Felix Knauf, MD
About
Research
Publications
2024
Recovery From Severe Heart Failure in a Patient With Primary Hyperoxaluria Type 1 After Treatment With Lumasiran, Pyridoxine, and Kidney Transplant
Choi M, Kahl A, Hawkins-van der Cingel G, Noriega M, Klingel K, Doeblin P, Schoenrath F, Eckardt K, Öllinger R, Knauf F, Halleck F. Recovery From Severe Heart Failure in a Patient With Primary Hyperoxaluria Type 1 After Treatment With Lumasiran, Pyridoxine, and Kidney Transplant. Annals Of Internal Medicine Clinical Cases 2024, 3 DOI: 10.7326/aimcc.2023.1428.Peer-Reviewed Original ResearchInterleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor
Brösecke F, Pfau A, Ermer T, Dein Terra Mota Ribeiro A, Rubenbauer L, Rao V, Burlein S, Genser B, Reichel M, Aronson P, Coca S, Knauf F. Interleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor. Scientific Reports 2024, 14: 11323. PMID: 38760468, PMCID: PMC11101424, DOI: 10.1038/s41598-024-61808-7.Peer-Reviewed Original ResearchConceptsIL-16 levelsIL-16Dialysis patientsCardiovascular eventsConcentrations of IL-16Kidney failureUremic toxinsCardiovascular diseaseCompared to healthy individualsPlasma oxalate concentrationActivated immune cellsAssociated with cardiovascular diseaseIL-16 concentrationCytokine IL-16Cardiovascular risk factorsNo significant associationPlasma oxalateInflammatory markersImmune cellsCytokine concentrationsInterleukin-16US patientsCohort 1Cardiovascular outcomesHealthy individualsOxalate Metabolism: From Kidney Stones to Cardiovascular Disease
Hawkins-van der Cingel G, Walsh S, Eckardt K, Knauf F. Oxalate Metabolism: From Kidney Stones to Cardiovascular Disease. Mayo Clinic Proceedings 2024, 99: 1149-1161. PMID: 38762815, DOI: 10.1016/j.mayocp.2024.02.006.Peer-Reviewed Original Research
2023
Design Research to Embed mHealth into a Community-Led Blood Pressure Management System in Uganda: Protocol for a Mixed Methods Study
Schwab J, Wachinger J, Munana R, Nabiryo M, Sekitoleko I, Cazier J, Ingenhoff R, Favaretti C, Pillai V, Weswa I, Wafula J, Emmrich J, Bärnighausen T, Knauf F, Knauss S, Nalwadda C, Sudharsanan N, Kalyesubula R, McMahon S. Design Research to Embed mHealth into a Community-Led Blood Pressure Management System in Uganda: Protocol for a Mixed Methods Study. JMIR Research Protocols 2023, 12: e46614. PMID: 38032702, PMCID: PMC10722357, DOI: 10.2196/46614.Peer-Reviewed Original ResearchINTERNATIONAL REGISTERED REPORT IDENTIFIERIntervention prototypeManagement of hypertensionHealth careChronic disease managementMixed-methods studyMobile health interventionsResource-constrained settingsHealth system challengesUncontrolled hypertensionAntihypertensive medicationsGerman RegistryHypertension managementRisk factorsClinical trialsCardiovascular diseaseHypertensionMethods studyBasic health careMedicationsHealth interventionsConcurrent trialsSuch diseasesDisease managementPrivate facilitiesChallenges to Implementation of Community Health Worker-Led Chronic Obstructive Pulmonary Disease (COPD) Screening and Referral in Rural Uganda: A Qualitative Study using the Implementation Outcomes Framework
