Robert Bradford Duckrow, MD
Research & Publications
Biography
News
Extensive Research Description
My early contributions to science were in the field of cerebral blood flow and metabolism. At that time, there was considerable interest in the role of hyperglycemia in the evolution of ischemic stroke in humans. Specifically, that it made stroke worse. My initial work found that cerebral blood flow decreased during hyperglycemia and appeared to exclude a causal role of serum osmolality. My subsequent studies eliminated other factors that could explain the finding, including metabolic rate, insulin release, and blood viscosity. Eventually, my application of a continuous laser Doppler blood flow method showed that increased serum osmolality was likely causal and explained the disparity of earlier findings. This work added to the existing body of work on the control of the cerebral circulation. I designed, executed, and reported this work.
Duckrow RB, Beard DC, Brennan RW. (1985) Regional cerebral blood flow decreases during hyperglycemia. Ann. Neurol. 17:267-272
Duckrow RB, Bryan RM. (1987) Regional cerebral glucose utilization during hyperglycemia. J. Neurochem. 48:989-993
Duckrow RB. (1988) Glucose transfer into rat brain during acute and chronic hyperglycemia. Metabolic Brain Disease 3:201-209
Duckrow RB. (1995) Decreased cerebral blood flow during acute hyperglycemia. Brain Res. 703:145-150,
While attempting to develop an acute stroke model, I found an opportunity to study cerebral vascular responses to cortical spreading depression in awake rats. At the time, reports of the blood flow response were variable with the concern that the variation was related to anesthesia. I found that the cerebral blood flow change during spreading depression was related to the baseline flow. This supported the position that eventually became widely accepted. More importantly, by subsequently developing an early form of three-dimensional image reconstruction, I demonstrated the role of nitric oxide synthesis in the modulation of cerebral blood flow during the initial phases of spreading depression. I was the first to report this mechanistic relationship, which was then used by larger groups to address pathophysiological process during acute stroke and migraine headache. I designed, executed, and reported this work.
Duckrow RB. (1991) Regional cerebral blood flow during spreading cortical depression in conscious rats. J. Cereb. Blood Flow Metab. 11:150-154
Duckrow RB. (1993) A brief hypoperfusion precedes spreading depression if nitric oxide synthesis is inhibited. Brain Res. 618:190-195
Analytic methods to measure coincidence and synchronization have been broadly applied to probe brain mechanisms such as synaptic potentiation and feature binding. Accordingly, they have also been applied to questions of seizure onset and propagation in animals and humans. Although correlational and coherence analysis of brain signals began in the 1950s, my work in the field represents an early application coherence analysis to the intracranial EEG of persons with epilepsy in the modern computer era. The central findings supported the concept of information transfer during seizure propagation in mesial temporal lobe structures. I also reported that this transfer did not need to be continuous and separate regions could independently maintain epileptic discharges; a controversial issue at that time. I designed, executed, and reported this work. Continuing collaborative work has included position statements on technical details to provoke a dialog to improve available methods.
Duckrow RB, Spencer SS. (1992) Regional coherence and the transfer of ictal activity during seizure onset in the medial temporal lobe. Electroenceph. clin. Neurophysiol. 82:415-422
Zaveri HP, Duckrow RB, Spencer SS. (2006) On the use of bipolar montages for time-series analysis of intracranial electroencephalograms. Clin. Neurophysiol. 117:2102-2108
Zaveri HP, Duckrow RB, Spencer SS. (2009) Concerning the observation of an electrical potential at a distance from an intracranial electrode contact. Clinical Neurophysiology 120(10):1873-1875
Diagnostic methods to locate and surgical approaches to resect brain tissue responsible for medically intractable epilepsy advanced during the 1980s and 90s. However, surgical failures and a hesitance to resect seizure onset zones that overlapped with areas of critical function spurred the development of implantable neurostimulator systems. Advances in compact signal processors allowed the detection of seizure onset and abortive electrical stimulation of the same region using electrodes on or in the brain. Our group participated in the initial testing of the safety and efficacy of such a device. It was clear from the start that it would provide a novel picture of brain activity by allowing long-term recording of the intracranial EEG in freely moving patients. I was the first to show the potential of this approach by using the device to characterize the daily (circadian) variation in an intracranial EEG feature that correlated with seizure occurrence. This general approach is now the focus of a funding initiative of the Epilepsy Foundation. I was the PI of our site’s participation in the multi-center study of the device, now approved by the FDA, and designed, executed, and reported the work on daily variation.
Duckrow RB, Tcheng TK. (2007) Daily variation in an intracranial EEG feature in humans detected by a responsive neurostimulator system. Epilepsia. 48(8):1614-20
Morrell M, RNS System in Epilepsy Study Group (Duckrow RB, Site Principal Investigator). (2011) Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology. 77(13):1295-304
Coauthors
Research Interests
Electroencephalography; Epilepsy, Generalized; Epilepsy, Complex Partial
Selected Publications
- Cellular recovery after prolonged warm ischaemia of the whole bodyAndrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, Dellal D, Thorn SL, Duckrow RB, Ma S, Duy PQ, Isiktas AU, Liang D, Li M, Kim SK, Daniele SG, Banu K, Perincheri S, Menon MC, Huttner A, Sheth KN, Gobeske KT, Tietjen GT, Zaveri HP, Latham SR, Sinusas AJ, Sestan N. Cellular recovery after prolonged warm ischaemia of the whole body. Nature 2022, 608: 405-412. PMID: 35922506, PMCID: PMC9518831, DOI: 10.1038/s41586-022-05016-1.
