Serena Spudich, MD, MA

• Adam Jasne
• Adeel Zubair
• Albert Ko
• Amit Mahajan
• Anne Wyllie
• Arman Fesharaki-Zadeh
• Benjamin Goldman-Israelow
• Bertie Geng
• Brinda Emu
• Carolina Lucas
• Chantal Vogels
• Charles Wira
• Craig B. Wilen
• David A. Hafler
• David van Dijk
• Fangyong Li
• Guido Falcone
• Guilin Wang
• Hardik P Amin
• Jennifer Ahjin Kim
• Jennifer Chiarella
• Jeremy J. Moeller
• Jonathan Siner
• Joseph Schindler
• Lauren Hachmann Sansing
• Lindsay McAlpine
• Lingeng Lu
• Lydia Aoun-Barakat
• Marie-Louise Landry
• Matthew Grant
• Mika Naganawa
• Nathan Grubaugh
• Phillip Chan
• Richard Carson
• Rolando Garcia Milian
• Sameet Mehta
• Shelli Farhadian
• Steven Kleinstein
• Ya-Chi Ho

Acquired Immunodeficiency Syndrome; Antiviral Agents; Cerebrospinal Fluid; Dementia; HIV; Nervous System; Neurology; Virology; Positron-Emission Tomography; Biomarkers, Pharmacological; COVID-19

Aging; Biomarkers; Disease Transmission; HIV/AIDS; Immunology; Infectious Diseases; Viruses

• Anti-SARS-CoV-2 and Autoantibody Profiling of a COVID-19 Patient With Subacute Psychosis Who Remitted After Treatment With Intravenous ImmunoglobulinMcAlpine L, Lifland B, Check J, Angarita G, Ngo T, Chen P, Dandekar R, Alvarenga B, Browne W, Pleasure S, Wilson M, Spudich S, Farhadian S, Bartley C. Anti-SARS-CoV-2 and Autoantibody Profiling of a COVID-19 Patient With Subacute Psychosis Who Remitted After Treatment With Intravenous Immunoglobulin Biological Psychiatry 2022 PMID: 36481066, PMCID: PMC9722219, DOI: 10.1016/j.biopsych.2022.09.007.
• Correlation between CD4/CD8 ratio and neurocognitive performance during early HIV infectionLe LT, Price RW, Gisslén M, Zetterberg H, Emu B, Fabre R, Christian P, Andersen S, Spudich S, Vassallo M. Correlation between CD4/CD8 ratio and neurocognitive performance during early HIV infection HIV Medicine 2022 PMID: 36134890, DOI: 10.1111/hiv.13411.
• Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8+ T cellsTakata H, Kakazu J, Mitchell J, Kroon E, Colby D, Sacdalan C, Bai H, Ehrenberg P, Geretz A, Buranapraditkun S, Pinyakorn S, Intasan J, Tipsuk S, Suttichom D, Prueksakaew P, Chalermchai T, Chomchey N, Phanuphak N, de Souza M, Michael N, Robb M, Haddad E, Crowell T, Vasan S, Valcour V, Douek D, Thomas R, Rolland M, Chomont N, Ananworanich J, Trautmann L, Teeratakulpisarn N, Pattanachaiwit S, Sriplienchan S, Tantivitayakul P, Kanaprach R, Ruxrungtham K, Dumrongpisutikul N, Rojnuckarin P, Chottanapund S, Poltavee K, Luekasemsuk T, Savadsuk H, Puttamsawin S, Benjapornpong K, Ratnaratorn N, Tangnaree K, Munkong C, Thaimanee R, Eamyoung P, Ubolyam S, Lerdlum S, Manasnayakorn S, Rerknimitr R, Sirivichayakul S, Wattanaboonyongcharoen P, Cowden J, Schuetz A, Akapirat S, Churikanont N, Getchalarat S, Hsu D, Turk E, Butterworth O, Milazzo M, Eller L, Ake J, Eller L, Spudich S, Fox L, Ratto-Kim S, DeGruttola V, Chinvarun Y, Sithinamsuwan P, Fletcher J, Shiramizu B, Schuetz A. Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8+ T cells EBioMedicine 2022, 84: 104253. PMID: 36088683, PMCID: PMC9471490, DOI: 10.1016/j.ebiom.2022.104253.
• Neuropathogenesis of HIV-1: insights from across the spectrum of acute through long-term treated infectionKillingsworth L, Spudich S. Neuropathogenesis of HIV-1: insights from across the spectrum of acute through long-term treated infection Seminars In Immunopathology 2022, 44: 709-724. PMID: 35882661, DOI: 10.1007/s00281-022-00953-5.
• HIV viral transcription and immune perturbations in the CNS of people with HIV despite ARTFarhadian SF, Lindenbaum O, Zhao J, Corley MJ, Im Y, Walsh H, Vecchio A, Garcia-Milian R, Chiarella J, Chintanaphol M, Calvi R, Wang G, Ndhlovu LC, Yoon J, Trotta D, Ma S, Kluger Y, Spudich S. HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART JCI Insight 2022, 7: e160267. PMID: 35801589, PMCID: PMC9310520, DOI: 10.1172/jci.insight.160267.
• Individual Differences in CD4/CD8 T-Cell Ratio Trajectories and Associated Risk Profiles Modeled From Acute HIV InfectionPaul R, Cho K, Bolzenius J, Sacdalan C, Ndhlovu LC, Trautmann L, Krebs S, Tipsuk S, Crowell TA, Suttichom D, Colby DJ, Premeaux TA, Phanuphak N, Chan P, Kroon E, Vasan S, Hsu D, Carrico A, Valcour V, Ananworanich J, Robb ML, Ake JA, Sriplienchan S, Spudich S, Team F. Individual Differences in CD4/CD8 T-Cell Ratio Trajectories and Associated Risk Profiles Modeled From Acute HIV Infection Psychosomatic Medicine 2022, 84: 976-983. PMID: 36162059, PMCID: PMC9553252, DOI: 10.1097/psy.0000000000001129.
