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Lawrence Hirsch, MD

Professor of Neurology; Director, Fellowship Program, Neurophysiology; Chief, Division of Epilepsy and EEG; Co-Director, Yale Comprehensive Epilepsy Center; Co-Director, Critical Care EEG Monitoring Program

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Lawrence Hirsch, MD

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203.785.3865
Fax
203.737.2799

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Yale School of Medicine
Lippard Lab for Clinical Investigation
15 York Street, Ste PO Box 208018
New Haven, CT 06510
Fax:203.737.2799
General Information:203.737.5098
Appointments:203.785.3865

Yale Comprehensive Epilepsy Center

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Research & Publications
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Research Summary

Dr. Hirsch's interests and publications are on topics including brain monitoring in the critically ill, status epilepticus, brain stimulation for epilepsy, epilepsy surgery, seizure clusters, effectiveness and tolerability of anti-seizure medications, and sudden death in epilepsy (SUDEP).

Extensive Research Description

See PubMed.

Coauthors

Research Interests

Electroencephalography; Epilepsy; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Epilepsies, Myoclonic; Epilepsy, Temporal Lobe; Seizures; Status Epilepticus; Epilepsy, Complex Partial; Epilepsy, Frontal Lobe; Epilepsia Partialis Continua; Deep Brain Stimulation; Implantable Neurostimulators