- Artificial neural network trained on smartphone behavior can trace epileptiform activity in epilepsyDuckrow RB, Ceolini E, Zaveri HP, Brooks C, Ghosh A. Artificial neural network trained on smartphone behavior can trace epileptiform activity in epilepsy. IScience 2021, 24: 102538. PMID: 34308281, PMCID: PMC8257969, DOI: 10.1016/j.isci.2021.102538.
- Video quality using outpatient smartphone videos in epilepsy: Results from the OSmartViE studyTatum WO, Hirsch LJ, Gelfand MA, Acton EK, LaFrance WC, Duckrow RB, Chen D, Blum AS, Hixson J, Drazkowski J, Benbadis S, Cascino GD, Collaborators T. Video quality using outpatient smartphone videos in epilepsy: Results from the OSmartViE study. European Journal Of Neurology 2021, 28: 1453-1462. PMID: 33465822, DOI: 10.1111/ene.14744.
- Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsyNair DR, Laxer KD, Weber PB, Murro AM, Park YD, Barkley GL, Smith BJ, Gwinn RP, Doherty MJ, Noe KH, Zimmerman RS, Bergey GK, Anderson WS, Heck C, Liu CY, Lee RW, Sadler T, Duckrow RB, Hirsch LJ, Wharen RE, Tatum W, Srinivasan S, McKhann GM, Agostini MA, Alexopoulos AV, Jobst BC, Roberts DW, Salanova V, Witt TC, Cash SS, Cole AJ, Worrell GA, Lundstrom BN, Edwards JC, Halford JJ, Spencer DC, Ernst L, Skidmore CT, Sperling MR, Miller I, Geller EB, Berg MJ, Fessler AJ, Rutecki P, Goldman AM, Mizrahi EM, Gross RE, Shields DC, Schwartz TH, Labar DR, Fountain NB, Elias WJ, Olejniczak PW, Villemarette-Pittman NR, Eisenschenk S, Roper SN, Boggs JG, Courtney TA, Sun FT, Seale CG, Miller KL, Skarpaas TL, Morrell MJ. Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy. Neurology 2020, 95: 10.1212/wnl.0000000000010154. PMID: 32690786, PMCID: PMC7538230, DOI: 10.1212/wnl.0000000000010154.
- Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventionsPercy J, Zaveri H, Duckrow RB, Gerrard J, Farooque P, Hirsch LJ, Spencer DD, Sivaraju A. Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions. Epilepsy & Behavior 2020, 111: 107231. PMID: 32615416, DOI: 10.1016/j.yebeh.2020.107231.
- Assessment of the Predictive Value of Outpatient Smartphone Videos for Diagnosis of Epileptic SeizuresTatum WO, Hirsch LJ, Gelfand MA, Acton EK, LaFrance WC, Duckrow RB, Chen DK, Blum AS, Hixson JD, Drazkowski JF, Benbadis SR, Cascino GD. Assessment of the Predictive Value of Outpatient Smartphone Videos for Diagnosis of Epileptic Seizures. JAMA Neurology 2020, 77: 593-600. PMID: 31961382, PMCID: PMC6990754, DOI: 10.1001/jamaneurol.2019.4785.
- Slowing less than 1 Hz is decreased near the seizure onset zoneLundstrom BN, Boly M, Duckrow R, Zaveri HP, Blumenfeld H. Slowing less than 1 Hz is decreased near the seizure onset zone. Scientific Reports 2019, 9: 6218. PMID: 30996228, PMCID: PMC6470162, DOI: 10.1038/s41598-019-42347-y.
- Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogramJoshi RB, Duckrow RB, Goncharova II, Gerrard JL, Spencer DD, Hirsch LJ, Godwin DW, Zaveri HP. Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogram. Epilepsia 2018, 59: 2075-2085. PMID: 30187919, DOI: 10.1111/epi.14559.
- T148. Slow wave activity from bilateral subdural electrode contacts during awake, sleep, and postictal statesLundstrom B, Boly M, Duckrow R, Zaveri H, Blumenfeld H. T148. Slow wave activity from bilateral subdural electrode contacts during awake, sleep, and postictal states. Clinical Neurophysiology 2018, 129: e59. DOI: 10.1016/j.clinph.2018.04.149.
- T08. Early changes in responsive neurostimulator detection rates after introduction: Of anti-seizure drugs predict efficacyMercier M, Hirsch L, Duckrow R, Quraishi I. T08. Early changes in responsive neurostimulator detection rates after introduction: Of anti-seizure drugs predict efficacy. Clinical Neurophysiology 2018, 129: e4. DOI: 10.1016/j.clinph.2018.04.009.
- Sudden unexpected death in epilepsy in patients treated with brain‐responsive neurostimulationDevinsky O, Friedman D, Duckrow RB, Fountain NB, Gwinn RP, Leiphart JW, Murro AM, Van Ness PC. Sudden unexpected death in epilepsy in patients treated with brain‐responsive neurostimulation. Epilepsia 2018, 59: 555-561. PMID: 29336029, DOI: 10.1111/epi.13998.