• Immunological, Cognitive and Psychiatric Outcomes after Initiating EFV- and DTG-based Antiretroviral Therapy during Acute HIV InfectionChan P, Yoon B, Colby D, Kroon E, Sacdalan C, Sriplienchan S, Pinyakorn S, Ananworanich J, Valcour V, Vasan S, Hsu D, Phanuphak N, Paul R, Spudich S, Team O. Immunological, Cognitive and Psychiatric Outcomes after Initiating EFV- and DTG-based Antiretroviral Therapy during Acute HIV Infection Clinical Infectious Diseases 2022, 76: ciac466-. PMID: 35687498, PMCID: PMC9907536, DOI: 10.1093/cid/ciac466.
• HIV Compartmentalization in the CNS and Its Impact in Treatment Outcomes and Cure StrategiesChan P, Spudich S. HIV Compartmentalization in the CNS and Its Impact in Treatment Outcomes and Cure Strategies Current HIV/AIDS Reports 2022, 19: 207-216. PMID: 35536438, DOI: 10.1007/s11904-022-00605-1.
• Infection and inflammation: New perspectives on Alzheimer's diseaseWhitson HE, Colton C, Khoury J, Gate D, Goate A, Heneka MT, Kaddurah-Daouk R, Klein RS, Shinohara ML, Sisodia S, Spudich SS, Stevens B, Tanzi R, Ting JP, Garden G, members S, Aiello A, Chiba-Falek O, Heitman J, Johnson K, Luftig M, Moseman A, Rawls J, Shinohara M, Swanstrom R, Terrando N. Infection and inflammation: New perspectives on Alzheimer's disease Brain Behavior & Immunity - Health 2022, 22: 100462. PMID: 36118272, PMCID: PMC9475126, DOI: 10.1016/j.bbih.2022.100462.
• Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clonesCollora JA, Liu R, Pinto-Santini D, Ravindra N, Ganoza C, Lama JR, Alfaro R, Chiarella J, Spudich S, Mounzer K, Tebas P, Montaner LJ, van Dijk D, Duerr A, Ho YC. Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones Immunity 2022, 55: 1013-1031.e7. PMID: 35320704, PMCID: PMC9203927, DOI: 10.1016/j.immuni.2022.03.004.
• HIV Disease Dynamics and Markers of Inflammation and CNS Injury During Primary HIV Infection and Their Relationship to Cognitive PerformanceLongino AA, Paul R, Wang Y, Lama JR, Brandes P, Ruiz E, Correa C, Keating S, Spudich SS, Pilcher C, Vecchio A, Pasalar S, Ignacio R, Valdez R, Dasgupta S, Robertson K, Duerr A. HIV Disease Dynamics and Markers of Inflammation and CNS Injury During Primary HIV Infection and Their Relationship to Cognitive Performance JAIDS Journal Of Acquired Immune Deficiency Syndromes 2022, 89: 183-190. PMID: 34629415, PMCID: PMC8752485, DOI: 10.1097/qai.0000000000002832.
• Nervous system consequences of COVID-19Spudich S, Nath A. Nervous system consequences of COVID-19 Science 2022, 375: 267-269. PMID: 35050660, DOI: 10.1126/science.abm2052.
• Cerebrospinal fluid CD4+ T cell infection in humans and macaques during acute HIV-1 and SHIV infectionSharma V, Creegan M, Tokarev A, Hsu D, Slike BM, Sacdalan C, Chan P, Spudich S, Ananworanich J, Eller MA, Krebs SJ, Vasan S, Bolton DL. Cerebrospinal fluid CD4+ T cell infection in humans and macaques during acute HIV-1 and SHIV infection PLOS Pathogens 2021, 17: e1010105. PMID: 34874976, PMCID: PMC8683024, DOI: 10.1371/journal.ppat.1010105.
• Cerebrospinal Fluid Viral Load Across the Spectrum of Untreated Human Immunodeficiency Virus Type 1 (HIV-1) Infection: A Cross-Sectional Multicenter StudyUlfhammer G, Edén A, Antinori A, Brew BJ, Calcagno A, Cinque P, De Zan V, Hagberg L, Lin A, Nilsson S, Oprea C, Pinnetti C, Spudich S, Trunfio M, Winston A, Price RW, Gisslén M. Cerebrospinal Fluid Viral Load Across the Spectrum of Untreated Human Immunodeficiency Virus Type 1 (HIV-1) Infection: A Cross-Sectional Multicenter Study Clinical Infectious Diseases 2021, 75: ciab943. PMID: 34747481, PMCID: PMC9427147, DOI: 10.1093/cid/ciab943.
• Prior Stroke and Age Predict Acute Ischemic Stroke Among Hospitalized COVID-19 Patients: A Derivation and Validation StudyPeng TJ, Jasne AS, Simonov M, Abdelhakim S, Kone G, Cheng YK, Rethana M, Tarasaria K, Herman AL, Baker AD, Yaghi S, Frontera JA, Sansing LH, Falcone GJ, Spudich S, Schindler J, Sheth KN, Sharma R. Prior Stroke and Age Predict Acute Ischemic Stroke Among Hospitalized COVID-19 Patients: A Derivation and Validation Study Frontiers In Neurology 2021, 12: 741044. PMID: 34675873, PMCID: PMC8524436, DOI: 10.3389/fneur.2021.741044.
• Neurological complications of HIV infectionSpudich S. Neurological complications of HIV infection Journal Of The Neurological Sciences 2021, 429: 118040. DOI: 10.1016/j.jns.2021.118040.
• Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ARTCorley MJ, Sacdalan C, Pang APS, Chomchey N, Ratnaratorn N, Valcour V, Kroon E, Cho KS, Belden AC, Colby D, Robb M, Hsu D, Spudich S, Paul R, Vasan S, Ndhlovu LC, . Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART PLOS Pathogens 2021, 17: e1009785. PMID: 34388205, PMCID: PMC8386872, DOI: 10.1371/journal.ppat.1009785.
