Shaili Gupta, MBBS
Associate Professor of Medicine (General Medicine); Director of Diversity, Equity and Inclusivity, GME, VA; Associate Program Director, Internal Medicine Residency Program, Department of Medicine; Vice-Chair of DEI at VACHS, Veterans Affairs Healthcare System of CT
Research & Publications
Biography
News
Research Summary
Clinical and Translational Research in Virology and Infectious Diseases, currently focused on SARS-CoV-2 and immune responses to mRNA vaccines against SARS-CoV-2.
Extensive Research Description
Dr. Gupta has extensive experience in viral variants and mutations that impact clinical outcomes of viral diseases. Her research work has ranged from investigation of minority resistant variants of HIV and the management of treatment-experienced HIV+ individuals, to evaluation of clinical outcomes among multidrug resistant HIV+ individuals, patients co-infected with HIV and viral Hepatitis, and individuals with bacterial pyogenic arthritis. She has written on rapid diagnostic platforms for bloodstream infections, and has been conducting research on DEI-related perceptions in healthcare settings. Since the onset of COVID-19 pandemic, her research has been focused on evaluating genomic and immunological interplay of SARS-CoV-2. She has been conducting epidemiologic and outcomes analyses on veterans diagnosed with COVID-19 across the six New England states through her active clinical and virologic repository, including dynamic evaluation of SARS-CoV-2 variants. She has also been conducting research into the clinical and demographic correlations of vaccine-generated immune responses.
Coauthors
Selected Publications
- Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH)Tuan JJ, Zapata H, Barakat L, Andrews L, Behnegar A, Kim YW, Kayani J, Mutic S, Ryall L, Turcotte B, Critch-Gilfillan T, Zhao M, Salahuddin S, Gupta S, Sutton R, Friedland G, Emu B, Ogbuagu O. Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH). BMC Infectious Diseases 2022, 22: 744. PMID: 36131232, PMCID: PMC9491266, DOI: 10.1186/s12879-022-07737-0.
- Serum Neutralizing Antibody Titers 12 Months After COVID-19 Messenger RNA Vaccination: Correlation to Clinical Variables in an Adult, US PopulationZhao M, Slotkin R, Sheth AH, Pischel L, Kyriakides TC, Emu B, McNamara C, Shi Q, Delgobbo J, Xu J, Marhoffer E, Mercer-Falkoff A, Holleck J, Ardito D, Sutton RE, Gupta S. Serum Neutralizing Antibody Titers 12 Months After COVID-19 Messenger RNA Vaccination: Correlation to Clinical Variables in an Adult, US Population. Clinical Infectious Diseases 2022, 76: ciac416. PMID: 35639598, PMCID: PMC9278145, DOI: 10.1093/cid/ciac416.
- Development of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2Ssenyange G, Kerfoot M, Zhao M, Farhadian S, Chen S, Peng L, Ren P, Dela Cruz CS, Gupta S, Sutton RE. Development of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2. Cell Reports Methods 2022, 2: 100252. PMID: 35757815, PMCID: PMC9213030, DOI: 10.1016/j.crmeth.2022.100252.
- Clinical and virologic factors associated with outcomes of COVID‐19 before and after vaccination among Veterans: Retrospective analysis from six New England statesLee M, Cosentino D, Kyriakides TC, Cavallaro T, Stack G, Gupta S. Clinical and virologic factors associated with outcomes of COVID‐19 before and after vaccination among Veterans: Retrospective analysis from six New England states. Journal Of Hospital Medicine 2022, 17: 534-538. PMID: 35661577, PMCID: PMC9348310, DOI: 10.1002/jhm.12852.
- Pancreatic Neuroendocrine Tumor Presenting with Chylous Ascites: Multidisciplinary Workup to Differentiate from Malignant AscitesIlagan-Ying YC, Park EY, Lam R, Gupta S. Pancreatic Neuroendocrine Tumor Presenting with Chylous Ascites: Multidisciplinary Workup to Differentiate from Malignant Ascites. Journal Of General Internal Medicine 2022, 37: 2082-2085. PMID: 35260958, PMCID: PMC9198176, DOI: 10.1007/s11606-022-07463-y.
- COVID-19 Outcomes and Genomic Characterization of SARS-CoV-2 Isolated From Veterans in New England States: Retrospective AnalysisLee M, Sallah YH, Petrone M, Ringer M, Cosentino D, Vogels CBF, Fauver JR, Alpert TD, Grubaugh ND, Gupta S. COVID-19 Outcomes and Genomic Characterization of SARS-CoV-2 Isolated From Veterans in New England States: Retrospective Analysis. JMIRx Med 2021, 2: e31503. PMID: 35014989, PMCID: PMC8722526, DOI: 10.2196/31503.