Selected Publications

Quantitative epileptiform burden and electroencephalography background features predict post-traumatic epilepsyChen Y, Li S, Ge W, Jing J, Chen HY, Doherty D, Herman A, Kaleem S, Ding K, Osman G, Swisher CB, Smith C, Maciel CB, Alkhachroum A, Lee JW, Dhakar MB, Gilmore EJ, Sivaraju A, Hirsch LJ, Omay SB, Blumenfeld H, Sheth KN, Struck AF, Edlow BL, Westover MB, Kim JA. Quantitative epileptiform burden and electroencephalography background features predict post-traumatic epilepsy. Journal Of Neurology Neurosurgery & Psychiatry 2022, 94: 245-249. PMID: 36241423, PMCID: PMC9931627, DOI: 10.1136/jnnp-2022-329542.
Electronic seizure diaries for clinical care and researchGray TE, Hirsch LJ, Quraishi IH. Electronic seizure diaries for clinical care and research. Epileptic Disorders 2022, 24: 803-811. PMID: 35811431, DOI: 10.1684/epd.2022.1451.
International consensus recommendations for management of new onset refractory status epilepticus including febrile infection‐related epilepsy syndrome: Statements and supporting evidenceWickstrom R, Taraschenko O, Dilena R, Payne ET, Specchio N, Nabbout R, Koh S, Gaspard N, Hirsch LJ, Group T, Auvin S, van Baalen A, Beghi E, Benseler S, Bergin P, Bleck T, Brunklaus A, Caraballo R, Cervenka M, Costello D, Drislane F, Farias‐Moeller R, Gallantine W, Gilmore E, Gofton T, Jimenez M, Hocker S, Kaliakatsos M, Kellogg M, Lee J, Loddenkemper T, Meletti S, Mizugushi M, Muscal E, Riviello J, Rosenthal E, Rossetti A, Ruegg S, Said R, Sculier C, Schmitt S, Schuele S, Stredny C, Trinka E, Wainwright M, VanHaerents S, Wells E, Wirrell E, Zuberi S. International consensus recommendations for management of new onset refractory status epilepticus including febrile infection‐related epilepsy syndrome: Statements and supporting evidence. Epilepsia 2022, 63: 2840-2864. PMID: 35997591, PMCID: PMC9828002, DOI: 10.1111/epi.17397.
Prevalence and Predictors of Seizure Clusters in Pediatric Patients With Epilepsy: The Harvard-Yale Pediatric Seizure Cluster StudyJafarpour S, Fong MWK, Detyniecki K, Khan A, Jackson-Shaheed E, Wang X, Lewis S, Benjamin R, Gaínza-Lein M, O'Bryan J, Hirsch LJ, Loddenkemper T. Prevalence and Predictors of Seizure Clusters in Pediatric Patients With Epilepsy: The Harvard-Yale Pediatric Seizure Cluster Study. Pediatric Neurology 2022, 137: 22-29. PMID: 36208614, DOI: 10.1016/j.pediatrneurol.2022.08.014.
Association of Serum Pyridoxal Phosphate Levels with Established Status EpilepticusRubinos C, Bruzzone MJ, Blodgett C, Tsai C, Patel P, Hianik R, Jadav R, Boudesseul J, Liu C, Zhu H, Wilson SE, Olm-Shipman C, Meeker R, Hirsch LJ. Association of Serum Pyridoxal Phosphate Levels with Established Status Epilepticus. Neurocritical Care 2022, 38: 41-51. PMID: 36071331, DOI: 10.1007/s12028-022-01579-z.
International consensus recommendations for management of new onset refractory status epilepticus (NORSE) including febrile infection‐related epilepsy syndrome (FIRES): Summary and clinical toolsWickström R, Taraschenko O, Dilena R, Payne ET, Specchio N, Nabbout R, Koh S, Gaspard N, Hirsch LJ, Group T, Auvin S, van Baalen A, Beghi E, Benseler S, Bergin P, Bleck T, Brunklaus A, Caraballo R, Cervenka M, Costello D, Drislane F, Farias‐Moeller R, Gallantine W, Gilmore E, Gofton T, Jimenez M, Hocker S, Kaliakatsos M, Kellogg M, Lee J, Loddenkemper T, Meletti S, Mizugushi M, Muscal E, Riviello J, Rosenthal E, Rossetti A, Ruegg S, Said R, Sculier C, Schmitt S, Schuele S, Stredny C, Trinka E, Wainwright M, VanHaerents S, Wells E, Wirrell E, Zuberi S. International consensus recommendations for management of new onset refractory status epilepticus (NORSE) including febrile infection‐related epilepsy syndrome (FIRES): Summary and clinical tools. Epilepsia 2022, 63: 2827-2839. PMID: 35951466, PMCID: PMC9826478, DOI: 10.1111/epi.17391.
Electroencephalogram in the intensive care unit: a focused look at acute brain injuryAlkhachroum A, Appavu B, Egawa S, Foreman B, Gaspard N, Gilmore EJ, Hirsch LJ, Kurtz P, Lambrecq V, Kromm J, Vespa P, Zafar SF, Rohaut B, Claassen J. Electroencephalogram in the intensive care unit: a focused look at acute brain injury. Intensive Care Medicine 2022, 48: 1443-1462. PMID: 35997792, PMCID: PMC10008537, DOI: 10.1007/s00134-022-06854-3.
Hippocampal recording via the RNS system reveals marked ipsilateral activation of epileptiform activity during Wada testingQuraishi IH, Brown FC, Johnson MH, Hirsch LJ. Hippocampal recording via the RNS system reveals marked ipsilateral activation of epileptiform activity during Wada testing. Epilepsy & Behavior 2022, 134: 108854. PMID: 35905518, DOI: 10.1016/j.yebeh.2022.108854.
Updated review of rescue treatments for seizure clusters and prolonged seizuresBlond BN, Hirsch LJ. Updated review of rescue treatments for seizure clusters and prolonged seizures. Expert Review Of Neurotherapeutics 2022, 22: 567-577. PMID: 35862983, DOI: 10.1080/14737175.2022.2105207.
Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory EpilepsySivaraju A, Hirsch L, Gaspard N, Farooque P, Gerrard J, Xu Y, Deng Y, Damisah E, Blumenfeld H, Spencer DD. Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy. Neurology 2022, 99: e1-e10. PMID: 35508395, PMCID: PMC9259091, DOI: 10.1212/wnl.0000000000200569.
Pregabalin for Recurrent Seizures in Critical Illness: A Promising Adjunctive Therapy, Especially for cyclic SeizuresBusl KM, Fong MWK, Newcomer Z, Patel M, Cohen SA, Jadav R, Smith CN, Mitropanopoulos S, Bruzzone M, Hella M, Eisenschenk S, Robinson CP, Roth WH, Ameli PA, Babi MA, Pizzi MA, Gilmore EJ, Hirsch LJ, Maciel CB. Pregabalin for Recurrent Seizures in Critical Illness: A Promising Adjunctive Therapy, Especially for cyclic Seizures. Neurocritical Care 2022, 37: 140-148. PMID: 35217998, DOI: 10.1007/s12028-022-01459-6.
Acute symptomatic seizures: an educational, evidence‐based reviewMauritz M, Hirsch LJ, Camfield P, Chin R, Nardone R, Lattanzi S, Trinka E. Acute symptomatic seizures: an educational, evidence‐based review. Epileptic Disorders 2022, 24: 26-49. PMID: 34789447, DOI: 10.1684/epd.2021.1376.
Developing a Standardized Approach to Grading the Level of Brain Dysfunction on EEGDhakar MB, Sheikh ZB, Desai M, Desai RA, Sternberg EJ, Popescu C, Baron-Lee J, Rampal N, Hirsch LJ, Gilmore EJ, Maciel CB. Developing a Standardized Approach to Grading the Level of Brain Dysfunction on EEG. Journal Of Clinical Neurophysiology 2022, 40: 553-561. PMID: 35239553, DOI: 10.1097/wnp.0000000000000919.
Early vigabatrin augmenting GABA-ergic pathways in post-anoxic status epilepticus (VIGAB-STAT) phase IIa clinical trial study protocolMaciel CB, Teixeira FJP, Dickinson KJ, Spana JC, Merck LH, Rabinstein AA, Sergott R, Shan G, Miao G, Peloquin CA, Busl KM, Hirsch LJ. Early vigabatrin augmenting GABA-ergic pathways in post-anoxic status epilepticus (VIGAB-STAT) phase IIa clinical trial study protocol. Neurological Research And Practice 2022, 4: 4. PMID: 35067230, PMCID: PMC8785535, DOI: 10.1186/s42466-022-00168-x.
International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after strokeMishra NK, Engel J, Liebeskind DS, Sharma VK, Hirsch LJ, Kasner SE, French JA, Devinsky O, Friedman A, Dawson J, Quinn TJ, Selim M, de Havenon A, Yasuda CL, Cendes F, Benninger F, Zaveri HP, Burneo JG, Srivastava P, Singh M, Bhatia R, Vishnu VY, Bentes C, Ferro J, Weiss S, Sivaraju A, Kim JA, Galovic M, Gilmore EJ, Pitkänen A, Davis K, Sansing LH, Sheth KN, Paz JT, Singh A, Sheth S, Worrall BB, Grotta JC, Casillas-Espinos PM, Chen Z, Nicolo JP, Yan B, Kwan P, Consortium F. International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke. Epilepsy & Behavior 2021, 127: 108502. PMID: 34968775, DOI: 10.1016/j.yebeh.2021.108502.
Hemisphere-Dependent Ictal Tachycardia Versus Ictal Bradycardia in a Critically Ill PatientFong MWK, Norris S, Percy J, Hirsch LJ, Herlopian A. Hemisphere-Dependent Ictal Tachycardia Versus Ictal Bradycardia in a Critically Ill Patient. Journal Of Clinical Neurophysiology 2021, 39: e15-e18. PMID: 34860703, DOI: 10.1097/wnp.0000000000000873.
Combining Transcranial Doppler and EEG Data to Predict Delayed Cerebral Ischemia After Subarachnoid HemorrhageChen HY, Elmer J, Zafar SF, Ghanta M, Moura Junior V, Rosenthal ES, Gilmore EJ, Hirsch LJ, Zaveri HP, Sheth KN, Petersen NH, Westover MB, Kim JA. Combining Transcranial Doppler and EEG Data to Predict Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. Neurology 2021, 98: e459-e469. PMID: 34845057, PMCID: PMC8826465, DOI: 10.1212/wnl.0000000000013126.
The rescue therapy in epilepsy project Part 2: Insights from people with epilepsy and families on expert-derived preferred practicesShafer PO, Santilli N, Buchhalter J, Gilchrist B, Kukla A, French JA, Hirsch LJ. The rescue therapy in epilepsy project Part 2: Insights from people with epilepsy and families on expert-derived preferred practices. Epilepsy & Behavior 2021, 125: 108444. PMID: 34839243, DOI: 10.1016/j.yebeh.2021.108444.
Simulated driving in the epilepsy monitoring unit: Effects of seizure type, consciousness, and motor impairmentKumar A, Martin R, Chen W, Bauerschmidt A, Youngblood MW, Cunningham C, Si Y, Ezeani C, Kratochvil Z, Bronen J, Thomson J, Riordan K, Yoo JY, Shirka R, Manganas L, Krestel H, Hirsch LJ, Blumenfeld H. Simulated driving in the epilepsy monitoring unit: Effects of seizure type, consciousness, and motor impairment. Epilepsia 2021, 63: e30-e34. PMID: 34816425, PMCID: PMC8883409, DOI: 10.1111/epi.17136.
Neuromodulation in epilepsy: state-of-the-art approved therapiesRyvlin P, Rheims S, Hirsch LJ, Sokolov A, Jehi L. Neuromodulation in epilepsy: state-of-the-art approved therapies. The Lancet Neurology 2021, 20: 1038-1047. PMID: 34710360, DOI: 10.1016/s1474-4422(21)00300-8.
Hospital Revisits for Post-Ischemic Stroke Epilepsy after Acute Stroke InterventionsKuohn LR, Herman AL, Soto AL, Brown SC, Gilmore EJ, Hirsch LJ, Matouk CC, Sheth KN, Kim JA. Hospital Revisits for Post-Ischemic Stroke Epilepsy after Acute Stroke Interventions. Journal Of Stroke And Cerebrovascular Diseases 2021, 31: 106155. PMID: 34688213, PMCID: PMC8766898, DOI: 10.1016/j.jstrokecerebrovasdis.2021.106155.
The Utility of Quantitative EEG in Detecting Delayed Cerebral Ischemia After Aneurysmal Subarachnoid HemorrhageBaang HY, Chen HY, Herman AL, Gilmore EJ, Hirsch LJ, Sheth KN, Petersen NH, Zafar SF, Rosenthal ES, Westover MB, Kim JA. The Utility of Quantitative EEG in Detecting Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage. Journal Of Clinical Neurophysiology 2021, 39: 207-215. PMID: 34510093, PMCID: PMC8901442, DOI: 10.1097/wnp.0000000000000754.
A systematic review of seizure clusters: Prevalence, risk factors, burden of disease and treatment patternsChung S, Szaflarski JP, Choi EJ, Wilson JC, Kharawala S, Kaur G, Hirsch LJ. A systematic review of seizure clusters: Prevalence, risk factors, burden of disease and treatment patterns. Epilepsy Research 2021, 177: 106748. PMID: 34521043, DOI: 10.1016/j.eplepsyres.2021.106748.
Miglustat Therapy for SCARB2-Associated Action Myoclonus–Renal Failure SyndromeQuraishi IH, Szekely AM, Shirali AC, Mistry PK, Hirsch LJ. Miglustat Therapy for SCARB2-Associated Action Myoclonus–Renal Failure Syndrome. Neurology Genetics 2021, 7: e614. PMID: 34337151, PMCID: PMC8320328, DOI: 10.1212/nxg.0000000000000614.
Gerstmann Syndrome Deconstructed by Cortical StimulationVaddiparti A, McGrath H, Benjamin C, Sivaraju A, Spencer DD, Hirsch LJ, Damisah E, Quraishi IH. Gerstmann Syndrome Deconstructed by Cortical Stimulation. Neurology 2021, 97: 420-422. PMID: 34187861, PMCID: PMC9246017, DOI: 10.1212/wnl.0000000000012441.
Patient‐detectable responsive neurostimulation as a seizure warning systemQuraishi IH, Hirsch LJ. Patient‐detectable responsive neurostimulation as a seizure warning system. Epilepsia 2021, 62: e110-e116. PMID: 34018182, PMCID: PMC8629031, DOI: 10.1111/epi.16933.
Highlights From AES2020, a Virtual American Epilepsy Society ExperienceJobst BC, Conner KR, Coulter D, Fried I, Guilfoyle S, Hirsch LJ, Hogan RE, Hopp JL, Naritoku D, Plueger M, Schevon C, Smith G, Valencia I, Gaillard WD. Highlights From AES2020, a Virtual American Epilepsy Society Experience. Epilepsy Currents 2021, 21: 303-303. PMID: 33998298, PMCID: PMC8512915, DOI: 10.1177/15357597211018219.
Pharmacotherapy for Nonconvulsive Seizures and Nonconvulsive Status EpilepticusBravo P, Vaddiparti A, Hirsch LJ. Pharmacotherapy for Nonconvulsive Seizures and Nonconvulsive Status Epilepticus. Drugs 2021, 81: 749-770. PMID: 33830480, DOI: 10.1007/s40265-021-01502-4.
Intrastimulation discharges during electrical stimulation mapping May help identify seizure onset networkSivaraju A, Spencer DD, Hirsch LJ. Intrastimulation discharges during electrical stimulation mapping May help identify seizure onset network. Brain Stimulation 2021, 14: 652-654. PMID: 33826933, DOI: 10.1016/j.brs.2021.04.003.
How to Help Your Patients Enroll in the New-Onset Refractory Status Epilepticus (NORSE) and Febrile Infection-Related Epilepsy Syndrome (FIRES) Family Registry, and Other Rare Epilepsy RegistriesKazazian K, Kellogg M, Wong N, Eschbach K, Moeller RF, Gaspard N, Hirsch LJ, Hocker S, Gofton T. How to Help Your Patients Enroll in the New-Onset Refractory Status Epilepticus (NORSE) and Febrile Infection-Related Epilepsy Syndrome (FIRES) Family Registry, and Other Rare Epilepsy Registries. Epilepsy Currents 2021, 21: 382-384. PMID: 33769129, PMCID: PMC8655258, DOI: 10.1177/15357597211002869.
Electroencephalographic Abnormalities are Common in COVID‐19 and are Associated with OutcomesLin L, Al‐Faraj A, Ayub N, Bravo P, Das S, Ferlini L, Karakis I, Lee JW, Mukerji SS, Newey CR, Pathmanathan J, Abdennadher M, Casassa C, Gaspard N, Goldenholz DM, Gilmore EJ, Jing J, Kim JA, Kimchi EY, Ladha HS, Tobochnik S, Zafar S, Hirsch LJ, Westover MB, Shafi MM. Electroencephalographic Abnormalities are Common in COVID‐19 and are Associated with Outcomes. Annals Of Neurology 2021, 89: 872-883. PMID: 33704826, PMCID: PMC8104061, DOI: 10.1002/ana.26060.
High epileptiform discharge burden predicts delayed cerebral ischemia after subarachnoid hemorrhageKim JA, Zheng WL, Elmer J, Jing J, Zafar SF, Ghanta M, Moura V, Gilmore EJ, Hirsch LJ, Patel A, Rosenthal E, Westover MB. High epileptiform discharge burden predicts delayed cerebral ischemia after subarachnoid hemorrhage. Clinical Neurophysiology 2021, 141: 139-146. PMID: 33812771, PMCID: PMC8429508, DOI: 10.1016/j.clinph.2021.01.022.