• VZV myelitis with secondary HIV CSF escapeWeiss JJ, Spudich S, Barakat L. VZV myelitis with secondary HIV CSF escape BMJ Case Reports 2021, 14: e241738. PMID: 34187795, PMCID: PMC8245447, DOI: 10.1136/bcr-2021-241738.
• Preliminary In Vivo Evidence of Reduced Synaptic Density in Human Immunodeficiency Virus (HIV) Despite Antiretroviral TherapyWeiss JJ, Calvi R, Naganawa M, Toyonaga T, Farhadian SF, Chintanaphol M, Chiarella J, Zheng MQ, Ropchan J, Huang Y, Pietrzak RH, Carson RE, Spudich S. Preliminary In Vivo Evidence of Reduced Synaptic Density in Human Immunodeficiency Virus (HIV) Despite Antiretroviral Therapy Clinical Infectious Diseases 2021, 73: ciab484. PMID: 34050746, PMCID: PMC8528400, DOI: 10.1093/cid/ciab484.
• Compartmentalization of cerebrospinal fluid inflammation across the spectrum of untreated HIV-1 infection, central nervous system injury and viral suppressionGisslen M, Keating SM, Spudich S, Arechiga V, Stephenson S, Zetterberg H, Di Germanio C, Blennow K, Fuchs D, Hagberg L, Norris PJ, Peterson J, Shacklett BL, Yiannoutsos CT, Price RW. Compartmentalization of cerebrospinal fluid inflammation across the spectrum of untreated HIV-1 infection, central nervous system injury and viral suppression PLOS ONE 2021, 16: e0250987. PMID: 33983973, PMCID: PMC8118251, DOI: 10.1371/journal.pone.0250987.
• Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 PatientsMcAlpine LS, Zubair AS, Maran I, Chojecka P, Lleva P, Jasne AS, Navaratnam D, Matouk C, Schindler J, Sheth KN, Chun H, Lee AI, Spudich S, Sharma R, Sansing LH. Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients Stroke 2021, 52: e233-e238. PMID: 33966492, PMCID: PMC8140646, DOI: 10.1161/strokeaha.120.031971.
• Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptomsSong E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Sunshine S, Liu J, Wu W, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J, Goldman-Israelow B, Vogels CBF, Grubaugh ND, Casanovas-Massana A, Phinney BS, Salemi M, Alexander JR, Gallego JA, Lencz T, Walsh H, Wapniarski AE, Mohanty S, Lucas C, Klein J, Mao T, Oh J, Ring A, Spudich S, Ko AI, Kleinstein SH, Pak J, DeRisi JL, Iwasaki A, Pleasure SJ, Wilson MR, Farhadian SF. Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms Cell Reports Medicine 2021, 2: 100288. PMID: 33969321, PMCID: PMC8091032, DOI: 10.1016/j.xcrm.2021.100288.
• Investigating vascular diseases in people living with HIV by nuclear imagingChan P, Spudich S. Investigating vascular diseases in people living with HIV by nuclear imaging Journal Of Nuclear Cardiology 2021, 29: 1576-1582. PMID: 33884573, DOI: 10.1007/s12350-021-02613-x.
• Neuropathogenesis of acute coronavirus disease 2019.Farhadian SF, Seilhean D, Spudich S. Neuropathogenesis of acute coronavirus disease 2019. Current Opinion In Neurology 2021, 34: 417-422. PMID: 33852526, DOI: 10.1097/wco.0000000000000944.
• Clinical and laboratory impact of concomitant syphilis infection during acute HIVChan P, Colby D, Kroon E, Sacdalan C, Pinyakorn S, Paul R, Robb M, Valcour V, Ananworanich J, Marra C, Spudich S. Clinical and laboratory impact of concomitant syphilis infection during acute HIV HIV Medicine 2021, 22: 502-511. PMID: 33728759, DOI: 10.1111/hiv.13079.
• Cognitive trajectories after treatment in acute HIV infectionChan P, Kerr SJ, Kroon E, Colby D, Sacdalan C, Hellmuth J, Reiss P, Vasan S, Ananworanich J, Valcour V, Spudich S, Paul R. Cognitive trajectories after treatment in acute HIV infection AIDS 2021, 35: 883-888. PMID: 33534200, DOI: 10.1097/qad.0000000000002831.
• Chapter 43 HIV and Other Retroviral Infections of the Nervous SystemPeluso M, Spudich S. Chapter 43 HIV and Other Retroviral Infections of the Nervous System 2021, 765-784. DOI: 10.1016/b978-0-12-819306-8.00043-5.
• Coronavirus disease 2019 and neurodegenerative disease: what will the future bring?McAlpine LS, Fesharaki-Zadeh A, Spudich S. Coronavirus disease 2019 and neurodegenerative disease: what will the future bring? Current Opinion In Psychiatry 2020, 34: 177-185. PMID: 33395100, PMCID: PMC7924921, DOI: 10.1097/yco.0000000000000688.
• Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement.Song E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J, Israelow B, Vogels CBF, Grubaugh ND, Casanovas-Massana A, Phinney BS, Salemi M, Alexander J, Gallego JA, Lencz T, Walsh H, Lucas C, Klein J, Mao T, Oh J, Ring A, Spudich S, Ko AI, Kleinstein SH, DeRisi JL, Iwasaki A, Pleasure SJ, Wilson MR, Farhadian SF. Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement. BioRxiv : The Preprint Server For Biology 2020 PMID: 32935102, PMCID: PMC7491516, DOI: 10.1101/2020.09.11.293464.