- Falling Through the CracksGupta S, Klebanoff MJ, Pathak A, Unaka NI, Herbst B. Falling Through the Cracks. Journal Of Hospital Medicine 2021, 16: 694-698. PMID: 34328836, DOI: 10.12788/jhm.3578.
- Advances in rapid diagnostics for bloodstream infectionsBriggs N, Campbell S, Gupta S. Advances in rapid diagnostics for bloodstream infections. Diagnostic Microbiology And Infectious Disease 2020, 99: 115219. PMID: 33059201, DOI: 10.1016/j.diagmicrobio.2020.115219.
- SARS-CoV-2 detection in setting of viral swabs scarcity: Are MRSA swabs and viral swabs equivalent?Federman DG, Gupta S, Stack G, Campbell SM, Peaper DR, Dembry LM, Fisher A, Tarabar AF, Kozal M, Ruser CB. SARS-CoV-2 detection in setting of viral swabs scarcity: Are MRSA swabs and viral swabs equivalent? PLOS ONE 2020, 15: e0237127. PMID: 32756602, PMCID: PMC7406068, DOI: 10.1371/journal.pone.0237127.
- Hospital preparedness for COVID-19 pandemic: experience from department of medicine at Veterans Affairs Connecticut Healthcare SystemGupta S, Federman DG. Hospital preparedness for COVID-19 pandemic: experience from department of medicine at Veterans Affairs Connecticut Healthcare System. Postgraduate Medicine 2020, 132: 489-494. PMID: 32331509, PMCID: PMC7212542, DOI: 10.1080/00325481.2020.1761668.
- Stethoscope hygiene: Using cultures and real-time feedback with bioluminescence-based adenosine triphosphate technology to change behaviorHolleck JL, Campbell S, Alrawili H, Frank C, Merchant N, Rodwin B, Perez MF, Gupta S, Federman DG, Chang JJ, Vientos W, Dembry L. Stethoscope hygiene: Using cultures and real-time feedback with bioluminescence-based adenosine triphosphate technology to change behavior. American Journal Of Infection Control 2019, 48: 380-385. PMID: 31761292, DOI: 10.1016/j.ajic.2019.10.005.
- Native Joint Septic Arthritis: Comparison of Outcomes with Medical and Surgical Management.Harada K, McConnell I, DeRycke EC, Holleck JL, Gupta S. Native Joint Septic Arthritis: Comparison of Outcomes with Medical and Surgical Management. Southern Medical Journal 2019, 112: 238-243. PMID: 30943544, DOI: 10.14423/smj.0000000000000958.
- Menace Elbow: Disseminated NocardiosisDatta R, Kramer E, Reinhart H, Campbell S, Wong E, Gupta S. Menace Elbow: Disseminated Nocardiosis. The American Journal Of Medicine 2018, 131: 1307-1309. PMID: 29729234, PMCID: PMC6482376, DOI: 10.1016/j.amjmed.2018.04.012.
- The “Hand-in” ProjectHolleck JL, Gunderson CG, Antony SM, Gupta S, Chang JJ, Merchant N, Lin S, Federman DG. The “Hand-in” Project. Southern Medical Journal 2017, 110: 694-698. PMID: 29100218, DOI: 10.14423/smj.0000000000000724.
- Can education influence stethoscope hygiene?Holleck JL, Merchant N, Lin S, Gupta S. Can education influence stethoscope hygiene? American Journal Of Infection Control 2017, 45: 811-812. PMID: 28668135, DOI: 10.1016/j.ajic.2017.02.004.
- Zika Virus Epidemic through the Americas: Epidemiology, Clinical Guidelines and a Review of New Developments.Gupta S, Martinello RA. Zika Virus Epidemic through the Americas: Epidemiology, Clinical Guidelines and a Review of New Developments. CT Medicine 2017, 81:487-497.
- Diagnostic accuracy of methicillin-resistant Staphylococcus aureus nasal colonization to predict methicillin-resistant S aureus soft tissue infectionsGunderson CG, Holleck JL, Chang JJ, Merchant N, Lin S, Gupta S. Diagnostic accuracy of methicillin-resistant Staphylococcus aureus nasal colonization to predict methicillin-resistant S aureus soft tissue infections. American Journal Of Infection Control 2016, 44: 1176-1177. PMID: 27311510, DOI: 10.1016/j.ajic.2016.03.039.
