Jianlei Gu
Postdoctoral Associate
Research & Publications
Biography
News
Coauthors
Selected Publications
- Profilin1 is required to prevent mitotic catastrophe in murine and human glomerular diseasesTian X, Pedigo C, Li K, Ma X, Bunda P, Pell J, Lek A, Gu J, Zhang Y, Rangel P, Li W, Schwartze E, Nagata S, Lerner G, Perincheri S, Priyadarshini A, Zhao H, Lek M, Menon M, Fu R, Ishibe S. Profilin1 is required to prevent mitotic catastrophe in murine and human glomerular diseases. Journal Of Clinical Investigation 2023, 133: e171237. PMID: 37847555, PMCID: PMC10721156, DOI: 10.1172/jci171237.
- Abstract 6762: Tumor immune microenvironment &genomic features of non-small cell lung carcinomas in patients with HIV (PWH)Desai S, Ranjan K, Salahuddin S, Yusuf R, Gu J, Tang D, Kong Y, Rajendran B, Zhao H, Kluger Y, Goldberg S, Emu B, Schalper K. Abstract 6762: Tumor immune microenvironment &genomic features of non-small cell lung carcinomas in patients with HIV (PWH). Cancer Research 2023, 83: 6762-6762. DOI: 10.1158/1538-7445.am2023-6762.
- HBV-infected hepatocellular carcinoma can be robustly classified into three clinically relevant subgroups by a novel analytical protocolCheng Z, Li L, Zhang Y, Ren Y, Gu J, Wang X, Zhao H, Lu H. HBV-infected hepatocellular carcinoma can be robustly classified into three clinically relevant subgroups by a novel analytical protocol. Briefings In Bioinformatics 2023, 24: bbac601. PMID: 36736372, DOI: 10.1093/bib/bbac601.
- Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2Rangel P, Cross E, Liu C, Pedigo C, Tian X, Gutiérrez-Calabrés E, Nagata S, Priyadarshini A, Lerner G, Bunda P, Perincheri S, Gu J, Zhao H, Wang Y, Inoue K, Ishibe S. Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2. Journal Of The American Society Of Nephrology 2022, 34: 433-450. PMID: 36414418, PMCID: PMC10103311, DOI: 10.1681/asn.2022050598.
- MIF is a Common Genetic Determinant of COVID-19 Symptomatic Infection and SeverityShin JJ, Fan W, Par-Young J, Piecychna M, Leng L, Israni-Winger K, Qing H, Gu J, Zhao H, Schulz WL, Unlu S, Kuster J, Young G, Liu J, Ko AI, Garcia A, Sauler M, Wisnewski AV, Young L, Orduña A, Wang A, Klementina O, Garcia AB, Hegyi P, Armstrong ME, Mitchell P, Ordiz DB, Garami A, Kang I, Bucala R. MIF is a Common Genetic Determinant of COVID-19 Symptomatic Infection and Severity. QJM 2022, 116: hcac234. PMID: 36222594, PMCID: PMC9620729, DOI: 10.1093/qjmed/hcac234.
- TET3 epigenetically controls feeding and stress response behaviors via AGRP neuronsXie D, Stutz B, Li F, Chen F, Lv H, Sestan-Pesa M, Catarino J, Gu J, Zhao H, Stoddard CE, Carmichael GG, Shanabrough M, Taylor HS, Liu ZW, Gao XB, Horvath TL, Huang Y. TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons. Journal Of Clinical Investigation 2022, 132: e162365. PMID: 36189793, PMCID: PMC9525119, DOI: 10.1172/jci162365.
- Short-Term Effects of Ambient Air Pollutants on Outpatient Visits for Childhood Allergic Diseases in Shanghai, ChinaHu Y, Gu J, Wu D, Wang X, Lü H, Yu G. Short-Term Effects of Ambient Air Pollutants on Outpatient Visits for Childhood Allergic Diseases in Shanghai, China. Journal Of Shanghai Jiaotong University (Science) 2022, 1-16. DOI: 10.1007/s12204-022-2454-1.
- Hemodynamic differences between women and men with elevated blood pressure in China: A non-invasive assessment of 45,082 adults using impedance cardiographyCaraballo C, Mahajan S, Gu J, Lu Y, Spatz ES, Dreyer RP, Zhang M, Sun N, Ren Y, Zheng X, Zhao H, Lu H, J. Z, Krumholz HM. Hemodynamic differences between women and men with elevated blood pressure in China: A non-invasive assessment of 45,082 adults using impedance cardiography. PLOS ONE 2022, 17: e0269777. PMID: 35700163, PMCID: PMC9197037, DOI: 10.1371/journal.pone.0269777.