• Minimal detection of cerebrospinal fluid escape after initiation of antiretroviral therapy in acute HIV-1 infection.Handoko R, Chan P, Jagodzinski L, Pinyakorn S, Ubolyam S, Phanuphak N, Sacdalan C, Kroon E, Dumrongpisutikul N, Paul R, Valcour V, Ananworanich J, Vasan S, Spudich S. Minimal detection of cerebrospinal fluid escape after initiation of antiretroviral therapy in acute HIV-1 infection. AIDS 2020, 35: 777-782. PMID: 33306551, PMCID: PMC7969409, DOI: 10.1097/qad.0000000000002786.
• Determinants of suboptimal CD4+ T cell recovery after antiretroviral therapy initiation in a prospective cohort of acute HIV‐1 infectionHandoko R, Colby DJ, Kroon E, Sacdalan C, Souza M, Pinyakorn S, Prueksakaew P, Munkong C, Ubolyam S, Akapirat S, Chiarella J, Krebs S, Sereti I, Valcour V, Paul R, Michael NL, Phanuphak N, Ananworanich J, Spudich S, Team T. Determinants of suboptimal CD4+ T cell recovery after antiretroviral therapy initiation in a prospective cohort of acute HIV‐1 infection Journal Of The International AIDS Society 2020, 23: e25585. PMID: 32949118, PMCID: PMC7507109, DOI: 10.1002/jia2.25585.
• Lessons from a neurology consult service for patients with COVID-19McAlpine LS, Zubair AS, Moeller J, Baehring J, Spudich S. Lessons from a neurology consult service for patients with COVID-19 The Lancet Neurology 2020, 19: 806-807. PMID: 32949536, PMCID: PMC7494315, DOI: 10.1016/s1474-4422(20)30316-1.
• Central Nervous System Safety During Brief Analytic Treatment Interruption of Antiretroviral Therapy Within 4 Human Immunodeficiency Virus Remission Trials: An Observational Study in Acutely Treated People Living With Human Immunodeficiency VirusHellmuth J, Muccini C, Colby DJ, Kroon E, de Souza M, Crowell TA, Chan P, Sacdalan C, Intasan J, Benjapornpong K, Tipsuk S, Puttamaswin S, Chomchey N, Valcour V, Sarnecki M, Tomaka F, Krebs SJ, Slike BM, Jagodzinski LL, Dumrongpisutikul N, Sailasuta N, Samboju V, Michael NL, Robb ML, Vasan S, Ananworanich J, Phanuphak P, Phanuphak N, Paul R, Spudich S, Group S. Central Nervous System Safety During Brief Analytic Treatment Interruption of Antiretroviral Therapy Within 4 Human Immunodeficiency Virus Remission Trials: An Observational Study in Acutely Treated People Living With Human Immunodeficiency Virus Clinical Infectious Diseases 2020, 73: e1885-e1892. PMID: 32916708, PMCID: PMC8492357, DOI: 10.1093/cid/ciaa1344.
• Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill PatientsSheth KN, Mazurek MH, Yuen MM, Cahn BA, Shah JT, Ward A, Kim JA, Gilmore EJ, Falcone GJ, Petersen N, Gobeske KT, Kaddouh F, Hwang DY, Schindler J, Sansing L, Matouk C, Rothberg J, Sze G, Siner J, Rosen MS, Spudich S, Kimberly WT. Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients JAMA Neurology 2020, 78: 41-47. PMID: 32897296, PMCID: PMC7489395, DOI: 10.1001/jamaneurol.2020.3263.
• Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral TherapyGandhi R, Cyktor J, Bosch R, Mar H, Laird G, Martin A, Collier A, Riddler S, Macatangay B, Rinaldo C, Eron J, Siliciano J, McMahon D, Mellors J, Team A, Hogg E, LeBlanc R, Scello C, Palm D, Gandhi M, Fletcher C, Podany A, Aweeka F, Halvas L, Dragavon J, Joseph J, Lagattuta R, Lin L, Pederson S, Robertson K, Rubin L, Smith D, Spudich S, Tsibris A. Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy The Journal Of Infectious Diseases 2020, 223: 225-233. PMID: 32823274, PMCID: PMC7857155, DOI: 10.1093/infdis/jiaa532.
• Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich S. Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019 JAMA Neurology 2020, 77: 1018-1027. PMID: 32469387, PMCID: PMC7484225, DOI: 10.1001/jamaneurol.2020.2065.
• Stroke Code Presentations, Interventions, and Outcomes Before and During the COVID-19 PandemicJasne AS, Chojecka P, Maran I, Mageid R, Eldokmak M, Zhang Q, Nystrom K, Vlieks K, Askenase M, Petersen N, Falcone GJ, Wira CR, Lleva P, Zeevi N, Narula R, Amin H, Navaratnam D, Loomis C, Hwang DY, Schindler J, Hebert R, Matouk C, Krumholz HM, Spudich S, Sheth KN, Sansing LH, Sharma R. Stroke Code Presentations, Interventions, and Outcomes Before and During the COVID-19 Pandemic Stroke 2020, 51: 2664-2673. PMID: 32755347, PMCID: PMC7446978, DOI: 10.1161/str.0000000000000347.
• A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infectionKroon EDMB, Ananworanich J, Pagliuzza A, Rhodes A, Phanuphak N, Trautmann L, Mitchell JL, Chintanaphol M, Intasan J, Pinyakorn S, Benjapornpong K, Chang JJ, Colby DJ, Chomchey N, Fletcher JLK, Eubanks K, Yang H, Kapson J, Dantanarayana A, Tennakoon S, Gorelick RJ, Maldarelli F, Robb ML, Kim JH, Spudich S, Chomont N, Phanuphak P, Lewin SR, de Souza MS, Teams F. A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection Journal Of Virus Eradication 2020, 6: 100004. PMID: 33251022, PMCID: PMC7646672, DOI: 10.1016/j.jve.2020.100004.
• Cognitive disorders in people living with HIVWinston A, Spudich S. Cognitive disorders in people living with HIV The Lancet HIV 2020, 7: e504-e513. PMID: 32621876, DOI: 10.1016/s2352-3018(20)30107-7.
• Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, Turcotte C, Steinle M, Paczkowski P, Dela Cruz C, Wilen C, Ko AI, MacKay S, Grubaugh ND, Spudich S, Barakat LA. Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19 BMC Neurology 2020, 20: 248. PMID: 32552792, PMCID: PMC7301053, DOI: 10.1186/s12883-020-01812-2.
• Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic targetLiu R, Yeh YJ, Varabyou A, Collora JA, Sherrill-Mix S, Talbot CC, Mehta S, Albrecht K, Hao H, Zhang H, Pollack RA, Beg SA, Calvi RM, Hu J, Durand CM, Ambinder RF, Hoh R, Deeks SG, Chiarella J, Spudich S, Douek DC, Bushman FD, Pertea M, Ho YC. Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target Science Translational Medicine 2020, 12 PMID: 32404504, PMCID: PMC7453882, DOI: 10.1126/scitranslmed.aaz0802.
• Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, Turcotte C, Steinle M, Paczkowski P, Cruz CD, Wilen C, Ko AI, MacKay S, Grubaugh ND, Spudich S, Aoun Barakat L. Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19. Research Square 2020 PMID: 32702723, PMCID: PMC7336693, DOI: 10.21203/rs.3.rs-28583/v1.
• Regional brain volumetric changes despite 2 years of treatment initiated during acute HIV infection.Kallianpur KJ, Jahanshad N, Sailasuta N, Benjapornpong K, Chan P, Pothisri M, Dumrongpisutikul N, Laws E, Ndhlovu LC, Clifford KM, Paul R, Jagodzinski L, Krebs S, Ananworanich J, Spudich S, Valcour V. Regional brain volumetric changes despite 2 years of treatment initiated during acute HIV infection. AIDS 2020, 34: 415-426. PMID: 31725432, PMCID: PMC6994348, DOI: 10.1097/qad.0000000000002436.
• Resting-state neural signatures of depressive symptoms in acute HIVPhilippi CL, Reyna L, Nedderman L, Chan P, Samboju V, Chang K, Phanuphak N, Ratnaratorn N, Hellmuth J, Benjapornpong K, Dumrongpisutikul N, Pothisri M, Robb ML, Ananworanich J, Spudich S, Valcour V, Paul R. Resting-state neural signatures of depressive symptoms in acute HIV Journal Of NeuroVirology 2020, 26: 226-240. PMID: 31989446, PMCID: PMC7261250, DOI: 10.1007/s13365-020-00826-3.
• Liver function test abnormalities in a longitudinal cohort of Thai individuals treated since acute HIV infectionPeluso MJ, Colby DJ, Pinyakorn S, Ubolyam S, Intasan J, Trichavaroj R, Chomchey N, Prueksakaew P, Slike BM, Krebs SJ, Jian N, Robb ML, Phanuphak P, Phanuphak N, Spudich S, Ananworanich J, Kroon E, , Teeratakulpisarn N, Pattanachaiwit S, Sacdalan C, Sriplienchan S, de Souza M, Tantivitayakul P, Poltavee K, Luekasemsuk T, Savadsuk H, Tipsuk S, Puttamsawin S, Benjapornpong K, Ratnaratorn N, Tangnaree K, Munkong C, Thaimanee R, Eamyoung P, Buranapraditkun S, Lerdlum S, Manasnayakorn S, Rerknimitr R, Sirivichayakul S, Wattanaboonyongcharoen P, Suttichom D, O'Connell R, Schuetz A, Hsu D, Akapirat S, Nuntapinit B, Tantibul N, Churikanont N, Getchalarat S, Michael N, Vasan S, Crowell T, Turk E, McCullough C, Butterworth O, Milazzo M, Anne Eller L. Liver function test abnormalities in a longitudinal cohort of Thai individuals treated since acute HIV infection Journal Of The International AIDS Society 2020, 23: e25444. PMID: 31953919, PMCID: PMC6968973, DOI: 10.1002/jia2.25444.
• Neuropsychiatric outcomes before and after switching to dolutegravir-based therapy in an acute HIV cohortChan P, Goh O, Kroon E, Colby D, Sacdalan C, Pinyakorn S, Prueksakaew P, Reiss P, Ananworanich J, Valcour V, Spudich S, Paul R. Neuropsychiatric outcomes before and after switching to dolutegravir-based therapy in an acute HIV cohort AIDS Research And Therapy 2020, 17: 1. PMID: 31907064, PMCID: PMC6945418, DOI: 10.1186/s12981-019-0257-8.
• Feasibility and safety of research sigmoid colon biopsy in a cohort of Thai men who have sex with men with acute HIV-1Chintanaphol M, Sacdalan C, Pinyakorn S, Rerknimitr R, Ridtitid W, Prueksapanich P, Sereti I, Schuetz A, Crowell TA, Colby DJ, Robb ML, Phanuphak N, Ananworanich J, Spudich SS, Kroon E. Feasibility and safety of research sigmoid colon biopsy in a cohort of Thai men who have sex with men with acute HIV-1 Journal Of Virus Eradication 2020, 6: 7-10. PMID: 32175085, PMCID: PMC7043900, DOI: 10.1016/s2055-6640(20)30011-x.
• Exosomal MicroRNAs Associate With Neuropsychological Performance in Individuals With HIV Infection on Antiretroviral Therapy.OʼMeara T, Kong Y, Chiarella J, Price RW, Chaudhury R, Liu X, Spudich S, Robertson K, Emu B, Lu L. Exosomal MicroRNAs Associate With Neuropsychological Performance in Individuals With HIV Infection on Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 82: 514-522. PMID: 31714431, PMCID: PMC6857839, DOI: 10.1097/qai.0000000000002187.
• HIV persistence in the central nervous system during antiretroviral therapy: evidence and implications.Spudich S, Clements JE. HIV persistence in the central nervous system during antiretroviral therapy: evidence and implications. AIDS 2019, 33 Suppl 2: s103-s106. PMID: 31789813, DOI: 10.1097/qad.0000000000002439.
