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Peter S. Aronson, MD

C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular And Molecular Physiology
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About

Titles

C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular And Molecular Physiology

Biography

Dr. Aronson received his undergraduate education at the University of Rochester and his medical education at New York University. He was an internal medicine resident at the University of North Carolina and a research fellow at the National Institutes of Health before coming to Yale as a nephrology fellow in 1974. He joined the Yale faculty in 1977, and was Chief of the Section of Nephrology from 1987-2002. Dr. Aronson has published articles and book chapters on the mechanisms regulating sodium, chloride, acid-base, and oxalate excretion by the kidney. He has received several awards and honors for his research work, including the Young Investigator Award of the American Society of Nephrology (ASN) and American Heart Association in 1985, the Homer W. Smith Award of the ASN in 1994, Fellow of the American Association for the Advancement of Science in 1996, Fellow of the American Academy of Arts and Sciences in 2009, the Robert W. Berliner Award of the American Physiological Society (APS) in 2016, and the Walter B. Cannon Award of the APS in 2019. He served as President of the American Society of Nephrology in 2008. Dr. Aronson actively participates in the teaching of undergraduate, graduate and medical students. He was a co-recipient of the Charles W. Bohmfalk Teaching Prize in the Basic Sciences in 2005, and received the Fund for Physician-Scientist Mentorship Award in 2023. Dr. Aronson is an Associate Director of the Yale M.D.-Ph.D. Program.

Appointments

Education & Training

Postdoctoral Fellow in Nephrology
Yale School of Medicine (1977)
Clinical Associate (Research Fellow)
Gerontology Research Center, NIH (1974)
Resident
University of North Carolina School of Medicine (1972)
MD
New York University (1970)
AB
University of Rochester, General Science (1967)

Board Certifications

  • Nephrology

    Certification Organization
    AB of Internal Medicine
    Original Certification Date
    1976
  • Internal Medicine

    Certification Organization
    AB of Internal Medicine
    Original Certification Date
    1973

Research

Overview

Our general goal is to characterize the mechanisms regulating sodium, acid-base, and anion excretion by the kidney. Our work is primarily focused on membrane transport proteins mediating ion exchange, namely NHE isoforms mediating Na+-H+ exchange, and SLC26 isoforms mediating anion exchange. One approach involves the generation of isoform- and phospho-specific polyclonal and monoclonal antibodies to identify the cellular and subcellular sites of expression of ion exchangers in the kidney and other tissues, and to study their regulation. A complementary approach uses mice with targeted gene disruption to elucidate the physiological roles of ion exchangers and associated proteins under in vivo conditions. For example, work with mice lacking anion exchanger Slc26a6, which can function as an oxalate transporter, revealed a phenotype of calcium oxalate kidney stones. This finding in turn has motivated studies on the mechanisms and regulation of oxalate transporters and their roles in oxalate homeostasis, urolithiasis, and crystal-induced inflammation in the kidney and other tissues.

Medical Subject Headings (MeSH)

Acid-Base Imbalance; Cell Membrane Permeability; Hyperoxaluria; Nephrolithiasis; Urinary Tract Physiological Phenomena; Water-Electrolyte Imbalance

Research at a Glance

Yale Co-Authors

Frequent collaborators of Peter S. Aronson's published research.

Publications

2024

2023

2022

2021

Academic Achievements & Community Involvement

  • honor

    Fellow

Get In Touch

Contacts

Academic Office Number
Office Fax Number

Administrative Support

Locations

  • Yale Nephrology

    Academic Office

    The Anlyan Center

    300 Cedar Street, Ste Room S255C

    New Haven, CT 06519