David Thompson

Associate Professor Adjunct of Epidemiology (Environmental Health)

Research & Publications
Biography

Coauthors

Selected Publications

Proteomic profiling reveals an association between ALDH and oxidative phosphorylation and DNA damage repair pathways in human colon adenocarcinoma stem cellsWang Y, Chen Y, Garcia-Milian R, Golla JP, Charkoftaki G, Lam TT, Thompson DC, Vasiliou V. Proteomic profiling reveals an association between ALDH and oxidative phosphorylation and DNA damage repair pathways in human colon adenocarcinoma stem cells. Chemico-Biological Interactions 2022, 368: 110175. PMID: 36162455, PMCID: PMC9891852, DOI: 10.1016/j.cbi.2022.110175.
Artificial turf and crumb rubber infill: An international policy review concerning the current state of regulationsZuccaro P, Thompson D, de Boer J, Watterson A, Wang Q, Tang S, Shi X, Llompart M, Ratola N, Vasiliou V. Artificial turf and crumb rubber infill: An international policy review concerning the current state of regulations. Environmental Challenges 2022, 9: 100620. PMID: 36644410, PMCID: PMC9838222, DOI: 10.1016/j.envc.2022.100620.
Oxidative stress, glutathione, and CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal modelsWang Y, Charkoftaki G, Davidson E, Orlicky D, Tanguay R, Thompson D, Vasiliou V, Chen Y. Oxidative stress, glutathione, and CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models. Current Opinion In Environmental Science & Health 2022, 29: 100389. PMID: 37483863, PMCID: PMC10361651, DOI: 10.1016/j.coesh.2022.100389.
Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in miceCharkoftaki G, Tan WY, Berrios-Carcamo P, Orlicky DJ, Golla JP, Garcia-Milian R, Aalizadeh R, Thomaidis NS, Thompson DC, Vasiliou V. Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in mice. Chemico-Biological Interactions 2022, 360: 109931. PMID: 35429548, PMCID: PMC9364420, DOI: 10.1016/j.cbi.2022.109931.
Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissuesThompson B, Davidson EA, Chen Y, Orlicky DJ, Thompson DC, Vasiliou V. Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues. Chemico-Biological Interactions 2022, 355: 109804. PMID: 35123994, PMCID: PMC9136680, DOI: 10.1016/j.cbi.2022.109804.
Interplay between APC and ALDH1B1 in a newly developed mouse model of colorectal cancerGolla JP, Kandyliari A, Tan WY, Chen Y, Orlicky DJ, Thompson DC, Shah YM, Vasiliou V. Interplay between APC and ALDH1B1 in a newly developed mouse model of colorectal cancer. Chemico-Biological Interactions 2020, 331: 109274. PMID: 33007288, PMCID: PMC9201852, DOI: 10.1016/j.cbi.2020.109274.
Abstract 6141: Role of aldehyde dehydrogenase 1B1 in colon carcinogenesis in a newly developed mouse modelTan W, Orlicky D, Chen Y, Shah Y, Thompson D, Vasiliou V. Abstract 6141: Role of aldehyde dehydrogenase 1B1 in colon carcinogenesis in a newly developed mouse model. Cancer Research 2020, 80: 6141-6141. DOI: 10.1158/1538-7445.am2020-6141.
COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmissionGodri Pollitt KJ, Peccia J, Ko AI, Kaminski N, Dela Cruz CS, Nebert DW, Reichardt JKV, Thompson DC, Vasiliou V. COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission. Human Genomics 2020, 14: 17. PMID: 32398162, PMCID: PMC7214856, DOI: 10.1186/s40246-020-00267-3.
Genetics and functions of the retinoic acid pathway, with special emphasis on the eyeThompson B, Katsanis N, Apostolopoulos N, Thompson DC, Nebert DW, Vasiliou V. Genetics and functions of the retinoic acid pathway, with special emphasis on the eye. Human Genomics 2019, 13: 61. PMID: 31796115, PMCID: PMC6892198, DOI: 10.1186/s40246-019-0248-9.
Glutathione deficiency-elicited reprogramming of hepatic metabolism protects against alcohol-induced steatosisChen Y, Manna SK, Golla S, Krausz KW, Cai Y, Garcia-Milian R, Chakraborty T, Chakraborty J, Chatterjee R, Thompson DC, Gonzalez FJ, Vasiliou V. Glutathione deficiency-elicited reprogramming of hepatic metabolism protects against alcohol-induced steatosis. Free Radical Biology And Medicine 2019, 143: 127-139. PMID: 31351176, PMCID: PMC6848780, DOI: 10.1016/j.freeradbiomed.2019.07.025.