• Potential for early antiretroviral therapy to reduce central nervous system HIV-1 persistence.Spudich S, Peterson J, Fuchs D, Price RW, Gisslen M. Potential for early antiretroviral therapy to reduce central nervous system HIV-1 persistence. AIDS 2019, 33 Suppl 2: s135-s144. PMID: 31789814, DOI: 10.1097/qad.0000000000002326.
• Defining cerebrospinal fluid HIV RNA escape: editorial review AIDS.Winston A, Antinori A, Cinque P, Fox HS, Gisslen M, Henrich TJ, Letendre S, Persaud D, Price RW, Spudich S. Defining cerebrospinal fluid HIV RNA escape: editorial review AIDS. AIDS 2019, 33 Suppl 2: s107-s111. PMID: 31790376, DOI: 10.1097/qad.0000000000002252.
• Markers of CNS injury in adults living with HIV with CSF HIV Not Detected versus Detected < 20 copies/mLFarhadian SF, Mistry H, Kirchwey T, Chiarella J, Calvi R, Chintanaphol M, Patel P, Landry ML, Robertson K, Spudich SS. Markers of CNS injury in adults living with HIV with CSF HIV Not Detected versus Detected < 20 copies/mL Open Forum Infectious Diseases 2019, 6: ofz528. PMID: 31893212, PMCID: PMC6934883, DOI: 10.1093/ofid/ofz528.
• PP 4.10 A modified TZM-bl assay (MoCo-TZA) documents replication-competent HIV in circulating monocytes despite 2 years of antiretroviral therapy initiated early during acute infectionMitchell B, Laws E, Paul R, Vasan S, Kroon E, Valcour V, Spudich S, Shikuma C, Ananworanich J, Ndhlovu L. PP 4.10 A modified TZM-bl assay (MoCo-TZA) documents replication-competent HIV in circulating monocytes despite 2 years of antiretroviral therapy initiated early during acute infection Journal Of Virus Eradication 2019, 5: 35-36. DOI: 10.1016/s2055-6640(20)30167-9.
• Neurosyphilis During Acute HIV Infection: A CNS Immunologic and Virologic Characterization.Chan P, Dumrongpisutikul N, Subra C, Colby DJ, Kroon E, Fletcher J, Sacdalan C, Phanuphak N, Valcour V, Ananworanich J, Trautmann L, Spudich S. Neurosyphilis During Acute HIV Infection: A CNS Immunologic and Virologic Characterization. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 82: e34-e37. PMID: 31180994, DOI: 10.1097/qai.0000000000002114.
• Trajectory Analysis of Cognitive Outcomes in Children With Perinatal HIV.Patel PB, Apornpong T, Puthanakit T, Thongpibul K, Kosalaraksa P, Hansudewechakul R, Kanjanavanit S, Ngampiyaskul C, Luesomboon W, Wongsawat J, Sun LP, Chettra K, Saphonn V, Mellins CA, Malee K, Spudich S, Ananworanich J, Kerr SJ, Paul R. Trajectory Analysis of Cognitive Outcomes in Children With Perinatal HIV. The Pediatric Infectious Disease Journal 2019, 38: 1038-1044. PMID: 31568142, PMCID: PMC6776249, DOI: 10.1097/inf.0000000000002427.
• Deep Sequencing Reveals Central Nervous System Compartmentalization in Multiple Transmitted/Founder Virus Acute HIV-1 InfectionTovanabutra S, Sirijatuphat R, Pham PT, Bonar L, Harbolick EA, Bose M, Song H, Chang D, Oropeza C, O’Sullivan A, Balinang J, Kroon E, Colby DJ, Sacdalan C, Hellmuth J, Chan P, Prueksakaew P, Pinyakorn S, Jagodzinski LL, Sutthichom D, Pattamaswin S, de Souza M, Gramzinski RA, Kim JH, Michael NL, Robb ML, Phanuphak N, Ananworanich J, Valcour V, Kijak GH, Sanders-Buell E, Spudich S, , . Deep Sequencing Reveals Central Nervous System Compartmentalization in Multiple Transmitted/Founder Virus Acute HIV-1 Infection Cells 2019, 8: 902. PMID: 31443253, PMCID: PMC6721674, DOI: 10.3390/cells8080902.
• Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performanceSpudich S, Robertson KR, Bosch RJ, Gandhi RT, Cyktor JC, Mar H, Macatangay BJ, Lalama CM, Rinaldo C, Collier AC, Godfrey C, Eron JJ, McMahon D, Jacobs JL, Koontz D, Hogg E, Vecchio A, Mellors JW. Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance Journal Of Clinical Investigation 2019, 129: 3339-3346. PMID: 31305262, PMCID: PMC6668666, DOI: 10.1172/jci127413.
• Switch to dolutegravir is well tolerated in Thais with HIV infectionGoh OQ, Colby DJ, Pinyakorn S, Sacdalan C, Kroon E, Chan P, Chomchey N, Kanaprach R, Prueksakaew P, Suttichom D, Trichavaroj R, Spudich S, Robb ML, Phanuphak P, Phanuphak N, Ananworanich J, Group O. Switch to dolutegravir is well tolerated in Thais with HIV infection Journal Of The International AIDS Society 2019, 22: e25324. PMID: 31294931, PMCID: PMC6621926, DOI: 10.1002/jia2.25324.
• Treatment of Central Nervous System Manifestations of HIV in the Current EraHandoko R, Spudich S. Treatment of Central Nervous System Manifestations of HIV in the Current Era Seminars In Neurology 2019, 39: 391-398. PMID: 31378874, DOI: 10.1055/s-0039-1688915.
