Sudhir Perincheri, PhD, MBBS
Assistant Professor of Pathology; Director of Digital Pathology, Pathology
Research & Publications
Biography
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Research Summary
My current clinical research work includes collaborations with faculty in the the Departments of Laboratory Medicine and Nephrology to apply multi photon microscopy technique in renal pathology. I also have active collaboration with a transplant immunology group at St. Joseph's Norton Thoracic Institute in Phoenix, AZ that studies animal models of transplant rejection.
Extensive Research Description
My graduate work at the University of Kentucky involved use of genetic methods to identify a transcriptional regulator of alpha-fetoprotein. Subsequently I performed post-doctoral research in stem cell biology that was partly funded by the Juvenile Diabetes Research Foundation.
My current research interests are in the field of Pathoogy; specifically in application of emerging tools in anatomic pathology. I collaborate with other faculty in the University in a study applying MultiPhoton Microscopy in renal pathology as well as prostate pathology. I also participate in studies using digital analysis tools in anatomic pathology. I have an active collaboration with a basic science lab investigating mechanisms of transplant rejection.
Coauthors
Research Interests
Hemic and Immune Systems; Hemic and Lymphatic Diseases; Neoplasms; Urogenital System
Research Image
Post-infectious glomerulonephritis
MultiPhoton Microscopy image of a kidney biopsy involved by post-infectious glomerulonephritis
Selected Publications
- Profilin1 is required to prevent mitotic catastrophe in murine and human glomerular diseasesTian X, Pedigo C, Li K, Ma X, Bunda P, Pell J, Lek A, Gu J, Zhang Y, Rangel P, Li W, Schwartze E, Nagata S, Lerner G, Perincheri S, Priyadarshini A, Zhao H, Lek M, Menon M, Fu R, Ishibe S. Profilin1 is required to prevent mitotic catastrophe in murine and human glomerular diseases. Journal Of Clinical Investigation 2023, 133: e171237. PMID: 37847555, PMCID: PMC10721156, DOI: 10.1172/jci171237.
- Severity of Coexisting Diabetic Glomerular Lesions Affects Outcomes in Primary Glomerular DiseasePerincheri S. Severity of Coexisting Diabetic Glomerular Lesions Affects Outcomes in Primary Glomerular Disease. Kidney360 2023, 4: 1345-1346. PMID: 37883998, PMCID: PMC10617791, DOI: 10.34067/kid.0000000000000267.
- A Rare Case of Methotrexate-Associated Lymphoproliferative Disease in the OrbitSpadaro J, Perzia B, Perincheri S, Habib L. A Rare Case of Methotrexate-Associated Lymphoproliferative Disease in the Orbit. Ophthalmic Plastic And Reconstructive Surgery 2023, 40: e28-e31. PMID: 37791841, DOI: 10.1097/iop.0000000000002528.
- IRF8 may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak CD123 expressionTang H, Panse G, Braddock D, Perincheri S, Xu M, McNiff J. IRF8 may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak CD123 expression. Journal Of Cutaneous Pathology 2023, 50: 595-600. PMID: 37082914, DOI: 10.1111/cup.14439.
- Downregulation of a tumor suppressor gene LKB1 in lung transplantation as a biomarker for chronic murine lung allograft rejectionRahman M, Ravichandran R, Sankpal N, Bansal S, Sureshbabu A, Fleming T, Perincheri S, Bharat A, Smith M, Bremner R, Mohanakumar T. Downregulation of a tumor suppressor gene LKB1 in lung transplantation as a biomarker for chronic murine lung allograft rejection. Cellular Immunology 2023, 386: 104690. PMID: 36812767, DOI: 10.1016/j.cellimm.2023.104690.
- “Double‐hit” ineffective erythropoiesis—concurrent β‐thalassemia with α‐gene triplication and myelodysplastic syndrome with SF3B1 mutationChen P, Gorshein E, Tormey C, Siddon A, Perincheri S. “Double‐hit” ineffective erythropoiesis—concurrent β‐thalassemia with α‐gene triplication and myelodysplastic syndrome with SF3B1 mutation. American Journal Of Hematology 2023, 98: 984-988. PMID: 36688500, DOI: 10.1002/ajh.26856.
- Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2Rangel P, Cross E, Liu C, Pedigo C, Tian X, Gutiérrez-Calabrés E, Nagata S, Priyadarshini A, Lerner G, Bunda P, Perincheri S, Gu J, Zhao H, Wang Y, Inoue K, Ishibe S. Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2. Journal Of The American Society Of Nephrology 2022, 34: 433-450. PMID: 36414418, PMCID: PMC10103311, DOI: 10.1681/asn.2022050598.
- Applying Deep Learning Cancer Subtyping Algorithms Trained on Physical Slides to Multiphoton Imaging of Unembedded SamplesMahmood F, Robbins C, Perincheri S, Torres R. Applying Deep Learning Cancer Subtyping Algorithms Trained on Physical Slides to Multiphoton Imaging of Unembedded Samples. American Journal Of Clinical Pathology 2022, 158: s117-s117. DOI: 10.1093/ajcp/aqac126.248.
- Lung Transplant Recipients with SARS-CoV-2 Infection Induce Circulating Exosomes with SARS-CoV-2 Spike Protein S2 Which Are Immunogenic in MiceBansal S, Fleming T, Perincheri S, Smith M, Bremner R, Mohanakumar T. Lung Transplant Recipients with SARS-CoV-2 Infection Induce Circulating Exosomes with SARS-CoV-2 Spike Protein S2 Which Are Immunogenic in Mice. The Journal Of Heart And Lung Transplantation 2022, 41: s134. PMCID: PMC8988572, DOI: 10.1016/j.healun.2022.01.314.
- Chronic Lung Allograft Dysfunction: Role for Tumor Suppressor Gene Liver Kinase B1Rahman M, Ravichandran R, Bansal S, Liu W, Perincheri S, Angara S, Fleming T, Bharat A, Hachem R, Smith M, Bremner R, Mohanakumar T. Chronic Lung Allograft Dysfunction: Role for Tumor Suppressor Gene Liver Kinase B1. The Journal Of Heart And Lung Transplantation 2021, 40: s60. DOI: 10.1016/j.healun.2021.01.1886.
- Daratumumab Interferes with Flow Cytometric Evaluation of Multiple MyelomaPerincheri S, Torres R, Tormey C, Smith B, Rinder H, Siddon A. Daratumumab Interferes with Flow Cytometric Evaluation of Multiple Myeloma. Blood 2016, 128: 5630. DOI: 10.1182/blood.v128.22.5630.5630.
- The HDAC Inhibitor TSA Inhibits Cell Proliferation, Induces Apoptosis and Down-Regulates HER2 Protein and Gene Expression as a Single Agent and in Combination with Trastuzumab in Trastuzumab-Sensitive and -Resistant Breast Cancer Cell Lines.Radke S, Perincheri S, Schulz V, Lerner B, Kumar A, Chandrasekan L, Tuck D, Harris L. The HDAC Inhibitor TSA Inhibits Cell Proliferation, Induces Apoptosis and Down-Regulates HER2 Protein and Gene Expression as a Single Agent and in Combination with Trastuzumab in Trastuzumab-Sensitive and -Resistant Breast Cancer Cell Lines. Cancer Research 2009, 69: 3133-3133. DOI: 10.1158/0008-5472.sabcs-09-3133.