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Sudhir Perincheri, PhD, MBBS

Assistant Professor of Pathology; Director of Digital Pathology, Pathology

Contact Information

Sudhir Perincheri, PhD, MBBS

Office Location

Mailing Address

  • Pathology

    310 Cedar Street, PO Box 208023

    New Haven, CT 06520-8023

    United States

Yale Medicine

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Research Summary

My current clinical research work includes collaborations with faculty in the the Departments of Laboratory Medicine and Nephrology to apply multi photon microscopy technique in renal pathology. I also have active collaboration with a transplant immunology group at St. Joseph's Norton Thoracic Institute in Phoenix, AZ that studies animal models of transplant rejection.

Extensive Research Description

My graduate work at the University of Kentucky involved use of genetic methods to identify a transcriptional regulator of alpha-fetoprotein. Subsequently I performed post-doctoral research in stem cell biology that was partly funded by the Juvenile Diabetes Research Foundation.

My current research interests are in the field of Pathoogy; specifically in application of emerging tools in anatomic pathology. I collaborate with other faculty in the University in a study applying MultiPhoton Microscopy in renal pathology as well as prostate pathology. I also participate in studies using digital analysis tools in anatomic pathology. I have an active collaboration with a basic science lab investigating mechanisms of transplant rejection.

Coauthors

Research Interests

Hemic and Immune Systems; Hemic and Lymphatic Diseases; Neoplasms; Urogenital System

Research Image

Post-infectious glomerulonephritis

MultiPhoton Microscopy image of a kidney biopsy involved by post-infectious glomerulonephritis

Selected Publications

  • Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2.Medina Rangel P, Cross E, Liu C, Pedigo C, Tian X, Guitierrez-Calabres E, Nagata S, Priyadarshini A, Lerner G, Bunda P, Perincheri S, Gu J, Zhao H, Wang Y, Inoue K, Ishibe S. Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2. Journal Of The American Society Of Nephrology 2022, asn.2022050598. PMID: 36414418, DOI: 10.1681/asn.2022050598.
  • Applying Deep Learning Cancer Subtyping Algorithms Trained on Physical Slides to Multiphoton Imaging of Unembedded SamplesMahmood F, Robbins C, Perincheri S, Torres R. Applying Deep Learning Cancer Subtyping Algorithms Trained on Physical Slides to Multiphoton Imaging of Unembedded Samples American Journal Of Clinical Pathology 2022, 158: s117-s117. DOI: 10.1093/ajcp/aqac126.248.
  • Lung Transplant Recipients with SARS-CoV-2 Infection Induce Circulating Exosomes with SARS-CoV-2 Spike Protein S2 Which Are Immunogenic in MiceBansal S, Fleming T, Perincheri S, Smith M, Bremner R, Mohanakumar T. Lung Transplant Recipients with SARS-CoV-2 Infection Induce Circulating Exosomes with SARS-CoV-2 Spike Protein S2 Which Are Immunogenic in Mice The Journal Of Heart And Lung Transplantation 2022, 41: s134. PMCID: PMC8988572, DOI: 10.1016/j.healun.2022.01.314.
  • Chronic Lung Allograft Dysfunction: Role for Tumor Suppressor Gene Liver Kinase B1Rahman M, Ravichandran R, Bansal S, Liu W, Perincheri S, Angara S, Fleming T, Bharat A, Hachem R, Smith M, Bremner R, Mohanakumar T. Chronic Lung Allograft Dysfunction: Role for Tumor Suppressor Gene Liver Kinase B1 The Journal Of Heart And Lung Transplantation 2021, 40: s60. DOI: 10.1016/j.healun.2021.01.1886.
  • Daratumumab Interferes with Flow Cytometric Evaluation of Multiple MyelomaPerincheri S, Torres R, Tormey C, Smith B, Rinder H, Siddon A. Daratumumab Interferes with Flow Cytometric Evaluation of Multiple Myeloma Blood 2016, 128: 5630-5630. DOI: 10.1182/blood.v128.22.5630.5630.
  • The HDAC Inhibitor TSA Inhibits Cell Proliferation, Induces Apoptosis and Down-Regulates HER2 Protein and Gene Expression as a Single Agent and in Combination with Trastuzumab in Trastuzumab-Sensitive and -Resistant Breast Cancer Cell Lines.Radke S, Perincheri S, Schulz V, Lerner B, Kumar A, Chandrasekan L, Tuck D, Harris L. The HDAC Inhibitor TSA Inhibits Cell Proliferation, Induces Apoptosis and Down-Regulates HER2 Protein and Gene Expression as a Single Agent and in Combination with Trastuzumab in Trastuzumab-Sensitive and -Resistant Breast Cancer Cell Lines. Cancer Research 2009, 69: 3133-3133. DOI: 10.1158/0008-5472.sabcs-09-3133.
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