Aline Herlopian, MD
Assistant Professor; Affiliated Faculty , Yale Institute for Global Health; Medical Director, Clinical Neurophysiology/EEG lab, Neurology; Director, Clinical trials in Epilepsy , Neurology
Research & Publications
Biography
Coauthors
Selected Publications
- Epilepsy Surgery: A Practical Case-Based Approach 2024th EditionPublished by Springer International Publishing, May 2023 DOI 10.1007/978-3-031-23828-4 ISBNs 978-3-03-123827-7, 978-3-03-123828-4
- On-demand EEG education through competition – A novel, app-based approach to learning to identify interictal epileptiform dischargesBarfuss J, Nascimento F, Duhaime E, Kapur S, Karakis I, Ng M, Herlopian A, Lam A, Maus D, Halford J, Cash S, Westover M, Jing J. On-demand EEG education through competition – A novel, app-based approach to learning to identify interictal epileptiform discharges. Clinical Neurophysiology Practice 2023, 8: 177-186. PMID: 37681118, PMCID: PMC10480673, DOI: 10.1016/j.cnp.2023.08.003.
- Inter-Rater Reliability of EEG-Based Encephalopathy Grading (S30.008)Zahoor A, Banks J, Tesh R, Eckhardt C, Sun H, Greenblatt A, Herlopian A, Karakis I, Katyal R, Nayak C, Ng M, Williams J, Sheikh I, Nascimento F, Westover M. Inter-Rater Reliability of EEG-Based Encephalopathy Grading (S30.008). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202773.
- Epileptiform Discharges in Patients with Psychogenic Non-Epileptic Attacks: A Case Series (P1-1.009)Afify M, Tolchin B, Altalib H, Hirsch L, Herlopian A. Epileptiform Discharges in Patients with Psychogenic Non-Epileptic Attacks: A Case Series (P1-1.009). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000204120.
- Ictal Thalamic Recordings in Patients with Deep Brain Stimulation Targeting Thalamic NucleiIdentify whether ictal thalamic EEG signals could be derived from ambulatory recordings in patients with pharmacoresistant epilepsy treated with deep brain stimulation (DBS) targeting either bilateral anterior thalamic nuclei (ATN) or centromedian nuclei (CMN). (P5-1.008)Saab L, Jiang J, Quraishi I, Herlopian A. Ictal Thalamic Recordings in Patients with Deep Brain Stimulation Targeting Thalamic NucleiIdentify whether ictal thalamic EEG signals could be derived from ambulatory recordings in patients with pharmacoresistant epilepsy treated with deep brain stimulation (DBS) targeting either bilateral anterior thalamic nuclei (ATN) or centromedian nuclei (CMN). (P5-1.008). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000204225.
- Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG InterpretationJing J, Ge W, Hong S, Fernandes M, Lin Z, Yang C, An S, Struck A, Herlopian A, Karakis I, Halford J, Ng M, Johnson E, Appavu B, Sarkis R, Osman G, Kaplan P, Dhakar M, Arcot Jayagopal L, Sheikh Z, Taraschenko O, Schmitt S, Haider H, Kim J, Swisher C, Gaspard N, Cervenka M, Rodriguez Ruiz A, Lee J, Tabaeizadeh M, Gilmore E, Nordstrom K, Yoo J, Holmes M, Herman S, Williams J, Pathmanathan J, Nascimento F, Fan Z, Nasiri S, Shafi M, Cash S, Hoch D, Cole A, Rosenthal E, Zafar S, Sun J, Westover M. Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation. Neurology 2023, 100: e1750-e1762. PMID: 36878708, PMCID: PMC10136013, DOI: 10.1212/wnl.0000000000207127.
- Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGsJing J, Ge W, Struck A, Fernandes M, Hong S, An S, Fatima S, Herlopian A, Karakis I, Halford J, Ng M, Johnson E, Appavu B, Sarkis R, Osman G, Kaplan P, Dhakar M, Jayagopal L, Sheikh Z, Taraschenko O, Schmitt S, Haider H, Kim J, Swisher C, Gaspard N, Cervenka M, Rodriguez Ruiz A, Lee J, Tabaeizadeh M, Gilmore E, Nordstrom K, Yoo J, Holmes M, Herman S, Williams J, Pathmanathan J, Nascimento F, Fan Z, Nasiri S, Shafi M, Cash S, Hoch D, Cole A, Rosenthal E, Zafar S, Sun J, Westover M. Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs. Neurology 2022, 100: e1737-e1749. PMID: 36460472, PMCID: PMC10136018, DOI: 10.1212/wnl.0000000000201670.