• Slowly progressive fatal PML-IRIS following antiretroviral initiation at CD4+ nadir of 350 cells/mm3 despite CD4+ cell count rise to 900 cells/mm3Sandhu MR, Rutledge R, Grant M, Mahajan A, Spudich S. Slowly progressive fatal PML-IRIS following antiretroviral initiation at CD4+ nadir of 350 cells/mm3 despite CD4+ cell count rise to 900 cells/mm3 International Journal Of STD & AIDS 2019, 30: 810-813. PMID: 31046614, DOI: 10.1177/0956462419835966.
• T146. Altered Resting-State Connectivity of the Amygdala in Acute HIVReyna L, Dumrongpisutikul N, Chan P, Phanuphak N, Ratnaratorn N, Pothisri M, Samboju V, Robb M, Benjapornpong K, Spudich S, Valcour V, Paul R, Philippi C. T146. Altered Resting-State Connectivity of the Amygdala in Acute HIV Biological Psychiatry 2019, 85: s185-s186. DOI: 10.1016/j.biopsych.2019.03.469.
• Very early ART initiation during acute HIV infection is associated with normalization of cerebrospinal fluid but not plasma markers of immune activationHellmuth J, Slike BM, Sacdalan C, Best J, Kroon E, Phanuphak N, Fletcher JLK, Prueksakaew P, Jagodzinski LL, Valcour V, Robb M, Ananworanich J, Allen IE, Krebs SJ, Spudich S. Very early ART initiation during acute HIV infection is associated with normalization of cerebrospinal fluid but not plasma markers of immune activation The Journal Of Infectious Diseases 2019, 220: jiz030. PMID: 30668739, PMCID: PMC6833977, DOI: 10.1093/infdis/jiz030.
• Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIVFarhadian SF, Mehta SS, Zografou C, Robertson K, Price RW, Pappalardo J, Chiarella J, Hafler DA, Spudich SS. Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV JCI Insight 2018, 3: e121718. PMID: 30232286, PMCID: PMC6237230, DOI: 10.1172/jci.insight.121718.
• Fever and Focal Cerebral DysfunctionSpudich S, Le L. Fever and Focal Cerebral Dysfunction 2018, 33-41. DOI: 10.1017/9781316597095.007.
• Distribution of Human Immunodeficiency Virus (HIV) Ribonucleic Acid in Cerebrospinal Fluid and Blood Is Linked to CD4/CD8 Ratio During Acute HIVChan P, Patel P, Hellmuth J, Colby DJ, Kroon E, Sacdalan C, Pinyakorn S, Jagodzinski L, Krebs S, Ananworanich J, Valcour V, Spudich S, . Distribution of Human Immunodeficiency Virus (HIV) Ribonucleic Acid in Cerebrospinal Fluid and Blood Is Linked to CD4/CD8 Ratio During Acute HIV The Journal Of Infectious Diseases 2018, 218: 937-945. PMID: 29741638, PMCID: PMC6093332, DOI: 10.1093/infdis/jiy260.
• Longitudinal Trajectories of Brain Volume and Cortical Thickness in Treated and Untreated Primary Human Immunodeficiency Virus InfectionSanford R, Ances BM, Meyerhoff DJ, Price RW, Fuchs D, Zetterberg H, Spudich S, Collins DL. Longitudinal Trajectories of Brain Volume and Cortical Thickness in Treated and Untreated Primary Human Immunodeficiency Virus Infection Clinical Infectious Diseases 2018, 67: 1697-1704. PMID: 29697762, PMCID: PMC6233681, DOI: 10.1093/cid/ciy362.
• Anti-Human Immunodeficiency Virus Antibodies in the Cerebrospinal Fluid: Evidence of Early Treatment Impact on Central Nervous System Reservoir?Burbelo PD, Price RW, Hagberg L, Hatano H, Spudich S, Deeks SG, Gisslén M. Anti-Human Immunodeficiency Virus Antibodies in the Cerebrospinal Fluid: Evidence of Early Treatment Impact on Central Nervous System Reservoir? The Journal Of Infectious Diseases 2018, 217: 1024-1032. PMID: 29401308, PMCID: PMC5939835, DOI: 10.1093/infdis/jix662.
• High Number of Activated CD8+ T Cells Targeting HIV Antigens Are Present in Cerebrospinal Fluid in Acute HIV InfectionKessing CF, Spudich S, Valcour V, Cartwright P, Chalermchai T, Fletcher JL, Takata H, Nichols C, Josey B, Slike B, Krebs S, Sailsuta N, Lerdlum S, Jagodzinski L, Tipsuk S, Suttichom D, Rattanamanee S, Zetterberg H, Hellmuth J, Phanuphak N, Robb M, Michael N, Ananworanich J, Trautmann L. High Number of Activated CD8+ T Cells Targeting HIV Antigens Are Present in Cerebrospinal Fluid in Acute HIV Infection JAIDS Journal Of Acquired Immune Deficiency Syndromes 2017, 75: 108-117. PMID: 28177966, PMCID: PMC5388590, DOI: 10.1097/qai.0000000000001301.
• Blood-Brain Barrier Disruption Is Initiated During Primary HIV Infection and Not Rapidly Altered by Antiretroviral TherapyRahimy E, Li FY, Hagberg L, Fuchs D, Robertson K, Meyerhoff DJ, Zetterberg H, Price RW, Gisslén M, Spudich S. Blood-Brain Barrier Disruption Is Initiated During Primary HIV Infection and Not Rapidly Altered by Antiretroviral Therapy The Journal Of Infectious Diseases 2017, 215: 1132-1140. PMID: 28368497, PMCID: PMC5426376, DOI: 10.1093/infdis/jix013.
• Past Substance Use Affects Central Nervous System (CNS) Inflammation in Human Immunodeficiency Virus InfectionChen L, Peterson J, Robertson K, Fuchs D, Price R, Spudich S. Past Substance Use Affects Central Nervous System (CNS) Inflammation in Human Immunodeficiency Virus Infection Open Forum Infectious Diseases 2016, 3: 853. DOI: 10.1093/ofid/ofw194.60.