How to Help Your Patients Enroll in the New-Onset Refractory Status Epilepticus (NORSE) and Febrile Infection-Related Epilepsy Syndrome (FIRES) Family Registry, and Other Rare Epilepsy Registries.Kazazian K, Kellogg M, Wong N, Eschbach K, Moeller RF, Gaspard N, Hirsch LJ, Hocker S, Gofton T. How to Help Your Patients Enroll in the New-Onset Refractory Status Epilepticus (NORSE) and Febrile Infection-Related Epilepsy Syndrome (FIRES) Family Registry, and Other Rare Epilepsy Registries. Epilepsy Currents 2021, 1535759721998329. PMID: 33663265, DOI: 10.1177/1535759721998329.
Assessment of a Study of Continuous vs Repeat-Spot Electroencephalography in Patients With Critical IllnessGaspard N, Westover MB, Hirsch LJ. Assessment of a Study of Continuous vs Repeat-Spot Electroencephalography in Patients With Critical Illness. JAMA Neurology 2021, 78: 369-369. PMID: 33523103, PMCID: PMC8136812, DOI: 10.1001/jamaneurol.2020.5348.
Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP preventionCutillo G, Tolba H, Hirsch LJ. Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP prevention. Epilepsy & Behavior 2021, 117: 107815. PMID: 33640562, DOI: 10.1016/j.yebeh.2021.107815.
Preferred practices for rescue treatment of seizure clusters: A consensus-driven, multi-stakeholder approachBuchhalter J, Shafer PO, Buelow JM, French JA, Gilchrist B, Hirsch LJ, Nasuta M, Santilli N. Preferred practices for rescue treatment of seizure clusters: A consensus-driven, multi-stakeholder approach. Epilepsy & Behavior 2021, 117: 107836. PMID: 33640567, DOI: 10.1016/j.yebeh.2021.107836.
Pearls and Pitfalls of Introducing Ketogenic Diet in Adult Status Epilepticus: A Practical Guide for the IntensivistKatz JB, Owusu K, Nussbaum I, Beekman R, DeFilippo NA, Gilmore EJ, Hirsch LJ, Cervenka MC, Maciel CB. Pearls and Pitfalls of Introducing Ketogenic Diet in Adult Status Epilepticus: A Practical Guide for the Intensivist. Journal Of Clinical Medicine 2021, 10: 881. PMID: 33671485, PMCID: PMC7926931, DOI: 10.3390/jcm10040881.
Brief potentially ictal rhythmic discharges and paroxysmal fast activity as scalp electroencephalographic biomarkers of seizure activity and seizure onset zoneYoo JY, Jetté N, Kwon C, Young J, Marcuse LV, Fields MC, Gaspard N, Hirsch LJ. Brief potentially ictal rhythmic discharges and paroxysmal fast activity as scalp electroencephalographic biomarkers of seizure activity and seizure onset zone. Epilepsia 2021, 62: 742-751. PMID: 33576500, DOI: 10.1111/epi.16822.
Video quality using outpatient smartphone videos in epilepsy: Results from the OSmartViE studyTatum WO, Hirsch LJ, Gelfand MA, Acton EK, LaFrance WC, Duckrow RB, Chen D, Blum AS, Hixson J, Drazkowski J, Benbadis S, Cascino GD, Collaborators T. Video quality using outpatient smartphone videos in epilepsy: Results from the OSmartViE study. European Journal Of Neurology 2021, 28: 1453-1462. PMID: 33465822, DOI: 10.1111/ene.14744.
Electrical cortical stimulation can impair production of the alphabet without impairing countingRojas PH, Sivaraju A, Quraishi IH, Vanderlind M, Rofes A, Połczynska-Bletsos MM, Spencer DD, Hirsch LJ, Benjamin CFA. Electrical cortical stimulation can impair production of the alphabet without impairing counting. Epilepsy & Behavior Reports 2021, 15: 100433. PMID: 33778464, PMCID: PMC7985277, DOI: 10.1016/j.ebr.2021.100433.
American Clinical Neurophysiology Society's Standardized Critical Care EEG Terminology: 2021 Version.Hirsch LJ, Fong MWK, Leitinger M, LaRoche SM, Beniczky S, Abend NS, Lee JW, Wusthoff CJ, Hahn CD, Westover MB, Gerard EE, Herman ST, Haider HA, Osman G, Rodriguez-Ruiz A, Maciel CB, Gilmore EJ, Fernandez A, Rosenthal ES, Claassen J, Husain AM, Yoo JY, So EL, Kaplan PW, Nuwer MR, van Putten M, Sutter R, Drislane FW, Trinka E, Gaspard N. American Clinical Neurophysiology Society's Standardized Critical Care EEG Terminology: 2021 Version. Journal Of Clinical Neurophysiology 2021, 38: 1-29. PMID: 33475321, PMCID: PMC8135051, DOI: 10.1097/wnp.0000000000000806.
Neuroimaging Correlates of Lateralized Rhythmic Delta Activity, Lateralized Periodic Discharges, and Generalized Rhythmic Delta Activity on EEG in Critically Ill PatientsAlzawahmah M, Fong MWK, Gilmore EJ, Hirsch LJ. Neuroimaging Correlates of Lateralized Rhythmic Delta Activity, Lateralized Periodic Discharges, and Generalized Rhythmic Delta Activity on EEG in Critically Ill Patients. Journal Of Clinical Neurophysiology 2020, 39: 228-234. PMID: 33235178, DOI: 10.1097/wnp.0000000000000763.
Seizure clusters, rescue treatments, seizure action plans: Unmet needs and emerging formulationsGidal B, Klein P, Hirsch LJ. Seizure clusters, rescue treatments, seizure action plans: Unmet needs and emerging formulations. Epilepsy & Behavior 2020, 112: 107391. PMID: 32898744, DOI: 10.1016/j.yebeh.2020.107391.
When and How to Treat Status Epilepticus: The Tortoise or the Hare?Fong MWK, Hirsch LJ. When and How to Treat Status Epilepticus: The Tortoise or the Hare? Journal Of Clinical Neurophysiology 2020, 37: 393-398. PMID: 32890060, DOI: 10.1097/wnp.0000000000000656.
Development and validation of a predictive model of drug-resistant genetic generalized epilepsy.Choi H, Detyniecki K, Bazil C, Thornton S, Crosta P, Tolba H, Muneeb M, Hirsch LJ, Heinzen EL, Sen A, Depondt C, Perucca P, Heiman GA. Development and validation of a predictive model of drug-resistant genetic generalized epilepsy. Neurology 2020, 95: e2150-e2160. PMID: 32759205, PMCID: PMC7713754, DOI: 10.1212/wnl.0000000000010597.
Detecting Seizures and Epileptiform Abnormalities in Acute Brain InjurySingla S, Garcia GE, Rovenolt GE, Soto AL, Gilmore EJ, Hirsch LJ, Blumenfeld H, Sheth KN, Omay SB, Struck AF, Westover MB, Kim JA. Detecting Seizures and Epileptiform Abnormalities in Acute Brain Injury. Current Neurology And Neuroscience Reports 2020, 20: 42. PMID: 32715371, PMCID: PMC9353690, DOI: 10.1007/s11910-020-01060-4.
Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsyNair DR, Laxer KD, Weber PB, Murro AM, Park YD, Barkley GL, Smith BJ, Gwinn RP, Doherty MJ, Noe KH, Zimmerman RS, Bergey GK, Anderson WS, Heck C, Liu CY, Lee RW, Sadler T, Duckrow RB, Hirsch LJ, Wharen RE, Tatum W, Srinivasan S, McKhann GM, Agostini MA, Alexopoulos AV, Jobst BC, Roberts DW, Salanova V, Witt TC, Cash SS, Cole AJ, Worrell GA, Lundstrom BN, Edwards JC, Halford JJ, Spencer DC, Ernst L, Skidmore CT, Sperling MR, Miller I, Geller EB, Berg MJ, Fessler AJ, Rutecki P, Goldman AM, Mizrahi EM, Gross RE, Shields DC, Schwartz TH, Labar DR, Fountain NB, Elias WJ, Olejniczak PW, Villemarette-Pittman NR, Eisenschenk S, Roper SN, Boggs JG, Courtney TA, Sun FT, Seale CG, Miller KL, Skarpaas TL, Morrell MJ. Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy. Neurology 2020, 95: 10.1212/wnl.0000000000010154. PMID: 32690786, PMCID: PMC7538230, DOI: 10.1212/wnl.0000000000010154.
Nonepileptic Electroencephalographic Correlates of Episodic Increases in Intracranial PressureSheikh ZB, Maciel CB, Dhakar MB, Hirsch LJ, Gilmore EJ. Nonepileptic Electroencephalographic Correlates of Episodic Increases in Intracranial Pressure. Journal Of Clinical Neurophysiology 2020, 39: 149-158. PMID: 32701765, DOI: 10.1097/wnp.0000000000000750.
Misperceptions on the chance of seizure freedom with antiseizure medications after two failed trialsBlond BN, Hirsch LJ, Mattson RH. Misperceptions on the chance of seizure freedom with antiseizure medications after two failed trials. Epilepsia 2020, 61: 1789-1790. PMID: 32640071, DOI: 10.1111/epi.16594.
Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventionsPercy J, Zaveri H, Duckrow RB, Gerrard J, Farooque P, Hirsch LJ, Spencer DD, Sivaraju A. Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions. Epilepsy & Behavior 2020, 111: 107231. PMID: 32615416, DOI: 10.1016/j.yebeh.2020.107231.
Evaluating the Clinical Impact of Rapid Response Electroencephalography: The DECIDE Multicenter Prospective Observational Clinical Study.Vespa PM, Olson DM, John S, Hobbs KS, Gururangan K, Nie K, Desai MJ, Markert M, Parvizi J, Bleck TP, Hirsch LJ, Westover MB. Evaluating the Clinical Impact of Rapid Response Electroencephalography: The DECIDE Multicenter Prospective Observational Clinical Study. Critical Care Medicine 2020, 48: 1249-1257. PMID: 32618687, PMCID: PMC7735649, DOI: 10.1097/ccm.0000000000004428.
Choosing Anticonvulsant Medications to Manage Status EpilepticusWu K, Hirsch LJ, Babl FE, Josephson SA. Choosing Anticonvulsant Medications to Manage Status Epilepticus. New England Journal Of Medicine 2020, 382: 2569-2572. PMID: 32579819, DOI: 10.1056/nejmclde2004317.
Validation of an algorithm of time-dependent electro-clinical risk stratification for electrographic seizures (TERSE) in critically ill patientsCissé FA, Osman GM, Legros B, Depondt C, Hirsch LJ, Struck AF, Gaspard N. Validation of an algorithm of time-dependent electro-clinical risk stratification for electrographic seizures (TERSE) in critically ill patients. Clinical Neurophysiology 2020, 131: 1956-1961. PMID: 32622337, DOI: 10.1016/j.clinph.2020.05.031.
Assessment of the Predictive Value of Outpatient Smartphone Videos for Diagnosis of Epileptic SeizuresTatum WO, Hirsch LJ, Gelfand MA, Acton EK, LaFrance WC, Duckrow RB, Chen DK, Blum AS, Hixson JD, Drazkowski JF, Benbadis SR, Cascino GD. Assessment of the Predictive Value of Outpatient Smartphone Videos for Diagnosis of Epileptic Seizures. JAMA Neurology 2020, 77: 593-600. PMID: 31961382, PMCID: PMC6990754, DOI: 10.1001/jamaneurol.2019.4785.
Deep Versus Lobar Intraparenchymal Hemorrhage: Seizures, Hyperexcitable Patterns, and Clinical Outcomes.Sheikh ZB, Stretz C, Maciel CB, Dhakar MB, Orgass H, Petroff OA, Hirsch LJ, Gilmore EJ. Deep Versus Lobar Intraparenchymal Hemorrhage: Seizures, Hyperexcitable Patterns, and Clinical Outcomes. Critical Care Medicine 2020, 48: e505-e513. PMID: 32301843, DOI: 10.1097/ccm.0000000000004317.
Neuropsychiatric Aspects of EpilepsyTolchin B, Hirsch LJ, LaFrance WC. Neuropsychiatric Aspects of Epilepsy. Psychiatric Clinics Of North America 2020, 43: 275-290. PMID: 32439022, DOI: 10.1016/j.psc.2020.02.002.
Assessment of the Validity of the 2HELPS2B Score for Inpatient Seizure Risk PredictionStruck AF, Tabaeizadeh M, Schmitt SE, Ruiz AR, Swisher CB, Subramaniam T, Hernandez C, Kaleem S, Haider HA, Cissé AF, Dhakar MB, Hirsch LJ, Rosenthal ES, Zafar SF, Gaspard N, Westover MB. Assessment of the Validity of the 2HELPS2B Score for Inpatient Seizure Risk Prediction. JAMA Neurology 2020, 77: 500-507. PMID: 31930362, PMCID: PMC6990873, DOI: 10.1001/jamaneurol.2019.4656.
Author response: New onset refractory status epilepticus research: What is on the horizon?Gofton TE, Hirsch LJ. Author response: New onset refractory status epilepticus research: What is on the horizon? Neurology 2020, 94: 596. PMID: 32229639, DOI: 10.1212/wnl.0000000000009187.
Validation of the 2HELPS2B Seizure Risk Score in Acute Brain Injury PatientsMoffet EW, Subramaniam T, Hirsch LJ, Gilmore EJ, Lee JW, Rodriguez-Ruiz AA, Haider HA, Dhakar MB, Jadeja N, Osman G, Gaspard N, Struck AF. Validation of the 2HELPS2B Seizure Risk Score in Acute Brain Injury Patients. Neurocritical Care 2020, 33: 701-707. PMID: 32107733, DOI: 10.1007/s12028-020-00939-x.
Mesial temporal resection following long‐term ambulatory intracranial EEG monitoring with a direct brain‐responsive neurostimulation systemHirsch LJ, Mirro EA, Salanova V, Witt TC, Drees CN, Brown M, Lee RW, Sadler TL, Felton EA, Rutecki P, Shin HW, Hadar E, Hegde M, Rao VR, Mnatsakanyan L, Madhavan DS, Zakaria TJ, Liu AA, Heck CN, Greenwood JE, Bigelow JK, Nair DR, Alexopoulos AV, Mackow M, Edwards JC, Sotudeh N, Kuzniecky RI, Gwinn RP, Doherty MJ, Geller EB, Morrell MJ. Mesial temporal resection following long‐term ambulatory intracranial EEG monitoring with a direct brain‐responsive neurostimulation system. Epilepsia 2020, 61: 408-420. PMID: 32072621, PMCID: PMC7154711, DOI: 10.1111/epi.16442.
Diagnostic Value of Electroencephalography with Ten Electrodes in Critically Ill PatientsWestover MB, Gururangan K, Markert MS, Blond BN, Lai S, Benard S, Bickel S, Hirsch LJ, Parvizi J. Diagnostic Value of Electroencephalography with Ten Electrodes in Critically Ill Patients. Neurocritical Care 2020, 33: 479-490. PMID: 32034656, PMCID: PMC7416437, DOI: 10.1007/s12028-019-00911-4.
Early detection rate changes from a brain‐responsive neurostimulation system predict efficacy of newly added antiseizure drugsQuraishi IH, Mercier MR, Skarpaas TL, Hirsch LJ. Early detection rate changes from a brain‐responsive neurostimulation system predict efficacy of newly added antiseizure drugs. Epilepsia 2019, 61: 138-148. PMID: 31849045, PMCID: PMC7003822, DOI: 10.1111/epi.16412.
Continuous EEG Findings in Autoimmune Encephalitis.Moise AM, Karakis I, Herlopian A, Dhakar M, Hirsch LJ, Cotsonis G, LaRoche S, Cabrera Kang CM, Westover B, Rodriguez A. Continuous EEG Findings in Autoimmune Encephalitis. Journal Of Clinical Neurophysiology 2019, 38: 124-129. PMID: 31800465, PMCID: PMC7263965, DOI: 10.1097/wnp.0000000000000654.
Author response: Adherence with psychotherapy and treatment outcomes for psychogenic nonepileptic seizures.Tolchin B, Dworetzky BA, Martino S, Blumenfeld H, Hirsch LJ, Baslet G. Author response: Adherence with psychotherapy and treatment outcomes for psychogenic nonepileptic seizures. Neurology 2019, 93: 981. PMID: 31767663, DOI: 10.1212/wnl.0000000000008560.
Quantitative Electroencephalogram Trends Predict Recovery in Hypoxic-Ischemic Encephalopathy.Ghassemi MM, Amorim E, Alhanai T, Lee JW, Herman ST, Sivaraju A, Gaspard N, Hirsch LJ, Scirica BM, Biswal S, Moura Junior V, Cash SS, Brown EN, Mark RG, Westover MB. Quantitative Electroencephalogram Trends Predict Recovery in Hypoxic-Ischemic Encephalopathy. Critical Care Medicine 2019, 47: 1416-1423. PMID: 31241498, PMCID: PMC6746597, DOI: 10.1097/ccm.0000000000003840.
Pathophysiology of Psychogenic Nonepileptic Attacks—ReplyTolchin B, Martino S, Hirsch LJ. Pathophysiology of Psychogenic Nonepileptic Attacks—Reply. JAMA 2019, 322: 1315-1316. PMID: 31573635, DOI: 10.1001/jama.2019.11509.
The connectivity index: an effective metric for grading epileptogenicity.Yan Q, Gaspard N, Zaveri HP, Blumenfeld H, Hirsch LJ, Spencer DD, Alkawadri R. The connectivity index: an effective metric for grading epileptogenicity. Journal Of Neurosurgery 2019, 133: 1-8. PMID: 31561212, DOI: 10.3171/2019.4.jns195.