Ingenhoff R, Robertson N, Munana R, Bodnar B, Weswa I, Sekitoleko I, Gaal J, Kirenga B, Kalyesubula R, Knauf F, Siddharthan T. Challenges to Implementation of Community Health Worker-Led Chronic Obstructive Pulmonary Disease (COPD) Screening and Referral in Rural Uganda: A Qualitative Study using the Implementation Outcomes Framework. International Journal Of Chronic Obstructive Pulmonary Disease 2023, 18: 2769-2783. PMID: 38046984, PMCID: PMC10693197, DOI: 10.2147/copd.s420137.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseImplementation Outcomes FrameworkCOPD screeningRural UgandaBurden of COPDReferral processCommunity health worker interventionHealth worker interventionObstructive pulmonary diseaseHealthcare providers' perceptionsCause of deathHigh patient volumeCommunity-based interventionsCHW supportCOPD awarenessCOPD careMiddle-income countriesPulmonary diseaseMedication accessBody of evidenceOutcomes FrameworkQualitative studyHealth outcomesProviders' perceptionsPatient volumeSLC26A6 Plays a Major Role in Release of Soluble Oxalate from Macrophages Following Internalization of Calcium Oxalate Crystals
Najenson A, Wagner T, Bachmann S, Thomson R, Knauf F, Aronson P. SLC26A6 Plays a Major Role in Release of Soluble Oxalate from Macrophages Following Internalization of Calcium Oxalate Crystals. Journal Of The American Society Of Nephrology 2023, 34: 490-490. DOI: 10.1681/asn.20233411s1490b.Peer-Reviewed Original ResearchHeart Failure Recovery After Lumasiran and Isolated Kidney Transplantation in Primary Hyperoxaluria Type 1
der Cingel G, Choi M, Kahl A, Schoenrath F, Rehse G, Eckardt K, Knauf F, Halleck F. Heart Failure Recovery After Lumasiran and Isolated Kidney Transplantation in Primary Hyperoxaluria Type 1. Journal Of The American Society Of Nephrology 2023, 34: 565-565. DOI: 10.1681/asn.20233411s1565d.Peer-Reviewed Original ResearchSystemic Immune Dysregulation in a Mouse Model of Oxalate Nephropathy
Bartolomaeus H, Wimmer M, Rauch A, Anandakumar H, Reichel M, Knauf F, Wilck N. Systemic Immune Dysregulation in a Mouse Model of Oxalate Nephropathy. Journal Of The American Society Of Nephrology 2023, 34: 1021-1021. DOI: 10.1681/asn.20233411s11021c.Peer-Reviewed Original ResearchPrinciples for task shifting hypertension and diabetes screening and referral: a qualitative study exploring patient, community health worker and healthcare professional perceptions in rural Uganda
Ingenhoff R, Munana R, Weswa I, Gaal J, Sekitoleko I, Mutabazi H, Bodnar B, Rabin T, Siddharthan T, Kalyesubula R, Knauf F, Nalwadda C. Principles for task shifting hypertension and diabetes screening and referral: a qualitative study exploring patient, community health worker and healthcare professional perceptions in rural Uganda. BMC Public Health 2023, 23: 881. PMID: 37173687, PMCID: PMC10176286, DOI: 10.1186/s12889-023-15704-w.Peer-Reviewed Original ResearchConceptsCommunity health workersNon-communicable diseasesHealthcare workersRural UgandaHealth workersCHW knowledgeNCD screeningDiabetes mellitusMiddle-income countriesCHW characteristicsHypertensionCHW programsCare deliveryHealthcare accessHealthcare professionalsReferralPatient accessHealthcare systemSuccessful program implementationDiabetesPatientsProfessionals' perceptionsFramework methodFocus group discussionsScreeningStrikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury
Sieckmann T, Schley G, Ögel N, Kelterborn S, Boivin F, Fähling M, Ashraf M, Reichel M, Vigolo E, Hartner A, Lichtenberger F, Breiderhoff T, Knauf F, Rosenberger C, Aigner F, Schmidt-Ott K, Scholz H, Kirschner K. Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury. Kidney International 2023, 104: 90-107. PMID: 37121432, DOI: 10.1016/j.kint.2023.04.005.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryKidney injuryKidney pathologyExperimental kidney injuryChronic kidney injuryUnilateral ureteral obstructionForms of injuryPolyamine synthesisCyclosporine treatmentArterial hypertensionKidney transplantationUreteral obstructionKidney levelsTissue injuryTubular castsHealthy kidneysHomeostasis contributesInjuryKidneyExperimental modelKidney cell linePutrescine contentReduced expressionGene expression changesTransplantation