Phillip Chan, MBChB, PhD, MRCP
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Neurology
Primary
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About
Titles
Associate Research Scientist
Biography
Dr Chan obtained his medical degree at the Chinese University of Hong Kong. He completed his fellowship training in internal medicine and neurology at the Queen Elizabeth Hospital of Hong Kong. Before joining the Yale School of Medicine, he served as a research fellow for NeuroHIV projects conducted in Bangkok, Thailand. He completed his PhD in neurological impacts of acute HIV infection at the University of Amsterdam in 2021. Between 2018 and 2022, he also worked with the Hong Kong University of Science and Technology on neurodegenerative disease research projects.
Appointments
Neurology
Associate Research ScientistPrimary
Other Departments & Organizations
- Center for Brain & Mind Health
- Neurological Infections and Global Neurology
- Neurology
- Spudich Lab
Education & Training
- PhD
- University of Amsterdam (2021)
- Higher Physician Trainee (Advanced Internal Medicine)
- Queen Elizabeth Hospital
- Higher Physician Trainee (Neurology)
- Queen Elizabeth Hospital
- Basic Physician Trainee
- Queen Elizabeth Hospital
- MBChB
- The Chinese University of Hong Kong (2004)
Research
Overview
Medical Subject Headings (MeSH)
AIDS Dementia Complex; Biomarkers; Cerebrospinal Fluid; Neurocognitive Disorders; Neurodegenerative Diseases; Neuroimaging
Research at a Glance
Yale Co-Authors
Frequent collaborators of Phillip Chan's published research.
Publications Timeline
A big-picture view of Phillip Chan's research output by year.
Research Interests
Research topics Phillip Chan is interested in exploring.
Serena Spudich, MD, MA
Mehran M Sadeghi, MD
30Publications
260Citations
Cerebrospinal Fluid
AIDS Dementia Complex
Biomarkers
Neuroimaging
Publications
2024
Framingham risk score based vascular outcomes in acute versus chronic HIV cohorts after 6 years of ART
Holroyd K, Han W, Apornpong T, Trautmann L, Gatechompol S, Hiransuthikul A, Ubolyam S, Sacdalan C, Sriplienchan S, Kanaprach R, Kerr S, Avihingsanon A, Spudich S, Chan P. Framingham risk score based vascular outcomes in acute versus chronic HIV cohorts after 6 years of ART. HIV Medicine 2024, 25: 725-736. PMID: 38383057, PMCID: PMC11153003, DOI: 10.1111/hiv.13621.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFramingham risk scoreYears of antiretroviral therapyAcute HIVHigher CD4 countsAntiretroviral therapyChronic HIVCD4 countFollow-upAtherosclerotic cardiovascular diseaseVascular outcomesAssociated with higher body mass indexCardiovascular diseaseRisk scoreHigher body mass indexRisk factorsPrevalence of syphilisVascular agingCD8 T-cell countsMetabolic risk factorsCohort of participantsBody mass indexMultivariate linear regression analysisCardiovascular risk factorsEffect of ART initiationStarted antiretroviral therapy
2023
Update on Central Nervous System Effects of the Intersection of HIV-1 and SARS-CoV-2.
Ocampo FF, Promsena P, Chan P. Update on Central Nervous System Effects of the Intersection of HIV-1 and SARS-CoV-2. Curr HIV/AIDS Rep 2023, 20: 345-356. PMID: 37950846, DOI: 10.1007/s11904-023-00676-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCerebrospinal fluid pleocytosis is associated with HIV-1 neuroinvasion during acute infection
Chan P, Moreland S, Sacdalan C, Kroon E, Colby D, Sriplienchan S, Pinyakorn S, Phanuphak N, Jagodzinski L, Valcour V, Vasan S, Paul R, Trautmann L, Spudich S, Team O. Cerebrospinal fluid pleocytosis is associated with HIV-1 neuroinvasion during acute infection. AIDS 2023, 38: 373-378. PMID: 37916464, PMCID: PMC10842649, DOI: 10.1097/qad.0000000000003777.Peer-Reviewed Original ResearchCitationsConceptsCSF HIV-1 RNAWhite blood cell countHIV-1 RNAAcute HIV infectionCp/mLCSF pleocytosisCSF samplesLower plasmaCerebrospinal fluid white blood cell countMedian CSF white blood cell countStage ICSF white blood cell countDetectable HIV-1 RNAFiebig stage IIIFiebig stages ICerebrospinal fluid pleocytosisT-cell countsAcute retroviral syndromeHigh viral loadBlood cell countCells/Blood CD4Acute infectionHIV infectionMedian agePsychological stress and vessel wall inflammation: Opportunity of reducing cardiovascular risk in people with HIV
Chan P, Sadeghi M. Psychological stress and vessel wall inflammation: Opportunity of reducing cardiovascular risk in people with HIV. Brain Behavior And Immunity 2023, 115: 118-119. PMID: 37820976, DOI: 10.1016/j.bbi.2023.10.007.Commentaries, Editorials and LettersConsensus Competencies for Post-Graduate Fellowship Training in Global Neurology.