- Measuring expertise in identifying interictal epileptiform dischargesHarid NM, Jing J, Hogan J, Nascimento FA, Ouyang A, Zheng W, Ge W, Zafar SF, Kim JA, Alice DL, Herlopian A, Maus D, Karakis I, Ng M, Hong S, Yu Z, Kaplan PW, Cash S, Shafi M, Martz G, Halford JJ, Westover MB. Measuring expertise in identifying interictal epileptiform discharges. Epileptic Disorders 2022, 24: 496-506. PMID: 35770748, PMCID: PMC9340812, DOI: 10.1684/epd.2021.1409.
- Electroencephalographic changes in purified pharmaceutical cannabidiol therapyHerlopian A, Barnett JR, Nascimento FA, Lee H, Thiele EA. Electroencephalographic changes in purified pharmaceutical cannabidiol therapy. Epilepsy & Behavior 2022, 128: 108558. PMID: 35078115, DOI: 10.1016/j.yebeh.2022.108558.
- Deep active learning for Interictal Ictal Injury Continuum EEG patternsGe W, Jing J, An S, Herlopian A, Ng M, Struck AF, Appavu B, Johnson EL, Osman G, Haider HA, Karakis I, Kim JA, Halford JJ, Dhakar MB, Sarkis RA, Swisher CB, Schmitt S, Lee JW, Tabaeizadeh M, Rodriguez A, Gaspard N, Gilmore E, Herman ST, Kaplan PW, Pathmanathan J, Hong S, Rosenthal ES, Zafar S, Sun J, Westover M. Deep active learning for Interictal Ictal Injury Continuum EEG patterns. Journal Of Neuroscience Methods 2020, 351: 108966. PMID: 33131680, PMCID: PMC8135050, DOI: 10.1016/j.jneumeth.2020.108966.
- Cannabidiol in treatment of refractory epileptic spasms: An open-label studyHerlopian A, Hess EJ, Barnett J, Geffrey AL, Pollack SF, Skirvin L, Bruno P, Sourbron J, Thiele EA. Cannabidiol in treatment of refractory epileptic spasms: An open-label study. Epilepsy & Behavior 2020, 106: 106988. PMID: 32169600, DOI: 10.1016/j.yebeh.2020.106988.
- Development of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram InterpretationJing J, Sun H, Kim JA, Herlopian A, Karakis I, Ng M, Halford JJ, Maus D, Chan F, Dolatshahi M, Muniz C, Chu C, Sacca V, Pathmanathan J, Ge W, Dauwels J, Lam A, Cole AJ, Cash SS, Westover MB. Development of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram Interpretation. JAMA Neurology 2020, 77: 103-108. PMID: 31633740, PMCID: PMC6806668, DOI: 10.1001/jamaneurol.2019.3485.
- Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in ElectroencephalogramsJing J, Herlopian A, Karakis I, Ng M, Halford JJ, Lam A, Maus D, Chan F, Dolatshahi M, Muniz C, Chu C, Sacca V, Pathmanathan J, Ge W, Sun H, Dauwels J, Cole AJ, Hoch DB, Cash SS, Westover MB. Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms. JAMA Neurology 2020, 77: 49-57. PMID: 31633742, PMCID: PMC6806666, DOI: 10.1001/jamaneurol.2019.3531.
- Preoperative Functional Mapping for Epilepsy SurgeryHerlopian A, Maus D. Preoperative Functional Mapping for Epilepsy Surgery. 2018 DOI: 10.1891/9781617052941.0022.
- EEG findings in CAR T-cell therapy-related encephalopathyHerlopian A, Dietrich J, Abramson JS, Cole AJ, Westover MB. EEG findings in CAR T-cell therapy-related encephalopathy. Neurology 2018, 91: 227-229. PMID: 29959264, PMCID: PMC6093761, DOI: 10.1212/wnl.0000000000005910.
- Predictive Value of Electrocorticography in Patients With Mesial Temporal Lobe Epilepsy Undergoing Selective AmygdalohippocampectomyHerlopian A, Shihabuddin B. Predictive Value of Electrocorticography in Patients With Mesial Temporal Lobe Epilepsy Undergoing Selective Amygdalohippocampectomy. Journal Of Clinical Neurophysiology 2017, 34: 370-374. PMID: 28306691, DOI: 10.1097/wnp.0000000000000376.
- Extreme delta brush evolving into status epilepticus in a patient with anti-NMDA encephalitisHerlopian A, Rosenthal ES, Chu CJ, Cole AJ, Struck AF. Extreme delta brush evolving into status epilepticus in a patient with anti-NMDA encephalitis. Epilepsy & Behavior Reports 2016, 7: 69-71. PMID: 28616386, PMCID: PMC5459970, DOI: 10.1016/j.ebcr.2016.09.002.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Diseases of the Nervous System; Mental Health & Behavioral Research | Human Epilepsy Project 3: Newly Diagnosed Idiopathic Generalized Epilepsy |
| Diseases of the Nervous System; Mental Health & Behavioral Research | SV2A PET Imaging in Healthy Subjects and Epilepsy Patients |