- Brain‐responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsyGeller EB, Skarpaas TL, Gross RE, Goodman RR, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Cash SS, Cole AJ, Duckrow RB, Edwards JC, Eisenschenk S, Fessler J, Fountain NB, Goldman AM, Gwinn RP, Heck C, Herekar A, Hirsch LJ, Jobst BC, King‐Stephens D, Labar DR, Leiphart JW, Marsh WR, Meador KJ, Mizrahi EM, Murro AM, Nair DR, Noe KH, Park YD, Rutecki PA, Salanova V, Sheth RD, Shields DC, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness PC, Vossler DG, Wharen RE, Worrell GA, Yoshor D, Zimmerman RS, Cicora K, Sun FT, Morrell MJ. Brain‐responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy. Epilepsia 2017, 58: 994-1004. PMID: 28398014, DOI: 10.1111/epi.13740.
- Brain‐responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areasJobst BC, Kapur R, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Boggs JG, Cash SS, Cole AJ, Duchowny MS, Duckrow RB, Edwards JC, Eisenschenk S, Fessler AJ, Fountain NB, Geller EB, Goldman AM, Goodman RR, Gross RE, Gwinn RP, Heck C, Herekar AA, Hirsch LJ, King‐Stephens D, Labar DR, Marsh WR, Meador KJ, Miller I, Mizrahi EM, Murro AM, Nair DR, Noe KH, Olejniczak PW, Park YD, Rutecki P, Salanova V, Sheth RD, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness P, Vossler DG, Wharen RE, Worrell GA, Yoshor D, Zimmerman RS, Skarpaas TL, Morrell MJ. Brain‐responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas. Epilepsia 2017, 58: 1005-1014. PMID: 28387951, DOI: 10.1111/epi.13739.
- Regional and network relationship in the intracranial EEG second spectrumJoshi RB, Gaspard N, Goncharova II, Duckrow RB, Duncan D, Gerrard JL, Spencer DD, Hirsch LJ, Zaveri HP. Regional and network relationship in the intracranial EEG second spectrum. Clinical Neurophysiology 2016, 127: 3485-3491. PMID: 27692590, DOI: 10.1016/j.clinph.2016.09.003.
- Elevated basal glutamate and unchanged glutamine and GABA in refractory epilepsy: Microdialysis study of 79 patients at the yale epilepsy surgery programÇavuş I, Romanyshyn JC, Kennard JT, Farooque P, Williamson A, Eid T, Spencer SS, Duckrow R, Dziura J, Spencer DD. Elevated basal glutamate and unchanged glutamine and GABA in refractory epilepsy: Microdialysis study of 79 patients at the yale epilepsy surgery program. Annals Of Neurology 2016, 80: 35-45. PMID: 27129611, DOI: 10.1002/ana.24673.
- The relationship between seizures, interictal spikes and antiepileptic drugsGoncharova II, Alkawadri R, Gaspard N, Duckrow RB, Spencer DD, Hirsch LJ, Spencer SS, Zaveri HP. The relationship between seizures, interictal spikes and antiepileptic drugs. Clinical Neurophysiology 2016, 127: 3180-3186. PMID: 27292227, DOI: 10.1016/j.clinph.2016.05.014.
- Progressive change in sleep over multiple nights of intracranial EEG monitoringJoshi RB, Gaspard N, Goncharova II, Pavlova M, Duckrow RB, Gerrard JL, Spencer DD, Hirsch LJ, Zaveri HP. Progressive change in sleep over multiple nights of intracranial EEG monitoring. Clinical Neurophysiology 2016, 127: 2302-2307. PMID: 27072103, DOI: 10.1016/j.clinph.2016.02.018.
- 50 Hz hippocampal stimulation in refractory epilepsy: Higher level of basal glutamate predicts greater release of glutamateCavus I, Widi GA, Duckrow RB, Zaveri H, Kennard JT, Krystal J, Spencer DD. 50 Hz hippocampal stimulation in refractory epilepsy: Higher level of basal glutamate predicts greater release of glutamate. Epilepsia 2016, 57: 288-297. PMID: 26749134, DOI: 10.1111/epi.13269.
- Long-term treatment with responsive brain stimulation in adults with refractory partial seizuresBergey GK, Morrell MJ, Mizrahi EM, Goldman A, King-Stephens D, Nair D, Srinivasan S, Jobst B, Gross RE, Shields DC, Barkley G, Salanova V, Olejniczak P, Cole A, Cash SS, Noe K, Wharen R, Worrell G, Murro AM, Edwards J, Duchowny M, Spencer D, Smith M, Geller E, Gwinn R, Skidmore C, Eisenschenk S, Berg M, Heck C, Van Ness P, Fountain N, Rutecki P, Massey A, O'Donovan C, Labar D, Duckrow RB, Hirsch LJ, Courtney T, Sun FT, Seale CG. Long-term treatment with responsive brain stimulation in adults with refractory partial seizures. Neurology 2015, 84: 810-817. PMID: 25616485, PMCID: PMC4339127, DOI: 10.1212/wnl.0000000000001280.
