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Spudich Lab

About Us

Our research group seeks to understand and address the mechanisms underlying damage to the central nervous system in HIV and other infections. Our studies focus on the effects of acute infection in the central nervous system and the extent to which pathogenic processes established early in the course of disease contribute to long-term viral reservoirs in the central nervous system or sustained, neurologic injury. All of our efforts are concentrated on data and samples collected from humans, with participant recruitment locally in the US and at international sites to understand varied aspects of viral neuropathogenesis. We work in diverse modalities - and with a wide range of collaborators at Yale and beyond - to study the processes of immune activation, neuroprotection, and neuropathogenesis that occur during early and chronic, untreated HIV and during suppressive HIV treatment, as well as after recovery from other acute viral infections. Recent tools include immunologic, viral, and biomarker analysis of cerebrospinal fluid, advanced neuroimaging with positron emission tomography (PET) and magnetic resonance spectroscopy (MRI), and examination of complex, cellular populations and viral persistence in brain tissue.

Research and Training Opportunities

Thank you for your interest in a research position in our lab. We are always interested in working with motivated postdocs, students, and other trainees on clinical and translational research projects, including those based both in the US and around the world. If you are interested in learning more about open positions and opportunities, please email Serena Spudich.

Director’s Innovation Speaker Series: HIV-1 and SARS-CoV-2 Effects on Brain and Mind Health

Serena Spudich, MD, MA, sits down with NIMH Director, Dr. Joshua Gordon, for a NIH Fireside Chat. Dr. Spudich discusses her early interest in neuroscience and how her residency work with HIV patients guided her toward acute HIV studies and her NeuroHIV consortium work in Bangkok, Thailand. Dr. Spudich also discusses how she became involved with long COVID research, and the COVID Mind Study at Yale and fields questions from the virtual audience.

Contact Information

Serena Spudich, MD, MA

300 George St., Rm. 8300C

New Haven, CT 06511