1,4-Dioxane as an emerging water contaminant: State of the science and evaluation of research needsGodri Pollitt K, Kim JH, Peccia J, Elimelech M, Zhang Y, Charkoftaki G, Hodges B, Zucker I, Huang H, Deziel N, Murphy K, Ishii M, Johnson CH, Boissevain A, O'Keefe E, Anastas P, Orlicky D, Thompson DC, Vasiliou V. 1,4-Dioxane as an emerging water contaminant: State of the science and evaluation of research needs. The Science Of The Total Environment 2019, 690: 853-866. PMID: 31302550, DOI: 10.1016/j.scitotenv.2019.06.443.
Expression, purification and crystallization of the novel Xenopus tropicalis ALDH16B1, a homologue of human ALDH16A1Pantouris G, Dioletis E, Chen Y, Thompson DC, Vasiliou V, Lolis EJ. Expression, purification and crystallization of the novel Xenopus tropicalis ALDH16B1, a homologue of human ALDH16A1. Chemico-Biological Interactions 2019, 304: 168-172. PMID: 30894314, PMCID: PMC6746316, DOI: 10.1016/j.cbi.2019.03.009.
Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cellsCharkoftaki G, Thompson DC, Golla JP, Garcia-Milian R, Lam TT, Engel J, Vasiliou V. Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cells. Chemico-Biological Interactions 2019, 304: 88-96. PMID: 30851239, PMCID: PMC7988342, DOI: 10.1016/j.cbi.2019.02.030.
Hepatic metabolic adaptation in a murine model of glutathione deficiencyChen Y, Golla S, Garcia-Milian R, Thompson DC, Gonzalez FJ, Vasiliou V. Hepatic metabolic adaptation in a murine model of glutathione deficiency. Chemico-Biological Interactions 2019, 303: 1-6. PMID: 30794799, PMCID: PMC6743730, DOI: 10.1016/j.cbi.2019.02.015.
Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom”Charkoftaki G, Wang Y, McAndrews M, Bruford EA, Thompson DC, Vasiliou V, Nebert DW. Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom”. Human Genomics 2019, 13: 11. PMID: 30782214, PMCID: PMC6381713, DOI: 10.1186/s40246-019-0191-9.
Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and CarcinogenesisChen Y, Han M, Matsumoto A, Wang Y, Thompson DC, Vasiliou V. Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis. 2018, 1032: 37-53. PMID: 30362089, PMCID: PMC6743726, DOI: 10.1007/978-3-319-98788-0_3.
Engineered Animal Models Designed for Investigating Ethanol Metabolism, Toxicity and CancerMarshall S, Chen Y, Singh S, Berrios-Carcamo P, Heit C, Apostolopoulos N, Golla JP, Thompson DC, Vasiliou V. Engineered Animal Models Designed for Investigating Ethanol Metabolism, Toxicity and Cancer. 2018, 1032: 203-221. PMID: 30362100, PMCID: PMC6743736, DOI: 10.1007/978-3-319-98788-0_14.
Evaluation of potential carcinogenicity of organic chemicals in synthetic turf crumb rubberPerkins AN, Inayat-Hussain SH, Deziel NC, Johnson CH, Ferguson SS, Garcia-Milian R, Thompson DC, Vasiliou V. Evaluation of potential carcinogenicity of organic chemicals in synthetic turf crumb rubber. Environmental Research 2018, 169: 163-172. PMID: 30458352, PMCID: PMC6396308, DOI: 10.1016/j.envres.2018.10.018.
Aldehyde Dehydrogenases☆Vasiliou V, Thompson D, Petersen D. Aldehyde Dehydrogenases☆. 2018, 146-163. DOI: 10.1016/b978-0-12-801238-3.99183-9.
Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathwayCharkoftaki G, Jester JV, Thompson DC, Vasiliou V. Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway. The Ocular Surface 2017, 16: 154-162. PMID: 29129753, PMCID: PMC7376578, DOI: 10.1016/j.jtos.2017.11.004.
Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancerMatsumoto A, Arcaroli J, Chen Y, Gasparetto M, Neumeister V, Thompson DC, Singh S, Smith C, Messersmith W, Vasiliou V. Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer. British Journal Of Cancer 2017, 117: 1537-1543. PMID: 28881356, PMCID: PMC5680456, DOI: 10.1038/bjc.2017.304.