- The spatial and signal characteristics of physiologic high frequency oscillationsAlkawadri R, Gaspard N, Goncharova II, Spencer DD, Gerrard JL, Zaveri H, Duckrow RB, Blumenfeld H, Hirsch LJ. The spatial and signal characteristics of physiologic high frequency oscillations. Epilepsia 2014, 55: 1986-1995. PMID: 25470216, PMCID: PMC5123742, DOI: 10.1111/epi.12851.
- Subclinical seizures during intracranial EEG recording: Are they clinically significant?Farooque P, Duckrow R. Subclinical seizures during intracranial EEG recording: Are they clinically significant? Epilepsy Research 2014, 108: 1790-1796. PMID: 25306063, DOI: 10.1016/j.eplepsyres.2014.09.020.
- Two‐year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trialHeck CN, King‐Stephens D, Massey AD, Nair DR, Jobst BC, Barkley GL, Salanova V, Cole AJ, Smith MC, Gwinn RP, Skidmore C, Van Ness PC, Bergey GK, Park YD, Miller I, Geller E, Rutecki PA, Zimmerman R, Spencer DC, Goldman A, Edwards JC, Leiphart JW, Wharen RE, Fessler J, Fountain NB, Worrell GA, Gross RE, Eisenschenk S, Duckrow RB, Hirsch LJ, Bazil C, O'Donovan CA, Sun FT, Courtney TA, Seale CG, Morrell MJ. Two‐year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial. Epilepsia 2014, 55: 432-441. PMID: 24621228, PMCID: PMC4233950, DOI: 10.1111/epi.12534.
- Reply to about the electrophysiological basis of resting state networksDuncan D, Duckrow RB, Pincus SM, Goncharova I, Hirsch LJ, Spencer DD, Coifman RR, Zaveri HP. Reply to about the electrophysiological basis of resting state networks. Clinical Neurophysiology 2013, 125: 1713-1714. PMID: 24440225, DOI: 10.1016/j.clinph.2013.12.098.
- 7T MR spectroscopic imaging in the localization of surgical epilepsyPan JW, Duckrow RB, Gerrard J, Ong C, Hirsch LJ, Resor SR, Zhang Y, Petroff O, Spencer S, Hetherington HP, Spencer DD. 7T MR spectroscopic imaging in the localization of surgical epilepsy. Epilepsia 2013, 54: 1668-1678. PMID: 23895497, PMCID: PMC3938332, DOI: 10.1111/epi.12322.
- Intracranially recorded interictal spikes: Relation to seizure onset area and effect of medication and time of dayGoncharova II, Spencer SS, Duckrow RB, Hirsch LJ, Spencer DD, Zaveri HP. Intracranially recorded interictal spikes: Relation to seizure onset area and effect of medication and time of day. Clinical Neurophysiology 2013, 124: 2119-2128. PMID: 23856192, DOI: 10.1016/j.clinph.2013.05.027.
- Intracranial EEG evaluation of relationship within a resting state networkDuncan D, Duckrow RB, Pincus SM, Goncharova I, Hirsch LJ, Spencer DD, Coifman RR, Zaveri HP. Intracranial EEG evaluation of relationship within a resting state network. Clinical Neurophysiology 2013, 124: 1943-1951. PMID: 23790525, DOI: 10.1016/j.clinph.2013.03.028.
- Metabolic networks in epilepsy by MR spectroscopic imagingPan JW, Spencer DD, Kuzniecky R, Duckrow RB, Hetherington H, Spencer SS. Metabolic networks in epilepsy by MR spectroscopic imaging. Acta Neurologica Scandinavica 2012, 126: 411-420. PMID: 22574807, PMCID: PMC3600585, DOI: 10.1111/j.1600-0404.2012.01665.x.
- Selective homonuclear polarization transfer for spectroscopic imaging of GABA at 7TPan JW, Duckrow RB, Spencer DD, Avdievich NI, Hetherington HP. Selective homonuclear polarization transfer for spectroscopic imaging of GABA at 7T. Magnetic Resonance In Medicine 2012, 69: 310-316. PMID: 22505305, PMCID: PMC3407348, DOI: 10.1002/mrm.24283.
- Proceedings of the Second International Workshop on Advances in ElectrocorticographyRitaccio A, Boatman-Reich D, Brunner P, Cervenka MC, Cole AJ, Crone N, Duckrow R, Korzeniewska A, Litt B, Miller KJ, Moran DW, Parvizi J, Viventi J, Williams J, Schalk G. Proceedings of the Second International Workshop on Advances in Electrocorticography. Epilepsy & Behavior 2011, 22: 641-650. PMID: 22036287, PMCID: PMC3847909, DOI: 10.1016/j.yebeh.2011.09.028.