- Comprehensive Analysis of Ubiquitously Expressed Genes in Humans from a Data-Driven PerspectiveGu J, Dai J, Lu H, Zhao H. Comprehensive Analysis of Ubiquitously Expressed Genes in Humans from a Data-Driven Perspective. Genomics Proteomics & Bioinformatics 2022, 21: 164-176. PMID: 35569803, PMCID: PMC10373092, DOI: 10.1016/j.gpb.2021.08.017.
- Effectiveness of an impedance cardiography guided treatment strategy to improve blood pressure control in a real-world setting: results from a pragmatic clinical trialWang L, Lu Y, Wang H, Gu J, J Z, Lian Z, Zhang Z, Krumholz H, Sun N. Effectiveness of an impedance cardiography guided treatment strategy to improve blood pressure control in a real-world setting: results from a pragmatic clinical trial. Open Heart 2021, 8: e001719. PMID: 34580169, PMCID: PMC8477318, DOI: 10.1136/openhrt-2021-001719.
- Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and functionHuang J, Peng J, Pearson JA, Efthimiou G, Hu Y, Tai N, Xing Y, Zhang L, Gu J, Jiang J, Zhao H, Zhou Z, Wong FS, Wen L. Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. Cellular & Molecular Immunology 2021, 18: 328-338. PMID: 33432061, PMCID: PMC8027372, DOI: 10.1038/s41423-020-00590-8.
- The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanismsXiao C, Fedirko V, Beitler J, Bai J, Peng G, Zhou C, Gu J, Zhao H, Lin IH, Chico CE, Jeon S, Knobf TM, Conneely KN, Higgins K, Shin DM, Saba N, Miller A, Bruner D. The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms. Supportive Care In Cancer 2020, 29: 3173-3182. PMID: 33078326, PMCID: PMC8055716, DOI: 10.1007/s00520-020-05820-3.
- Gut Microbiome Associated with the Psychoneurological Symptom Cluster in Patients with Head and Neck CancersBai J, Bruner DW, Fedirko V, Beitler JJ, Zhou C, Gu J, Zhao H, Lin IH, Chico CE, Higgins KA, Shin DM, Saba NF, Miller AH, Xiao C. Gut Microbiome Associated with the Psychoneurological Symptom Cluster in Patients with Head and Neck Cancers. Cancers 2020, 12: 2531. PMID: 32899975, PMCID: PMC7563252, DOI: 10.3390/cancers12092531.
- Improving the Diagnosis of Phenylketonuria by Using a Machine Learning–Based Screening Model of Neonatal MRM DataZhu Z, Gu J, Genchev G, Cai X, Wang Y, Guo J, Tian G, Lu H. Improving the Diagnosis of Phenylketonuria by Using a Machine Learning–Based Screening Model of Neonatal MRM Data. Frontiers In Molecular Biosciences 2020, 7: 115. PMID: 32733913, PMCID: PMC7358370, DOI: 10.3389/fmolb.2020.00115.
- Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitorsSchalper KA, Carleton M, Zhou M, Chen T, Feng Y, Huang SP, Walsh AM, Baxi V, Pandya D, Baradet T, Locke D, Wu Q, Reilly TP, Phillips P, Nagineni V, Gianino N, Gu J, Zhao H, Perez-Gracia JL, Sanmamed MF, Melero I. Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors. Nature Medicine 2020, 26: 688-692. PMID: 32405062, PMCID: PMC8127102, DOI: 10.1038/s41591-020-0856-x.
- Relationship of Age With the Hemodynamic Parameters in Individuals With Elevated Blood PressureMahajan S, Gu J, Caraballo C, Lu Y, Spatz ES, Zhao H, Zhang M, Sun N, Zheng X, Lu H, Yuan H, J. Z, Krumholz HM. Relationship of Age With the Hemodynamic Parameters in Individuals With Elevated Blood Pressure. Journal Of The American Geriatrics Society 2020, 68: 1520-1528. PMID: 32212398, DOI: 10.1111/jgs.16411.
- Genomic analysis of a spinal muscular atrophy (SMA) discordant family identifies a novel mutation in TLL2, an activator of growth differentiation factor 8 (myostatin): a case reportJiang J, Huang J, Gu J, Cai X, Zhao H, Lu H. Genomic analysis of a spinal muscular atrophy (SMA) discordant family identifies a novel mutation in TLL2, an activator of growth differentiation factor 8 (myostatin): a case report. BMC Medical Genomics 2019, 20: 204. PMID: 31888525, PMCID: PMC6938020, DOI: 10.1186/s12881-019-0935-3.
- Hemodynamic Phenotypes of Hypertension Based on Cardiac Output and Systemic Vascular ResistanceMahajan S, Gu J, Lu Y, Khera R, Spatz ES, Zhang M, Sun N, Zheng X, Zhao H, Lu H, Ma ZJ, Krumholz HM. Hemodynamic Phenotypes of Hypertension Based on Cardiac Output and Systemic Vascular Resistance. The American Journal Of Medicine 2019, 133: e127-e139. PMID: 31525336, DOI: 10.1016/j.amjmed.2019.08.042.
- Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinomaGuerra MT, Florentino RM, Franca A, Lima Filho AC, Dos Santos ML, Fonseca RC, Lemos FO, Fonseca MC, Kruglov E, Mennone A, Njei B, Gibson J, Guan F, Cheng YC, Ananthanarayanan M, Gu J, Jiang J, Zhao H, Lima CX, Vidigal PT, Oliveira AG, Nathanson MH, Leite MF. Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma. Gut 2019, 68: 1676. PMID: 31315892, PMCID: PMC7087395, DOI: 10.1136/gutjnl-2018-317811.
- VCF‐Server: A web‐based visualization tool for high‐throughput variant data mining and managementJiang J, Gu J, Zhao T, Lu H. VCF‐Server: A web‐based visualization tool for high‐throughput variant data mining and management. Molecular Genetics & Genomic Medicine 2019, 7: e00641. PMID: 31127704, PMCID: PMC6625089, DOI: 10.1002/mgg3.641.
- Assessment of tumor mutation burden calculation from gene panel sequencing dataXu Z, Dai J, Wang D, Lu H, Dai H, Ye H, Gu J, Chen S, Huang B. Assessment of tumor mutation burden calculation from gene panel sequencing data. OncoTargets And Therapy 2019, 12: 3401-3409. PMID: 31123404, PMCID: PMC6510391, DOI: 10.2147/ott.s196638.
- A statistical framework for cross-tissue transcriptome-wide association analysisHu Y, Li M, Lu Q, Weng H, Wang J, Zekavat SM, Yu Z, Li B, Gu J, Muchnik S, Shi Y, Kunkle BW, Mukherjee S, Natarajan P, Naj A, Kuzma A, Zhao Y, Crane PK, Lu H, Zhao H. A statistical framework for cross-tissue transcriptome-wide association analysis. Nature Genetics 2019, 51: 568-576. PMID: 30804563, PMCID: PMC6788740, DOI: 10.1038/s41588-019-0345-7.
- Identifying and characterizing the effects of calendar and environmental conditions on pediatric admissions in ShanghaiYu G, Gu J, Cui W, Jiang J, Wang Y, Genchev G, Lu T, Lu H. Identifying and characterizing the effects of calendar and environmental conditions on pediatric admissions in Shanghai. Journal Of Big Data 2019, 6: 14. DOI: 10.1186/s40537-019-0171-x.
- RNA-seq Based Transcription Characterization of Fusion Breakpoints as a Potential Estimator for Its Oncogenic PotentialGu J, Chukhman M, Lu Y, Liu C, Liu S, Lu H. RNA-seq Based Transcription Characterization of Fusion Breakpoints as a Potential Estimator for Its Oncogenic Potential. BioMed Research International 2017, 2017: 9829175. PMID: 29181411, PMCID: PMC5664375, DOI: 10.1155/2017/9829175.
- 16S rDNA Gene Sequencing Analysis in Functional Dyspepsia Treated With Fecal Microbiota TransplantationWang J, Gu J, Wang Y, Lin K, Liu S, Lu H, Zhang T, Yu G. 16S rDNA Gene Sequencing Analysis in Functional Dyspepsia Treated With Fecal Microbiota Transplantation. Journal Of Pediatric Gastroenterology And Nutrition 2017, 64: e80-e82. PMID: 28230610, DOI: 10.1097/mpg.0000000000001476.
- High-dimensional omics data analysis using a variable screening protocol with prior knowledge integration (SKI)Liu C, Jiang J, Gu J, Yu Z, Wang T, Lu H. High-dimensional omics data analysis using a variable screening protocol with prior knowledge integration (SKI). BMC Systems Biology 2016, 10: 118. PMID: 28155690, PMCID: PMC5260139, DOI: 10.1186/s12918-016-0358-0.
- Implementation of a City-Wide Health Information Exchange Solution in the Largest Metropolitan Region in ChinaYu G, Cui W, Zhou L, Bates D, Gu J, Lu H. Implementation of a City-Wide Health Information Exchange Solution in the Largest Metropolitan Region in China. 2016, 795-798. DOI: 10.1109/bibm.2016.7822626.
- A Novel Scoring Estimator to Screening for Oncogenic Chimeric Transcripts in Cancer Transcriptome SequencingGu J, Lu Y, Liu S, Lu H, Liu C. A Novel Scoring Estimator to Screening for Oncogenic Chimeric Transcripts in Cancer Transcriptome Sequencing. 2016, 1800-1805. DOI: 10.1109/bibm.2016.7822792.