Motivational Interviewing Techniques to Improve Psychotherapy Adherence and Outcomes for Patients With Psychogenic Nonepileptic SeizuresTolchin B, Baslet G, Martino S, Suzuki J, Blumenfeld H, Hirsch LJ, Altalib H, Dworetzky BA. Motivational Interviewing Techniques to Improve Psychotherapy Adherence and Outcomes for Patients With Psychogenic Nonepileptic Seizures. Journal Of Neuropsychiatry 2019, 32: 125-131. PMID: 31466516, DOI: 10.1176/appi.neuropsych.19020045.
Nonconvulsive seizures and nonconvulsive status epilepticus in the neuro ICU should or should not be treated aggressively: A debateRossetti AO, Hirsch LJ, Drislane FW. Nonconvulsive seizures and nonconvulsive status epilepticus in the neuro ICU should or should not be treated aggressively: A debate. Clinical Neurophysiology Practice 2019, 4: 170-177. PMID: 31886441, PMCID: PMC6921236, DOI: 10.1016/j.cnp.2019.07.001.
Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unitOwusu KA, Dhakar MB, Bautista C, McKimmy D, Cotugno S, Sukumar N, Deng Y, Farooque P, Hirsch LJ, Maciel CB. Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unit. Epilepsy & Behavior 2019, 98: 161-167. PMID: 31374472, DOI: 10.1016/j.yebeh.2019.07.021.
Contralateral ictal ptosis: Is it a reliable lateralizing sign in epilepsy?Sheikh Z, Blumenfeld H, Hirsch LJ. Contralateral ictal ptosis: Is it a reliable lateralizing sign in epilepsy? Neurology Clinical Practice 2019, 9: 513-515. PMID: 32042495, PMCID: PMC6927437, DOI: 10.1212/cpj.0000000000000690.
Comparison of machine learning models for seizure prediction in hospitalized patientsStruck AF, Rodriguez‐Ruiz A, Osman G, Gilmore EJ, Haider HA, Dhakar MB, Schrettner M, Lee JW, Gaspard N, Hirsch LJ, Westover MB, Consortium C. Comparison of machine learning models for seizure prediction in hospitalized patients. Annals Of Clinical And Translational Neurology 2019, 6: 1239-1247. PMID: 31353866, PMCID: PMC6649418, DOI: 10.1002/acn3.50817.
Treatment of Patients With Psychogenic Nonepileptic AttacksTolchin B, Martino S, Hirsch LJ. Treatment of Patients With Psychogenic Nonepileptic Attacks. JAMA 2019, 321: 1967-1968. PMID: 31026015, DOI: 10.1001/jama.2019.3520.
Effectiveness of Levetiracetam Monotherapy in Pediatric Patients With EpilepsyMazur RD, Wang B, Kato B, Buchsbaum B, Bonito B, Choi H, Hirsch L, Detyniecki K. Effectiveness of Levetiracetam Monotherapy in Pediatric Patients With Epilepsy. Journal Of Child Neurology 2019, 34: 593-597. PMID: 31113283, DOI: 10.1177/0883073819846804.
Treatment of drug-resistant epilepsy in patients with periventricular nodular heterotopia using RNS® System: Efficacy and description of chronic electrophysiological recordingsNune G, Arcot Desai S, Razavi B, Agostini MA, Bergey GK, Herekar AA, Hirsch LJ, Lee RW, Rutecki PA, Srinivasan S, Van Ness PC, Tcheng TK, Morrell MJ. Treatment of drug-resistant epilepsy in patients with periventricular nodular heterotopia using RNS® System: Efficacy and description of chronic electrophysiological recordings. Clinical Neurophysiology 2019, 130: 1196-1207. PMID: 31163364, DOI: 10.1016/j.clinph.2019.04.706.
Highlights From the Annual Meeting of the American Epilepsy Society 2018Jobst BC, Ben-Menachem E, Chapman KE, Fu A, Goldman A, Hirsch LJ, Jehi LE, Kossoff EH, Plueger M, Rho JM, Schevon CA, Shinnar S, Sperling MR, Simeone TA, Wagner JL, Lado F. Highlights From the Annual Meeting of the American Epilepsy Society 2018. Epilepsy Currents 2019, 19: 152-158. PMID: 31050308, PMCID: PMC6610384, DOI: 10.1177/1535759719844486.
How long would it take to try all the antiepileptic drugs available?Montenegro MA, Novais A, Hirsch LJ. How long would it take to try all the antiepileptic drugs available? Epilepsy Research 2019, 154: 77-78. PMID: 31096069, DOI: 10.1016/j.eplepsyres.2019.04.012.
Randomized controlled trial of motivational interviewing for psychogenic nonepileptic seizuresTolchin B, Baslet G, Suzuki J, Martino S, Blumenfeld H, Hirsch LJ, Altalib H, Dworetzky BA. Randomized controlled trial of motivational interviewing for psychogenic nonepileptic seizures. Epilepsia 2019, 60: 986-995. PMID: 30980679, DOI: 10.1111/epi.14728.
Communication Challenges: A Spotlight on New-Onset Refractory Status EpilepticusGofton TE, Wong N, Hirsch LJ, Hocker SE. Communication Challenges: A Spotlight on New-Onset Refractory Status Epilepticus. Mayo Clinic Proceedings 2019, 94: 857-863. PMID: 30935709, DOI: 10.1016/j.mayocp.2018.12.004.
New onset refractory status epilepticus research: What is on the horizon?Gofton TE, Gaspard N, Hocker SE, Loddenkemper T, Hirsch LJ. New onset refractory status epilepticus research: What is on the horizon? Neurology 2019, 92: 802-810. PMID: 30894443, DOI: 10.1212/wnl.0000000000007322.
Generalized Periodic Discharges With and Without Triphasic MorphologyFong MWK, Gaspard N, Hirsch LJ. Generalized Periodic Discharges With and Without Triphasic Morphology. Journal Of Clinical Neurophysiology 2019, 36: 173-174. PMID: 30550491, DOI: 10.1097/wnp.0000000000000549.
Adherence with psychotherapy and treatment outcomes for psychogenic nonepileptic seizures.Tolchin B, Dworetzky BA, Martino S, Blumenfeld H, Hirsch LJ, Baslet G. Adherence with psychotherapy and treatment outcomes for psychogenic nonepileptic seizures. Neurology 2019, 92: e675-e679. PMID: 30610097, PMCID: PMC6382361, DOI: 10.1212/wnl.0000000000006848.
EEG Reactivity Evaluation Practices for Adult and Pediatric Hypoxic-Ischemic Coma Prognostication in North AmericaAmorim E, Gilmore EJ, Abend NS, Hahn CD, Gaspard N, Herman ST, Hirsch LJ, Lee JW, Cash SS, Westover MB. EEG Reactivity Evaluation Practices for Adult and Pediatric Hypoxic-Ischemic Coma Prognostication in North America. Journal Of Clinical Neurophysiology 2018, 35: 510-514. PMID: 30216207, PMCID: PMC6424574, DOI: 10.1097/wnp.0000000000000517.
Prevalence and predictors of seizure clusters: A prospective observational study of adult patients with epilepsyDetyniecki K, O'Bryan J, Choezom T, Rak G, Ma C, Zhang S, Bonito J, Hirsch LJ. Prevalence and predictors of seizure clusters: A prospective observational study of adult patients with epilepsy. Epilepsy & Behavior 2018, 88: 349-356. PMID: 30344026, DOI: 10.1016/j.yebeh.2018.09.035.
Cross-sensitivity of psychiatric and behavioral side effects with antiepileptic drug useChen B, Choi H, Hirsch LJ, Legge A, Buchsbaum R, Detyniecki K. Cross-sensitivity of psychiatric and behavioral side effects with antiepileptic drug use. Seizure 2018, 62: 38-42. PMID: 30273800, DOI: 10.1016/j.seizure.2018.09.014.
Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogramJoshi RB, Duckrow RB, Goncharova II, Gerrard JL, Spencer DD, Hirsch LJ, Godwin DW, Zaveri HP. Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogram. Epilepsia 2018, 59: 2075-2085. PMID: 30187919, DOI: 10.1111/epi.14559.
Bilateral independent periodic discharges are associated with electrographic seizures and poor outcome: A case-control studyOsman G, Rahangdale R, Britton JW, Gilmore EJ, Haider HA, Hantus S, Herlopian A, Hocker SE, Woo Lee J, Legros B, Mendoza M, Punia V, Rampal N, Szaflarski JP, Wallace AD, Westover MB, Hirsch LJ, Gaspard N. Bilateral independent periodic discharges are associated with electrographic seizures and poor outcome: A case-control study. Clinical Neurophysiology 2018, 129: 2284-2289. PMID: 30227348, PMCID: PMC6785981, DOI: 10.1016/j.clinph.2018.07.025.
Association between death and loss of stage N2 sleep features among critically Ill patients with deliriumKnauert MP, Gilmore EJ, Murphy TE, Yaggi HK, Van Ness PH, Han L, Hirsch LJ, Pisani MA. Association between death and loss of stage N2 sleep features among critically Ill patients with delirium. Journal Of Critical Care 2018, 48: 124-129. PMID: 30179762, PMCID: PMC6226351, DOI: 10.1016/j.jcrc.2018.08.028.
Seizures, periodic and rhythmic patterns in primary intraventricular hemorrhageStretz C, Sheikh Z, Maciel CB, Hirsch LJ, Gilmore EJ. Seizures, periodic and rhythmic patterns in primary intraventricular hemorrhage. Annals Of Clinical And Translational Neurology 2018, 5: 1104-1111. PMID: 30250866, PMCID: PMC6144442, DOI: 10.1002/acn3.627.
The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocolVespa PM, Shrestha V, Abend N, Agoston D, Au A, Bell MJ, Bleck TP, Blanco MB, Claassen J, Diaz-Arrastia R, Duncan D, Ellingson B, Foreman B, Gilmore EJ, Hirsch L, Hunn M, Kamnaksh A, McArthur D, Morokoff A, O'Brien T, O'Phelan K, Robertson CL, Rosenthal E, Staba R, Toga A, Willyerd FA, Zimmermann L, Yam E, Martinez S, Real C, Engel J. The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol. Neurobiology Of Disease 2018, 123: 110-114. PMID: 30048805, PMCID: PMC6344322, DOI: 10.1016/j.nbd.2018.07.025.
Presurgical language fMRI: Technical practices in epilepsy surgical planningBenjamin CFA, Dhingra I, Li AX, Blumenfeld H, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen RA, Warfield SK, Peters JM, Reutens D, Połczyńska MM, Hirsch LJ, Spencer DD. Presurgical language fMRI: Technical practices in epilepsy surgical planning. Human Brain Mapping 2018, 39: 4032-4042. PMID: 29962111, PMCID: PMC6175127, DOI: 10.1002/hbm.24229.
Fast, Very Fast, Ultrafast, and Even Faster: How High Frequency Should We be Recording on Intracranial EEG?Alkawadri R, Hirsch LJ. Fast, Very Fast, Ultrafast, and Even Faster: How High Frequency Should We be Recording on Intracranial EEG? Epilepsy Currents 2018, 18: 217-219. PMID: 30254511, PMCID: PMC6145394, DOI: 10.5698/1535-7597.18.4.217.
Electro-clinical characteristics and prognostic significance of post anoxic myoclonusDhakar MB, Sivaraju A, Maciel CB, Youn TS, Gaspard N, Greer DM, Hirsch LJ, Gilmore EJ. Electro-clinical characteristics and prognostic significance of post anoxic myoclonus. Resuscitation 2018, 131: 114-120. PMID: 29964146, DOI: 10.1016/j.resuscitation.2018.06.030.
Clinical Correlates of Periodic Discharges and Nonconvulsive Seizures in Posterior Reversible Encephalopathy Syndrome (PRES)Bastide L, Legros B, Rampal N, Gilmore EJ, Hirsch LJ, Gaspard N. Clinical Correlates of Periodic Discharges and Nonconvulsive Seizures in Posterior Reversible Encephalopathy Syndrome (PRES). Neurocritical Care 2018, 29: 481-490. PMID: 29949000, DOI: 10.1007/s12028-018-0548-2.
Randomized trial of lacosamide versus fosphenytoin for nonconvulsive seizuresHusain AM, Lee JW, Kolls BJ, Hirsch LJ, Halford JJ, Gupta PK, Minazad Y, Jones JM, LaRoche SM, Herman ST, Swisher CB, Sinha SR, Palade A, Dombrowski KE, Gallentine WB, Hahn CD, Gerard EE, Bhapkar M, Lokhnygina Y, Westover MB, Consortium F. Randomized trial of lacosamide versus fosphenytoin for nonconvulsive seizures. Annals Of Neurology 2018, 83: 1174-1185. PMID: 29733464, PMCID: PMC6785201, DOI: 10.1002/ana.25249.
Seizure cluster: Definition, prevalence, consequences, and managementJafarpour S, Hirsch LJ, Gaínza-Lein M, Kellinghaus C, Detyniecki K. Seizure cluster: Definition, prevalence, consequences, and management. Seizure 2018, 68: 9-15. PMID: 29871784, DOI: 10.1016/j.seizure.2018.05.013.
Changing Cardiopulmonary Resuscitation to Cardiocerebral ResuscitationMaciel CB, Hirsch LJ. Changing Cardiopulmonary Resuscitation to Cardiocerebral Resuscitation. Critical Care Medicine 2018, 46: 823-825. PMID: 29652712, DOI: 10.1097/ccm.0000000000003046.
Definition and Classification of Periodic and Rhythmic PatternsMaciel CB, Hirsch LJ. Definition and Classification of Periodic and Rhythmic Patterns. Journal Of Clinical Neurophysiology 2018, 35: 179-188. PMID: 29718827, DOI: 10.1097/wnp.0000000000000462.
Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planningBenjamin CFA, Li AX, Blumenfeld H, Constable RT, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen R, Warfield SK, Peters JM, Reutens D, Połczyńska M, Spencer DD, Hirsch LJ. Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning. Human Brain Mapping 2018, 39: 2777-2785. PMID: 29528160, PMCID: PMC6033659, DOI: 10.1002/hbm.24039.
Comparative efficacy of unique antiepileptic drug regimens in focal epilepsy: An exploratory studyLegge AW, Detyniecki K, Javed A, Hirsch LJ, Kato K, Buchsbaum R, Chen B, Choi H. Comparative efficacy of unique antiepileptic drug regimens in focal epilepsy: An exploratory study. Epilepsy Research 2018, 142: 73-80. PMID: 29571152, DOI: 10.1016/j.eplepsyres.2018.03.011.
New‐onset refractory status epilepticus (NORSE) and febrile infection–related epilepsy syndrome (FIRES): State of the art and perspectivesGaspard N, Hirsch LJ, Sculier C, Loddenkemper T, Baalen A, Lancrenon J, Emmery M, Specchio N, Farias‐Moeller R, Wong N, Nabbout R. New‐onset refractory status epilepticus (NORSE) and febrile infection–related epilepsy syndrome (FIRES): State of the art and perspectives. Epilepsia 2018, 59: 745-752. PMID: 29476535, DOI: 10.1111/epi.14022.
Proposed consensus definitions for new‐onset refractory status epilepticus (NORSE), febrile infection‐related epilepsy syndrome (FIRES), and related conditionsHirsch LJ, Gaspard N, Baalen A, Nabbout R, Demeret S, Loddenkemper T, Navarro V, Specchio N, Lagae L, Rossetti AO, Hocker S, Gofton TE, Abend NS, Gilmore EJ, Hahn C, Khosravani H, Rosenow F, Trinka E. Proposed consensus definitions for new‐onset refractory status epilepticus (NORSE), febrile infection‐related epilepsy syndrome (FIRES), and related conditions. Epilepsia 2018, 59: 739-744. PMID: 29399791, DOI: 10.1111/epi.14016.
The importance of early immunotherapy in patients with faciobrachial dystonic seizuresThompson J, Bi M, Murchison AG, Makuch M, Bien CG, Chu K, Farooque P, Gelfand JM, Geschwind MD, Hirsch LJ, Somerville E, Lang B, Vincent A, Leite MI, Waters P, Irani SR, Dogan-Onugoren M, Rae-Grant A, Illes Z, Szots M, Malter M, Widman G, Surges R, Archibald N, Reid J, Duncan C, Richardson A, Lilleker J, Iorio R, Blaabjerg M, Abeler K, Shin Y. The importance of early immunotherapy in patients with faciobrachial dystonic seizures. Brain 2017, 141: 348-356. PMID: 29272336, PMCID: PMC5837230, DOI: 10.1093/brain/awx323.
Commonalities in epileptogenic processes from different acute brain insults: Do they translate?Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks‐Kayal A, Engel J, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D, Sillanpää M, Sloviter RS, Steinhäuser C, Vezzani A, Walker MC, Löscher W. Commonalities in epileptogenic processes from different acute brain insults: Do they translate? Epilepsia 2017, 59: 37-66. PMID: 29247482, PMCID: PMC5993212, DOI: 10.1111/epi.13965.
