Ping Ren, PhD, MSc
Associate Research Scientist in Genetics
Research & Publications
Biography
Research Summary
Antibody Library Display Technologies丨Immunology丨mAb discovery丨CAR-T丨Chimeric TCR-T丨BsAb engineering丨LNP-mRNA丨Pooled CRISPR-Cas screen
Coauthors
Selected Publications
- Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineagesRen P, Hu Y, Peng L, Yang L, Suzuki K, Fang Z, Bai M, Zhou L, Feng Y, Zou Y, Xiong Y, Chen S. Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages. Signal Transduction And Targeted Therapy 2023, 8: 281. PMID: 37518189, PMCID: PMC10387464, DOI: 10.1038/s41392-023-01509-1.
- RAMIHM generates fully human monoclonal antibodies by rapid mRNA immunization of humanized mice and BCR-seqRen P, Peng L, Yang L, Suzuki K, Fang Z, Renauer P, Lin Q, Bai M, Li T, Clark P, Klein D, Chen S. RAMIHM generates fully human monoclonal antibodies by rapid mRNA immunization of humanized mice and BCR-seq. Cell Chemical Biology 2023, 30: 85-96.e6. PMID: 36640761, PMCID: PMC9868106, DOI: 10.1016/j.chembiol.2022.12.005.
- LRRC15 inhibits SARS-CoV-2 cellular entry in transSong J, Chow RD, Peña-Hernández MA, Zhang L, Loeb SA, So EY, Liang OD, Ren P, Chen S, Wilen CB, Lee S. LRRC15 inhibits SARS-CoV-2 cellular entry in trans. PLOS Biology 2022, 20: e3001805. PMID: 36228039, PMCID: PMC9595563, DOI: 10.1371/journal.pbio.3001805.
- Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2Fang Z, Peng L, Lucas C, Lin Q, Zhou L, Yang L, Feng Y, Ren P, Renauer PA, Monteiro VS, Hahn AM, Park JJ, Zhou X, Grubaugh N, Wilen C, Chen S. Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2. Cell Discovery 2022, 8: 69. PMID: 35853867, PMCID: PMC9295082, DOI: 10.1038/s41421-022-00435-w.
- Development of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2Ssenyange G, Kerfoot M, Zhao M, Farhadian S, Chen S, Peng L, Ren P, Dela Cruz CS, Gupta S, Sutton RE. Development of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2. Cell Reports Methods 2022, 2: 100252. PMID: 35757815, PMCID: PMC9213030, DOI: 10.1016/j.crmeth.2022.100252.
- Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2Fang Z, Peng L, Filler R, Suzuki K, McNamara A, Lin Q, Renauer PA, Yang L, Menasche B, Sanchez A, Ren P, Xiong Q, Strine M, Clark P, Lin C, Ko AI, Grubaugh ND, Wilen CB, Chen S. Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2. Nature Communications 2022, 13: 3250. PMID: 35668119, PMCID: PMC9169595, DOI: 10.1038/s41467-022-30878-4.
- CAR‐T Therapy in Clinical Practice: Technical Advances and Current ChallengesRen P, Zhang C, Li W, Wang X, Liang A, Yang G, Xu H, Ma P. CAR‐T Therapy in Clinical Practice: Technical Advances and Current Challenges. Advanced Biology 2022, 6: e2101262. PMID: 35652169, DOI: 10.1002/adbi.202101262.
- Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617Peng L, Hu Y, Mankowski MC, Ren P, Chen RE, Wei J, Zhao M, Li T, Tripler T, Ye L, Chow RD, Fang Z, Wu C, Dong MB, Cook M, Wang G, Clark P, Nelson B, Klein D, Sutton R, Diamond MS, Wilen CB, Xiong Y, Chen S. Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617. Nature Communications 2022, 13: 1638. PMID: 35347138, PMCID: PMC8960874, DOI: 10.1038/s41467-022-29288-3.
- Avidity‐Based Selection of Tissue‐Specific CAR‐T Cells from a Combinatorial Cellular Library of CARsMa P, Ren P, Zhang C, Tang J, Yu Z, Zhu X, Fan K, Li G, Zhu W, Sang W, Min C, Chen W, Huang X, Yang G, Lerner RA. Avidity‐Based Selection of Tissue‐Specific CAR‐T Cells from a Combinatorial Cellular Library of CARs. Advanced Science 2021, 8: 2003091. PMID: 33747727, PMCID: PMC7967050, DOI: 10.1002/advs.202003091.
- An optimized yeast display strategy for efficient scFv antibody selection using ribosomal skipping system and thermo resistant yeastJia Y, Ren P, Duan S, Zeng P, Xie D, Zeng F. An optimized yeast display strategy for efficient scFv antibody selection using ribosomal skipping system and thermo resistant yeast. Biotechnology Letters 2019, 41: 1067-1076. PMID: 31300936, DOI: 10.1007/s10529-019-02710-5.
- Cdk1‐interacting protein Cip1 is regulated by the S phase checkpoint in response to genotoxic stressZhang Z, Ren P, Vashisht AA, Wohlschlegel JA, Quintana DG, Zeng F. Cdk1‐interacting protein Cip1 is regulated by the S phase checkpoint in response to genotoxic stress. Genes To Cells 2017, 22: 850-860. PMID: 28771906, PMCID: PMC5643225, DOI: 10.1111/gtc.12518.
- Identification of YPL014W (Cip1) as a novel negative regulator of cyclin‐dependent kinase in Saccharomyces cerevisiaeRen P, Malik A, Zeng F. Identification of YPL014W (Cip1) as a novel negative regulator of cyclin‐dependent kinase in Saccharomyces cerevisiae. Genes To Cells 2016, 21: 543-552. PMID: 27005485, DOI: 10.1111/gtc.12361.
- G1 cyclin driven DNA replicationPalou R, Malik A, Palou G, Zeng F, Ren P, Quintana DG. G1 cyclin driven DNA replication. Cell Cycle 2015, 14: 3842-3850. PMID: 26176277, PMCID: PMC4825731, DOI: 10.1080/15384101.2015.1070995.
- Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person SyndromeGu Urban GJ, Friedman M, Ren P, Törn C, Fex M, Hampe CS, Lernmark Å, Landegren U, Kamali-Moghaddam M. Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome. Scientific Reports 2015, 5: 11196. PMID: 26080009, PMCID: PMC4468815, DOI: 10.1038/srep11196.