- Classification of Benign and Malignant Thyroid Nodules Using a Combined Clinical Information and Gene Expression SignaturesZheng B, Liu J, Gu J, Du J, Wang L, Gu S, Cheng J, Yang J, Lu H. Classification of Benign and Malignant Thyroid Nodules Using a Combined Clinical Information and Gene Expression Signatures. PLOS ONE 2016, 11: e0164570. PMID: 27776138, PMCID: PMC5077123, DOI: 10.1371/journal.pone.0164570.
- Gut microbiota community adaption during young children fecal microbiota transplantation by 16s rDNA sequencingGu J, Wang Y, Liu S, Yu G, Zhang T, Lu H. Gut microbiota community adaption during young children fecal microbiota transplantation by 16s rDNA sequencing. Neurocomputing 2016, 206: 66-72. DOI: 10.1016/j.neucom.2016.01.095.
- Regulation of CBL and ESR1 expression by microRNA-22-3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthmaDong X, Xu M, Ren Z, Gu J, Lu M, Lu Q, Zhong N. Regulation of CBL and ESR1 expression by microRNA-22-3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthma. International Journal Of Molecular Medicine 2016, 38: 446-456. PMID: 27277384, PMCID: PMC4935459, DOI: 10.3892/ijmm.2016.2634.
- Identification of cancer‐related genes and motifs in the human gene regulatory networkCarson M, Gu J, Yu G, Lu H. Identification of cancer‐related genes and motifs in the human gene regulatory network. IET Systems Biology 2015, 9: 128-134. PMID: 26243828, PMCID: PMC8687282, DOI: 10.1049/iet-syb.2014.0058.
- Comparing Mycobacterium tuberculosis genomes using genome topology networksJiang J, Gu J, Zhang L, Zhang C, Deng X, Dou T, Zhao G, Zhou Y. Comparing Mycobacterium tuberculosis genomes using genome topology networks. BMC Genomics 2015, 16: 85. PMID: 25766780, PMCID: PMC4342819, DOI: 10.1186/s12864-015-1259-0.
- A three‐gene panel that distinguishes benign from malignant thyroid nodulesZheng B, Liu J, Gu J, Lu Y, Zhang W, Li M, Lu H. A three‐gene panel that distinguishes benign from malignant thyroid nodules. International Journal Of Cancer 2014, 136: 1646-1654. PMID: 25175491, DOI: 10.1002/ijc.29172.
- Multiclass classification of sarcomas using pathway based feature selection methodGu J, Lu Y, Liu C, Lu H. Multiclass classification of sarcomas using pathway based feature selection method. Journal Of Theoretical Biology 2014, 362: 3-8. PMID: 25014475, DOI: 10.1016/j.jtbi.2014.06.038.
- Deep mRNA Sequencing Analysis to Capture the Transcriptome Landscape of Zebrafish Embryos and LarvaeYang H, Zhou Y, Gu J, Xie S, Xu Y, Zhu G, Wang L, Huang J, Ma H, Yao J. Deep mRNA Sequencing Analysis to Capture the Transcriptome Landscape of Zebrafish Embryos and Larvae. PLOS ONE 2013, 8: e64058. PMID: 23700457, PMCID: PMC3659048, DOI: 10.1371/journal.pone.0064058.
- Hox genes from the parasitic flatworm Schistosoma japonicumGu J, Chen S, Dou T, Xu M, Xu J, Zhang L, Hu W, Wang S, Zhou Y. Hox genes from the parasitic flatworm Schistosoma japonicum. Genomics 2011, 99: 59-65. PMID: 22100282, DOI: 10.1016/j.ygeno.2011.10.008.
- Analysis of floral transcription factors from Lycoris longitubaHe Q, Cui S, Gu J, Zhang H, Wang M, Zhou Y, Zhang L, Huang M. Analysis of floral transcription factors from Lycoris longituba. Genomics 2010, 96: 119-127. PMID: 20406677, DOI: 10.1016/j.ygeno.2010.04.002.
- Evolution of peroxisome proliferator-activated receptor gamma alternative splicing.Dou T, Xu J, Gao Y, Gu J, Ji C, Xie Y, Zhou Y. Evolution of peroxisome proliferator-activated receptor gamma alternative splicing. Frontiers In Bioscience-Elite 2010, 2: 1334-43. PMID: 20515805, DOI: 10.2741/e193.
- Improving detection of differentially expressed gene sets by applying cluster enrichment analysis to Gene OntologyXu T, Gu J, Zhou Y, Du L. Improving detection of differentially expressed gene sets by applying cluster enrichment analysis to Gene Ontology. BMC Bioinformatics 2009, 10: 240. PMID: 19653916, PMCID: PMC2731756, DOI: 10.1186/1471-2105-10-240.