Association of an Electroencephalography-Based Risk Score With Seizure Probability in Hospitalized PatientsStruck AF, Ustun B, Ruiz AR, Lee JW, LaRoche SM, Hirsch LJ, Gilmore EJ, Vlachy J, Haider HA, Rudin C, Westover MB. Association of an Electroencephalography-Based Risk Score With Seizure Probability in Hospitalized Patients. JAMA Neurology 2017, 74: 1419-1424. PMID: 29052706, PMCID: PMC5822188, DOI: 10.1001/jamaneurol.2017.2459.
A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious PerceptionHerman WX, Smith RE, Kronemer SI, Watsky RE, Chen WC, Gober LM, Touloumes GJ, Khosla M, Raja A, Horien CL, Morse EC, Botta KL, Hirsch LJ, Alkawadri R, Gerrard JL, Spencer DD, Blumenfeld H. A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception. Cerebral Cortex 2017, 29: 461-474. PMID: 29194517, PMCID: PMC6319177, DOI: 10.1093/cercor/bhx327.
Psychiatric and behavioral side effects of antiepileptic drugs in adults with epilepsyChen B, Choi H, Hirsch LJ, Katz A, Legge A, Buchsbaum R, Detyniecki K. Psychiatric and behavioral side effects of antiepileptic drugs in adults with epilepsy. Epilepsy & Behavior 2017, 76: 24-31. PMID: 28931473, DOI: 10.1016/j.yebeh.2017.08.039.
Disruption of Brain–Heart Coupling in SepsisAdmiraal MM, Gilmore EJ, Van Putten MJAM, Zaveri HP, Hirsch LJ, Gaspard N. Disruption of Brain–Heart Coupling in Sepsis. Journal Of Clinical Neurophysiology 2017, 34: 413-420. PMID: 28520632, DOI: 10.1097/wnp.0000000000000381.
Standardized computer-based organized reporting of EEG: SCORE – Second versionBeniczky S, Aurlien H, Brøgger JC, Hirsch LJ, Schomer DL, Trinka E, Pressler RM, Wennberg R, Visser GH, Eisermann M, Diehl B, Lesser RP, Kaplan PW, Nguyen The Tich S, Lee JW, Martins-da-Silva A, Stefan H, Neufeld M, Rubboli G, Fabricius M, Gardella E, Terney D, Meritam P, Eichele T, Asano E, Cox F, van Emde Boas W, Mameniskiene R, Marusic P, Zárubová J, Schmitt FC, Rosén I, Fuglsang-Frederiksen A, Ikeda A, MacDonald DB, Terada K, Ugawa Y, Zhou D, Herman ST. Standardized computer-based organized reporting of EEG: SCORE – Second version. Clinical Neurophysiology 2017, 128: 2334-2346. PMID: 28838815, DOI: 10.1016/j.clinph.2017.07.418.
Time‐dependent risk of seizures in critically ill patients on continuous electroencephalogramStruck AF, Osman G, Rampal N, Biswal S, Legros B, Hirsch LJ, Westover MB, Gaspard N. Time‐dependent risk of seizures in critically ill patients on continuous electroencephalogram. Annals Of Neurology 2017, 82: 177-185. PMID: 28681492, PMCID: PMC5842678, DOI: 10.1002/ana.24985.
The new ILAE seizure classification: 63 seizure types?Beniczky S, Rubboli G, Aurlien H, Hirsch LJ, Trinka E, Schomer DL, consortium T. The new ILAE seizure classification: 63 seizure types? Epilepsia 2017, 58: 1298-1300. PMID: 28677857, DOI: 10.1111/epi.13799.
Presurgical language fMRI: Mapping of six critical regionsBenjamin CF, Walshaw PD, Hale K, Gaillard WD, Baxter LC, Berl MM, Polczynska M, Noble S, Alkawadri R, Hirsch LJ, Constable RT, Bookheimer SY. Presurgical language fMRI: Mapping of six critical regions. Human Brain Mapping 2017, 38: 4239-4255. PMID: 28544168, PMCID: PMC5518223, DOI: 10.1002/hbm.23661.
Brief Potentially Ictal Rhythmic Discharges [B(I)RDs] in Noncritically Ill AdultsYoo JY, Marcuse LV, Fields MC, Rosengard JL, Traversa MV, Gaspard N, Hirsch LJ. Brief Potentially Ictal Rhythmic Discharges [B(I)RDs] in Noncritically Ill Adults. Journal Of Clinical Neurophysiology 2017, 34: 222-229. PMID: 28463933, DOI: 10.1097/wnp.0000000000000357.
Prevalence and risk factors of seizure clusters in adult patients with epilepsyChen B, Choi H, Hirsch LJ, Katz A, Legge A, Wong RA, Jiang A, Kato K, Buchsbaum R, Detyniecki K. Prevalence and risk factors of seizure clusters in adult patients with epilepsy. Epilepsy Research 2017, 133: 98-102. PMID: 28475999, DOI: 10.1016/j.eplepsyres.2017.04.016.
Brain‐responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsyGeller EB, Skarpaas TL, Gross RE, Goodman RR, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Cash SS, Cole AJ, Duckrow RB, Edwards JC, Eisenschenk S, Fessler J, Fountain NB, Goldman AM, Gwinn RP, Heck C, Herekar A, Hirsch LJ, Jobst BC, King‐Stephens D, Labar DR, Leiphart JW, Marsh WR, Meador KJ, Mizrahi EM, Murro AM, Nair DR, Noe KH, Park YD, Rutecki PA, Salanova V, Sheth RD, Shields DC, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness PC, Vossler DG, Wharen RE, Worrell GA, Yoshor D, Zimmerman RS, Cicora K, Sun FT, Morrell MJ. Brain‐responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy. Epilepsia 2017, 58: 994-1004. PMID: 28398014, DOI: 10.1111/epi.13740.
Brain‐responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areasJobst BC, Kapur R, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Boggs JG, Cash SS, Cole AJ, Duchowny MS, Duckrow RB, Edwards JC, Eisenschenk S, Fessler AJ, Fountain NB, Geller EB, Goldman AM, Goodman RR, Gross RE, Gwinn RP, Heck C, Herekar AA, Hirsch LJ, King‐Stephens D, Labar DR, Marsh WR, Meador KJ, Miller I, Mizrahi EM, Murro AM, Nair DR, Noe KH, Olejniczak PW, Park YD, Rutecki P, Salanova V, Sheth RD, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness P, Vossler DG, Wharen RE, Worrell GA, Yoshor D, Zimmerman RS, Skarpaas TL, Morrell MJ. Brain‐responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas. Epilepsia 2017, 58: 1005-1014. PMID: 28387951, DOI: 10.1111/epi.13739.
Accurate Neuroprognostication in Cardiac Arrest Survivors: Details Matter!Maciel CB, Hirsch LJ, Greer DM, Alkawadri R. Accurate Neuroprognostication in Cardiac Arrest Survivors: Details Matter! Resuscitation 2017, 115: e3-e4. PMID: 28363821, DOI: 10.1016/j.resuscitation.2017.03.030.
Surgical outcome in adolescents with mesial temporal sclerosis: Is it different?Farooque P, Hirsch L, Levy S, Testa F, Mattson R, Spencer D. Surgical outcome in adolescents with mesial temporal sclerosis: Is it different? Epilepsy & Behavior 2017, 69: 24-27. PMID: 28235653, DOI: 10.1016/j.yebeh.2016.10.028.
Association of Periodic and Rhythmic Electroencephalographic Patterns With Seizures in Critically Ill PatientsRuiz A, Vlachy J, Lee JW, Gilmore EJ, Ayer T, Haider HA, Gaspard N, Ehrenberg JA, Tolchin B, Fantaneanu TA, Fernandez A, Hirsch LJ, LaRoche S. Association of Periodic and Rhythmic Electroencephalographic Patterns With Seizures in Critically Ill Patients. JAMA Neurology 2017, 74: 181-188. PMID: 27992625, DOI: 10.1001/jamaneurol.2016.4990.
Cyclic seizures in critically ill patients: Clinical correlates, DC recordings and outcomesPinto LF, Gilmore EJ, Petroff OA, Sivaraju A, Rampal N, Hirsch LJ, Gaspard N. Cyclic seizures in critically ill patients: Clinical correlates, DC recordings and outcomes. Clinical Neurophysiology 2017, 128: 1083-1090. PMID: 28214108, DOI: 10.1016/j.clinph.2017.01.015.
The use and yield of continuous EEG in critically ill patients: A comparative study of three centersAlvarez V, Ruiz A, LaRoche S, Hirsch LJ, Parres C, Voinescu PE, Fernandez A, Petroff OA, Rampal N, Haider HA, Lee JW, Consortium T. The use and yield of continuous EEG in critically ill patients: A comparative study of three centers. Clinical Neurophysiology 2017, 128: 570-578. PMID: 28231475, DOI: 10.1016/j.clinph.2017.01.001.
Brief Potentially Ictal Rhythmic Discharges [B(I)RDs] in Non-critically Ill Adults.Yoo JY, Marcuse LV, Fields MC, Rosengard J, Traversa MV, Gaspard N, Hirsch LJ. Brief Potentially Ictal Rhythmic Discharges [B(I)RDs] in Non-critically Ill Adults. Journal Of Clinical Neurophysiology : Official Publication Of The American Electroencephalographic Society 2016 PMID: 27763963, DOI: 10.1097/WNP.0000000000000357.
Regional and network relationship in the intracranial EEG second spectrumJoshi RB, Gaspard N, Goncharova II, Duckrow RB, Duncan D, Gerrard JL, Spencer DD, Hirsch LJ, Zaveri HP. Regional and network relationship in the intracranial EEG second spectrum. Clinical Neurophysiology 2016, 127: 3485-3491. PMID: 27692590, DOI: 10.1016/j.clinph.2016.09.003.
Review of the Utility of Prophylactic Anticonvulsant Use in Critically Ill Patients With Intracerebral HemorrhageGilmore EJ, Maciel CB, Hirsch LJ, Sheth KN. Review of the Utility of Prophylactic Anticonvulsant Use in Critically Ill Patients With Intracerebral Hemorrhage. Stroke 2016, 47: 2666-2672. PMID: 27608820, DOI: 10.1161/strokeaha.116.012410.
In response: Drug‐resistant epilepsy in adults: outcome trajectories after failure of two medicationsChoi H, Hayat MJ, Zhang R, Hirsch LJ, Bazil C, Mendiratta A, Kato K, Javed A, Legge AW, Buchsbaum R, Resor S, Heiman G. In response: Drug‐resistant epilepsy in adults: outcome trajectories after failure of two medications. Epilepsia 2016, 57: 1526-1527. PMID: 27594402, DOI: 10.1111/epi.13487.
Sensitivity of quantitative EEG for seizure identification in the intensive care unitHaider HA, Esteller R, Hahn CD, Westover MB, Halford JJ, Lee JW, Shafi MM, Gaspard N, Herman ST, Gerard EE, Hirsch LJ, Ehrenberg JA, LaRoche SM. Sensitivity of quantitative EEG for seizure identification in the intensive care unit. Neurology 2016, 87: 935-944. PMID: 27466474, PMCID: PMC5035158, DOI: 10.1212/wnl.0000000000003034.
Drug‐resistant epilepsy in adults: Outcome trajectories after failure of two medicationsChoi H, Hayat MJ, Zhang R, Hirsch LJ, Bazil CW, Mendiratta A, Kato K, Javed A, Legge AW, Buchsbaum R, Resor S, Heiman GA. Drug‐resistant epilepsy in adults: Outcome trajectories after failure of two medications. Epilepsia 2016, 57: 1152-1160. PMID: 27265407, DOI: 10.1111/epi.13406.
The relationship between seizures, interictal spikes and antiepileptic drugsGoncharova II, Alkawadri R, Gaspard N, Duckrow RB, Spencer DD, Hirsch LJ, Spencer SS, Zaveri HP. The relationship between seizures, interictal spikes and antiepileptic drugs. Clinical Neurophysiology 2016, 127: 3180-3186. PMID: 27292227, DOI: 10.1016/j.clinph.2016.05.014.
Seizure clusters: A common, understudied and undertreated phenomenon in refractory epilepsyKomaragiri A, Detyniecki K, Hirsch LJ. Seizure clusters: A common, understudied and undertreated phenomenon in refractory epilepsy. Epilepsy & Behavior 2016, 59: 83-86. PMID: 27116535, DOI: 10.1016/j.yebeh.2016.02.030.
Development and Feasibility Testing of a Critical Care EEG Monitoring Database for Standardized Clinical Reporting and Multicenter Collaborative ResearchLee JW, LaRoche S, Choi H, Ruiz A, Fertig E, Politsky JM, Herman ST, Loddenkemper T, Sansevere AJ, Korb PJ, Abend NS, Goldstein JL, Sinha SR, Dombrowski KE, Ritzl EK, Westover MB, Gavvala JR, Gerard EE, Schmitt SE, Szaflarski JP, Ding K, Haas KF, Buchsbaum R, Hirsch LJ, Wusthoff CJ, Hopp JL, Hahn CD. Development and Feasibility Testing of a Critical Care EEG Monitoring Database for Standardized Clinical Reporting and Multicenter Collaborative Research. Journal Of Clinical Neurophysiology 2016, 33: 133-140. PMID: 26943901, PMCID: PMC4878836, DOI: 10.1097/wnp.0000000000000230.
Assessment of Treatment Side Effects and Quality of Life in People with EpilepsyBlond BN, Detyniecki K, Hirsch LJ. Assessment of Treatment Side Effects and Quality of Life in People with Epilepsy. Neurologic Clinics 2016, 34: 395-410. PMID: 27086986, DOI: 10.1016/j.ncl.2015.11.002.
Progressive change in sleep over multiple nights of intracranial EEG monitoringJoshi RB, Gaspard N, Goncharova II, Pavlova M, Duckrow RB, Gerrard JL, Spencer DD, Hirsch LJ, Zaveri HP. Progressive change in sleep over multiple nights of intracranial EEG monitoring. Clinical Neurophysiology 2016, 127: 2302-2307. PMID: 27072103, DOI: 10.1016/j.clinph.2016.02.018.
Treatment of Convulsive Status EpilepticusGrover EH, Nazzal Y, Hirsch LJ. Treatment of Convulsive Status Epilepticus. Current Treatment Options In Neurology 2016, 18: 11. PMID: 26920416, DOI: 10.1007/s11940-016-0394-5.
Cannabidiol for epilepsy: trying to see through the hazeDetyniecki K, Hirsch LJ. Cannabidiol for epilepsy: trying to see through the haze. The Lancet Neurology 2016, 15: 235-237. PMID: 26776916, DOI: 10.1016/s1474-4422(16)00002-8.
Human bedside evaluation versus automatic responsiveness testing in epilepsy (ARTiE)Touloumes G, Morse E, Chen WC, Gober L, Dente J, Lilenbaum R, Katzenstein E, Pacelli A, Johnson E, Si Y, Sivaraju A, Grover E, Khozein R, Cunningham C, Hirsch LJ, Blumenfeld H. Human bedside evaluation versus automatic responsiveness testing in epilepsy (ARTiE). Epilepsia 2015, 57: e28-e32. PMID: 26663137, PMCID: PMC4707993, DOI: 10.1111/epi.13262.
Clinical Correlates and Prognostic Significance of Lateralized Periodic Discharges in Patients Without Acute or Progressive Brain InjurySainju RK, Manganas LN, Gilmore EJ, Petroff OA, Rampal N, Hirsch LJ, Gaspard N. Clinical Correlates and Prognostic Significance of Lateralized Periodic Discharges in Patients Without Acute or Progressive Brain Injury. Journal Of Clinical Neurophysiology 2015, 32: 495-500. PMID: 26200591, DOI: 10.1097/wnp.0000000000000206.
Finding the Lesser of Two Evils: Treating Refractory Status EpilepticusHirsch LJ. Finding the Lesser of Two Evils: Treating Refractory Status Epilepticus. Epilepsy Currents 2015, 15: 313-316. PMID: 26633946, PMCID: PMC4657779, DOI: 10.5698/1535-7511-15.6.313.
The enigma of the latent period in the development of symptomatic acquired epilepsy — Traditional view versus new conceptsLöscher W, Hirsch LJ, Schmidt D. The enigma of the latent period in the development of symptomatic acquired epilepsy — Traditional view versus new concepts. Epilepsy & Behavior 2015, 52: 78-92. PMID: 26409135, DOI: 10.1016/j.yebeh.2015.08.037.
Epileptic auras and their role in driving safety in people with epilepsyPunia V, Farooque P, Chen W, Hirsch LJ, Berg AT, Surgery T, Blumenfeld H. Epileptic auras and their role in driving safety in people with epilepsy. Epilepsia 2015, 56: e182-e185. PMID: 26391317, PMCID: PMC4626266, DOI: 10.1111/epi.13189.
Spatial memory for asymmetrical dot locations predicts lateralization among patients with presurgical mesial temporal lobe epilepsyBrown FC, Hirsch LJ, Spencer DD. Spatial memory for asymmetrical dot locations predicts lateralization among patients with presurgical mesial temporal lobe epilepsy. Epilepsy & Behavior 2015, 52: 19-24. PMID: 26398592, DOI: 10.1016/j.yebeh.2015.08.020.
Marijuana Use in Epilepsy: The Myth and the RealityDetyniecki K, Hirsch L. Marijuana Use in Epilepsy: The Myth and the Reality. Current Neurology And Neuroscience Reports 2015, 15: 65. PMID: 26299273, DOI: 10.1007/s11910-015-0586-5.
