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Ya-Chi Ho, MD, PhD

Associate Professor Term; Investigator, REACH Martin Delaney Collaboratory; Member, Center for the Structural Biology of Cellular Host Elements in Egress, Trafficking, and Assembly of HIV (CHEETAH)



Dr. Ho takes molecular virology, immunology, and single-cell and genomics approaches to examine HIV persistence and HIV-induced immune dysfunction. Using clinical samples from HIV-infected individuals, the Ho lab investigates host-HIV interactions with particular interests in HIV-host RNA landscape (using single-cell RNAseq), CD4 T cell expansion dynamics, HIV-host genome interactions, and HIV-specific silencing, and immune escape mechanisms. Dr. Ho was a board-certified infectious disease attending physician in Taiwan. She received her PhD (2013) and postdoctoral training at Johns Hopkins University School of Medicine in Dr. Robert F. Siliciano's lab. She developed the first near-full-length single genome HIV proviral profiling (Cell 2013), identified defective HIV proviruses as a source of chronic immune activation in virally suppressed HIV-infected individuals (Cell Host Microbe 2017), and identified HIV-driven aberrant cancer gene expression as a mechanism of HIV persistence (Science Translational Medicine 2020). The Ho lab has active collaborations with physicians, immunologists, computer scientists, and HIV investigators both within Yale and in NIH-funded multi-center collaborations.

Education & Training

  • Postdoctoral fellow
    Johns Hopkins School of Medicine (2014)
  • PhD
    Johns Hopkins University School of Medicine, Cellular and Molecular Medicine (2013)
  • MMS
    National Taiwan University, Clinical Medicine (2007)
  • Clinical fellow
    National Taiwan University Hospital (2007)
  • Resident
    National Taiwan University Hospital (2005)
  • MD
    National Cheng Kung University, Medicine (2002)
  • Clinical clerkship
    Duke University Medical Center (2002)
  • Clinical clerkship
    Yale University (2000)

Honors & Recognition

AwardAwarding OrganizationDate
Andy Kaplan PrizeCold Spring Harbor Laboratory Meetings on Retroviruses2018
Gilead Sciences Research Scholar in HIVGilead Sciences2018
Rudolf J. Anderson FellowshipYale University2018
Lois E. and Franklin H. Top, Jr. Yale ScholarYale University School of Medicine2017
Distinguished Alumni AwardNational Cheng Kung University2016
W. W. Smith Charitable Foundation AIDS Research AwardW. W. Smith Charitable Foundation2016
Phi Beta KappaPhi Beta Kappa Honorary Society2014
Michael Shanoff Johns Hopkins Young Investigator AwardJohns Hopkins University School of Medicine2014
Howard Hughes International Student Research FellowshipHoward Hughes Medical Institute2011
Best Teaching Resident AwardNational Taiwan University Hospital2007
Scholarship for PhD Studies AbroadMinistry of Education, Taiwan2007
Best Resident AwardDepartment of Medicine, National Taiwan University Hospital2003, 2004
Phi Tau PhiPhi Tau Phi Honorary Society, Taiwan2002

Departments & Organizations