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Lydia Aoun-Barakat, MD

Associate Professor of Medicine (Infectious Diseases); Project Director, Connecticut AIDS Education & Training Center; Director, Yale Infectious Disease Ambulatory Services, Infectious Diseases; Medical Director Nathan Smith Clinic, Infectious Diseases; Program Director, HIV Primary Care Training Track, Internal Medicine

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Selected Publications

Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH)Tuan JJ, Zapata H, Barakat L, Andrews L, Behnegar A, Kim YW, Kayani J, Mutic S, Ryall L, Turcotte B, Critch-Gilfillan T, Zhao M, Salahuddin S, Gupta S, Sutton R, Friedland G, Emu B, Ogbuagu O. Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH) BMC Infectious Diseases 2022, 22: 744. PMID: 36131232, PMCID: PMC9491266, DOI: 10.1186/s12879-022-07737-0.
Tenofovir disoproxil fumarate and coronavirus disease 2019 outcomes in men with HIVLi G, Park LS, Lodi S, Logan RW, Cartwright EJ, Aoun-Barakat L, Casas JP, Dickerman BA, Rentsch CT, Justice AC, Hernán MA. Tenofovir disoproxil fumarate and coronavirus disease 2019 outcomes in men with HIV AIDS 2022, 36: 1689-1696. PMID: 35848570, PMCID: PMC9444875, DOI: 10.1097/qad.0000000000003314.
Willingness to Be Vaccinated Against COVID-19 Among People With HIV in the United States: Results From a National SurveyWickersham JA, Meyer JP, Shenoi S, Altice FL, Barakat LA, Virata M, Olivares M, Maviglia F, Khati A, Shrestha R. Willingness to Be Vaccinated Against COVID-19 Among People With HIV in the United States: Results From a National Survey Frontiers In Medicine 2022, 9: 886936. PMID: 35847816, PMCID: PMC9280331, DOI: 10.3389/fmed.2022.886936.
Longitudinal Improvements in Viral Suppression for Persons With New HIV Diagnosis Receiving Care in the Ryan White Program: A 10-Year Experience in New Haven, CT (2009–2018)Zhao A, Rizk C, Zhao X, Esu A, Deng Y, Barakat L, Villanueva M. Longitudinal Improvements in Viral Suppression for Persons With New HIV Diagnosis Receiving Care in the Ryan White Program: A 10-Year Experience in New Haven, CT (2009–2018) Open Forum Infectious Diseases 2022, 9: ofac196. PMID: 35794946, PMCID: PMC9251657, DOI: 10.1093/ofid/ofac196.
COVID-19 Vaccine Hesitancy and Associated Factors among People with HIV in the United States: Findings from a National SurveyShrestha R, Meyer JP, Shenoi S, Khati A, Altice FL, Mistler C, Aoun-Barakat L, Virata M, Olivares M, Wickersham JA. COVID-19 Vaccine Hesitancy and Associated Factors among People with HIV in the United States: Findings from a National Survey Vaccines 2022, 10: 424. PMID: 35335054, PMCID: PMC8949562, DOI: 10.3390/vaccines10030424.
Experiences with Telemedicine for HIV Care During the COVID-19 Pandemic: A Mixed-Methods StudyHarsono D, Deng Y, Chung S, Barakat LA, Friedland G, Meyer JP, Porter E, Villanueva M, Wolf MS, Yager JE, Edelman EJ. Experiences with Telemedicine for HIV Care During the COVID-19 Pandemic: A Mixed-Methods Study AIDS And Behavior 2022, 26: 2099-2111. PMID: 35064390, PMCID: PMC8782707, DOI: 10.1007/s10461-021-03556-7.
Longitudinal Improvements in Viral Suppression for Persons with New HIV Diagnosis Receiving Care in the Ryan White Program: A 10-year experience in New Haven, CT (2009-2018)33. Zhao A, Rizk Ch, Zhao X, Esu A, Deng Y, Barakat LA, Villanueva M. Open Forum Infectious Diseases, 2022. https://doi.org/10.1093/ofid/ofac196
87. Infectious Disease Diversity, Equity, and Antiracism (ID2EA): A Dedicated Curriculum for Infectious Disease ProfessionalsGleeson S, Bathgate M, Frederick J, Desruisseaux M, Meyer J, Virata M, Zapata H, Shenoi S, Radin J, Golden M, Trubin P, Shaw A, Friedland G, Aoun-Barakat L. 87. Infectious Disease Diversity, Equity, and Antiracism (ID2EA): A Dedicated Curriculum for Infectious Disease Professionals Open Forum Infectious Diseases 2021, 8: s55-s55. PMCID: PMC8644171, DOI: 10.1093/ofid/ofab466.087.