New-onset refractory status epilepticusGaspard N, Foreman BP, Alvarez V, Cabrera Kang C, Probasco JC, Jongeling AC, Meyers E, Espinera A, Haas KF, Schmitt SE, Gerard EE, Gofton T, Kaplan PW, Lee JW, Legros B, Szaflarski JP, Westover BM, LaRoche SM, Hirsch LJ. New-onset refractory status epilepticus. Neurology 2015, 85: 1604-1613. PMID: 26296517, PMCID: PMC4642147, DOI: 10.1212/wnl.0000000000001940.
Generalized periodic discharges and ‘triphasic waves’: A blinded evaluation of inter-rater agreement and clinical significanceForeman B, Mahulikar A, Tadi P, Claassen J, Szaflarski J, Halford JJ, Dean BC, Kaplan PW, Hirsch LJ, LaRoche S, Consortium C. Generalized periodic discharges and ‘triphasic waves’: A blinded evaluation of inter-rater agreement and clinical significance. Clinical Neurophysiology 2015, 127: 1073-1080. PMID: 26294138, DOI: 10.1016/j.clinph.2015.07.018.
Quantification of EEG reactivity in comatose patientsHermans MC, Westover MB, van Putten MJ, Hirsch LJ, Gaspard N. Quantification of EEG reactivity in comatose patients. Clinical Neurophysiology 2015, 127: 571-580. PMID: 26183757, PMCID: PMC4885124, DOI: 10.1016/j.clinph.2015.06.024.
Status epilepticus epidemiology—tracking a moving targetGilmore EJ, Hirsch LJ. Status epilepticus epidemiology—tracking a moving target. Nature Reviews Neurology 2015, 11: 377-378. PMID: 26100743, DOI: 10.1038/nrneurol.2015.104.
Delta rhythm in wakefulness: evidence from intracranial recordings in human beingsSachdev RN, Gaspard N, Gerrard JL, Hirsch LJ, Spencer DD, Zaveri HP. Delta rhythm in wakefulness: evidence from intracranial recordings in human beings. Journal Of Neurophysiology 2015, 114: 1248-1254. PMID: 26084904, PMCID: PMC4725112, DOI: 10.1152/jn.00249.2015.
Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticographyKing-Stephens D, Mirro E, Weber PB, Laxer KD, Van Ness PC, Salanova V, Spencer DC, Heck CN, Goldman A, Jobst B, Shields DC, Bergey GK, Eisenschenk S, Worrell GA, Rossi MA, Gross RE, Cole AJ, Sperling MR, Nair DR, Gwinn RP, Park YD, Rutecki PA, Fountain NB, Wharen RE, Hirsch LJ, Miller IO, Barkley GL, Edwards JC, Geller EB, Berg MJ, Sadler TL, Sun FT, Morrell MJ. Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography. Epilepsia 2015, 56: 959-967. PMID: 25988840, PMCID: PMC4676303, DOI: 10.1111/epi.13010.
Prognostication of post-cardiac arrest coma: early clinical and electroencephalographic predictors of outcomeSivaraju A, Gilmore EJ, Wira CR, Stevens A, Rampal N, Moeller JJ, Greer DM, Hirsch LJ, Gaspard N. Prognostication of post-cardiac arrest coma: early clinical and electroencephalographic predictors of outcome. Intensive Care Medicine 2015, 41: 1264-1272. PMID: 25940963, DOI: 10.1007/s00134-015-3834-x.
Cross-sensitivity of patient-perceived adverse cognitive effects with antiepileptic drug useChen B, Detyniecki K, Hirsch LJ, Moeller J, Javed A, Kato K, Legge A, Buchsbaum R, Choi H. Cross-sensitivity of patient-perceived adverse cognitive effects with antiepileptic drug use. Epilepsy & Behavior 2015, 46: 151-157. PMID: 25935515, DOI: 10.1016/j.yebeh.2015.03.020.
Teaching NeuroImagesSainju RK, Moeller JJ, Hirsch LJ. Teaching NeuroImages. Neurology 2015, 84: e115-e116. PMID: 25870457, DOI: 10.1212/wnl.0000000000001463.
Quantitative EEG Is an Objective, Sensitive, and Reliable Indicator of Transient Anesthetic Effects During Wada TestsTu B, Assassi NJ, Bazil CW, Hamberger MJ, Hirsch LJ. Quantitative EEG Is an Objective, Sensitive, and Reliable Indicator of Transient Anesthetic Effects During Wada Tests. Journal Of Clinical Neurophysiology 2015, 32: 152-158. PMID: 25580802, PMCID: PMC4385440, DOI: 10.1097/wnp.0000000000000154.
Consensus Statement on Continuous EEG in Critically Ill Adults and Children, Part IHerman ST, Abend NS, Bleck TP, Chapman KE, Drislane FW, Emerson RG, Gerard EE, Hahn CD, Husain AM, Kaplan PW, LaRoche SM, Nuwer MR, Quigg M, Riviello JJ, Schmitt SE, Simmons LA, Tsuchida TN, Hirsch LJ. Consensus Statement on Continuous EEG in Critically Ill Adults and Children, Part I. Journal Of Clinical Neurophysiology 2015, 32: 87-95. PMID: 25626778, PMCID: PMC4435533, DOI: 10.1097/wnp.0000000000000166.
Consensus Statement on Continuous EEG in Critically Ill Adults and Children, Part IIHerman ST, Abend NS, Bleck TP, Chapman KE, Drislane FW, Emerson RG, Gerard EE, Hahn CD, Husain AM, Kaplan PW, LaRoche SM, Nuwer MR, Quigg M, Riviello JJ, Schmitt SE, Simmons LA, Tsuchida TN, Hirsch LJ. Consensus Statement on Continuous EEG in Critically Ill Adults and Children, Part II. Journal Of Clinical Neurophysiology 2015, 32: 96-108. PMID: 25626777, PMCID: PMC4434600, DOI: 10.1097/wnp.0000000000000165.
Rates and predictors of patient-reported cognitive side effects of antiepileptic drugs: An extended follow-upJaved A, Cohen B, Detyniecki K, Hirsch LJ, Legge A, Chen B, Bazil C, Kato K, Buchsbaum R, Choi H. Rates and predictors of patient-reported cognitive side effects of antiepileptic drugs: An extended follow-up. Seizure 2015, 29: 34-40. PMID: 26076842, DOI: 10.1016/j.seizure.2015.03.013.
Acute brain failure in severe sepsis: a prospective study in the medical intensive care unit utilizing continuous EEG monitoringGilmore EJ, Gaspard N, Choi HA, Cohen E, Burkart KM, Chong DH, Claassen J, Hirsch LJ. Acute brain failure in severe sepsis: a prospective study in the medical intensive care unit utilizing continuous EEG monitoring. Intensive Care Medicine 2015, 41: 686-694. PMID: 25763756, DOI: 10.1007/s00134-015-3709-1.
Long-term treatment with responsive brain stimulation in adults with refractory partial seizuresBergey GK, Morrell MJ, Mizrahi EM, Goldman A, King-Stephens D, Nair D, Srinivasan S, Jobst B, Gross RE, Shields DC, Barkley G, Salanova V, Olejniczak P, Cole A, Cash SS, Noe K, Wharen R, Worrell G, Murro AM, Edwards J, Duchowny M, Spencer D, Smith M, Geller E, Gwinn R, Skidmore C, Eisenschenk S, Berg M, Heck C, Van Ness P, Fountain N, Rutecki P, Massey A, O'Donovan C, Labar D, Duckrow RB, Hirsch LJ, Courtney T, Sun FT, Seale CG. Long-term treatment with responsive brain stimulation in adults with refractory partial seizures. Neurology 2015, 84: 810-817. PMID: 25616485, PMCID: PMC4339127, DOI: 10.1212/wnl.0000000000001280.
The spatial and signal characteristics of physiologic high frequency oscillationsAlkawadri R, Gaspard N, Goncharova II, Spencer DD, Gerrard JL, Zaveri H, Duckrow RB, Blumenfeld H, Hirsch LJ. The spatial and signal characteristics of physiologic high frequency oscillations. Epilepsia 2014, 55: 1986-1995. PMID: 25470216, PMCID: PMC5123742, DOI: 10.1111/epi.12851.
Proceedings of the Fifth International Workshop on Advances in ElectrocorticographyRitaccio A, Brunner P, Gunduz A, Hermes D, Hirsch LJ, Jacobs J, Kamada K, Kastner S, Knight RT, Lesser RP, Miller K, Sejnowski T, Worrell G, Schalk G. Proceedings of the Fifth International Workshop on Advances in Electrocorticography. Epilepsy & Behavior 2014, 41: 183-192. PMID: 25461213, PMCID: PMC4268064, DOI: 10.1016/j.yebeh.2014.09.015.
Respiratory Artifact on EEG Independent of the RespiratorYoo JY, Gaspard N, Hirsch LJ, Alkawadri R. Respiratory Artifact on EEG Independent of the Respirator. Journal Of Clinical Neurophysiology 2014, 31: e16-e17. PMID: 25271694, DOI: 10.1097/wnp.0000000000000027.
Brief Rhythmic Discharges in Electroencephalography on an Interictal to Ictal Continuum—ReplyGaspard N, Yoo JY, Hirsch LJ. Brief Rhythmic Discharges in Electroencephalography on an Interictal to Ictal Continuum—Reply. JAMA Neurology 2014, 71: 1193-1194. PMID: 25200548, DOI: 10.1001/jamaneurol.2014.1865.
Skepticism should not result in ignoring a treatment optionBenbadis S, Helmers S, Hirsch L, Sirven J, Vale FL, Wheless J. Skepticism should not result in ignoring a treatment option. Neurology 2014, 83: 849-850. PMID: 25156351, DOI: 10.1212/wnl.0000000000000743.
Yes, neurostimulation has a role in the management of epilepsyBenbadis S, Helmers S, Hirsch L, Sirven J, Vale FL, Wheless J. Yes, neurostimulation has a role in the management of epilepsy. Neurology 2014, 83: 845-847. PMID: 25156348, DOI: 10.1212/wnl.0000000000000739.
The consequences of refractory epilepsy and its treatmentLaxer KD, Trinka E, Hirsch LJ, Cendes F, Langfitt J, Delanty N, Resnick T, Benbadis SR. The consequences of refractory epilepsy and its treatment. Epilepsy & Behavior 2014, 37: 59-70. PMID: 24980390, DOI: 10.1016/j.yebeh.2014.05.031.
Interrater agreement for Critical Care EEG TerminologyGaspard N, Hirsch LJ, LaRoche SM, Hahn CD, Westover MB, Consortium T. Interrater agreement for Critical Care EEG Terminology. Epilepsia 2014, 55: 1366-1373. PMID: 24888711, PMCID: PMC4879939, DOI: 10.1111/epi.12653.
Finally, a Flood of Fascinating Facts and Findings on Final Outcomes after Frontal Lobe Epilepsy SurgeryHirsch LJ. Finally, a Flood of Fascinating Facts and Findings on Final Outcomes after Frontal Lobe Epilepsy Surgery. Epilepsy Currents 2014, 14: 139-142. PMID: 24940158, PMCID: PMC4038279, DOI: 10.5698/1535-7597-14.3.139.
Brief Potentially Ictal Rhythmic Discharges in Critically Ill AdultsYoo JY, Rampal N, Petroff OA, Hirsch LJ, Gaspard N. Brief Potentially Ictal Rhythmic Discharges in Critically Ill Adults. JAMA Neurology 2014, 71: 454-462. PMID: 24535702, DOI: 10.1001/jamaneurol.2013.6238.
Two‐year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trialHeck CN, King‐Stephens D, Massey AD, Nair DR, Jobst BC, Barkley GL, Salanova V, Cole AJ, Smith MC, Gwinn RP, Skidmore C, Van Ness PC, Bergey GK, Park YD, Miller I, Geller E, Rutecki PA, Zimmerman R, Spencer DC, Goldman A, Edwards JC, Leiphart JW, Wharen RE, Fessler J, Fountain NB, Worrell GA, Gross RE, Eisenschenk S, Duckrow RB, Hirsch LJ, Bazil C, O'Donovan CA, Sun FT, Courtney TA, Seale CG, Morrell MJ. Two‐year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial. Epilepsia 2014, 55: 432-441. PMID: 24621228, PMCID: PMC4233950, DOI: 10.1111/epi.12534.
A new encephalitis with GABAA receptor antibodiesHirsch LJ. A new encephalitis with GABAA receptor antibodies. The Lancet Neurology 2014, 13: 239-240. PMID: 24462239, DOI: 10.1016/s1474-4422(14)70013-4.
Ictal spread of medial temporal lobe seizures with and without secondary generalization: An intracranial electroencephalography analysisYoo JY, Farooque P, Chen WC, Youngblood MW, Zaveri HP, Gerrard JL, Spencer DD, Hirsch LJ, Blumenfeld H. Ictal spread of medial temporal lobe seizures with and without secondary generalization: An intracranial electroencephalography analysis. Epilepsia 2014, 55: 289-295. PMID: 24417694, PMCID: PMC4103687, DOI: 10.1111/epi.12505.
Limbic Encephalitis Associated With Anti–Voltage-Gated Potassium Channel Complex Antibodies Mimicking Creutzfeldt-Jakob DiseaseYoo JY, Hirsch LJ. Limbic Encephalitis Associated With Anti–Voltage-Gated Potassium Channel Complex Antibodies Mimicking Creutzfeldt-Jakob Disease. JAMA Neurology 2014, 71: 79-82. PMID: 24247910, DOI: 10.1001/jamaneurol.2013.5179.
Reply to about the electrophysiological basis of resting state networksDuncan D, Duckrow RB, Pincus SM, Goncharova I, Hirsch LJ, Spencer DD, Coifman RR, Zaveri HP. Reply to about the electrophysiological basis of resting state networks. Clinical Neurophysiology 2013, 125: 1713-1714. PMID: 24440225, DOI: 10.1016/j.clinph.2013.12.098.
High-dose midazolam infusion for refractory status epilepticusFernandez A, Lantigua H, Lesch C, Shao B, Foreman B, Schmidt JM, Hirsch LJ, Mayer SA, Claassen J. High-dose midazolam infusion for refractory status epilepticus. Neurology 2013, 82: 359-365. PMID: 24363133, PMCID: PMC3929199, DOI: 10.1212/wnl.0000000000000054.
Seizure control for intracranial arteriovenous malformations is directly related to treatment modality: a meta-analysisBaranoski JF, Grant RA, Hirsch LJ, Visintainer P, Gerrard JL, Günel M, Matouk CC, Spencer DD, Bulsara KR. Seizure control for intracranial arteriovenous malformations is directly related to treatment modality: a meta-analysis. Journal Of NeuroInterventional Surgery 2013, 6: 684. PMID: 24319021, DOI: 10.1136/neurintsurg-2013-010945.
Continuous electroencephalography in a surgical intensive care unitKurtz P, Gaspard N, Wahl AS, Bauer RM, Hirsch LJ, Wunsch H, Claassen J. Continuous electroencephalography in a surgical intensive care unit. Intensive Care Medicine 2013, 40: 228-234. PMID: 24240843, DOI: 10.1007/s00134-013-3149-8.
Proceedings of the Fourth International Workshop on Advances in ElectrocorticographyRitaccio A, Brunner P, Crone NE, Gunduz A, Hirsch LJ, Kanwisher N, Litt B, Miller K, Moran D, Parvizi J, Ramsey N, Richner TJ, Tandon N, Williams J, Schalk G. Proceedings of the Fourth International Workshop on Advances in Electrocorticography. Epilepsy & Behavior 2013, 29: 259-268. PMID: 24034899, PMCID: PMC3896917, DOI: 10.1016/j.yebeh.2013.08.012.
Unified EEG terminology and criteria for nonconvulsive status epilepticusBeniczky S, Hirsch LJ, Kaplan PW, Pressler R, Bauer G, Aurlien H, Brøgger JC, Trinka E. Unified EEG terminology and criteria for nonconvulsive status epilepticus. Epilepsia 2013, 54: 28-29. PMID: 24001066, DOI: 10.1111/epi.12270.
Similarity of Lateralized Rhythmic Delta Activity to Periodic Lateralized Epileptiform Discharges in Critically Ill PatientsGaspard N, Manganas L, Rampal N, Petroff OA, Hirsch LJ. Similarity of Lateralized Rhythmic Delta Activity to Periodic Lateralized Epileptiform Discharges in Critically Ill Patients. JAMA Neurology 2013, 70: 1288-1295. PMID: 23921464, DOI: 10.1001/jamaneurol.2013.3475.
7T MR spectroscopic imaging in the localization of surgical epilepsyPan JW, Duckrow RB, Gerrard J, Ong C, Hirsch LJ, Resor SR, Zhang Y, Petroff O, Spencer S, Hetherington HP, Spencer DD. 7T MR spectroscopic imaging in the localization of surgical epilepsy. Epilepsia 2013, 54: 1668-1678. PMID: 23895497, PMCID: PMC3938332, DOI: 10.1111/epi.12322.
Intracranially recorded interictal spikes: Relation to seizure onset area and effect of medication and time of dayGoncharova II, Spencer SS, Duckrow RB, Hirsch LJ, Spencer DD, Zaveri HP. Intracranially recorded interictal spikes: Relation to seizure onset area and effect of medication and time of day. Clinical Neurophysiology 2013, 124: 2119-2128. PMID: 23856192, DOI: 10.1016/j.clinph.2013.05.027.
