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Karla M Neugebauer, PhD

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R. Selden Rose Professor of Molecular Biophysics and Biochemistry and Professor of Cell Biology
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Additional Titles

Director, Yale Center for RNA Science and Medicine

About

Titles

R. Selden Rose Professor of Molecular Biophysics and Biochemistry and Professor of Cell Biology

Director, Yale Center for RNA Science and Medicine

Biography

Karla Neugebauer holds a BS in Biology from Cornell University and a PhD in Neuroscience from UCSF. She switched gears to RNA biology as a postdoc with Mark Roth at Fred Hutchinson Cancer Research Center. There she participated in the initial description of the SR protein family of splicing regulators and was inspired to study RNA metabolism in vivo by combining imaging, genomics, and sequencing strategies. From 2001-2013 she was a Research Group Leader at the Max Planck Institute of Cell biology and Genetics in Dresden Germany. In 2013, she moved to Yale as a Professor of Molecular Biophysics and Biochemistry and of Cell Biology. She has been the Director of the Yale Center for RNA Science and Biomedicine since 2018 and was recognized internationally for her work in RNA Biology by the RNA Society (2017 mid-career award). She has studied splicing in relation to nuclear speckles and discovered that most introns are removed during the process, or co-transcriptionally. Her lab has shown that snRNP assembly occurs in membraneless organelles called Cajal bodies (CBs) and that depletion of the CB scaffolding protein coilin is lethal in zebrafish embryos, due to a deficit in splicing. She is passionate about climate change, believing that everyone has something to contribute to meet its challenges. She is currently developing biochemistry curriculum to show the relevance of the discipline to meeting the current and future needs of our planet.

Appointments

Education & Training

PhD
University of California-San Francisco, Neuroscience (1990)
BS
Cornell University, Biology/Neuroscience (1984)

Research

Overview

Medical Subject Headings (MeSH)

Alternative Splicing; Biochemistry; Biophysics; Cell Biology; Cell Nucleus; Genomics; Molecular Biology; Nuclear Cap-Binding Protein Complex; RNA Splicing; Saccharomyces cerevisiae; Schizosaccharomyces; Transcription, Genetic; Zebrafish

Research at a Glance

Yale Co-Authors

Frequent collaborators of Karla M Neugebauer's published research.

Publications

2024

2023

Academic Achievements & Community Involvement

  • activity

    Committee on Admissions and Financial Aid (Yale College)

  • activity

    Yale Center for RNA Science and Medicine

  • activity

    Faculty Committee on Athletics

  • activity

    Biological Sciences Area Committee

  • activity

    MB&B Graduate Studies (DGS)

Get In Touch

Contacts

Academic Office Number
Lab Number
Mailing Address

Molecular Biophysics and Biochemistry

333 Cedar St, P.O. Box 208024

New Haven, Connecticut 06520

United States

Locations

  • Sterling Hall of Medicine

    Lab

    333 Cedar Street, Rm C-111

    New Haven, CT 06510

  • Sterling Hall of Medicine

    Academic Office

    333 Cedar Street, Rm C-123

    New Haven, CT 06510