- Responsive cortical stimulation for the treatment of medically intractable partial epilepsy.Morrell M, RNS System in Epilepsy Study Group (Duckrow RB, Site Principal Investigator). Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology 77:1295-1304, 2011
- A prospective study of loss of consciousness in epilepsy using virtual reality driving simulation and other video gamesYang L, Morland TB, Schmits K, Rawson E, Narasimhan P, Motelow JE, Purcaro MJ, Peng K, Raouf S, DeSalvo MN, Oh T, Wilkerson J, Bod J, Srinivasan A, Kurashvili P, Anaya J, Manza P, Danielson N, Ransom CB, Huh L, Elrich S, Padin-Rosado J, Naidu Y, Detyniecki K, Hamid H, Farooque P, Astur R, Xiao B, Duckrow RB, Blumenfeld H. A prospective study of loss of consciousness in epilepsy using virtual reality driving simulation and other video games. Epilepsy & Behavior 2010, 18: 238-246. PMID: 20537593, PMCID: PMC2914099, DOI: 10.1016/j.yebeh.2010.04.011.
- Comment on intracranial evidence for the far-field effect of a dipoleZaveri H, Duckrow R. Comment on intracranial evidence for the far-field effect of a dipole. Clinical Neurophysiology 2010, 121: 262-263. DOI: 10.1016/j.clinph.2009.10.008.
- Background intracranial EEG spectral changes with anti-epileptic drug taperZaveri HP, Pincus SM, Goncharova II, Novotny EJ, Duckrow RB, Spencer DD, Blumenfeld H, Spencer SS. Background intracranial EEG spectral changes with anti-epileptic drug taper. Clinical Neurophysiology 2010, 121: 311-317. PMID: 20075002, DOI: 10.1016/j.clinph.2009.11.081.
- Concerning the observation of an electrical potential at a distance from an intracranial electrode contactZaveri HP, Duckrow RB, Spencer SS. Concerning the observation of an electrical potential at a distance from an intracranial electrode contact. Clinical Neurophysiology 2009, 120: 1873-1875. PMID: 19748311, DOI: 10.1016/j.clinph.2009.08.001.
- Spatial distribution of intracranially recorded spikes in medial and lateral temporal epilepsiesGoncharova II, Zaveri HP, Duckrow RB, Novotny EJ, Spencer SS. Spatial distribution of intracranially recorded spikes in medial and lateral temporal epilepsies. Epilepsia 2009, 50: 2575-2585. PMID: 19674048, DOI: 10.1111/j.1528-1167.2009.02258.x.
- A decrease in EEG energy accompanies anti-epileptic drug taper during intracranial monitoringZaveri HP, Pincus SM, Goncharova II, Novotny EJ, Duckrow RB, Spencer DD, Spencer SS. A decrease in EEG energy accompanies anti-epileptic drug taper during intracranial monitoring. Epilepsy Research 2009, 86: 153-162. PMID: 19632096, DOI: 10.1016/j.eplepsyres.2009.06.002.
- Invasive EEG in Presurgical Evaluation of EpilepsySpencer S, Nguyen D, Duckrow R. Invasive EEG in Presurgical Evaluation of Epilepsy. 2009, 767-798. DOI: 10.1002/9781444316667.ch62.
- Localization-related epilepsy exhibits significant connectivity away from the seizure-onset areaZaveri HP, Pincus SM, Goncharova II, Duckrow RB, Spencer DD, Spencer SS. Localization-related epilepsy exhibits significant connectivity away from the seizure-onset area. Neuroreport 2009, 20: 891-895. PMID: 19424095, DOI: 10.1097/wnr.0b013e32832c78e0.
- Local spatial effect of 50 Hz cortical stimulation in humansGwinn RP, Spencer DD, Spencer SS, Duckrow RB, Vives K, Wu K, Tkeshelashvili D, Zaveri HP. Local spatial effect of 50 Hz cortical stimulation in humans. Epilepsia 2008, 49: 1602-1610. PMID: 18435750, DOI: 10.1111/j.1528-1167.2008.01628.x.
- Large scale brain networks in epilepsyZaveri H, Pincus S, Goncharova I, Duckrow R, Spencer S. Large scale brain networks in epilepsy. Proceedings Of SPIE 2008, 7074: 70740t-70740t-10. DOI: 10.1117/12.801365.
- Chaos, Boltzmann, Shannon and ElectroencephalographyAlbano A, Duckrow R. Chaos, Boltzmann, Shannon and Electroencephalography. AIP Conference Proceedings 2008, 1021: 79-90. DOI: 10.1063/1.2956804.
- Interictal spikes on intracranial recording: Behavior, physiology, and implicationsSpencer SS, Goncharova II, Duckrow RB, Novotny EJ, Zaveri HP. Interictal spikes on intracranial recording: Behavior, physiology, and implications. Epilepsia 2008, 49: 1881-1892. PMID: 18479398, DOI: 10.1111/j.1528-1167.2008.01641.x.
- Temporal distributions of seizure occurrence from various epileptogenic regionsDurazzo TS, Spencer SS, Duckrow RB, Novotny EJ, Spencer DD, Zaveri HP. Temporal distributions of seizure occurrence from various epileptogenic regions. Neurology 2008, 70: 1265-1271. PMID: 18391158, DOI: 10.1212/01.wnl.0000308938.84918.3f.
- Daily Variation in an Intracranial EEG Feature in Humans Detected by a Responsive Neurostimulator SystemDuckrow RB, Tcheng TK. Daily Variation in an Intracranial EEG Feature in Humans Detected by a Responsive Neurostimulator System. Epilepsia 2007, 48: 1614-1620. PMID: 17442001, DOI: 10.1111/j.1528-1167.2007.01091.x.