Seizure localization using three-dimensional surface projections of intracranial EEG powerLee HW, Youngblood MW, Farooque P, Han X, Jhun S, Chen WC, Goncharova I, Vives K, Spencer DD, Zaveri H, Hirsch LJ, Blumenfeld H. Seizure localization using three-dimensional surface projections of intracranial EEG power. NeuroImage 2013, 83: 616-626. PMID: 23850575, PMCID: PMC3815983, DOI: 10.1016/j.neuroimage.2013.07.010.
Nonconvulsive seizures after subarachnoid hemorrhage: Multimodal detection and outcomesClaassen J, Perotte A, Albers D, Kleinberg S, Schmidt JM, Tu B, Badjatia N, Lantigua H, Hirsch LJ, Mayer SA, Connolly ES, Hripcsak G. Nonconvulsive seizures after subarachnoid hemorrhage: Multimodal detection and outcomes. Annals Of Neurology 2013, 74: 53-64. PMID: 23813945, PMCID: PMC3775941, DOI: 10.1002/ana.23859.
Intracranial EEG evaluation of relationship within a resting state networkDuncan D, Duckrow RB, Pincus SM, Goncharova I, Hirsch LJ, Spencer DD, Coifman RR, Zaveri HP. Intracranial EEG evaluation of relationship within a resting state network. Clinical Neurophysiology 2013, 124: 1943-1951. PMID: 23790525, DOI: 10.1016/j.clinph.2013.03.028.
Intravenous ketamine for the treatment of refractory status epilepticus: A retrospective multicenter studyGaspard N, Foreman B, Judd LM, Brenton JN, Nathan BR, McCoy BM, Al‐Otaibi A, Kilbride R, Fernández IS, Mendoza L, Samuel S, Zakaria A, Kalamangalam GP, Legros B, Szaflarski JP, Loddenkemper T, Hahn CD, Goodkin HP, Claassen J, Hirsch LJ, LaRoche SM. Intravenous ketamine for the treatment of refractory status epilepticus: A retrospective multicenter study. Epilepsia 2013, 54: 1498-1503. PMID: 23758557, PMCID: PMC3731413, DOI: 10.1111/epi.12247.
Status EpilepticusHirsch LJ, Gaspard N. Status Epilepticus. CONTINUUM Lifelong Learning In Neurology 2013, 19: 767-794. PMID: 23739110, DOI: 10.1212/01.con.0000431395.16229.5a.
In ReplyLaRoche S, Mani R, Arif H, Hirsch LJ, Gerard E. In Reply. Journal Of Clinical Neurophysiology 2013, 30: 210. PMID: 23545774, DOI: 10.1097/wnp.0b013e3182826a4e.
American Clinical Neurophysiology Society’s Standardized Critical Care EEG TerminologyHirsch LJ, LaRoche SM, Gaspard N, Gerard E, Svoronos A, Herman ST, Mani R, Arif H, Jette N, Minazad Y, Kerrigan JF, Vespa P, Hantus S, Claassen J, Young GB, So E, Kaplan PW, Nuwer MR, Fountain NB, Drislane FW. American Clinical Neurophysiology Society’s Standardized Critical Care EEG Terminology. Journal Of Clinical Neurophysiology 2013, 30: 1-27. PMID: 23377439, DOI: 10.1097/wnp.0b013e3182784729.
In ReplyLaRoche S, Mani R, Arif H, Gerard EE, Hirsch LJ. In Reply. Journal Of Clinical Neurophysiology 2013, 30: 102-103. PMID: 23377454, DOI: 10.1097/wnp.0b013e31827edcdc.
Pitfalls in ictal EEG interpretationGaspard N, Hirsch LJ. Pitfalls in ictal EEG interpretation. Neurology 2012, 80: s26-s42. PMID: 23267042, DOI: 10.1212/wnl.0b013e31827974f8.
Prospective assessment of ictal behavior using the revised Responsiveness in Epilepsy Scale (RES-II)Bauerschmidt A, Koshkelashvili N, Ezeani CC, Yoo JY, Zhang Y, Manganas LN, Kapadia K, Palenzuela D, Schmidt C, Lief R, Kiely BT, Choezom T, McClurkin M, Shorten A, Detyniecki K, Hirsch LJ, Giacino JT, Blumenfeld H. Prospective assessment of ictal behavior using the revised Responsiveness in Epilepsy Scale (RES-II). Epilepsy & Behavior 2012, 26: 25-28. PMID: 23201609, PMCID: PMC3741052, DOI: 10.1016/j.yebeh.2012.10.022.
Generalized periodic discharges in the critically illForeman B, Claassen J, Khaled K, Jirsch J, Alschuler DM, Wittman J, Emerson RG, Hirsch LJ. Generalized periodic discharges in the critically ill. Neurology 2012, 79: 1951-1960. PMID: 23035068, PMCID: PMC3484988, DOI: 10.1212/wnl.0b013e3182735cd7.
Sudden unexpected death in epilepsy in lamotrigine randomized‐controlled trialsTomson T, Hirsch LJ, Friedman D, Bester N, Hammer A, Irizarry M, Ishihara L, Krishen A, Spaulding T, Wamil A, Leadbetter R. Sudden unexpected death in epilepsy in lamotrigine randomized‐controlled trials. Epilepsia 2012, 54: 135-140. PMID: 23030403, DOI: 10.1111/j.1528-1167.2012.03689.x.
Extreme delta brushSchmitt SE, Pargeon K, Frechette ES, Hirsch LJ, Dalmau J, Friedman D. Extreme delta brush. Neurology 2012, 79: 1094-1100. PMID: 22933737, PMCID: PMC3525298, DOI: 10.1212/wnl.0b013e3182698cd8.
Long-Term Outcome after Epilepsy Surgery: Relapsing, Remitting Disorder?Hirsch LJ. Long-Term Outcome after Epilepsy Surgery: Relapsing, Remitting Disorder? Epilepsy Currents 2012, 12: 140-142. PMID: 22936885, PMCID: PMC3423211, DOI: 10.5698/1535-7511-12.4.140.
Interrater Reliability of ICU EEG Research TerminologyMani R, Arif H, Hirsch LJ, Gerard EE, LaRoche SM. Interrater Reliability of ICU EEG Research Terminology. Journal Of Clinical Neurophysiology 2012, 29: 203-212. PMID: 22659712, DOI: 10.1097/wnp.0b013e3182570f83.
Intramuscular versus Intravenous Benzodiazepines for Prehospital Treatment of Status EpilepticusHirsch LJ. Intramuscular versus Intravenous Benzodiazepines for Prehospital Treatment of Status Epilepticus. New England Journal Of Medicine 2012, 366: 659-660. PMID: 22335744, DOI: 10.1056/nejme1114206.
Epilepsy Emergencies: Diagnosis and ManagementForeman B, Hirsch LJ. Epilepsy Emergencies: Diagnosis and Management. Neurologic Clinics 2012, 30: 11-41. PMID: 22284053, DOI: 10.1016/j.ncl.2011.09.005.
Classification of EEG patterns in patients with impaired consciousnessHirsch LJ. Classification of EEG patterns in patients with impaired consciousness. Epilepsia 2011, 52: 21-24. PMID: 21967354, DOI: 10.1111/j.1528-1167.2011.03228.x.
Recovery after severe refractory status epilepticus and 4 months of comaBausell R, Svoronos A, Lennihan L, Hirsch LJ. Recovery after severe refractory status epilepticus and 4 months of coma. Neurology 2011, 77: 1494-1495. PMID: 21956717, DOI: 10.1212/wnl.0b013e318232abc0.
Imaging findings in encephalocraniocutaneous lipomatosisSvoronos A, Hirsch LJ, Khandji AG. Imaging findings in encephalocraniocutaneous lipomatosis. Neurology 2011, 77: 694. PMID: 21844526, DOI: 10.1212/wnl.0b013e3182299fa9.
The effect of age and comedication on lamotrigine clearance, tolerability, and efficacyArif H, Svoronos A, Resor SR, Buchsbaum R, Hirsch LJ. The effect of age and comedication on lamotrigine clearance, tolerability, and efficacy. Epilepsia 2011, 52: 1905-1913. PMID: 21838791, DOI: 10.1111/j.1528-1167.2011.03217.x.
Abbreviated report of the NIH/NINDS workshop on sudden unexpected death in epilepsy(e–Pub ahead of print)Hirsch LJ, Donner EJ, So EL, Jacobs M, Nashef L, Noebels JL, Buchhalter JR. Abbreviated report of the NIH/NINDS workshop on sudden unexpected death in epilepsy(e–Pub ahead of print). Neurology 2011, 76: 1932-1938. PMID: 21543734, PMCID: PMC3115809, DOI: 10.1212/wnl.0b013e31821de7de.
Is sudden unexpected death in epilepsy due to postictal brain shutdown?Hirsch LJ. Is sudden unexpected death in epilepsy due to postictal brain shutdown? Annals Of Neurology 2010, 68: 773-775. PMID: 21194146, DOI: 10.1002/ana.22242.
Intracortical EEG for the Detection of Vasospasm in Patients with Poor-Grade Subarachnoid HemorrhageStuart RM, Waziri A, Weintraub D, Schmidt MJ, Fernandez L, Helbok R, Kurtz P, Lee K, Badjatia N, Emerson R, Mayer SA, Connolly ES, Hirsch LJ, Claassen J. Intracortical EEG for the Detection of Vasospasm in Patients with Poor-Grade Subarachnoid Hemorrhage. Neurocritical Care 2010, 13: 355-358. PMID: 20652443, DOI: 10.1007/s12028-010-9414-6.
Urgent Continuous EEG (cEEG) Monitoring Leads to Changes in Treatment in Half of CasesHirsch LJ. Urgent Continuous EEG (cEEG) Monitoring Leads to Changes in Treatment in Half of Cases. Epilepsy Currents 2010, 10: 82-85. PMID: 20697500, PMCID: PMC2912537, DOI: 10.1111/j.1535-7511.2010.01364.x.
Seizures and CNS HemorrhageGilmore E, Choi HA, Hirsch LJ, Claassen J. Seizures and CNS Hemorrhage. The Neurologist 2010, 16: 165-175. PMID: 20445426, DOI: 10.1097/nrl.0b013e3181c7cd0b.
Comparative Effectiveness of 10 Antiepileptic Drugs in Older Adults With EpilepsyArif H, Buchsbaum R, Pierro J, Whalen M, Sims J, Resor SR, Bazil CW, Hirsch LJ. Comparative Effectiveness of 10 Antiepileptic Drugs in Older Adults With Epilepsy. JAMA Neurology 2010, 67: 408-415. PMID: 20385905, DOI: 10.1001/archneurol.2010.49.
Use of EEG Monitoring and Management of Non-Convulsive Seizures in Critically Ill Patients: A Survey of NeurologistsAbend NS, Dlugos DJ, Hahn CD, Hirsch LJ, Herman ST. Use of EEG Monitoring and Management of Non-Convulsive Seizures in Critically Ill Patients: A Survey of Neurologists. Neurocritical Care 2010, 12: 382-389. PMID: 20198513, PMCID: PMC2944658, DOI: 10.1007/s12028-010-9337-2.
Intracranial Multimodal Monitoring for Acute Brain Injury: A Single Institution Review of Current PracticesStuart RM, Schmidt M, Kurtz P, Waziri A, Helbok R, Mayer SA, Lee K, Badjatia N, Hirsch LJ, Connolly ES, Claassen J. Intracranial Multimodal Monitoring for Acute Brain Injury: A Single Institution Review of Current Practices. Neurocritical Care 2010, 12: 188-198. PMID: 20107926, DOI: 10.1007/s12028-010-9330-9.
Breathing New Life into the Fight against Sudden Death in EpilepsyHirsch LJ. Breathing New Life into the Fight against Sudden Death in Epilepsy. Epilepsy Currents 2009, 9: 137-139. PMID: 19826505, PMCID: PMC2759044, DOI: 10.1111/j.1535-7511.2009.01319.x.
Continuous Electroencephalogram Monitoring in the Intensive Care UnitFriedman D, Claassen J, Hirsch LJ. Continuous Electroencephalogram Monitoring in the Intensive Care Unit. Anesthesia & Analgesia 2009, 109: 506-523. PMID: 19608827, DOI: 10.1213/ane.0b013e3181a9d8b5.
How Long Does It Take to Make an Accurate Diagnosis in an Epilepsy Monitoring Unit?Friedman DE, Hirsch LJ. How Long Does It Take to Make an Accurate Diagnosis in an Epilepsy Monitoring Unit? Journal Of Clinical Neurophysiology 2009, 26: 213-217. PMID: 19584746, DOI: 10.1097/wnp.0b013e3181b2f2da.
Seizures in Patients Undergoing Resection of Low‐Grade GliomasHirsch LJ. Seizures in Patients Undergoing Resection of Low‐Grade Gliomas. Epilepsy Currents 2009, 9: 98-100. PMID: 19693324, PMCID: PMC2728484, DOI: 10.1111/j.1535-7511.2009.01305.x.
Continuous electroencephalography in the medical intensive care unit*Oddo M, Carrera E, Claassen J, Mayer SA, Hirsch LJ. Continuous electroencephalography in the medical intensive care unit*. Critical Care Medicine 2009, 37: 2051-2056. PMID: 19384197, DOI: 10.1097/ccm.0b013e3181a00604.
Intracortical electroencephalography in acute brain injuryWaziri A, Claassen J, Stuart RM, Arif H, Schmidt JM, Mayer SA, Badjatia N, Kull LL, Connolly ES, Emerson RG, Hirsch LJ. Intracortical electroencephalography in acute brain injury. Annals Of Neurology 2009, 66: 366-377. PMID: 19798724, DOI: 10.1002/ana.21721.
Cortical and subcortical networks in human secondarily generalized tonic–clonic seizuresBlumenfeld H, Varghese GI, Purcaro MJ, Motelow JE, Enev M, McNally KA, Levin AR, Hirsch LJ, Tikofsky R, Zubal IG, Paige AL, Spencer SS. Cortical and subcortical networks in human secondarily generalized tonic–clonic seizures. Brain 2009, 132: 999-1012. PMID: 19339252, PMCID: PMC2724910, DOI: 10.1093/brain/awp028.
Clinical use of ictal SPECT in secondarily generalized tonic–clonic seizuresVarghese GI, Purcaro MJ, Motelow JE, Enev M, McNally KA, Levin AR, Hirsch LJ, Tikofsky R, Paige AL, Zubal IG, Spencer SS, Blumenfeld H. Clinical use of ictal SPECT in secondarily generalized tonic–clonic seizures. Brain 2009, 132: 2102-2113. PMID: 19339251, PMCID: PMC2714057, DOI: 10.1093/brain/awp027.
Patient-reported cognitive side effects of antiepileptic drugs: Predictors and comparison of all commonly used antiepileptic drugsArif H, Buchsbaum R, Weintraub D, Pierro J, Resor SR, Hirsch LJ. Patient-reported cognitive side effects of antiepileptic drugs: Predictors and comparison of all commonly used antiepileptic drugs. Epilepsy & Behavior 2008, 14: 202-209. PMID: 19010446, DOI: 10.1016/j.yebeh.2008.10.017.
Continuous Electroencephalographic Monitoring in Critically Ill Patients With Central Nervous System InfectionsCarrera E, Claassen J, Oddo M, Emerson RG, Mayer SA, Hirsch LJ. Continuous Electroencephalographic Monitoring in Critically Ill Patients With Central Nervous System Infections. JAMA Neurology 2008, 65: 1612-1618. PMID: 19064748, DOI: 10.1001/archneur.65.12.1612.
Report of the American Epilepsy Society and the Epilepsy Foundation Joint Task Force on Sudden Unexplained Death in EpilepsySo EL, Bainbridge J, Buchhalter JR, Donalty J, Donner EJ, Finucane A, Graves NM, Hirsch LJ, Montouris GD, Temkin NR, Wiebe S, Sierzant TL. Report of the American Epilepsy Society and the Epilepsy Foundation Joint Task Force on Sudden Unexplained Death in Epilepsy. Epilepsia 2008, 50: 917-922. PMID: 19054406, DOI: 10.1111/j.1528-1167.2008.01906.x.
Cross-sensitivity of skin rashes with antiepileptic drug useHirsch LJ, Arif H, Nahm EA, Buchsbaum R, Resor SR, Bazil CW. Cross-sensitivity of skin rashes with antiepileptic drug use. Neurology 2008, 71: 1527-1534. PMID: 18981374, DOI: 10.1212/01.wnl.0000334295.50403.4c.
Efficacy of Clobazam as Add-on Therapy for Refractory EpilepsyMontenegro MA, Arif H, Nahm EA, Resor SR, Hirsch LJ. Efficacy of Clobazam as Add-on Therapy for Refractory Epilepsy. Clinical Neuropharmacology 2008, 31: 333-338. PMID: 19050410, DOI: 10.1097/wnf.0b013e31815cd960.
Levitating Levetiracetam's Status for Status EpilepticusHirsch LJ. Levitating Levetiracetam's Status for Status Epilepticus. Epilepsy Currents 2008, 8: 125-126. PMID: 18852834, PMCID: PMC2566612, DOI: 10.1111/j.1535-7511.2008.00266.x.
Nonconvulsive Seizures in Traumatic Brain Injury: What You Don't See Can Hurt YouHirsch LJ. Nonconvulsive Seizures in Traumatic Brain Injury: What You Don't See Can Hurt You. Epilepsy Currents 2008, 8: 97-99. PMID: 18596875, PMCID: PMC2442151, DOI: 10.1111/j.1535-7511.2008.00254.x.
Updates in the Management of Seizures and Status Epilepticus in Critically Ill PatientsKhaled K, Hirsch LJ. Updates in the Management of Seizures and Status Epilepticus in Critically Ill Patients. Neurologic Clinics 2008, 26: 385-408. PMID: 18514819, DOI: 10.1016/j.ncl.2008.03.017.
Focal motor seizures induced by alerting stimuli in critically ill patientsHirsch LJ, Pang T, Claassen J, Chang C, Khaled KA, Wittman J, Emerson RG. Focal motor seizures induced by alerting stimuli in critically ill patients. Epilepsia 2008, 49: 968-973. PMID: 18177364, DOI: 10.1111/j.1528-1167.2007.01481.x.
To Sleep, Perchance to Seize: Surgery Ameliorates Nocturnal Frontal Lobe SeizuresHirsch LJ. To Sleep, Perchance to Seize: Surgery Ameliorates Nocturnal Frontal Lobe Seizures. Epilepsy Currents 2007, 8: 12-14. PMID: 18265881, PMCID: PMC2238651, DOI: 10.1111/j.1535-7511.2007.00219.x.