856. Barriers to PrEP Implementation among Patient-Facing Staff in Three Urban ClinicsShenoi S, Sideleau R, McKay S, Aoun-Barakat L. 856. Barriers to PrEP Implementation among Patient-Facing Staff in Three Urban Clinics Open Forum Infectious Diseases 2021, 8: s519-s519. DOI: 10.1093/ofid/ofab466.1051.
Cumulative burden of non-communicable diseases predicts COVID hospitalization among people with HIV: A one-year retrospective cohort studyVirata MD, Shenoi SV, Ladines-Lim J, Villanueva MS, Barakat LA. Cumulative burden of non-communicable diseases predicts COVID hospitalization among people with HIV: A one-year retrospective cohort study PLOS ONE 2021, 16: e0260251. PMID: 34851963, PMCID: PMC8635326, DOI: 10.1371/journal.pone.0260251.
High HIV Detection in a Tertiary Facility in Liberia: Implications and OpportunitiesOgbuagu O, Wachekwa I, Yasin F, Nuta C, Donato S, Toomey J, Adeiza M, Barakat LA. High HIV Detection in a Tertiary Facility in Liberia: Implications and Opportunities Annals Of Global Health 2021, 87: 117. PMID: 34900617, PMCID: PMC8622250, DOI: 10.5334/aogh.3243.
Qualitative assessment of anti‐SARS‐CoV‐2 spike protein immunogenicity (QUASI) after COVID‐19 vaccination in older people living with HIVTuan JJ, Zapata H, Critch‐Gilfillan T, Ryall L, Turcotte B, Mutic S, Andrews L, Roh ME, Friedland G, Barakat L, Ogbuagu O. Qualitative assessment of anti‐SARS‐CoV‐2 spike protein immunogenicity (QUASI) after COVID‐19 vaccination in older people living with HIV HIV Medicine 2021, 23: 178-185. PMID: 34632695, PMCID: PMC8652674, DOI: 10.1111/hiv.13188.
VZV myelitis with secondary HIV CSF escapeWeiss JJ, Spudich S, Barakat L. VZV myelitis with secondary HIV CSF escape BMJ Case Reports 2021, 14: e241738. PMID: 34187795, PMCID: PMC8245447, DOI: 10.1136/bcr-2021-241738.
Race and ethnicity do not impact eligibility for remdesivir: A single-center experiencePischel L, Walelo M, Benson J, Osborn R, Schrier R, Tuan J, Barakat L, Ogbuagu O. Race and ethnicity do not impact eligibility for remdesivir: A single-center experience PLOS ONE 2021, 16: e0250735. PMID: 33956849, PMCID: PMC8101938, DOI: 10.1371/journal.pone.0250735.
Lower Gastrointestinal Syphilis: Case Series and Literature ReviewFerzacca E, Barbieri A, Barakat L, Olave MC, Dunne D. Lower Gastrointestinal Syphilis: Case Series and Literature Review Open Forum Infectious Diseases 2021, 8: ofab157-. PMID: 34631920, PMCID: PMC8494075, DOI: 10.1093/ofid/ofab157.
543. SARS-CoV-2 Viral Dynamics For Symptomatic People Living with HIV Requiring Hospitalization For COVID-19Virata M, Villanueva M, Shenoi S, Ladines-Lim J, Aoun-Barakat L. 543. SARS-CoV-2 Viral Dynamics For Symptomatic People Living with HIV Requiring Hospitalization For COVID-19 Open Forum Infectious Diseases 2020, 7: s338-s338. PMCID: PMC7777445, DOI: 10.1093/ofid/ofaa439.737.
111. Outcomes Related to COVID-19 Among People Living with HIV: Cohort from a Large Academic CenterVirata M, Shenoi S, Ladines-Lim J, Villanueva M, Aoun-Barakat L. 111. Outcomes Related to COVID-19 Among People Living with HIV: Cohort from a Large Academic Center Open Forum Infectious Diseases 2020, 7: s184-s184. PMCID: PMC7777957, DOI: 10.1093/ofid/ofaa439.421.