Transcriptomic analysis and plasma metabolomics in Aldh16a1-null mice reveals a potential role of ALDH16A1 in renal functionCharkoftaki G, Chen Y, Han M, Sandoval M, Yu X, Zhao H, Orlicky DJ, Thompson DC, Vasiliou V. Transcriptomic analysis and plasma metabolomics in Aldh16a1-null mice reveals a potential role of ALDH16A1 in renal function. Chemico-Biological Interactions 2017, 276: 15-22. PMID: 28254523, PMCID: PMC5725231, DOI: 10.1016/j.cbi.2017.02.013.
Corneal haze phenotype in Aldh3a1-null mice: In vivo confocal microscopy and tissue imaging mass spectrometryChen Y, Jester JV, Anderson DM, Marchitti SA, Schey KL, Thompson DC, Vasiliou V. Corneal haze phenotype in Aldh3a1-null mice: In vivo confocal microscopy and tissue imaging mass spectrometry. Chemico-Biological Interactions 2016, 276: 9-14. PMID: 28038895, DOI: 10.1016/j.cbi.2016.12.017.
Catalase deletion promotes prediabetic phenotype in miceHeit C, Marshall S, Singh S, Yu X, Charkoftaki G, Zhao H, Orlicky DJ, Fritz KS, Thompson DC, Vasiliou V. Catalase deletion promotes prediabetic phenotype in mice. Free Radical Biology And Medicine 2016, 103: 48-56. PMID: 27939935, PMCID: PMC5513671, DOI: 10.1016/j.freeradbiomed.2016.12.011.
Roles of defective ALDH2 polymorphism on liver protection and cancer developmentMatsumoto A, Thompson DC, Chen Y, Kitagawa K, Vasiliou V. Roles of defective ALDH2 polymorphism on liver protection and cancer development. Environmental Health And Preventive Medicine 2016, 21: 395-402. PMID: 27714678, PMCID: PMC5112207, DOI: 10.1007/s12199-016-0579-2.
Quantification of Neural Ethanol and Acetaldehyde Using Headspace GC‐MSHeit C, Eriksson P, Thompson DC, Charkoftaki G, Fritz KS, Vasiliou V. Quantification of Neural Ethanol and Acetaldehyde Using Headspace GC‐MS. Alcohol Clinical And Experimental Research 2016, 40: 1825-1831. PMID: 27501276, PMCID: PMC5008984, DOI: 10.1111/acer.13156.
Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase PathwayChen Y, Singh S, Matsumoto A, Manna SK, Abdelmegeed MA, Golla S, Murphy RC, Dong H, Song BJ, Gonzalez FJ, Thompson DC, Vasiliou V. Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway. Scientific Reports 2016, 6: 29743. PMID: 27403993, PMCID: PMC4940737, DOI: 10.1038/srep29743.
Letter to the editor for “Update of the human and mouse Fanconi anemia genes”Nebert DW, Dong H, Bruford EA, Thompson DC, Joenje H, Vasiliou V. Letter to the editor for “Update of the human and mouse Fanconi anemia genes”. Human Genomics 2016, 10: 25. PMID: 27377885, PMCID: PMC4932714, DOI: 10.1186/s40246-016-0081-3.
Heme oxygenase 1 protects ethanol-administered liver tissue in Aldh2 knockout miceMatsumoto A, Thompson D, Chen Y, Vasiliou V, Kawamoto T, Ichiba M. Heme oxygenase 1 protects ethanol-administered liver tissue in Aldh2 knockout mice. Alcohol 2016, 52: 49-54. PMID: 27139237, DOI: 10.1016/j.alcohol.2016.02.004.
ALDH3A1 Plays a Functional Role in Maintenance of Corneal Epithelial HomeostasisKoppaka V, Chen Y, Mehta G, Orlicky DJ, Thompson DC, Jester JV, Vasiliou V. ALDH3A1 Plays a Functional Role in Maintenance of Corneal Epithelial Homeostasis. PLOS ONE 2016, 11: e0146433. PMID: 26751691, PMCID: PMC4708999, DOI: 10.1371/journal.pone.0146433.
Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic AdenocarcinomaSingh S, Arcaroli JJ, Orlicky DJ, Chen Y, Messersmith WA, Bagby S, Purkey A, Quackenbush KS, Thompson DC, Vasiliou V. Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma. Pancreas 2016, 45: 117-122. PMID: 26566217, PMCID: PMC5175203, DOI: 10.1097/mpa.0000000000000542.