- On the use of bipolar montages for time-series analysis of intracranial electroencephalogramsZaveri HP, Duckrow RB, Spencer SS. On the use of bipolar montages for time-series analysis of intracranial electroencephalograms. Clinical Neurophysiology 2006, 117: 2102-2108. PMID: 16887380, DOI: 10.1016/j.clinph.2006.05.032.
- CORRELATION OF MAGNETIC RESONANCE SPECTROSCOPIC IMAGING AND INTRACRANIAL EEG LOCALIZATION OF SEIZURESNovotny E, Scharff E, Zaveri H, Papademetris X, Blumenfeld H, Duckrow R, Hetherington H, Spencer S, Spencer D, Duncan J. CORRELATION OF MAGNETIC RESONANCE SPECTROSCOPIC IMAGING AND INTRACRANIAL EEG LOCALIZATION OF SEIZURES. Neuropediatrics 2006, 37 DOI: 10.1055/s-2006-945791.
- Development of a Research Interface for Image Guided Intervention: Initial Application to Epilepsy NeurosurgeryPapademetris X, Vives K, DiStasio M, Staib L, Neff M, Flossman S, Frielinghaus N, Zaveri H, Novotny E, Blumenfeld H, Constable R, Hetherington H, Duckrow R, Spencer S, Spencer D, Duncan J. Development of a Research Interface for Image Guided Intervention: Initial Application to Epilepsy Neurosurgery. 2006, 490-493. DOI: 10.1109/isbi.2006.1624960.
- Correlation of Magnetic Resonance Spectroscopic Imaging and Intracranial Eeg Localization of SeizuresScharff E, Papademetris X, Hetherington H, Pan J, Zaveri H, Blumenfeld H, Duckrow R, Spencer S, Spencer D, Duncan J, Novotny E. Correlation of Magnetic Resonance Spectroscopic Imaging and Intracranial Eeg Localization of Seizures. 2006, 510-513. DOI: 10.1109/isbi.2006.1624965.
- Normal magnetic resonance imaging and medial temporal lobe epilepsy: the clinical syndrome of paradoxical temporal lobe epilepsy.Cohen-Gadol AA, Bradley CC, Williamson A, Kim JH, Westerveld M, Duckrow RB, Spencer DD. Normal magnetic resonance imaging and medial temporal lobe epilepsy: the clinical syndrome of paradoxical temporal lobe epilepsy. Journal Of Neurosurgery 2005, 102: 902-9. PMID: 15926717, DOI: 10.3171/jns.2005.102.5.0902.
- Coherence of the electroencephalogram during the first sleep cycleDuckrow RB, Zaveri HP. Coherence of the electroencephalogram during the first sleep cycle. Clinical Neurophysiology 2005, 116: 1088-1095. PMID: 15826849, DOI: 10.1016/j.clinph.2004.12.002.
- Seizure associated with sleep deprivation and sustained-release bupropion.Oncken CA, Duckrow RB. Seizure associated with sleep deprivation and sustained-release bupropion. Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco 2003, 5: 131-3. PMID: 12745515, DOI: 10.1080/1462220021000060509.
- Distinguishing Subtypes of Temporal Lobe Epilepsy with Background Hippocampal ActivityZaveri H, Duckrow R, De Lanerolle N, Spencer S. Distinguishing Subtypes of Temporal Lobe Epilepsy with Background Hippocampal Activity. Epilepsia 2001, 42: 725-730. PMID: 11422326, DOI: 10.1046/j.1528-1157.2001.00500.x.
- The effect of a scalp reference signal on coherence measurements of intracranial electroencephalogramsZaveri H, Duckrow R, Spencer S. The effect of a scalp reference signal on coherence measurements of intracranial electroencephalograms. Clinical Neurophysiology 2000, 111: 1293-1299. PMID: 10880805, DOI: 10.1016/s1388-2457(00)00321-7.
- Stance perturbation-evoked potentials in old people with poor gait and balanceDuckrow RB, Abu-Hasaballah K, Whipple R, Wolfson L. Stance perturbation-evoked potentials in old people with poor gait and balance. Clinical Neurophysiology 1999, 110: 2026-2032. PMID: 10616107, DOI: 10.1016/s1388-2457(99)00195-9.
- Measuring the coherence of intracranial electroencephalogramsZaveri H, Williams W, Sackellares J, Beydoun A, Duckrow R, Spencer S. Measuring the coherence of intracranial electroencephalograms. Clinical Neurophysiology 1999, 110: 1717-1725. PMID: 10574287, DOI: 10.1016/s1388-2457(99)00136-4.
- Cerebral blood flow velocity decreases during cognitive stimulation in Huntington's diseaseDeckel A, Cohen D, Duckrow R. Cerebral blood flow velocity decreases during cognitive stimulation in Huntington's disease. Neurology 1998, 51: 1576-1583. PMID: 9855504, DOI: 10.1212/wnl.51.6.1576.
- Bicoherence of intracranial EEG in sleep, wakefulness and seizuresBullock TH, Achimowicz JZ, Duckrow RB, Spencer SS, Iragui-Madoz VJ. Bicoherence of intracranial EEG in sleep, wakefulness and seizures. Clinical Neurophysiology 1997, 103: 661-678. PMID: 9546494, DOI: 10.1016/s0013-4694(97)00087-4.