1546. Update in Syphilis Proctitis: Insights from a Case Series and Literature ReviewFerzacca E, Dunne D, Barbieri A, Aoun-Barakat L. 1546. Update in Syphilis Proctitis: Insights from a Case Series and Literature Review Open Forum Infectious Diseases 2020, 7: s772-s773. PMCID: PMC7777609, DOI: 10.1093/ofid/ofaa439.1726.
961. Implementing an HIV Ambulatory Curriculum in Internal Medicine Residency ProgramsAoun-Barakat L, McKay S, Danvers K, Sideleau R, Brooks R, Villanueva M. 961. Implementing an HIV Ambulatory Curriculum in Internal Medicine Residency Programs Open Forum Infectious Diseases 2020, 7: s511-s511. PMCID: PMC7776830, DOI: 10.1093/ofid/ofaa439.1147.
Decreased Overall Survival in HIV-associated Non–small-cell Lung CancerHysell K, Yusuf R, Barakat L, Virata M, Gan G, Deng Y, Perez-Irizarry J, Vega T, Goldberg SB, Emu B. Decreased Overall Survival in HIV-associated Non–small-cell Lung Cancer Clinical Lung Cancer 2020, 22: e498-e505. PMID: 33468393, PMCID: PMC8169710, DOI: 10.1016/j.cllc.2020.11.006.
Substantial gap in primary care: older adults with HIV presenting late to care.Yasin F, Rizk C, Taylor B, Barakat LA. Substantial gap in primary care: older adults with HIV presenting late to care. BMC Geriatrics 2020, 20: 438. PMID: 33129258, PMCID: PMC7603686, DOI: 10.1186/s12877-020-01842-y.
Unilateral laterothoracic exanthem in association with coronavirus disease 2019.Glick LR, Fogel AL, Ramachandran S, Barakat LA. Unilateral laterothoracic exanthem in association with coronavirus disease 2019. JAAD Case Reports 2020, 6: 900-901. PMID: 32835047, PMCID: PMC7372280, DOI: 10.1016/j.jdcr.2020.07.020.
Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, Turcotte C, Steinle M, Paczkowski P, Dela Cruz C, Wilen C, Ko AI, MacKay S, Grubaugh ND, Spudich S, Barakat LA. Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19 BMC Neurology 2020, 20: 248. PMID: 32552792, PMCID: PMC7301053, DOI: 10.1186/s12883-020-01812-2.
Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized Patients With Coronavirus Disease 2019 Survival and Clinical OutcomesPrice CC, Altice FL, Shyr Y, Koff A, Pischel L, Goshua G, Azar MM, Mcmanus D, Chen SC, Gleeson SE, Britto CJ, Azmy V, Kaman K, Gaston DC, Davis M, Burrello T, Harris Z, Villanueva MS, Aoun-Barakat L, Kang I, Seropian S, Chupp G, Bucala R, Kaminski N, Lee AI, LoRusso PM, Topal JE, Dela Cruz C, Malinis M. Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized Patients With Coronavirus Disease 2019 Survival and Clinical Outcomes CHEST Journal 2020, 158: 1397-1408. PMID: 32553536, PMCID: PMC7831876, DOI: 10.1016/j.chest.2020.06.006.
Confronting Another Pandemic: Lessons from HIV can Inform Our COVID-19 ResponseEdelman EJ, Aoun-Barakat L, Villanueva M, Friedland G. Confronting Another Pandemic: Lessons from HIV can Inform Our COVID-19 Response AIDS And Behavior 2020, 24: 1977-1979. PMID: 32399798, PMCID: PMC7215127, DOI: 10.1007/s10461-020-02908-z.
Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, Turcotte C, Steinle M, Paczkowski P, Cruz CD, Wilen C, Ko AI, MacKay S, Grubaugh ND, Spudich S, Aoun Barakat L. Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19. Research Square 2020 PMID: 32702723, PMCID: PMC7336693, DOI: 10.21203/rs.3.rs-28583/v1.
Dysregulation of sterol regulatory element-binding protein 2 gene in HIV treatment-experienced individualsSopeyin A, Zhou L, Li M, Barakat L, Paintsil E. Dysregulation of sterol regulatory element-binding protein 2 gene in HIV treatment-experienced individuals PLOS ONE 2019, 14: e0226573. PMID: 31846498, PMCID: PMC6917281, DOI: 10.1371/journal.pone.0226573.
