Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsJonas Christian Schupp, MD
Assistant Professor AdjunctAbout
Research
Publications
2026
Management von SARD-ILD im Wandel
Witte T, Schupp J. Management von SARD-ILD im Wandel. Zeitschrift Für Rheumatologie 2026, 1-8. PMID: 41879828, DOI: 10.1007/s00393-026-01807-3.Peer-Reviewed Original ResearchProgressive pulmonary fibrosisSystematic PubMed searchWell-tolerated treatment optionInterstitial lung diseaseInhaled treprostinilCTD-ILDUnfavourable prognosisAnti-inflammatory propertiesPulmonary fibrosisAdverse eventsTreatment optionsAntifibrotic agentsLung function lossLung diseaseClinical studiesPubMed searchClinical investigationTherapeutic strategiesTherapeutic approachesLung functionRheumatic diseasesRespiratory symptomsObjectivesThis reviewTherapeutic perspectivesMethodsA systematic PubMed searchExtent of alveolar collapse in expiratory CT as a prognostic marker in idiopathic pulmonary fibrosis
Scharm S, Schaefer-Prokop C, Schreuder A, Ehmig J, Hunkemöller A, Fuge J, Seeliger B, Schupp J, Wacker F, Shin H. Extent of alveolar collapse in expiratory CT as a prognostic marker in idiopathic pulmonary fibrosis. PLOS ONE 2026, 21: e0345308. PMID: 41843601, PMCID: PMC12994813, DOI: 10.1371/journal.pone.0345308.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisAlveolar collapseCT scanPulmonary fibrosisAttenuation histogramPrognostic imaging markerBaseline forced vital capacityMann-Whitney U testRetrospective longitudinal studyBaseline FVC%Baseline CTExpiratory CTIPF patientsHistogram measuresPredictive markerPrognostic markerLogistic regression modelsPatient subgroupsPatient populationMann-WhitneyPatientsU testVital capacityImaging markersOutcome predictionOptimized culture of primary human alveolar type II cell–derived 3D organoids from fibrotic lung tissue with phenotypic and metabolic profiling
Schröder L, Rückoldt J, Schubert S, Knudsen L, Janciauskiene S, Werlein C, Knoll M, Engelhardt R, Petzold-Mügge C, Schupp J, Hoeper M, Gottlieb J, Ius F, Zardo P, Lindenberg M, Riehle C, Neubert L, Kamp J. Optimized culture of primary human alveolar type II cell–derived 3D organoids from fibrotic lung tissue with phenotypic and metabolic profiling. Respiratory Research 2026 PMID: 41792753, DOI: 10.1186/s12931-026-03610-9.Peer-Reviewed Original ResearchAT-II cellsOrganoid-forming capacityLung tissueMetabolic reprogrammingLung organoidsMetabolic profileExtracellular flux assaysPulmonary disease modelsHuman alveolar typeMagnetic bead sortingFibrotic lung tissueEpithelial dysfunctionBasaloid featuresModel in vitroAT I cellsSurfactant secretionAlveolar repairMetabolic alterationsImmune regulationAT-IIGlycolytic shiftEpithelial cellsPulmonary diseaseAlveolar typeFlow cytometryKlinische Implikationen von Traktionsbronchiektasen bei IPF und fibrosierender RA-ILD – Eine retrospektive monozentrische Kohortenstudie
Raith J, Ruwisch J, Schupp J, Graalmann T, Drick N, Hoeper M, Prasse A, Fuge J, Ringshausen F, Knegendorf L, Rademacher J, Dettmer S, Seeliger B. Klinische Implikationen von Traktionsbronchiektasen bei IPF und fibrosierender RA-ILD – Eine retrospektive monozentrische Kohortenstudie. Pneumologie 2026, 80: s51-s51. DOI: 10.1055/s-0046-1816203.Peer-Reviewed Original ResearchNeue Autoantikörper-Profile bei primärem Sjögren-Syndrom mit interstitieller Lungenerkrankung
Gras J, Ruwisch J, Engelke F, Graalmann T, Schupp J, Fuge J, Prasse A, Dettmer S, Witte T, Seeliger B. Neue Autoantikörper-Profile bei primärem Sjögren-Syndrom mit interstitieller Lungenerkrankung. Pneumologie 2026, 80: s51-s52. DOI: 10.1055/s-0046-1816204.Peer-Reviewed Original ResearchAltered cholesterol immunometabolism activates the macrophage NLRP3-inflammasome in lung fibrosis.
