContinuous hemodialysisHigher BMIHaemodialysis patientsSingle-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injury
Yuan Y, Sharma L, Tang W, Raredon M, Ahangari F, Khoury J, Wu D, Niklason L, Kaminski N. Single-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injury. Physiology 2024, 39: 1314. DOI: 10.1152/physiol.2024.39.s1.1314.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisAcute lung injuryChronic obstructive pulmonary diseaseAcute respiratory distress syndromeAnalysis of cell-cell communicationVEGF-DMicrovascular nicheSingle-cell RNA-seqLung injury modelSingle-cell RNA-seq analysisLung injuryCell-cell communicationLigand-receptor pairsLPS-induced lung injury modelRNA-seqAdjacent cell typesPulmonary diseaseInjury modelHuman lung endothelial cellsBarrier functionImmune cell infiltrationTumor necrosis factor-aRespiratory distress syndromeLung vascular integrityGene expression
Academic Achievements & Community Involvement
Activities
activity Stem Cell Research
01/01/2007 - PresentResearchDetailsUnited KingdomAbstract/SynopsisProfessor Niklason collaborates with Dr. Sanjay Sinha and Dr. Roger Pedersen of Cambridge University. Their work centers on stem cell research.
Links
Get In Touch
Contacts
Anesthesiology
PO Box 208089, 10 Amistad Street, Room 301D
New Haven, CT 06520-8089
United States