Update of the human and mouse Fanconi anemia genesDong H, Nebert DW, Bruford EA, Thompson DC, Joenje H, Vasiliou V. Update of the human and mouse Fanconi anemia genes. Human Genomics 2015, 9: 32. PMID: 26596371, PMCID: PMC4657327, DOI: 10.1186/s40246-015-0054-y.
Dead enzymes in the aldehyde dehydrogenase gene family: role in drug metabolism and toxicologyJackson BC, Thompson DC, Charkoftaki G, Vasiliou V. Dead enzymes in the aldehyde dehydrogenase gene family: role in drug metabolism and toxicology. Expert Opinion On Drug Metabolism & Toxicology 2015, 11: 1839-1847. PMID: 26558415, PMCID: PMC4937717, DOI: 10.1517/17425255.2016.1108406.
186 Redox Activation of LKB1/AMPK Pathway Protects Against Alcohol-Induced SteatosisChen Y, Singh S, Matsumoto A, Manna S, Abdelmegeed M, Golla S, Murphy R, Dong H, Song B, Gonzalez F, Thompson D, Vasiliou V. 186 Redox Activation of LKB1/AMPK Pathway Protects Against Alcohol-Induced Steatosis. Free Radical Biology And Medicine 2015, 87: s87-s88. DOI: 10.1016/j.freeradbiomed.2015.10.230.
ALDH1B1 links alcohol consumption and diabetesSingh S, Chen Y, Matsumoto A, Orlicky DJ, Dong H, Thompson DC, Vasiliou V. ALDH1B1 links alcohol consumption and diabetes. Biochemical And Biophysical Research Communications 2015, 463: 768-773. PMID: 26086111, PMCID: PMC4517591, DOI: 10.1016/j.bbrc.2015.06.011.
ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling PathwaysSingh S, Arcaroli J, Chen Y, Thompson DC, Messersmith W, Jimeno A, Vasiliou V. ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways. PLOS ONE 2015, 10: e0121648. PMID: 25950950, PMCID: PMC4423958, DOI: 10.1371/journal.pone.0121648.
Human ALDH1B1 Polymorphisms may Affect the Metabolism of Acetaldehyde and All-trans retinaldehyde—In Vitro Studies and Computational ModelingJackson BC, Reigan P, Miller B, Thompson DC, Vasiliou V. Human ALDH1B1 Polymorphisms may Affect the Metabolism of Acetaldehyde and All-trans retinaldehyde—In Vitro Studies and Computational Modeling. Pharmaceutical Research 2014, 32: 1648-1662. PMID: 25413692, PMCID: PMC4382438, DOI: 10.1007/s11095-014-1564-3.
Acetaldehyde and Retinaldehyde-Metabolizing Enzymes in Colon and Pancreatic CancersSingh S, Arcaroli J, Thompson DC, Messersmith W, Vasiliou V. Acetaldehyde and Retinaldehyde-Metabolizing Enzymes in Colon and Pancreatic Cancers. 2014, 815: 281-294. PMID: 25427913, PMCID: PMC4347404, DOI: 10.1007/978-3-319-09614-8_16.
Transgenic Mouse Models for Alcohol Metabolism, Toxicity, and CancerHeit C, Dong H, Chen Y, Shah YM, Thompson DC, Vasiliou V. Transgenic Mouse Models for Alcohol Metabolism, Toxicity, and Cancer. 2014, 815: 375-387. PMID: 25427919, PMCID: PMC4323349, DOI: 10.1007/978-3-319-09614-8_22.
Cellular responses to oxidative stress: From glutathione to aldehyde dehydrogenasesVasiliou V, Thompson D, Chen Y. Cellular responses to oxidative stress: From glutathione to aldehyde dehydrogenases. Toxicology Letters 2014, 229: s17. DOI: 10.1016/j.toxlet.2014.06.091.
Improved drug therapy: triangulating phenomics with genomics and metabolomicsMonte AA, Brocker C, Nebert DW, Gonzalez FJ, Thompson DC, Vasiliou V. Improved drug therapy: triangulating phenomics with genomics and metabolomics. Human Genomics 2014, 8: 16. PMID: 25181945, PMCID: PMC4445687, DOI: 10.1186/s40246-014-0016-9.
Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicityJang JH, Bruse S, Liu Y, Duffy V, Zhang C, Oyamada N, Randell S, Matsumoto A, Thompson DC, Lin Y, Vasiliou V, Tesfaigzi Y, Nyunoya T. Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicity. Free Radical Biology And Medicine 2013, 68: 80-86. PMID: 24316006, PMCID: PMC3941192, DOI: 10.1016/j.freeradbiomed.2013.11.028.
Update of the human and mouse SERPINgene superfamilyHeit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V. Update of the human and mouse SERPINgene superfamily. Human Genomics 2013, 7: 22. PMID: 24172014, PMCID: PMC3880077, DOI: 10.1186/1479-7364-7-22.
Glutathione defense mechanism in liver injury: Insights from animal modelsChen Y, Dong H, Thompson DC, Shertzer HG, Nebert DW, Vasiliou V. Glutathione defense mechanism in liver injury: Insights from animal models. Food And Chemical Toxicology 2013, 60: 38-44. PMID: 23856494, PMCID: PMC3801188, DOI: 10.1016/j.fct.2013.07.008.
ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein–protein interactions with HPRT1Vasiliou V, Sandoval M, Backos DS, Jackson BC, Chen Y, Reigan P, Lanaspa MA, Johnson RJ, Koppaka V, Thompson DC. ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein–protein interactions with HPRT1. Chemico-Biological Interactions 2013, 202: 22-31. PMID: 23348497, PMCID: PMC3746320, DOI: 10.1016/j.cbi.2012.12.018.
The Role of CYP2E1 in Alcohol Metabolism and Sensitivity in the Central Nervous SystemHeit C, Dong H, Chen Y, Thompson DC, Deitrich RA, Vasiliou VK. The Role of CYP2E1 in Alcohol Metabolism and Sensitivity in the Central Nervous System. 2013, 67: 235-247. PMID: 23400924, PMCID: PMC4314297, DOI: 10.1007/978-94-007-5881-0_8.
Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2Jackson BC, Holmes RS, Backos DS, Reigan P, Thompson DC, Vasiliou V. Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2. Chemico-Biological Interactions 2012, 202: 11-21. PMID: 23247008, PMCID: PMC3687035, DOI: 10.1016/j.cbi.2012.11.022.
Aldehyde dehydrogenases in cellular responses to oxidative/electrophilicstressSingh S, Brocker C, Koppaka V, Chen Y, Jackson BC, Matsumoto A, Thompson DC, Vasiliou V. Aldehyde dehydrogenases in cellular responses to oxidative/electrophilicstress. Free Radical Biology And Medicine 2012, 56: 89-101. PMID: 23195683, PMCID: PMC3631350, DOI: 10.1016/j.freeradbiomed.2012.11.010.
Aldehyde dehydrogenases: From eye crystallins to metabolic disease and cancer stem cellsVasiliou V, Thompson DC, Smith C, Fujita M, Chen Y. Aldehyde dehydrogenases: From eye crystallins to metabolic disease and cancer stem cells. Chemico-Biological Interactions 2012, 202: 2-10. PMID: 23159885, PMCID: PMC4128326, DOI: 10.1016/j.cbi.2012.10.026.
Characteristics Valued by the Pharmacy Practice Community When Hiring a Recently Graduated PharmacistThompson D, Nuffer W, Brown K. Characteristics Valued by the Pharmacy Practice Community When Hiring a Recently Graduated Pharmacist. American Journal Of Pharmaceutical Education 2012, 76: 170. PMID: 23193334, PMCID: PMC3508484, DOI: 10.5688/ajpe769170.
Ocular aldehyde dehydrogenases: Protection against ultraviolet damage and maintenance of transparency for visionChen Y, Thompson DC, Koppaka V, Jester JV, Vasiliou V. Ocular aldehyde dehydrogenases: Protection against ultraviolet damage and maintenance of transparency for vision. Progress In Retinal And Eye Research 2012, 33: 28-39. PMID: 23098688, PMCID: PMC3570594, DOI: 10.1016/j.preteyeres.2012.10.001.
ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic TargetsLuo Y, Dallaglio K, Chen Y, Robinson WA, Robinson SE, McCarter MD, Wang J, Gonzalez R, Thompson DC, Norris DA, Roop DR, Vasiliou V, Fujita M. ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic Targets. Stem Cells 2012, 30: 2100-2113. PMID: 22887839, PMCID: PMC3448863, DOI: 10.1002/stem.1193.
Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere culturesSaw YT, Yang J, Ng SK, Liu S, Singh S, Singh M, Welch WR, Tsuda H, Fong WP, Thompson D, Vasiliou V, Berkowitz RS, Ng SW. Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures. BMC Cancer 2012, 12: 329. PMID: 22852552, PMCID: PMC3458927, DOI: 10.1186/1471-2407-12-329.
Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical ApplicationKoppaka V, Thompson DC, Chen Y, Ellermann M, Nicolaou KC, Juvonen RO, Petersen D, Deitrich RA, Hurley TD, Vasiliou V. Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical Application. Pharmacological Reviews 2012, 64: 520-539. PMID: 22544865, PMCID: PMC3400832, DOI: 10.1124/pr.111.005538.
The role of hyperosmotic stress in inflammation and diseaseBrocker C, Thompson DC, Vasiliou V. The role of hyperosmotic stress in inflammation and disease. BioMolecular Concepts 2012, 3: 345-364. PMID: 22977648, PMCID: PMC3438915, DOI: 10.1515/bmc-2012-0001.
Molecular mechanisms of ALDH3A1-mediated cellular protection against 4-hydroxy-2-nonenalBlack W, Chen Y, Matsumoto A, Thompson DC, Lassen N, Pappa A, Vasiliou V. Molecular mechanisms of ALDH3A1-mediated cellular protection against 4-hydroxy-2-nonenal. Free Radical Biology And Medicine 2012, 52: 1937-1944. PMID: 22406320, PMCID: PMC3457646, DOI: 10.1016/j.freeradbiomed.2012.02.050.
Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell developmentGasparetto M, Sekulovic S, Brocker C, Tang P, Zakaryan A, Xiang P, Kuchenbauer F, Wen M, Kasaian K, Witty MF, Rosten P, Chen Y, Imren S, Duester G, Thompson DC, Humphries RK, Vasiliou V, Smith C. Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development. Experimental Hematology 2011, 40: 318-329.e2. PMID: 22198153, DOI: 10.1016/j.exphem.2011.12.006.
Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamilyJackson BC, Thompson DC, Wright MW, McAndrews M, Bernard A, Nebert DW, Vasiliou V. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. Human Genomics 2011, 5: 691. PMID: 22155607, PMCID: PMC3251818, DOI: 10.1186/1479-7364-5-6-691.
Ultraviolet Radiation: Cellular Antioxidant Response and the Role of Ocular Aldehyde Dehydrogenase EnzymesMarchitti SA, Chen Y, Thompson DC, Vasiliou V. Ultraviolet Radiation: Cellular Antioxidant Response and the Role of Ocular Aldehyde Dehydrogenase Enzymes. Eye & Contact Lens Science & Clinical Practice 2011, 37: 206-213. PMID: 21670692, PMCID: PMC3356694, DOI: 10.1097/icl.0b013e3182212642.
Update on the aldehyde dehydrogenase gene (ALDH) superfamilyJackson B, Brocker C, Thompson DC, Black W, Vasiliou K, Nebert DW, Vasiliou V. Update on the aldehyde dehydrogenase gene (ALDH) superfamily. Human Genomics 2011, 5: 283. PMID: 21712190, PMCID: PMC3392178, DOI: 10.1186/1479-7364-5-4-283.
Focus on Molecules: ALDH1A1: From lens and corneal crystallin to stem cell markerChen Y, Koppaka V, Thompson DC, Vasiliou V. Focus on Molecules: ALDH1A1: From lens and corneal crystallin to stem cell marker. Experimental Eye Research 2011, 102: 105-106. PMID: 21536030, PMCID: PMC3423494, DOI: 10.1016/j.exer.2011.04.008.
Importance of inverse correlation between ALDH3A1 and PPARγ in tumor cells and tissue regenerationOraldi M, Saracino S, Maggiora M, Chiaravalloti A, Buemi C, Martinasso G, Paiuzzi E, Thompson D, Vasiliou V, Canuto R. Importance of inverse correlation between ALDH3A1 and PPARγ in tumor cells and tissue regeneration. Chemico-Biological Interactions 2011, 191: 171-176. PMID: 21251908, DOI: 10.1016/j.cbi.2011.01.011.
Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancerChen Y, Orlicky DJ, Matsumoto A, Singh S, Thompson DC, Vasiliou V. Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer. Biochemical And Biophysical Research Communications 2011, 405: 173-179. PMID: 21216231, PMCID: PMC3112362, DOI: 10.1016/j.bbrc.2011.01.002.
