Jose Gomez Villalobos, MD, MS

Assistant Professor of Medicine (Pulmonary)

Research Departments & Organizations

Internal Medicine: Gomez Lab | Pulmonary, Critical Care & Sleep Medicine: The Center for Precision Pulmonary Medicine (P2MED)

Yale Stem Cell Center

Research Interests

Asthma; Computational Biology; Genomics; Informatics; Pulmonary Disease, Chronic Obstructive

Research Summary

My research is focused on the impact of second-hand smoke in the biology of asthma and the role of microRNAs in asthma severity. Cigarette smoke is a strong environmental influence with a negative effect in lung function and asthma. MicroRNAs are important in the epigenetic regulation of biologic processes, we have identified a microRNA that is associated with airflow obstruction and we are working to understand its biologic function.

Extensive Research Description

Our current projects are focused on the characterization of the molecular response to SHS in airway macrophages of asthmatics and the characterization of microRNA profiles on the airway of individuals with asthma.

My laboratory is also interested in the integration of high-throughput data generated in our laboratory and publicly accessible datasets to understand the biology of airway diseases and the fundamental molecular processes present across pulmonary disease in general.

I'm a believer in interdisciplinary approaches to resolve important problems in medicine and I welcome internal and external collaborations that share this vision.

Clinical Trials

Conditions Study Title
Diseases of the Lung A Study to Assess the Efficacy and Safety of Multiple Dose Levels of AZD7594 Administered Once Daily by Inhalation in Asthmatic Subjects
Diseases of the Blood Expanded access to mepolizumab for patients with hypereosinophilic syndrome
Diseases of the Blood A Multi-center, Open-label Extension, Safety Study of Mepolizumab in Subjects With Hypereosinophilic Syndrome (HES) From Study 200622
Asthma Study of Efficacy and Safety of QAW039 in Patients With Severe Asthma Inadequately Controlled With Standard of Care Asthma Treatment.
Asthma, Men's Health, Women's Health Study to Evaluate Tezepelumab in Adults & Adolescents With Severe Uncontrolled Asthma (NAVIGATOR)
Asthma, Diseases of the Lung A Study of the Safety and Effectiveness of Benralizumab to Treat Patients With Severe Uncontrolled Asthma. (ANDHI)
Asthma, Diseases of the Blood Evaluate the Safety and Efficacy of FG-3019 in Patients With Idiopathic Pulmonary Fibrosis
Children's Health, Diseases of the Blood, Diseases of the Respiratory System, Immune System Compassionate Use of Mepolizumab in Subjects With Hypereosinophilic Syndrome (HES)

Selected Publications

  • Noninvasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma.

    Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL. Noninvasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma. American Journal Of Respiratory And Critical Care Medicine 2015, 191:1116-25. 2015

  • Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40.

    Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N, Cohn L, Chupp GL. Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40. The Journal Of Allergy And Clinical Immunology 2015, 136:51-58.e10. 2015

  • Acid-Base State: The Stewart Approach. In: Nefrologia Critica (Critical Care Nephrology).

    Kellum JA, Hoste E, Gomez JL. Acid-Base State: The Stewart Approach. In: Nefrologia Critica (Critical Care Nephrology). 1st ed. Buenos Aires, Argentina. Ediciones Journal. Chapter 16. 2015

  • Definition of Acute Renal Failure. In: Nefrologia Critica (Critical Care Nephrology)

    Kellum JA, Hoste E, Gomez JL. Definition of Acute Renal Failure. In: Nefrologia Critica (Critical Care Nephrology). 1st ed. Buenos Aires, Argentina. Ediciones Journal. Chapter 1. 2015

  • Effects of hypercapnia on BP in hypoalbuminemic and Nagase analbuminemic rats.

    Gómez JL, Gunnerson KJ, Song M, Li J, Kellum JA. Effects of hypercapnia on BP in hypoalbuminemic and Nagase analbuminemic rats. Chest 2007, 131:1295-300. 2007

See list of PubMed publications

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Contact Info

Jose Gomez Villalobos, MD, MS
Mailing Address
Pulmonary, Critical Care & Sleep Medicine300 Cedar Street, TAC–441 South
P.O. Box 208057

New Haven, CT 06520-8057

The Gomez Laboratory