Megan C. King, PhD

Associate Professor of Cell Biology

Research Departments & Organizations

Cell Biology: Cytoskeletal Dynamics

Yale Cancer Center: Radiobiology & Radiotherapy

Office of Cooperative Research

Research Interests

Cell Biology; Cell Nucleus; DNA Repair; Microtubules; Nuclear Envelope; Telomere

Research Summary

Macromolecular complexes embedded in the nuclear envelope physically couple the cytoskeleton to the nucleus. These molecular bridges allow the cytoskeleton to regulate nuclear position within the cell. In addition, they provide a mechanism for signals to be mechanically transduced between the cytoplasm and nucleus.

My laboratory is interested in investigating the role(s) of these nuclear envelope bridges in both processes. We are focused on three primary questions. First, we are defining the macromolecular components that link microtubules (and thereby microtubule-dependent force) to the nucleus.

Second, we are interested in the dynamics and mechanism by which microtubule-nuclear interfaces form and dissolve. Finally, we are investigating the means by which cytoplasmic microtubules can affect chromatin organization and dynamics, as well as the biological implications of these effects. We primarily use fission yeast as our model system, taking advantage of the outstanding imaging, biochemical and genetic tools in this organism.

Specialized Terms: Microtubules; Nucleus; Nuclear envelope; DNA repair; Cellular mechanics; Telomere biology

Extensive Research Description

  1. Investigating how association of DNA double strand breaks with the LINC complex and cytoplasmic microtubules impacts genome integrity
  2. Testing how association of telomeres with the nuclear envelope impacts telomere maintenance
  3. Using advanced microscopy and force spectroscopy techniques to define the basis for the mechanical behavior of nuclei
  4. Probing the role that the nucleus plays in tissue level mechanics, particularly focusing on the skin.

Selected Publications

See list of PubMed publications

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Contact Info

Megan C. King, PhD
Lab Location
Boyer Center for Molecular Medicine
295 Congress Avenue, Ste 245

New Haven, CT 06510
Office Location
Boyer Center for Molecular Medicine
295 Congress Avenue, Ste Room 254D

New Haven, CT 06510
Mailing Address
Cell BiologyPO Box 208002
333 Cedar Street

New Haven, CT 06520-8002

King Lab Website