Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsFelix Knauf, MD
Assistant Professor AdjunctAbout
Research
Publications
2025
SLC26A1 directs sulfate homeostasis in health and disease
Pitzken F, Köttgen A, Aronson P, Knauf F. SLC26A1 directs sulfate homeostasis in health and disease. Current Opinion In Nephrology & Hypertension 2025, 35: 126-132. PMID: 41056011, DOI: 10.1097/mnh.0000000000001123.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOxalate homeostasisMouse modelKidney stone diseaseSulfate homeostasisStone diseaseOxalate transportTissue-specific gene deletionAcetaminophen-induced liver injuryKnockout mouse modelSulfation of proteoglycansDamaging variantsClinical outcomesMusculoskeletal abnormalitiesLiver injuryGene deletionHuman diseasesDisease pathogenesisSkeletal integrityAssociated diseasesCell functionSlc26a1DiseaseKidneyFunctional assaysHomeostasisShift Work and the Risk of Kidney Stones
Knauf F, Luft F, Nath K. Shift Work and the Risk of Kidney Stones. Mayo Clinic Proceedings 2025, 100: 1693-1695. PMID: 41031993, DOI: 10.1016/j.mayocp.2025.08.018.Commentaries, Editorials and LettersUrine Oxalate Excretion and CKD Stage in Patients With Primary Hyperoxaluria Type 1
Vaughan L, Schulte P, Knauf F, Sas D, Milliner D, Lieske J. Urine Oxalate Excretion and CKD Stage in Patients With Primary Hyperoxaluria Type 1. American Journal Of Kidney Diseases 2025, 87: 138-140. PMID: 40983145, PMCID: PMC12462907, DOI: 10.1053/j.ajkd.2025.07.013.Peer-Reviewed Original ResearchCoupling metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and human traits
Scherer N, Fässler D, Borisov O, Cheng Y, Schlosser P, Wuttke M, Haug S, Li Y, Telkämper F, Patil S, Meiselbach H, Wong C, Berger U, Sekula P, Hoppmann A, Schultheiss U, Mozaffari S, Xi Y, Graham R, Schmidts M, Köttgen M, Oefner P, Knauf F, Eckardt K, Grünert S, Estrada K, Thiele I, Hertel J, Köttgen A. Coupling metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and human traits. Nature Genetics 2025, 57: 193-205. PMID: 39747595, PMCID: PMC11735408, DOI: 10.1038/s41588-024-01965-7.Peer-Reviewed Original ResearchConceptsWhole-exome sequencing dataGene-metabolite associationsHuman traitsHuman metabolic reactionsSequence dataAllelic seriesGene functionExome sequencingFunctional variantsGenetic studiesInborn errors of metabolismHeterozygous variantsErrors of metabolismMusculoskeletal traitsMetabolic reactionsHuman heightUrine metabolitesHeterozygous stateSulfate reabsorptionInborn errorsTraitsAggregation testVariantsHuman metabolismMetabolomics
2024
Pre-emptive use of glucose 5% as the standard drug solvent reduces hypernatremia in critically ill patients
Hardenberg J, Kunz J, Rubarth K, Mittermaier M, Pigorsch M, Balzer F, Witzenrath M, Hinz R, Körner R, Eckardt K, Knauf F, Hinrichs C, Enghard P. Pre-emptive use of glucose 5% as the standard drug solvent reduces hypernatremia in critically ill patients. Clinical Kidney Journal 2024, 17: sfae328. PMID: 39582778, PMCID: PMC11584513, DOI: 10.1093/ckj/sfae328.Peer-Reviewed Original ResearchGlucose 5% solutionGlucose 5%Severe hypernatremiaDrug diluentDrug solventSodium concentrationAssociated with increased mortalityResults Baseline characteristicsAdult COVID-19 patientsRetrospective before-and-after studyCritically ill patientsIntensive care unitPre-emptive usePrevalence of hypernatremiaStudy intensive care unitVenous blood gasesLength of stayCOVID-19 patientsBaseline characteristicsClinical outcomesICU admissionHypernatremiaMedical ICUCare unitBlood gasesOpportunities in Primary and Enteric Hyperoxaluria at the Cross-Roads Between the Clinic and Laboratory
Cellini B, Baum M, Frishberg Y, Groothoff J, Harris P, Hulton S, Knauf F, Knight J, Lieske J, Lowther W, Moochhala S, Nazzal L, Tasian G, Whittamore J, Sas D. Opportunities in Primary and Enteric Hyperoxaluria at the Cross-Roads Between the Clinic and Laboratory. Kidney International Reports 2024, 9: 3083-3096. PMID: 39534212, PMCID: PMC11551133, DOI: 10.1016/j.ekir.2024.08.031.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPrimäre Hyperoxalurie
Saadé C, Knauf F. Primäre Hyperoxalurie. Nephrologie Aktuell 2024, 28: 272-278. DOI: 10.1055/a-2270-5042.Peer-Reviewed Original ResearchRecovery From Severe Heart Failure in a Patient With Primary Hyperoxaluria Type 1 After Treatment With Lumasiran, Pyridoxine, and Kidney Transplant
Choi M, Kahl A, Hawkins-van der Cingel G, Noriega M, Klingel K, Doeblin P, Schoenrath F, Eckardt K, Öllinger R, Knauf F, Halleck F. Recovery From Severe Heart Failure in a Patient With Primary Hyperoxaluria Type 1 After Treatment With Lumasiran, Pyridoxine, and Kidney Transplant. Annals Of Internal Medicine Clinical Cases 2024, 3 DOI: 10.7326/aimcc.2023.1428.Peer-Reviewed Original ResearchInterleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor
Brösecke F, Pfau A, Ermer T, Dein Terra Mota Ribeiro A, Rubenbauer L, Rao V, Burlein S, Genser B, Reichel M, Aronson P, Coca S, Knauf F. Interleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor. Scientific Reports 2024, 14: 11323. PMID: 38760468, PMCID: PMC11101424, DOI: 10.1038/s41598-024-61808-7.Peer-Reviewed Original ResearchConceptsIL-16 levelsIL-16Dialysis patientsCardiovascular eventsConcentrations of IL-16Kidney failureUremic toxinsCardiovascular diseaseCompared to healthy individualsPlasma oxalate concentrationActivated immune cellsAssociated with cardiovascular diseaseIL-16 concentrationCytokine IL-16Cardiovascular risk factorsNo significant associationPlasma oxalateInflammatory markersImmune cellsCytokine concentrationsInterleukin-16US patientsCohort 1Cardiovascular outcomesHealthy individualsOxalate Metabolism: From Kidney Stones to Cardiovascular Disease
Hawkins-van der Cingel G, Walsh S, Eckardt K, Knauf F. Oxalate Metabolism: From Kidney Stones to Cardiovascular Disease. Mayo Clinic Proceedings 2024, 99: 1149-1161. PMID: 38762815, DOI: 10.1016/j.mayocp.2024.02.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
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