- Concurrence of Graves' Disease and Dysplastic Cerebral Blood Vessels of the Moyamoya VarietyTendler BE, Shoukri K, Malchoff C, MacGillivray D, Duckrow R, Talmadge T, Ramsby GR. Concurrence of Graves' Disease and Dysplastic Cerebral Blood Vessels of the Moyamoya Variety. Thyroid 1997, 7: 625-629. PMID: 9292953, DOI: 10.1089/thy.1997.7.625.
- TEMPORAL-SPATIAL CHARACTERISTICS OF INTERICTAL INTRACRANIAL EEG COHERENCEZaveri* H, Duckrow** R, Spencer* S. TEMPORAL-SPATIAL CHARACTERISTICS OF INTERICTAL INTRACRANIAL EEG COHERENCE. Journal Of Clinical Neurophysiology 1996, 13: 443. DOI: 10.1097/00004691-199609000-00039.
- Decreased cerebral blood flow during acute hyperglycemiaDuckrow R. Decreased cerebral blood flow during acute hyperglycemia. Brain Research 1995, 703: 145-150. PMID: 8719626, DOI: 10.1016/0006-8993(95)01077-7.
- Localization of muscarinic receptor subtypes in brain stem areas regulating sleepBaghdoyan H, Mallios V, Duckrow R, Mash D. Localization of muscarinic receptor subtypes in brain stem areas regulating sleep. Neuroreport 1994, 5: 1631-1634. PMID: 7819535, DOI: 10.1097/00001756-199408150-00022.
- A brief hypoperfusion precedes spreading depression if nitric oxide synthesis is inhibitedDuckrow R. A brief hypoperfusion precedes spreading depression if nitric oxide synthesis is inhibited. Brain Research 1993, 618: 190-195. PMID: 8374751, DOI: 10.1016/0006-8993(93)91265-t.
- Hyperglycemia and Blood-Brain Barrier Glucose TransportPelligrino DA, LaManna JC, Duckrow RB, Bryan RM, Harik SI. Hyperglycemia and Blood-Brain Barrier Glucose Transport. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 887-899. PMID: 1400643, DOI: 10.1038/jcbfm.1992.126.
- Computer simulation of the blood-brain barrier: a model including two membranes, blood flow, facilitated and non-facilitated diffusionOyler G, Duckrow R, Hawkins R. Computer simulation of the blood-brain barrier: a model including two membranes, blood flow, facilitated and non-facilitated diffusion. Journal Of Neuroscience Methods 1992, 44: 179-196. PMID: 1474851, DOI: 10.1016/0165-0270(92)90010-b.
- Regional coherence and the transfer of ictal activity during seizure onset in the medial temporal lobeDuckrow R, Spencer S. Regional coherence and the transfer of ictal activity during seizure onset in the medial temporal lobe. Clinical Neurophysiology 1992, 82: 415-422. PMID: 1375548, DOI: 10.1016/0013-4694(92)90046-k.
- Cortical hypoperfusion following spreading depression is not altered by tirilazad mesylate (U-74006F) in awake ratsDuckrow R, Beard D. Cortical hypoperfusion following spreading depression is not altered by tirilazad mesylate (U-74006F) in awake rats. Brain Research 1992, 572: 296-299. PMID: 1611527, DOI: 10.1016/0006-8993(92)90488-u.
- Regional Cerebral Blood Flow during Spreading Cortical Depression in Conscious RatsDuckrow R. Regional Cerebral Blood Flow during Spreading Cortical Depression in Conscious Rats. Cerebrovascular And Brain Metabolism Reviews 1991, 11: 150-154. PMID: 1983999, DOI: 10.1038/jcbfm.1991.18.
- Brain mitochondrial redox state, tissue haemodynamic and extracellular ion responses to four-vessel occlusion and spreading depression in the rat.Mayevsky A, Duckrow RB, Yoles E, Zarchin N, Kaushausky D. Brain mitochondrial redox state, tissue haemodynamic and extracellular ion responses to four-vessel occlusion and spreading depression in the rat. Neurological Research 1990, 12: 243-8. PMID: 1982168, DOI: 10.1080/01616412.1990.11739951.
- Effect of hemodilution on regional cerebral blood flow during chronic hyperglycemia in rats.Duckrow RB. Effect of hemodilution on regional cerebral blood flow during chronic hyperglycemia in rats. Stroke 1990, 21: 1072-1076. PMID: 2368109, DOI: 10.1161/01.str.21.7.1072.
- Regional cerebral blood flow and glucose utilization during hyperinsulinemiaDuckrow R. Regional cerebral blood flow and glucose utilization during hyperinsulinemia. Brain Research 1988, 462: 363-366. PMID: 3191397, DOI: 10.1016/0006-8993(88)90566-5.
- Glucose transfer into rat brain during acute and chronic hyperglycemiaDuckrow R. Glucose transfer into rat brain during acute and chronic hyperglycemia. Metabolic Brain Disease 1988, 3: 201-209. PMID: 3221811, DOI: 10.1007/bf00999236.