Vaso M, Dukic M, Pennitz P, Manukyan A, Collum S, Lin W, Winder C, Dunn W, Schupp J, Braubach P, Wygrecka M, Ren D, Suarez E, Huang H, Hussain R, Patel B, Karmouty-Quintana H, Akalin A, Landthaler M, Nouailles G, Ochs M, Lopez-Rodriguez E, Giambelluca S. Altered cholesterol immunometabolism activates the macrophage NLRP3-inflammasome in lung fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2026 PMID: 41738296, DOI: 10.1093/ajrcmb/aanag029.Peer-Reviewed Original ResearchBronchoalveolar lavage fluidBronchoalveolar lavage fluid cellsMurine modelLung fibrosisFibrosis patientsNLRP3 inflammasome activationNLRP3 inflammasomeBALF cellsInflammasome activationMurine model of lung fibrosisWild-type (WT) miceCholesterol metabolismModel of lung fibrosisLipidomic analysisIL-18 levelsHuman macrophage modelLung fibrosis progressionIPF patientsNLRP3 inflammasome componentsPatient cohortPulmonary fibrosisFibrosis progressionLavage fluidFibrosis markersMacrophage NLRP3 inflammasomeSpatial Transcriptomics Uncovers Hybrid, Pro-Inflammatory and Pro-Fibrotic Cellular Niches in Pulmonary Granuloma of Patients with Chronic Sarcoidosis.
Christian L, Yilmaz H, Ruwisch J, Giercke L, Seeliger B, Kamp J, Bayraktar S, Ewen R, Graalmann T, Fuge J, Greer M, Ius F, Welte T, Liao S, Yang I, Hohlfeld J, Hoeper M, Gottlieb J, Kaminski N, Prasse A, Jonigk D, Li Y, Falk C, Neubert L, Schupp J. Spatial Transcriptomics Uncovers Hybrid, Pro-Inflammatory and Pro-Fibrotic Cellular Niches in Pulmonary Granuloma of Patients with Chronic Sarcoidosis. American Journal Of Respiratory And Critical Care Medicine 2026 PMID: 41738160, DOI: 10.1093/ajrccm/aamaf089.Peer-Reviewed Original ResearchPulmonary granulomasPro-inflammatoryChronic sarcoidosisSarcoidosis patientsPulmonary fibrosisMacrophage nicheChronic sarcoidosis patientsGranulomas of patientsCD3+ TImmune cell accumulationPeriphery of granulomasIdiopathic pulmonary fibrosisRNA in situ hybridizationCellular nicheGene expressionLigand-receptor analysisValidation of gene expressionSpatial transcriptomicsIFN-gLung remodelingCTHRC1 expressionSarcoidosis granulomasLung explantsSpatial gene expressionSarcoidosisClinical implications of traction bronchiectasis in IPF and fibrotic RA-ILD – a retrospective single-center cohort study
Raith J, Ruwisch J, Schupp J, Graalmann T, Drick N, Hoeper M, Prasse A, Fuge J, Ringshausen F, Knegendorf L, Rademacher J, Dettmer S, Seeliger B. Clinical implications of traction bronchiectasis in IPF and fibrotic RA-ILD – a retrospective single-center cohort study. Respiratory Research 2026, 27: 31. PMID: 41530804, PMCID: PMC12849085, DOI: 10.1186/s12931-026-03497-6.Peer-Reviewed Original ResearchConceptsRheumatoid arthritis-associated interstitial lung diseaseIdiopathic pulmonary fibrosisSingle-center cohort studyRA-ILD patientsHigh-resolution computed tomographyBrody scoreTraction bronchiectasisBronchiectasis scoreCohort studyCox regressionRetrospective single-center cohort studyFibrosis extentTransplant-free survivalRespiratory pathogen detectionMultivariate Cox regressionInterstitial lung diseaseClinical implicationsAssociated with survivalAssociated with mortalityFibrosing ILDsFibrotic extentCDC criteriaPrognostic significanceBaseline FVCPulmonary fibrosis
2025
PDE-4 Inhibition in Sarcoidosis Patients: A Retrospective Single-Center Analysis of 51 Patients
Feineis M, Terschluse C, Jouanjan L, Soriano D, Agarwal P, Schupp J, Müller-Quernheim J, Stolz D, Frye B. PDE-4 Inhibition in Sarcoidosis Patients: A Retrospective Single-Center Analysis of 51 Patients. Pharmaceuticals 2025, 18: 1729. PMID: 41304973, PMCID: PMC12654997, DOI: 10.3390/ph18111729.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseSarcoidosis patientsModerate gastrointestinal side effectsNo severe AEsRetrospective single-center analysisSide effectsAssociated with numerous side effectsSingle-center analysisTreatment of chronic obstructive pulmonary diseaseEscalation of therapyDepartment of PneumologySevere adverse eventsGastrointestinal side effectsDetrimental to patientsNumerous side effectsObstructive pulmonary diseaseUniversity Hospital FreiburgTherapy escalationTherapeutic optionsAdverse eventsLung function lossSarcoidosisOff-labelOrgan damageControl symptomsSegDecon bridges histology and transcriptomics through AI-based nuclei segmentation and image-informed spatial deconvolution
Xi Y, Jiang X, Schupp J, Xu C, Li Y. SegDecon bridges histology and transcriptomics through AI-based nuclei segmentation and image-informed spatial deconvolution. Computational And Structural Biotechnology Journal 2025, 27: 4586-4596. PMID: 41234485, PMCID: PMC12605641, DOI: 10.1016/j.csbj.2025.10.041.Peer-Reviewed Original Research