Evolutionary divergence and functions of the human interleukin (IL) gene familyBrocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V. Evolutionary divergence and functions of the human interleukin (IL) gene family. Human Genomics 2010, 5: 30. PMID: 21106488, PMCID: PMC3390169, DOI: 10.1186/1479-7364-5-1-30.
Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing EnzymeStagos D, Chen Y, Brocker C, Donald E, Jackson BC, Orlicky DJ, Thompson DC, Vasiliou V. Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing Enzyme. Drug Metabolism And Disposition 2010, 38: 1679-1687. PMID: 20616185, PMCID: PMC2957164, DOI: 10.1124/dmd.110.034678.
Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell linesDwyer-Nield L, Srebernak M, Barrett B, Ahn J, Cosper P, Meyer A, Kisley L, Bauer A, Thompson D, Malkinson A. Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines. Carcinogenesis 2005, 26: 1196-1206. PMID: 15746162, DOI: 10.1093/carcin/bgi061.
Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis.Kisley L, Barrett B, Bauer A, Dwyer-Nield L, Barthel B, Meyer A, Thompson D, Malkinson A. Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. Cancer Research 2002, 62: 6850-6. PMID: 12460898.
Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in miceKisley L, Barrett B, Dwyer-Nield L, Bauer A, Thompson D, Malkinson A. Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice. Carcinogenesis 2002, 23: 1653-1660. PMID: 12376474, DOI: 10.1093/carcin/23.10.1653.
Growth inhibition in G1 and altered expression of cyclin D1 and p27kip‐1 after forced connexin expression in lung and liver carcinoma cellsKoffler L, Roshong S, Park I, Cesen‐Cummings K, Thompson D, Dwyer‐Nield L, Rice P, Mamay C, Malkinson A, Ruch R. Growth inhibition in G1 and altered expression of cyclin D1 and p27kip‐1 after forced connexin expression in lung and liver carcinoma cells. Journal Of Cellular Biochemistry 2000, 79: 347-354. PMID: 10972973, DOI: 10.1002/1097-4644(20001201)79:3<347::aid-jcb10>3.0.co;2-2.
Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell linesThompson D, Porter S, Bauer A, Das K, Ou B, Dwyer-Nield L, White C, Malkinson A. Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell lines. American Journal Of Physiology 1998, 274: l922-l932. PMID: 9609731, DOI: 10.1152/ajplung.1998.274.6.l922.
Differential susceptibility of tracheal contraction to nonadrenergic noncholinergic relaxation.Thompson D, Altiere R. Differential susceptibility of tracheal contraction to nonadrenergic noncholinergic relaxation. Journal Of Pharmacology And Experimental Therapeutics 1998, 284: 19-24. PMID: 9435155.
Absence of tachykinin involvement in leukotriene D4 and antigen-induced contraction of guinea pig isolated bronchus.Cibulsky S, Thompson D. Absence of tachykinin involvement in leukotriene D4 and antigen-induced contraction of guinea pig isolated bronchus. Journal Of Pharmacology And Experimental Therapeutics 1997, 283: 1102-9. PMID: 9399982.
Nitric Oxide Role as a Relaxant Agonist and Transmitter of Nonadrenergic Noncholinergic Inhibitory Nerves in Guinea Pig TracheaLindsay G, Diamond L, Thompson D, Cibulsky S, Altiere R. Nitric Oxide Role as a Relaxant Agonist and Transmitter of Nonadrenergic Noncholinergic Inhibitory Nerves in Guinea Pig Trachea. CHEST Journal 1995, 107: 125s. PMID: 7874990, DOI: 10.1378/chest.107.3_supplement.125s.
The Role of Nitric Oxide in Nonadrenergic Noncholingergic Neural Relaxation of Mammalian Airway Smooth MuscleDiamond L, Altiere R, Lindsay G, Thompson D. The Role of Nitric Oxide in Nonadrenergic Noncholingergic Neural Relaxation of Mammalian Airway Smooth Muscle. 1995, 123-130. DOI: 10.1007/978-1-4615-1903-4_14.
Characterization of acetylcholinesterase in rabbit intrapulmonary arteriesAltiere R, Travis D, Thompson D. Characterization of acetylcholinesterase in rabbit intrapulmonary arteries. American Journal Of Physiology 1994, 267: l745-l752. PMID: 7810679, DOI: 10.1152/ajplung.1994.267.6.l745.