- Regional Cerebral Glucose Utilization During HyperglycemiaDuckrow R, Bryan R. Regional Cerebral Glucose Utilization During Hyperglycemia. Journal Of Neurochemistry 1987, 48: 989-993. PMID: 2949062, DOI: 10.1111/j.1471-4159.1987.tb05614.x.
- Regional cerebral blood flow decreases during chronic and acute hyperglycemia.Duckrow RB, Beard DC, Brennan RW. Regional cerebral blood flow decreases during chronic and acute hyperglycemia. Stroke 1987, 18: 52-58. PMID: 2949400, DOI: 10.1161/01.str.18.1.52.
- Effect of bilirubin on brainstem auditory evoked potentials in the asphyxiated rat.Jirka JH, Duckrow RB, Kendig JW, Maisels MJ. Effect of bilirubin on brainstem auditory evoked potentials in the asphyxiated rat. Pediatric Research 1985, 19: 556-60. PMID: 4011337, DOI: 10.1203/00006450-198506000-00011.
- Regional cerebral blood flow decreases during hyperglycemiaDuckrow R, Beard D, Brennan R. Regional cerebral blood flow decreases during hyperglycemia. Annals Of Neurology 1985, 17: 267-272. PMID: 3922283, DOI: 10.1002/ana.410170308.
- A simplified method for computerized densitometry of complex shapes in 2-deoxyglucose autoradiographsKauer J, Reddy D, Duckrow R, Shepherd G. A simplified method for computerized densitometry of complex shapes in 2-deoxyglucose autoradiographs. Journal Of Neuroscience Methods 1984, 11: 143-158. PMID: 6492858, DOI: 10.1016/0165-0270(84)90032-3.
- Regional optic nerve blood flow and its autoregulation.Weinstein JM, Duckrow RB, Beard D, Brennan RW. Regional optic nerve blood flow and its autoregulation. Investigative Ophthalmology & Visual Science 1983, 24: 1559-65. PMID: 6654637.
- Sensitive and inexpensive dual-wavelength reflection spectrophotometry using interference filtersDuckrow RB, LaManna JC, Rosenthal M. Sensitive and inexpensive dual-wavelength reflection spectrophotometry using interference filters. Analytical Biochemistry 1982, 125: 13-23. PMID: 6293337, DOI: 10.1016/0003-2697(82)90377-3.
- Disparate recovery of resting and stimulated oxidative metabolism following transient ischemia.Duckrow RB, LaManna JS, Rosenthal M. Disparate recovery of resting and stimulated oxidative metabolism following transient ischemia. Stroke 1981, 12: 677-686. PMID: 6272454, DOI: 10.1161/01.str.12.5.677.
- Cerebral compensation for chronic noradrenergic denervation induced by locus ceruleus lesion: recovery of receptor binding, isoproterenol- induced adenylate cyclase activity, and oxidative metabolismHarik SI, Duckrow RB, LaManna JC, Rosenthal M, Sharma VK, Banerjee SP. Cerebral compensation for chronic noradrenergic denervation induced by locus ceruleus lesion: recovery of receptor binding, isoproterenol- induced adenylate cyclase activity, and oxidative metabolism. Journal Of Neuroscience 1981, 1: 641-649. PMID: 7346572, PMCID: PMC6564177, DOI: 10.1523/jneurosci.01-06-00641.1981.
- Oxidative metabolic activity of cerebral cortex after fluid-percussion head injury in the cat.Duckrow R, LaManna J, Rosenthal M, Levasseur J, Patterson J. Oxidative metabolic activity of cerebral cortex after fluid-percussion head injury in the cat. Journal Of Neurosurgery 1981, 54: 607-14. PMID: 7229699, DOI: 10.3171/jns.1981.54.5.0607.
- The role of distributed viscoelastic coupling in sensory adaptation in an insect mechanoreceptorChapman K, Mosinger J, Duckrow R. The role of distributed viscoelastic coupling in sensory adaptation in an insect mechanoreceptor. Journal Of Comparative Physiology A 1979, 131: 1-12. DOI: 10.1007/bf00613078.
- The effect of diphenylhydantoin on self-mutilation in rats produced by unilateral multiple dorsal rhizotomyDuckrow RB, Taub A. The effect of diphenylhydantoin on self-mutilation in rats produced by unilateral multiple dorsal rhizotomy. Experimental Neurology 1977, 54: 33-41. PMID: 556697, DOI: 10.1016/0014-4886(77)90232-1.
- Compliance and sensitivity of a mechanoreceptor of the insect exoskeletonChapman K, Duckrow R. Compliance and sensitivity of a mechanoreceptor of the insect exoskeleton. Journal Of Comparative Physiology A 1975, 100: 251-268. DOI: 10.1007/bf00614534.
- Form and Role of Deformation in Excitation of an Insect MechanoreceptorCHAPMAN KM, DUCKROW RB, MORAN DT. Form and Role of Deformation in Excitation of an Insect Mechanoreceptor. Nature 1973, 244: 453-454. PMID: 4582504, DOI: 10.1038/244453a0.
Clinical Trials
Conditions | Study Title |
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Diseases of the Nervous System; Mental Health & Behavioral Research | Human Epilepsy Project 3: Newly Diagnosed Idiopathic Generalized Epilepsy |