Development of a Novel Competency-Based Evaluation System for HIV Primary Care Training: the HIV Entrustable Professional ActivitiesDunne D, Green M, Tetrault J, Barakat LA. Development of a Novel Competency-Based Evaluation System for HIV Primary Care Training: the HIV Entrustable Professional Activities Journal Of General Internal Medicine 2019, 35: 331-335. PMID: 31667752, PMCID: PMC6957645, DOI: 10.1007/s11606-019-04956-1.
Implementing a Comprehensive HCV Clinic within an HIV Clinic: A Model of Care for HCV Micro-eliminationRizk C, Miceli J, Shiferaw B, Malinis M, Barakat L, Ogbuagu O, Villanueva M. Implementing a Comprehensive HCV Clinic within an HIV Clinic: A Model of Care for HCV Micro-elimination Open Forum Infectious Diseases 2019, 6: ofz361. PMID: 31412130, PMCID: PMC6785669, DOI: 10.1093/ofid/ofz361.
Training the next generation of HIV providers: impact of trainees on patient satisfaction in an urban HIV clinic.Sherbuk JE, Barakat LA. Training the next generation of HIV providers: impact of trainees on patient satisfaction in an urban HIV clinic. AIDS Care 2019, 31: 41-44. PMID: 29779395, DOI: 10.1080/09540121.2018.1476663.
The Changing Face of HIV CareBarakat LA, Dunne DW, Tetrault JM, Soares S, Chia D, Ogbuagu OE, Moriarty JP, Huot SJ, Green ML. The Changing Face of HIV Care Academic Medicine 2018, 93: 1673-1678. PMID: 29901657, DOI: 10.1097/acm.0000000000002317.
Dolutegravir/rilpivirine for the treatment of HIV-1 infectionDowers E, Zamora F, Barakat LA, Ogbuagu O. Dolutegravir/rilpivirine for the treatment of HIV-1 infection HIV/AIDS - Research And Palliative Care 2018, 10: 215-224. PMID: 30464642, PMCID: PMC6220428, DOI: 10.2147/hiv.s157855.
Impact of Aging and HIV Infection on the Function of the C-Type Lectin Receptor MINCLE in Monocytes.Zapata HJ, Van Ness PH, Avey S, Siconolfi B, Allore HG, Tsang S, Wilson J, Barakat L, Mohanty S, Shaw AC. Impact of Aging and HIV Infection on the Function of the C-Type Lectin Receptor MINCLE in Monocytes. The Journals Of Gerontology Series A 2018, 74: 794-801. PMID: 30239628, PMCID: PMC6521921, DOI: 10.1093/gerona/gly209.
Prevalence and Correlates of Unhealthy Alcohol and Drug Use Among Men Who Have Sex with Men Prescribed HIV Pre-exposure Prophylaxis in Real-World Clinical SettingsOgbuagu O, Marshall BDL, Tiberio P, Ogunbajo A, Barakat L, Montgomery M, Almonte A, Wray T, Williams EC, Edelman EJ, Chan PA. Prevalence and Correlates of Unhealthy Alcohol and Drug Use Among Men Who Have Sex with Men Prescribed HIV Pre-exposure Prophylaxis in Real-World Clinical Settings AIDS And Behavior 2018, 23: 190-200. PMID: 30145707, PMCID: PMC7020905, DOI: 10.1007/s10461-018-2260-9.
Characterizing Patients with Very-Low-Level HIV Viremia: A Community-Based StudyHelou E, Shenoi S, Kyriakides T, Landry ML, Kozal M, Barakat LA. Characterizing Patients with Very-Low-Level HIV Viremia: A Community-Based Study Journal Of The International Association Of Providers Of AIDS Care (JIAPAC) 2016, 16: 261-266. PMID: 27903948, PMCID: PMC5423832, DOI: 10.1177/2325957416680028.
Unusual presentation of disseminated Nocardia abscessus infection in a patient with AIDSSherbuk J, Saly D, Barakat L, Ogbuagu O. Unusual presentation of disseminated Nocardia abscessus infection in a patient with AIDS BMJ Case Reports 2016, 2016: bcr2016215649. PMID: 27440848, PMCID: PMC4964189, DOI: 10.1136/bcr-2016-215649.
Steroid-exacerbated HIV-associated cutaneous Kaposi’s sarcoma immune reconstitution inflammatory syndrome: ‘Where a good intention turns bad’Chabria S, Barakat L, Ogbuagu O. Steroid-exacerbated HIV-associated cutaneous Kaposi’s sarcoma immune reconstitution inflammatory syndrome: ‘Where a good intention turns bad’ International Journal Of STD & AIDS 2016, 27: 1026-1029. PMID: 26769754, DOI: 10.1177/0956462415627735.