• 50LB Central nervous system impact of vorinostat, hydroxychloroquine and maraviroc combination therapy followed by treatment interruption in individuals treated during acute HIV infectionKroon E, Ananworanich J, Le L, Intasan J, Benjapornpong K, Pinyakorn S, Karnsomlap P, Tipsuk S, Rattanamanee S, Hellmuth J, Eamyoung P, Eubanks K, Yang H, Phanuphak N, Souza M, Valcour V, Spudich S, Groups S. 50LB Central nervous system impact of vorinostat, hydroxychloroquine and maraviroc combination therapy followed by treatment interruption in individuals treated during acute HIV infection Journal Of Virus Eradication 2016, 2: 27. DOI: 10.1016/s2055-6640(20)30995-x.
• Neurologic signs and symptoms frequently manifest in acute HIV infectionHellmuth J, Fletcher JL, Valcour V, Kroon E, Ananworanich J, Intasan J, Lerdlum S, Narvid J, Pothisri M, Allen I, Krebs SJ, Slike B, Prueksakaew P, Jagodzinski LL, Puttamaswin S, Phanuphak N, Spudich S. Neurologic signs and symptoms frequently manifest in acute HIV infection Neurology 2016, 87: 148-154. PMID: 27287217, PMCID: PMC4940060, DOI: 10.1212/wnl.0000000000002837.
• Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of InfectionSturdevant CB, Joseph SB, Schnell G, Price RW, Swanstrom R, Spudich S. Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection PLOS Pathogens 2015, 11: e1004720. PMID: 25811757, PMCID: PMC4374811, DOI: 10.1371/journal.ppat.1004720.
• 641Acute Retroviral Syndrome is Associated with Gut Mucosal CD4 Depletion, Inflammation and High Viral and Proviral Burden in Systemic and Tissue CompartmentsCrowell T, Fletcher J, Kroon E, Pinyakorn S, Schuetz A, Sereti I, Krebs S, Slike B, Chomont N, Jagodzinski L, Sandler N, Dewar R, Rerknimitr R, Rattanamanee S, Trichavaroj R, Valcour V, Spudich S, Robb M, Kim J, Michael N, Phanuphak N, Ananworanich J. 641Acute Retroviral Syndrome is Associated with Gut Mucosal CD4 Depletion, Inflammation and High Viral and Proviral Burden in Systemic and Tissue Compartments Open Forum Infectious Diseases 2014, 1: s32-s32. PMCID: PMC5781688, DOI: 10.1093/ofid/ofu051.86.
• Chapter 44 HIV and other Retroviral Infections of the Nervous SystemPeluso M, Spudich S. Chapter 44 HIV and other Retroviral Infections of the Nervous System 2014, 885-909. DOI: 10.1016/b978-0-12-407710-2.00044-8.
• Depression and Mood States and Correlations with Biomarkers of Central Nervous System Disease in Primary-HIV Infection (P01.262)Gold J, Peterson J, Lee E, Fuchs D, Price R, Yiannoutsos C, Robertson K, Spudich S. Depression and Mood States and Correlations with Biomarkers of Central Nervous System Disease in Primary-HIV Infection (P01.262) Neurology 2012, 78: p01.262-p01.262. DOI: 10.1212/wnl.78.1_meetingabstracts.p01.262.
• The CNS in Acute and Early InfectionSpudich S. The CNS in Acute and Early Infection 2011, 504-517. DOI: 10.1093/med/9780195399349.003.0040.
• Reply to SeligmanEdén A, Fuchs D, Hagberg L, Nilsson S, Spudich S, Svennerholm B, Price R, Gisslén M. Reply to Seligman The Journal Of Infectious Diseases 2011, 204: 174-175. PMCID: PMC3307163, DOI: 10.1093/infdis/jir235.
• Where are macrophage‐tropic viruses?Schnell G, Joseph S, Spudich S, Price R, Swanstrom R. Where are macrophage‐tropic viruses? Journal Of The International AIDS Society 2010, 13: o3-o3. PMCID: PMC2999388, DOI: 10.1186/1758-2652-13-s3-o3.
• 110. CSF t-tau, p-tau and Amyloid Beta 1-42 in HIV InfectionBrew B, Gisslen M, Pemberton L, Cinque P, Hagberg L, Price R, Blennow K, Spudich S. 110. CSF t-tau, p-tau and Amyloid Beta 1-42 in HIV Infection Journal Of Clinical Neuroscience 2009, 16: 464. DOI: 10.1016/j.jocn.2008.07.009.
• Fever and Focal Cerebral DysfunctionSpudich S. Fever and Focal Cerebral Dysfunction 2008, 233-240. DOI: 10.1017/cbo9780511547454.041.
• HIV/AIDS of the Central Nervous SystemSpudich S. HIV/AIDS of the Central Nervous System 2008, 430-445. DOI: 10.1016/b978-012373960-5.00019-8.
• Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System DiseaseFatkin D, MacRae C, Sasaki T, Wolff M, Porcu M, Frenneaux M, Atherton J, Vidaillet H, Spudich S, De Girolami U, Seidman JG, Muntoni F, Müehle G, Johnson W, McDonough B, Seidman C. Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease New England Journal Of Medicine 1999, 341: 1715-1724. PMID: 10580070, DOI: 10.1056/nejm199912023412302.
• Complete Penetrance of Creutzfeldt-Jakob Disease in Libyan Jews Carrying the E200K Mutation in the Prion Protein GeneSpudich S, Mastrianni J, Wrensch M, Gabizon R, Meiner Z, Kahana I, Rosenmann H, Kahana E, Prusiner S. Complete Penetrance of Creutzfeldt-Jakob Disease in Libyan Jews Carrying the E200K Mutation in the Prion Protein Gene Molecular Medicine 1995, 1: 607-613. PMID: 8529127, PMCID: PMC2229975, DOI: 10.1007/bf03401601.