Heping Zhang, PhD

Susan Dwight Bliss Professor of Biostatistics, Professor in the Child Study Center and Professor of Statistics and Data Science

Research Departments & Organizations

School of Public Health: Collaborative Center for Statistics in Science (C2S2) | YSPH Global Health Concentration

High Performance Computation

Stress & Addiction Clinical Research Program

Yale Institute for Global Health

Global Health Studies

Office of Cooperative Research

Research Interests

Biostatistics; Child Psychiatry; Computational Biology; Epidemiology; Genomics; Infertility; Mental Health; Pregnancy; Psychiatry; Statistics

Research Summary

Professor Zhang and members in his center conduct research in both the general area of regression and classification analyses and the methodologies for post-genome data analyses. In particular, with funding from multiple National Institutes of Health (NIH) grants, his group has been developing and implementing flexible and powerful approaches to the analyses of complex data including longitudinal data with multi- dimensional responses, neuroimaging data, genetic and genomic data. Zhang also has made major research efforts in: (a) child health ranging from the identification of neurological and genetic pathways in developing brain to the assessment of risk factors for pregnancy outcomes and to the understanding of cognitive and behavioral development in children; and (b) substance use, especially in understanding the transition from use to abuse. In addition, Dr. Zhang serves as Principal Investigator of the data coordination and statistics center for the National Genomic and Proteomic Network for Preterm Birth Research and Reproductive Medicine Network.

Specialized Terms: Biostatistics; Genomics; Epidemiology; Psychiatry; Pregnancy; Infertility; Substance Use; Bioinformatics

Extensive Research Description

  • Analysis of Genomic Data for Complex Traits
  • Research Training in Mental Health Epidemiology
  • Data Management, Statistics, and Informatics Core
  • Data Coordination Center for Reproductive Medicine


  • Analysis of High Throughput Data Guangzhou, China (2013 - 2016)

    This project is funded by National Science Foundation of China for China-Oversea collaboration. We will develop statistical methods to analyze high throughput data for complex diseases.

  • Research and Program Development in Statistics Guangzhou, China (2013 - 2016)

    This activities were supported through a short-term 1000-plan. It was to strengthen the statistics program at Sun Yat-Sen University.

  • Live Birth After Fresh Embryo Transfer Vs Frozen-thawed Embryo Transfer in Women With Polycystic Ovary Syndrome (FreFro-PCOS) Jinan, China (2012 - 2014)

    From http://Clinicaltrials.gov: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of childbearing age. However, the optimal infertility treatment for PCOS patients is still a matter of controversy. Despite producing more follicles and more oocytes than other...

  • Effect of Acupuncture and Clomiphene Citrate on Live Birth in Anovulatory Women with Polycystic Ovary Syndrome: a Randomized Controlled Trial Harbin, China (2011 - 2014)

    This is a 2x2 factorial, double-blind, randomized trial to evaluate the effectiveness of acupuncture to increase live birth rate in PCOS women in China.

  • Statistics, Genomics, and Medicine Guangzhou, China (2009 - 2012)

    Chang-Jiang Scholar

Selected Publications

See list of PubMed publications

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Contact Info

Heping Zhang, PhD
Office Location
300 George Street, Ste 523
New Haven, CT 06511
Mailing Address
BiostatisticsPO Box 208034
60 College Street

New Haven, CT 06520-8034

Collaborative Center for Statistics in Science