Schiess N, Kulo V, Anand P, Bearden DR, Berkowitz AL, Birbeck GL, Cervantes-Arslanian A, Chan P, Chishimba LC, Chow FC, Elicer I, Fleury A, Kinikar A, Kvalsund M, Mateen FJ, Mbonde AA, Meyer AL, O'Carroll CB, Ogunniyi A, Patel AA, Rubenstein M, Siddiqi OK, Spudich S, Tackett SA, Thakur KT, Vora N, Zunt J, Saylor DR. Consensus Competencies for Post-Graduate Fellowship Training in Global Neurology. Neurology 2023 PMID: 36997322, DOI: 10.1212/WNL.0000000000207184.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCognitive Health in Persons With Human Immunodeficiency Virus: The Impact of Early Treatment, Comorbidities, and Aging.
Aung HL, Alagaratnam J, Chan P, Chow FC, Joska J, Falutz J, Letendre SL, Lin W, Muñoz-Moreno JA, Cinque P, Taylor J, Brew B, Winston A. Cognitive Health in Persons With Human Immunodeficiency Virus: The Impact of Early Treatment, Comorbidities, and Aging. J Infect Dis 2023, 227: S38-S47. PMID: 36930639, DOI: 10.1093/infdis/jiac388.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsBrain volumetrics differ by Fiebig stage in acute HIV infection
Bolzenius J, Sacdalan C, Ndhlovu L, Sailasuta N, Trautmann L, Tipsuk S, Crowell T, Suttichom D, Colby D, Phanuphak N, Chan P, Premeaux T, Kroon E, Vasan S, Hsu D, Valcour V, Ananworanich J, Robb M, Ake J, Pohl K, Sriplienchan S, Spudich S, Paul R. Brain volumetrics differ by Fiebig stage in acute HIV infection. AIDS 2023, 37: 861-869. PMID: 36723491, PMCID: PMC10079583, DOI: 10.1097/qad.0000000000003496.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute HIV infectionNucleus accumbensFiebig stagesAcute infectionHIV infectionCaudate nucleusBrain volumeLower regional brain volumesAntiretroviral therapy initiationMarkers of neuroinflammationBrain volume alterationsCross-sectional studyRegional brain volumesT1-weighted scansTherapy initiationChronic infectionBrain volumetricsBrain disruptionThai malesViral factorsPutamenVolume alterationsAccumbensInfectionStimulant use
2022
Effects of syphilis infection among HIV-1-positive individuals on suppressive antiretroviral therapy.
Chan P, Tang THC, Kwong RTS, Chan L, Chan HSY, Lam KW, Ting WM, Yung SK, Lam ECT, Chu MY, Lam W, Wu TC, Li P, Lee MP. Effects of syphilis infection among HIV-1-positive individuals on suppressive antiretroviral therapy. AIDS Res Ther 2022, 19: 69. PMID: 36587188, DOI: 10.1186/s12981-022-00493-w.Peer-Reviewed Original ResearchNeurocognition and the Aging Brain in People With HIV: Implications for Screening.
Chan P, Valcour V. Neurocognition and the Aging Brain in People With HIV: Implications for Screening. Topics In Antiviral Medicine 2022, 29: 423-429. PMID: 35191658, PMCID: PMC8862751.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIndividual Differences in CD4/CD8 T-Cell Ratio Trajectories and Associated Risk Profiles Modeled From Acute HIV Infection
Paul R, Cho K, Bolzenius J, Sacdalan C, Ndhlovu LC, Trautmann L, Krebs S, Tipsuk S, Crowell TA, Suttichom D, Colby DJ, Premeaux TA, Phanuphak N, Chan P, Kroon E, Vasan S, Hsu D, Carrico A, Valcour V, Ananworanich J, Robb ML, Ake JA, Sriplienchan S, Spudich S, Team F. Individual Differences in CD4/CD8 T-Cell Ratio Trajectories and Associated Risk Profiles Modeled From Acute HIV Infection. Psychosomatic Medicine 2022, 84: 976-983. PMID: 36162059, PMCID: PMC9553252, DOI: 10.1097/psy.0000000000001129.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute HIV infectionCD4/CD8 T-cell ratioCD8 T-cell ratioAntiretroviral therapyT-cell countsT-cell recoveryT cell ratioHigh viral loadViral loadHigh CD8Slower CD4HIV infectionLower white blood cell countWeeks of ARTRisk profileWhite blood cell countT-cell trajectoriesMedian viral loadStandard antiretroviral therapyBlood cell countLower eosinophil countsWorse mental healthAHI participantsART onsetFiebig I
Academic Achievements and Community Involvement
activity Member
Professional OrganizationsNeurology Collaborative Science Group, AIDS clinical trials group (ACTG)Details2021 - Presentactivity Member
Professional OrganizationsRoyal Colleges of Physicians (UK)Details2008 - Presentactivity Fellow
Professional OrganizationsHong Kong College of Physicians (Neurology)Details2011 - Presentactivity Fellow
Professional OrganizationsHong Kong Academy of Medicine (Medicine)Details2012 - Presentactivity Member
Professional OrganizationsHong Kong Neurological SocietyDetails2008 - Present
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