- Clinical characteristics and outcomes of veterans hospitalised with purulent soft tissue infections with and without systemic signs of infectionGunderson CG, Holleck J, Chang JJ, Lin S, Merchant N, Gupta S. Clinical characteristics and outcomes of veterans hospitalised with purulent soft tissue infections with and without systemic signs of infection. Infectious Diseases 2016, 48: 503-508. PMID: 26950290, DOI: 10.3109/23744235.2016.1154599.
- Parvimonas micra: A rare cause of native joint septic arthritisBaghban A, Gupta S. Parvimonas micra: A rare cause of native joint septic arthritis. Anaerobe 2016, 39: 26-27. PMID: 26911898, DOI: 10.1016/j.anaerobe.2016.02.004.
- One Physician’s Unusual Dilemma.Holleck, JL, and Gupta S. One Physician’s Unusual Dilemma. Journal of Virology and Emerging Diseases 2015, 1.
- Low-Frequency NNRTI-Resistant HIV-1 Variants and Relationship to Mutational Load in Antiretroviral-Naïve SubjectsGupta S, Lataillade M, Kyriakides TC, Chiarella J, St. John EP, Webb S, Moreno EA, Simen BB, Kozal MJ. Low-Frequency NNRTI-Resistant HIV-1 Variants and Relationship to Mutational Load in Antiretroviral-Naïve Subjects. Viruses 2014, 6: 3428-3437. PMID: 25256391, PMCID: PMC4189030, DOI: 10.3390/v6093428.
- Deep Sequencing of HIV: Clinical and Research ApplicationsChabria SB, Gupta S, Kozal MJ. Deep Sequencing of HIV: Clinical and Research Applications. Annual Review Of Genomics And Human Genetics 2014, 15: 1-31. PMID: 24821496, DOI: 10.1146/annurev-genom-091212-153406.
- Treatment of Highly Experienced HIV Patients: Managing a Patient with Drug Resistant HIVGupta S, Kozal MJ. Treatment of Highly Experienced HIV Patients: Managing a Patient with Drug Resistant HIV. Federal Practitioner 2013, Supplement 1:19S-28S.
- Raltegravir With Unboosted Atazanavir 300 mg Twice Daily in Antiretroviral Treatment-Experienced ParticipantsGupta S, Lataillade M, Farber S, Kozal MJ. Raltegravir With Unboosted Atazanavir 300 mg Twice Daily in Antiretroviral Treatment-Experienced Participants. Journal Of The International Association Of Providers Of AIDS Care (JIAPAC) 2009, 8: 87-92. PMID: 19270153, DOI: 10.1177/1545109709332471.
- Hepatitis B Virus Infection in US Correctional Facilities: A Review of Diagnosis, Management, and Public Health ImplicationsGupta S, Altice FL. Hepatitis B Virus Infection in US Correctional Facilities: A Review of Diagnosis, Management, and Public Health Implications. Journal Of Urban Health 2009, 86: 263-279. PMID: 19184447, PMCID: PMC2648882, DOI: 10.1007/s11524-008-9338-z.
- Persistent and relapsing babesiosis in immunocompromised patients.Krause PJ, Gewurz BE, Hill D, Marty FM, Vannier E, Foppa IM, Furman RR, Neuhaus E, Skowron G, Gupta S, McCalla C, Pesanti EL, Young M, Heiman D, Hsue G, Gelfand JA, Wormser GP, Dickason J, Bia FJ, Hartman B, Telford SR, Christianson D, Dardick K, Coleman M, Girotto JE, Spielman A. Persistent and relapsing babesiosis in immunocompromised patients. Clinical Infectious Diseases 2008, 46: 370-6. PMID: 18181735, DOI: 10.1086/525852.
- Prostatic Abscess with Candida glabrata Treated with MicafunginGupta S, Topal J. Prostatic Abscess with Candida glabrata Treated with Micafungin. Infectious Diseases in Clinical Practice 2008, 16:387-390.
- Fever and High-Grade Parasitemia after SplenectomyGupta S, Torres-Viera C. Fever and High-Grade Parasitemia after Splenectomy. Travel Medicine Advisor 2007, June 1.
- Camurati-Engelmann disease in conjunction with hypogonadism.Gupta S, Cheikh IE. Camurati-Engelmann disease in conjunction with hypogonadism. Endocrine Practice : Official Journal Of The American College Of Endocrinology And The American Association Of Clinical Endocrinologists 2005, 11: 399-407. PMID: 16638728, DOI: 10.4158/EP.11.6.399.
- The Resistant Learner: Challenges of Resident Evaluation.Gupta S. The Resistant Learner: Challenges of Resident Evaluation. Academic Internal Medicine Insight 2005, 4.