Heidi J Zapata, MD, PhD
Assistant Professor
Research & Publications
Biography
News
Research Summary
The complex interplay between microbes and the host inflammatory response determines how individuals respond to infection and disease. This relationship is individual to each patient, and is affected by the immune dysregulation seen in older adults and HIV patients. Both aging and HIV disease (even the subset of HIV-infected elite controllers) are associated with elevated levels of cytokines, acute phase reactants, and clotting factors; the term “inflamm-aging” was coined to describe this age-associated pro-inflammatory environment. However, the source of these elevated plasma biomarkers is less well described, and may reflect innate immune dysfunction. My research interests are aimed towards understanding how the innate immune response is affected by aging and HIV-infection, and how it may contribute to the pro-inflammatory environment that is present in both older adults and HIV-infected individuals.
Coauthors
Research Interests
Aging; HIV; Immune System; Immunity, Innate
Selected Publications
- Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and agingKumar A, Wang J, Esterly A, Radcliffe C, Zhou H, Wyk B, Allore H, Tsang S, Barakat L, Mohanty S, Zhao H, Shaw A, Zapata H. Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging. Aging 2023, 15: 7866-7908. PMID: 37606991, PMCID: PMC10497004, DOI: 10.18632/aging.204927.
- Building an Infectious Disease Diversity, Equity, and Antiracism (ID2EA) Curriculum: A Single Center's Experience and ReflectionsGleeson S, Zapata H, Bathgate M, Emu B, Frederick J, Friedland G, Golden M, Meyer J, Radin J, Sideleau R, Shaw A, Shenoi S, Trubin P, Virata M, Barakat L, Desruisseaux M. Building an Infectious Disease Diversity, Equity, and Antiracism (ID2EA) Curriculum: A Single Center's Experience and Reflections. Clinical Infectious Diseases 2023, 77: 703-710. PMID: 37078888, DOI: 10.1093/cid/ciad236.
- 492. Dectin-1 Stimulation Promotes a Distinct Inflammatory Signature in the Setting of Aging and HIV-infectionZapata H, Kumar A, Wang J, Shaw A, Zhou H, Radcliffe C, Barakat L, Wyk B, Allore H, Zhao H, Tsang S, Manager D, Mohanty S. 492. Dectin-1 Stimulation Promotes a Distinct Inflammatory Signature in the Setting of Aging and HIV-infection. Open Forum Infectious Diseases 2022, 9: ofac492.550. PMCID: PMC9751937, DOI: 10.1093/ofid/ofac492.550.
- Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH)Tuan JJ, Zapata H, Barakat L, Andrews L, Behnegar A, Kim YW, Kayani J, Mutic S, Ryall L, Turcotte B, Critch-Gilfillan T, Zhao M, Salahuddin S, Gupta S, Sutton R, Friedland G, Emu B, Ogbuagu O. Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH). BMC Infectious Diseases 2022, 22: 744. PMID: 36131232, PMCID: PMC9491266, DOI: 10.1186/s12879-022-07737-0.
- 87. Infectious Disease Diversity, Equity, and Antiracism (ID2EA): A Dedicated Curriculum for Infectious Disease ProfessionalsGleeson S, Bathgate M, Frederick J, Desruisseaux M, Meyer J, Virata M, Zapata H, Shenoi S, Radin J, Golden M, Trubin P, Shaw A, Friedland G, Aoun-Barakat L. 87. Infectious Disease Diversity, Equity, and Antiracism (ID2EA): A Dedicated Curriculum for Infectious Disease Professionals. Open Forum Infectious Diseases 2021, 8: s55-s55. PMCID: PMC8644171, DOI: 10.1093/ofid/ofab466.087.
- Qualitative assessment of anti‐SARS‐CoV‐2 spike protein immunogenicity (QUASI) after COVID‐19 vaccination in older people living with HIVTuan JJ, Zapata H, Critch‐Gilfillan T, Ryall L, Turcotte B, Mutic S, Andrews L, Roh ME, Friedland G, Barakat L, Ogbuagu O. Qualitative assessment of anti‐SARS‐CoV‐2 spike protein immunogenicity (QUASI) after COVID‐19 vaccination in older people living with HIV. HIV Medicine 2021, 23: 178-185. PMID: 34632695, PMCID: PMC8652674, DOI: 10.1111/hiv.13188.
- Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older AdultsAvey S, Mohanty S, Chawla DG, Meng H, Bandaranayake T, Ueda I, Zapata HJ, Park K, Blevins TP, Tsang S, Belshe RB, Kaech SM, Shaw AC, Kleinstein SH. Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults. The Journal Of Immunology 2020, 204: 1661-1673. PMID: 32060136, PMCID: PMC7755271, DOI: 10.4049/jimmunol.1900922.
- Impact of Aging and HIV Infection on the Function of the C-Type Lectin Receptor MINCLE in MonocytesZapata HJ, Van Ness PH, Avey S, Siconolfi B, Allore HG, Tsang S, Wilson J, Barakat L, Mohanty S, Shaw AC. Impact of Aging and HIV Infection on the Function of the C-Type Lectin Receptor MINCLE in Monocytes. The Journals Of Gerontology Series A 2018, 74: 794-801. PMID: 30239628, PMCID: PMC6521921, DOI: 10.1093/gerona/gly209.
- Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responsesAvey S, Cheung F, Fermin D, Frelinger J, Gaujoux R, Gottardo R, Khatri P, Kleinstein S, Kotliarov Y, Meng H, Sauteraud R, Shen-Orr S, Tsang J, Vallania F, Anguiano E, Baisch J, Baldwin N, Belshe R, Blevins T, Chaussabel D, Davis M, Fikrig E, Grill D, Hafler D, Henrich E, Joshi S, Kaech S, Kennedy R, Mohanty S, Montgomery R, Oberg A, Obermoser G, Ovsyannikova I, Palucka A, Pascual V, Poland G, Pulendran B, Reinherz E, Shaw A, Siconolfi B, Stuart K, Tsang S, Ueda I, Wilson J, Zapata H. Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responses. Science Immunology 2017, 2 PMID: 28842433, PMCID: PMC5800877, DOI: 10.1126/sciimmunol.aal4656.
- Multiple network-constrained regressions expand insights into influenza vaccination responsesAvey S, Mohanty S, Wilson J, Zapata H, Joshi SR, Siconolfi B, Tsang S, Shaw AC, Kleinstein SH. Multiple network-constrained regressions expand insights into influenza vaccination responses. Bioinformatics 2017, 33: i208-i216. PMID: 28881994, PMCID: PMC5870750, DOI: 10.1093/bioinformatics/btx260.
- Effect of Aging and HIV Infection on the Function of Mincle, an Innate Immune Receptor for Cord Factor from M. tuberculosisZapata H, Siconolfi B, Mohanty S, Wilson J, Van Ness P, Han L, Barakat L, Shaw A. Effect of Aging and HIV Infection on the Function of Mincle, an Innate Immune Receptor for Cord Factor from M. tuberculosis. Open Forum Infectious Diseases 2016, 3: 2192. DOI: 10.1093/ofid/ofw172.1740.
- The Microbiota and Microbiome in Aging: Potential Implications in Health and Age‐Related DiseasesZapata HJ, Quagliarello VJ. The Microbiota and Microbiome in Aging: Potential Implications in Health and Age‐Related Diseases. Journal Of The American Geriatrics Society 2015, 63: 776-781. PMID: 25851728, PMCID: PMC4406803, DOI: 10.1111/jgs.13310.
- Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite ControllersWalker WE, Kurscheid S, Joshi S, Lopez CA, Goh G, Choi M, Barakat L, Francis J, Fisher A, Kozal M, Zapata H, Shaw A, Lifton R, Sutton RE, Fikrig E. Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers. Journal Of Virology 2015, 89: 5502-5514. PMID: 25740989, PMCID: PMC4442529, DOI: 10.1128/jvi.00118-15.
- Aging of the human innate immune system in HIV infectionZapata HJ, Shaw AC. Aging of the human innate immune system in HIV infection. Current Opinion In Immunology 2014, 29: 127-136. PMID: 24997358, PMCID: PMC4145838, DOI: 10.1016/j.coi.2014.06.007.
- Control of Simultaneous Outbreaks of Carbapenemase-Producing Enterobacteriaceae and Extensively Drug-Resistant Acinetobacter baumannii Infection in an Intensive Care Unit Using Interventions Promoted in the Centers for Disease Control and Prevention 2012 Carbapenemase-Resistant Enterobacteriaceae ToolkitEnfield KB, Huq NN, Gosseling MF, Low DJ, Hazen KC, Toney DM, Slitt G, Zapata HJ, Cox HL, Lewis JD, Kundzins JR, Mathers AJ, Sifri CD. Control of Simultaneous Outbreaks of Carbapenemase-Producing Enterobacteriaceae and Extensively Drug-Resistant Acinetobacter baumannii Infection in an Intensive Care Unit Using Interventions Promoted in the Centers for Disease Control and Prevention 2012 Carbapenemase-Resistant Enterobacteriaceae Toolkit. Infection Control And Hospital Epidemiology 2014, 35: 810-817. PMID: 24915208, DOI: 10.1086/676857.
- Initial diagnosis of HIV/AIDS in a 56-year-old man with non-healing forearm lesionZapata HJ, Villanueva M, Shenoi S. Initial diagnosis of HIV/AIDS in a 56-year-old man with non-healing forearm lesion. BMJ Case Reports 2013, 2013: bcr2013201184. PMID: 24248316, PMCID: PMC3841407, DOI: 10.1136/bcr-2013-201184.
- Conserved Residues in the Extracellular Loops of Short-Wavelength Cone Visual PigmentsChen MH, Sandberg DJ, Babu KR, Bubis J, Surya A, Ramos LS, Zapata HJ, Galan JF, Sandberg MN, Birge RR, Knox BE. Conserved Residues in the Extracellular Loops of Short-Wavelength Cone Visual Pigments. Biochemistry 2011, 50: 6763-6773. PMID: 21688771, PMCID: PMC3518856, DOI: 10.1021/bi101557m.
- Listerial Rhomboencephalitis: Not Just for the Weakened Immune SystemZapata H, Bose A, Javaid W, Blair D. Listerial Rhomboencephalitis: Not Just for the Weakened Immune System. Clinical Microbiology Newsletter 2009, 31: 108-110. DOI: 10.1016/j.clinmicnews.2009.06.004.
- Varicella-Zoster Virus Infection of Human Fibroblast Cells Activates the c-Jun N-Terminal Kinase Pathway▿Zapata HJ, Nakatsugawa M, Moffat JF. Varicella-Zoster Virus Infection of Human Fibroblast Cells Activates the c-Jun N-Terminal Kinase Pathway▿. Journal Of Virology 2006, 81: 977-990. PMID: 17079291, PMCID: PMC1797429, DOI: 10.1128/jvi.01470-06.