Junjie Guo, PhD
Cards
About
Titles
Assistant Professor of Neuroscience
Co-Director of Graduate Studies, Interdepartmental Neuroscience ProgramBiography
Junjie Guo received his B.A. in Biology from Peking University and completed his Ph.D. thesis in the Solomon H. Snyder Department of Neuroscience at Johns Hopkins University School of Medicine, working on neuronal DNA methylation. During his postdoctoral training at the Whitehead Institute/MIT, he developed a series of high-throughput computational and experimental methods to investigate circular RNAs and intracellular RNA folding. He joined the Department of Neuroscience at Yale School of Medicine in Fall 2017.
The Guo lab is broadly interested in questions at the intersection of RNA biology and Neuroscience, with a focus on understanding the mechanisms and functions of mRNA translation control in the nervous system as well as its dysregulation in neurological disorders caused by nucleotide repeat expansions.
Appointments
Neuroscience
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellow
- Whitehead Institute/MIT/HHMI (2017)
- Postdoctoral Associate
- Johns Hopkins University School of Medicine (2012)
- PhD
- Johns Hopkins University School of Medicine, Neuroscience (2011)
- BA
- Peking University, Biology (2006)
Research
Academic Achievements and Community Involvement
Teaching & Mentoring
Links & Media
Media
RNA metabolism defects in ALS/FTD
ALS/FTD-associated poly(glycine-arginine) peptides cause the recruitment of UPF1, an RNA quality control factor, into stress granules in mouse primary cortical neurons. Ataxin-2-positive stress granules are indicated by arrowheads.
News
- July 31, 2023Source: McKnight Foundation
Guo receives 2023 Neurobiology of Brain Disorders Awards from the McKnight Foundation
- July 25, 2023
Midsummer's RNA Dreams happy hour
- July 05, 2020
The Mechanisms Behind Neurodegenerative Diseases: New Insights on Alzheimer’s, Parkinson’s, and ALS
- May 14, 2019
Yale Neuroscientist Awarded Grant to Investigate ALS