Trends in hospital deaths among human immunodeficiency virus–infected patients during the antiretroviral therapy era, 1995 to 2011Cowell A, Shenoi SV, Kyriakides TC, Friedland G, Barakat LA. Trends in hospital deaths among human immunodeficiency virus–infected patients during the antiretroviral therapy era, 1995 to 2011 Journal Of Hospital Medicine 2015, 10: 608-614. PMID: 26130520, PMCID: PMC4560992, DOI: 10.1002/jhm.2409.
Clinical outcomes of HIV‐infected men with CAPBarakat LA, Juthani-Mehta M, Allore H, Trentalange M, Tate J, Rimland D, Pisani M, Akgün KM, Goetz MB, Butt AA, Rodriguez-Barradas M, Duggal M, Crothers K, Justice AC, Quagliarello VJ. Clinical outcomes of HIV‐infected men with CAP HIV Medicine 2015, 16: 421-430. PMID: 25959543, PMCID: PMC5015437, DOI: 10.1111/hiv.12244.
Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite ControllersWalker WE, Kurscheid S, Joshi S, Lopez CA, Goh G, Choi M, Barakat L, Francis J, Fisher A, Kozal M, Zapata H, Shaw A, Lifton R, Sutton RE, Fikrig E. Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers Journal Of Virology 2015, 89: 5502-5514. PMID: 25740989, PMCID: PMC4442529, DOI: 10.1128/jvi.00118-15.
Antiretroviral Therapy–Induced Mitochondrial Toxicity: Potential Mechanisms Beyond Polymerase‐γ InhibitionSelvaraj S, Ghebremichael M, Li M, Foli Y, Langs-Barlow A, Ogbuagu A, Barakat L, Tubridy E, Edifor R, Lam W, Cheng Y, Paintsil E. Antiretroviral Therapy–Induced Mitochondrial Toxicity: Potential Mechanisms Beyond Polymerase‐γ Inhibition Clinical Pharmacology & Therapeutics 2014, 96: 110-120. PMID: 24637942, PMCID: PMC4065195, DOI: 10.1038/clpt.2014.64.
Infectious mimicry complicates diagnosis in hemophagocytic syndrome caused by anaplastic large-cell lymphoma.Peluso MJ, Chia D, Sheen W, Hutchinson C, Barakat L. Infectious mimicry complicates diagnosis in hemophagocytic syndrome caused by anaplastic large-cell lymphoma. Case Reports In Medicine 2012, 2012: 968706. PMID: 22761627, PMCID: PMC3385285, DOI: 10.1155/2012/968706.
Complicated Left-Sided Native Valve Endocarditis in Adults: Risk Classification for MortalityHasbun R, Vikram HR, Barakat LA, Buenconsejo J, Quagliarello VJ. Complicated Left-Sided Native Valve Endocarditis in Adults: Risk Classification for Mortality JAMA 2003, 289: 1933-1940. PMID: 12697795, DOI: 10.1001/jama.289.15.1933.
Fatal Inhalational Anthrax in a 94-Year-Old Connecticut WomanBarakat LA, Quentzel HL, Jernigan JA, Kirschke DL, Griffith K, Spear SM, Kelley K, Barden D, Mayo D, Stephens DS, Popovic T, Marston C, Zaki SR, Guarner J, Shieh WJ, Carver HW, Meyer RF, Swerdlow DL, Mast EE, Hadler JL, Team F. Fatal Inhalational Anthrax in a 94-Year-Old Connecticut Woman JAMA 2002, 287: 863-868. PMID: 11851578, DOI: 10.1001/jama.287.7.863.

Clinical Trials

Conditions	Study Title
HIV/AIDS	A Study to Evaluate Efficacy and Safety of Cabotegravir (CAB) Long Acting (LA) Plus (+) Rilpivirine (RPV) LA Versus BIKTARVY® (BIK) in Participants With Human Immunodeficiency Virus (HIV)-1 Who Are Virologically Suppressed (SOLAR)
Diseases of the Digestive System - Liver; HIV/AIDS; Infectious Diseases	HOPE in Action Trial of HIV+ Deceased Donor Liver Transplants for HIV+ Recipients
HIV/AIDS	Mechanisms of HIV latency

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Lydia Aoun-Barakat, MD

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Clinical Trials