ApoE, MemorE, and EpilepsEHirsch LJ. ApoE, MemorE, and EpilepsE. Epilepsy Currents 2007, 7: 149-150. PMID: 18049720, PMCID: PMC2096726, DOI: 10.1111/j.1535-7511.2007.00208.x.
Cyclic electrographic seizures in critically ill patientsFriedman DE, Schevon C, Emerson RG, Hirsch LJ. Cyclic electrographic seizures in critically ill patients. Epilepsia 2007, 49: 281-287. PMID: 17900293, DOI: 10.1111/j.1528-1167.2007.01327.x.
The Status of Intravenous Valproate for StatusHirsch LJ. The Status of Intravenous Valproate for Status. Epilepsy Currents 2007, 7: 96-98. PMID: 17694164, PMCID: PMC1941916, DOI: 10.1111/j.1535-7511.2007.00185.x.
Generalized convulsive status epilepticus after nontraumatic subarachnoid hemorrhage: the nationwide inpatient sample.Claassen J, Bateman BT, Willey JZ, Inati S, Hirsch LJ, Mayer SA, Sacco RL, Schumacher HC. Generalized convulsive status epilepticus after nontraumatic subarachnoid hemorrhage: the nationwide inpatient sample. Neurosurgery 2007, 61: 60-4; discussion 64-5. PMID: 17621019, DOI: 10.1227/01.neu.0000279724.05898.e7.
Effect of Age and Comedication on Levetiracetam Pharmacokinetics and TolerabilityHirsch LJ, Arif H, Buchsbaum R, Weintraub D, Lee J, Chang JT, Resor SR, Bazil CW. Effect of Age and Comedication on Levetiracetam Pharmacokinetics and Tolerability. Epilepsia 2007, 48: 1351-1359. PMID: 17573925, DOI: 10.1111/j.1528-1167.2007.01043.x.
Convulsive status epilepticus after ischemic stroke and intracerebral hemorrhage: frequency, predictors, and impact on outcome in a large administrative datasetBateman BT, Claassen J, Willey JZ, Hirsch LJ, Mayer SA, Sacco RL, Schumacher HC. Convulsive status epilepticus after ischemic stroke and intracerebral hemorrhage: frequency, predictors, and impact on outcome in a large administrative dataset. Neurocritical Care 2007, 7: 187-193. PMID: 17503112, DOI: 10.1007/s12028-007-0056-2.
A Randomized, Double‐Blind, Placebo‐Controlled Trial of Donepezil to Improve Memory in EpilepsyHamberger MJ, Palmese CA, Scarmeas N, Weintraub D, Choi H, Hirsch LJ. A Randomized, Double‐Blind, Placebo‐Controlled Trial of Donepezil to Improve Memory in Epilepsy. Epilepsia 2007, 48: 1283-1291. PMID: 17484756, DOI: 10.1111/j.1528-1167.2007.01114.x.
Diagnostic Utility of an Epilepsy Monitoring UnitSmolowitz JL, Hopkins SC, Perrine T, Eck KE, Hirsch LJ, Mundinger M. Diagnostic Utility of an Epilepsy Monitoring Unit. American Journal Of Medical Quality 2007, 22: 117-122. PMID: 17395968, DOI: 10.1177/1062860606298295.
Frequency and Predictors of Nonconvulsive Seizures During Continuous Electroencephalographic Monitoring in Critically Ill ChildrenJette N, Claassen J, Emerson RG, Hirsch LJ. Frequency and Predictors of Nonconvulsive Seizures During Continuous Electroencephalographic Monitoring in Critically Ill Children. JAMA Neurology 2006, 63: 1750-1755. PMID: 17172615, DOI: 10.1001/archneur.63.12.1750.
Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disordersMalik S, Arif H, Hirsch LJ. Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders. Expert Review Of Neurotherapeutics 2006, 6: 1609-1627. PMID: 17144777, DOI: 10.1586/14737175.6.11.1609.
In Nonconvulsive Status Epilepticus (NCSE), Treat to Burst‐Suppression: Pro and ConJordan KG, Hirsch LJ. In Nonconvulsive Status Epilepticus (NCSE), Treat to Burst‐Suppression: Pro and Con. Epilepsia 2006, 47: 41-45. PMID: 17044825, DOI: 10.1111/j.1528-1167.2006.00659.x.
Advances in the Management of Seizures and Status Epilepticus in Critically Ill PatientsKhaled K, Hirsch LJ. Advances in the Management of Seizures and Status Epilepticus in Critically Ill Patients. Critical Care Clinics 2006, 22: 637-659. PMID: 17239748, DOI: 10.1016/j.ccc.2006.06.004.
Nonconvulsive Status Epilepticus in Children: Clinical and EEG CharacteristicsTay SK, Hirsch LJ, Leary L, Jette N, Wittman J, Akman CI. Nonconvulsive Status Epilepticus in Children: Clinical and EEG Characteristics. Epilepsia 2006, 47: 1504-1509. PMID: 16981867, DOI: 10.1111/j.1528-1167.2006.00623.x.
Facial Emotion Recognition after Curative Nondominant Temporal Lobectomy in Patients with Mesial Temporal SclerosisMcClelland S, Garcia RE, Peraza DM, Shih TT, Hirsch LJ, Hirsch J, Goodman RR. Facial Emotion Recognition after Curative Nondominant Temporal Lobectomy in Patients with Mesial Temporal Sclerosis. Epilepsia 2006, 47: 1337-1342. PMID: 16922878, DOI: 10.1111/j.1528-1167.2006.00557.x.
Autoantibodies: A novel etiology for refractory epilepsy?Bazil CW, Hirsch LJ. Autoantibodies: A novel etiology for refractory epilepsy? Current Neurology And Neuroscience Reports 2006, 6: 309-310. PMID: 16822351, DOI: 10.1007/s11910-006-0023-x.
Prognostic significance of continuous EEG monitoring in patients with poor-grade subarachnoid hemorrhageClaassen J, Hirsch LJ, Frontera JA, Fernandez A, Schmidt M, Kapinos G, Wittman J, Connolly ES, Emerson RG, Mayer SA. Prognostic significance of continuous EEG monitoring in patients with poor-grade subarachnoid hemorrhage. Neurocritical Care 2006, 4: 103-112. PMID: 16627897, DOI: 10.1385/ncc:4:2:103.
Predictors of Lamotrigine‐associated RashHirsch LJ, Weintraub DB, Buchsbaum R, Spencer HT, Straka T, Hager M, Resor SR. Predictors of Lamotrigine‐associated Rash. Epilepsia 2006, 47: 318-322. PMID: 16499755, DOI: 10.1111/j.1528-1167.2006.00423.x.
Topiramate for the treatment of epilepsy and other nervous system disordersvan Passel L, Arif H, Hirsch LJ. Topiramate for the treatment of epilepsy and other nervous system disorders. Expert Review Of Neurotherapeutics 2006, 6: 19-31. PMID: 16466308, DOI: 10.1586/14737175.6.1.19.
Effect of Antiepileptic Drug Comedication on Lamotrigine ClearanceWeintraub D, Buchsbaum R, Resor SR, Hirsch LJ. Effect of Antiepileptic Drug Comedication on Lamotrigine Clearance. JAMA Neurology 2005, 62: 1432-1436. PMID: 16157751, DOI: 10.1001/archneur.62.9.1432.
Continuous electroencephalogram monitoring in critically ill patientsJette N, Hirsch LJ. Continuous electroencephalogram monitoring in critically ill patients. Current Neurology And Neuroscience Reports 2005, 5: 312-321. PMID: 15987616, DOI: 10.1007/s11910-005-0077-1.
Treatment of convulsive and nonconvulsive status epilepticusPang T, Hirsch LJ. Treatment of convulsive and nonconvulsive status epilepticus. Current Treatment Options In Neurology 2005, 7: 247-259. PMID: 15967088, DOI: 10.1007/s11940-005-0035-x.
Continuous electroencephalogram monitoring in the critically IIIWittman JJ, Hirsch LJ. Continuous electroencephalogram monitoring in the critically III. Neurocritical Care 2005, 2: 330-341. PMID: 16159085, DOI: 10.1385/ncc:2:3:330.
Which EEG Patterns Warrant Treatment in the Critically Ill? Reviewing the Evidence for Treatment of Periodic Epileptiform Discharges and Related PatternsChong DJ, Hirsch LJ. Which EEG Patterns Warrant Treatment in the Critically Ill? Reviewing the Evidence for Treatment of Periodic Epileptiform Discharges and Related Patterns. Journal Of Clinical Neurophysiology 2005, 22: 79-91. PMID: 15805807, DOI: 10.1097/01.wnp.0000158699.78529.af.
Continuous EEG Monitoring in Patients With Subarachnoid HemorrhageClaassen J, Mayer SA, Hirsch LJ. Continuous EEG Monitoring in Patients With Subarachnoid Hemorrhage. Journal Of Clinical Neurophysiology 2005, 22: 92-98. PMID: 15805808, DOI: 10.1097/01.wnp.0000145006.02048.3a.
The ACNS Subcommittee on Research Terminology for Continuous EEG Monitoring: Proposed Standardized Terminology for Rhythmic and Periodic EEG Patterns Encountered in Critically Ill PatientsHirsch LJ, Brenner RP, Drislane FW, So E, Kaplan PW, Jordan KG, Herman ST, LaRoche SM, Young B, Bleck TP, Scheuer ML, Emerson RG. The ACNS Subcommittee on Research Terminology for Continuous EEG Monitoring: Proposed Standardized Terminology for Rhythmic and Periodic EEG Patterns Encountered in Critically Ill Patients. Journal Of Clinical Neurophysiology 2005, 22: 128-135. PMID: 15805813, DOI: 10.1097/01.wnp.0000158701.89576.4c.
Quantitative continuous EEG for detecting delayed cerebral ischemia in patients with poor-grade subarachnoid hemorrhageClaassen J, Hirsch LJ, Kreiter KT, Du EY, Connolly ES, Emerson RG, Mayer SA. Quantitative continuous EEG for detecting delayed cerebral ischemia in patients with poor-grade subarachnoid hemorrhage. Clinical Neurophysiology 2004, 115: 2699-2710. PMID: 15546778, DOI: 10.1016/j.clinph.2004.06.017.
Can sudden unexplained death in epilepsy be prevented?Hirsch LJ, Hauser WA. Can sudden unexplained death in epilepsy be prevented? The Lancet 2004, 364: 2157-2158. PMID: 15610785, DOI: 10.1016/s0140-6736(04)17605-8.
The hazards of lack of co-registration of ictal brain SPECT with MRI: A case report of sinusitis mimicking a brainstem seizure focusButler T, Hirsch LJ, Claassen J. The hazards of lack of co-registration of ictal brain SPECT with MRI: A case report of sinusitis mimicking a brainstem seizure focus. BMC Medical Physics 2004, 4: 2. PMID: 15569392, PMCID: PMC535895, DOI: 10.1186/1471-2385-4-2.
Inadequacy of Standard Screen Resolution for Localization of Seizures Recorded from Intracranial ElectrodesSchevon CA, Thompson T, Hirsch LJ, Emerson RG. Inadequacy of Standard Screen Resolution for Localization of Seizures Recorded from Intracranial Electrodes. Epilepsia 2004, 45: 1453-1458. PMID: 15509247, DOI: 10.1111/j.0013-9580.2004.67603.x.
Correlating lamotrigine serum concentrations with tolerability in patients with epilepsyHirsch LJ, Weintraub D, Du Y, Buchsbaum R, Spencer HT, Hager M, Straka T, Bazil CW, Adams DJ, Resor SR, Morrell MJ. Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. Neurology 2004, 63: 1022-1026. PMID: 15452293, DOI: 10.1212/01.wnl.0000138424.33979.0c.
Continuous EEG Monitoring in the Intensive Care UnitHirsch LJ, Kull LL. Continuous EEG Monitoring in the Intensive Care Unit. The Neurodiagnostic Journal 2004, 44: 137-158. PMID: 15521467, DOI: 10.1080/1086508x.2004.11079478.
“Tectonic” hippocampal malformations in patients with temporal lobe epilepsySloviter RS, Kudrimoti HS, Laxer KD, Barbaro NM, Chan S, Hirsch LJ, Goodman RR, Pedley TA. “Tectonic” hippocampal malformations in patients with temporal lobe epilepsy. Epilepsy Research 2004, 59: 123-153. PMID: 15246116, DOI: 10.1016/j.eplepsyres.2004.04.001.
Stimulus‐induced Rhythmic, Periodic, or Ictal Discharges (SIRPIDs): A Common EEG Phenomenon in the Critically IllHirsch LJ, Claassen J, Mayer SA, Emerson RG. Stimulus‐induced Rhythmic, Periodic, or Ictal Discharges (SIRPIDs): A Common EEG Phenomenon in the Critically Ill. Epilepsia 2004, 45: 109-123. PMID: 14738418, DOI: 10.1111/j.0013-9580.2004.38103.x.
Brain monitoring: the next frontier of ICU monitoring.Hirsch LJ. Brain monitoring: the next frontier of ICU monitoring. Journal Of Clinical Neurophysiology 2004, 21: 305-6. PMID: 15592004.
Continuous EEG Monitoring in the Intensive Care Unit: An OverviewHirsch LJ. Continuous EEG Monitoring in the Intensive Care Unit: An Overview. Journal Of Clinical Neurophysiology 2004, 21: 332-340. PMID: 15592007, DOI: 10.1097/01.wnp.0000147129.80917.0e.
Absence Epilepsy with Onset before Age Three Years: Could this Be Glut‐1 Deficiency Syndrome (De Vivo Syndrome)?Hirsch LJ. Absence Epilepsy with Onset before Age Three Years: Could this Be Glut‐1 Deficiency Syndrome (De Vivo Syndrome)? Epilepsia 2003, 45: 92-93. PMID: 14692915, DOI: 10.1111/j.0013-9580.2004.41503.x.
Treatment of status epilepticus: a survey of neurologistsClaassen J, Hirsch LJ, Mayer SA. Treatment of status epilepticus: a survey of neurologists. Journal Of The Neurological Sciences 2003, 211: 37-41. PMID: 12767495, DOI: 10.1016/s0022-510x(03)00036-4.
Tonic–Absence Seizures: An Underrecognized Seizure TypeShih TT, Hirsch LJ. Tonic–Absence Seizures: An Underrecognized Seizure Type. Epilepsia 2003, 44: 461-465. PMID: 12614405, DOI: 10.1046/j.1528-1157.2003.39602.x.
Heart rate and EKG changes in 102 seizures: analysis of influencing factorsOpherk C, Coromilas J, Hirsch LJ. Heart rate and EKG changes in 102 seizures: analysis of influencing factors. Epilepsy Research 2002, 52: 117-127. PMID: 12458028, DOI: 10.1016/s0920-1211(02)00215-2.
Levetiracetam May Be More Effective for Late-Onset Partial EpilepsyBazil CW, Rose A, Resor S, Yapicular B, Hirsch LJ. Levetiracetam May Be More Effective for Late-Onset Partial Epilepsy. JAMA Neurology 2002, 59: 1905-1908. PMID: 12470178, DOI: 10.1001/archneur.59.12.1905.
Nonconvulsive Status Epilepticus after Subarachnoid HemorrhageDennis LJ, Claassen J, Hirsch LJ, Emerson RG, Connolly ES, Mayer SA. Nonconvulsive Status Epilepticus after Subarachnoid Hemorrhage. Neurosurgery 2002, 51: 1136. PMID: 12383358, DOI: 10.1097/00006123-200211000-00006.
The current state of treatment of status epilepticusHirsch LJ, Claassen J. The current state of treatment of status epilepticus. Current Neurology And Neuroscience Reports 2002, 2: 345-356. PMID: 12044254, DOI: 10.1007/s11910-002-0010-9.
Ictal heart rate differentiates epileptic from non-epileptic seizuresOpherk C, Hirsch LJ. Ictal heart rate differentiates epileptic from non-epileptic seizures. Neurology 2002, 58: 636-638. PMID: 11865145, DOI: 10.1212/wnl.58.4.636.
Treatment of Refractory Status Epilepticus with Pentobarbital, Propofol, or Midazolam: A Systematic ReviewClaassen J, Hirsch LJ, Emerson RG, Mayer SA. Treatment of Refractory Status Epilepticus with Pentobarbital, Propofol, or Midazolam: A Systematic Review. Epilepsia 2002, 43: 146-153. PMID: 11903460, DOI: 10.1046/j.1528-1157.2002.28501.x.
Video‐EEG Monitoring in the Elderly: A Review of 94 PatientsMcBride AE, Shih TT, Hirsch LJ. Video‐EEG Monitoring in the Elderly: A Review of 94 Patients. Epilepsia 2002, 43: 165-169. PMID: 11903463, DOI: 10.1046/j.1528-1157.2002.24401.x.

Clinical Trials

Conditions	Study Title
Diseases of the Nervous System; Mental Health & Behavioral Research	Human Epilepsy Project 3: Newly Diagnosed Idiopathic Generalized Epilepsy
Diseases of the Nervous System	A Trial of the Efficacy and Safety of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures
Diseases of the Cardiovascular System	Multimodal Outcome CHAracterization (MOCHA) in comatose cardiac arrest patients
Diseases of the Nervous System; Mental Health & Behavioral Research	SV2A PET Imaging in Healthy Subjects and Epilepsy Patients

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