Pharmacological characterization of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries.Altiere R, Travis D, Roberts J, Thompson D. Pharmacological characterization of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries. Journal Of Pharmacology And Experimental Therapeutics 1994, 270: 269-76. PMID: 8035325.
Atypical presynaptic alpha-adrenoceptor modulation of neurally-mediated cholinergic responses in guinea-pig tracheal smooth muscleThompson D, Diamond L, Altiere R. Atypical presynaptic alpha-adrenoceptor modulation of neurally-mediated cholinergic responses in guinea-pig tracheal smooth muscle. Pulmonary Pharmacology & Therapeutics 1992, 5: 251-255. PMID: 1477481, DOI: 10.1016/0952-0600(92)90067-q.
Modulation of cholinergic responses by Nω-nitro-l-arginine in rabbit intrapulmonary arteriesAltiere R, Thompson D. Modulation of cholinergic responses by Nω-nitro-l-arginine in rabbit intrapulmonary arteries. Pulmonary Pharmacology & Therapeutics 1992, 5: 149-151. PMID: 1611234, DOI: 10.1016/0952-0600(92)90034-e.
Omega-conotoxin-sensitive calcium channels modulate autonomic neurotransmission in guinea pig airways.Altiere R, Diamond L, Thompson D. Omega-conotoxin-sensitive calcium channels modulate autonomic neurotransmission in guinea pig airways. Journal Of Pharmacology And Experimental Therapeutics 1992, 260: 98-103. PMID: 1309883.
Enzymatic Modulation of Vasoactive Intestinal Peptide and Nonadrenergic Noncholinergic Inhibitory Responses in Guinea Pig TracheaeThompson D, Diamond L, Altiere R. Enzymatic Modulation of Vasoactive Intestinal Peptide and Nonadrenergic Noncholinergic Inhibitory Responses in Guinea Pig Tracheae. American Journal Of Respiratory And Critical Care Medicine 1990, 142: 1119-1123. PMID: 2240834, DOI: 10.1164/ajrccm/142.5.1119.
Nonadrenergic bronchodilation induced by high concentrations of sulfur dioxideThompson D, Szarek J, Altiere R, Diamond L. Nonadrenergic bronchodilation induced by high concentrations of sulfur dioxide. Journal Of Applied Physiology 1990, 69: 1786-1791. PMID: 2272972, DOI: 10.1152/jappl.1990.69.5.1786.
Presynaptic alpha adrenoceptor modulation of neurally mediated cholinergic excitatory and nonadrenergic noncholinergic inhibitory responses in guinea pig trachea.Thompson D, Diamond L, Altiere R. Presynaptic alpha adrenoceptor modulation of neurally mediated cholinergic excitatory and nonadrenergic noncholinergic inhibitory responses in guinea pig trachea. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 306-11. PMID: 2164097.
NICOTINIC AGONIST MODULATION OF FELINE BRONCHOMOTOR TONEThompson D, Altiere R, Diamond L. NICOTINIC AGONIST MODULATION OF FELINE BRONCHOMOTOR TONE. Clinical And Experimental Pharmacology And Physiology 1990, 17: 83-97. PMID: 2328544, DOI: 10.1111/j.1440-1681.1990.tb01291.x.
The Airway Nonadrenergic Noncholinergic Inhibitory Nervous SystemDiamond L, Altiere R, Thompson D. The Airway Nonadrenergic Noncholinergic Inhibitory Nervous System. CHEST Journal 1988, 93: 1283-1285. PMID: 3286146, DOI: 10.1378/chest.93.6.1283.
The effects of antagonists of vasoactive intestinal peptide on nonadrenergic noncholinergic inhibitory responses in feline airwaysThompson D, Altiere R, Diamond L. The effects of antagonists of vasoactive intestinal peptide on nonadrenergic noncholinergic inhibitory responses in feline airways. Peptides 1988, 9: 443-447. PMID: 3131749, DOI: 10.1016/0196-9781(88)90284-7.
The effect of epithelium removal on non-adrenergic, non-cholinergic inhibitory responses in the isolated central airways of the cat and guinea pigThompson D, Wells J, Altiere R, Diamond L. The effect of epithelium removal on non-adrenergic, non-cholinergic inhibitory responses in the isolated central airways of the cat and guinea pig. European Journal Of Pharmacology 1988, 145: 231-237. PMID: 3350044, DOI: 10.1016/0014-2999(88)90237-3.

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