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Nallakkandi Rajeevan, PhD

Senior Research Scientist of Biomedical Informatics and Data Science; Associate Director for Bioinformatics, Yale Center for Medical Informatics

Research & Publications
Biography

Coauthors

Selected Publications

Effectiveness of Nirmatrelvir-Ritonavir Against the Development of Post-COVID-19 Conditions Among U.S. Veterans : A Target Trial Emulation.Ioannou G, Berry K, Rajeevan N, Li Y, Mutalik P, Yan L, Bui D, Cunningham F, Hynes D, Rowneki M, Bohnert A, Boyko E, Iwashyna T, Maciejewski M, Osborne T, Viglianti E, Aslan M, Huang G, Bajema K. Effectiveness of Nirmatrelvir-Ritonavir Against the Development of Post-COVID-19 Conditions Among U.S. Veterans : A Target Trial Emulation. Annals Of Internal Medicine 2023, 176: 1486-1497. PMID: 37903369, PMCID: PMC10620954, DOI: 10.7326/m23-1394.
Metformin prescription for U.S. veterans with prediabetes, 2010–2019Gulanski B, Goulet J, Radhakrishnan K, Ko J, Li Y, Rajeevan N, Lee K, Heberer K, Lynch J, Streja E, Mutalik P, Cheung K, Concato J, Shih M, Lee J, Aslan M. Metformin prescription for U.S. veterans with prediabetes, 2010–2019. Journal Of Investigative Medicine 2023, 72: 139-150. PMID: 37668313, DOI: 10.1177/10815589231201141.
Late Mortality After COVID-19 Infection Among US Veterans vs Risk-Matched ComparatorsIwashyna T, Seelye S, Berkowitz T, Pura J, Bohnert A, Bowling C, Boyko E, Hynes D, Ioannou G, Maciejewski M, O’Hare A, Viglianti E, Womer J, Prescott H, Smith V, Admon A, Akgun K, Anderson S, Aslan M, Au D, Backus L, Bajema K, Baraff A, Batten L, Berkowitz T, Bernstein T, Berry Wyatt K, Bogdan J, Bosworth H, Boucher N, Burwick N, Cabrales A, Cano J, Chai W, Chen J, Cheung K, Crothers K, Curtis J, Davis M, Del Monico E, Dobalian A, Doll J, Dominitz J, Eastment M, Fan V, Ferguson J, Floyd B, Fox A, Goetz M, Govier D, Green P, Hastings S, Hauschildt K, Hawkins E, Hebert P, Helfand M, Hickok A, Horowitz D, Hough C, Hu E, Ikuta K, Jones B, Jones M, Kamphuis L, Kaufman B, Knight S, Korpak A, Korpela P, Kumbier K, Langa K, Laundry R, Lavin S, Li Y, Linquist J, McCready H, Michel M, Miles A, Milne J, Monahan M, Morelli D, Mutalik P, Naylor J, Neiderhausen M, Newell S, Nugent S, Ong M, Osborne T, Peterson M, Peterson A, Rajeevan N, Reddy A, Rouse M, Rowneki M, Saha S, Saini S, Shah J, Shahoumian T, Shaukat A, Shepherd-Banigan M, Showalter W, Slatore C, Smith N, Smith B, Suri P, Sussman J, Takata Y, Teo A, Thomas E, Thomas L, Tuepker A, Veigulis Z, Vig E, Vranas K, Wang X, Wicks K, Winchell K, Wong E, Woods C, Wysham K, Yan L, Zulman D. Late Mortality After COVID-19 Infection Among US Veterans vs Risk-Matched Comparators. JAMA Internal Medicine 2023, 183: 1111-1119. PMID: 37603339, PMCID: PMC10442778, DOI: 10.1001/jamainternmed.2023.3587.
Anti–SARS-CoV-2 Pharmacotherapies Among Nonhospitalized US Veterans, January 2022 to January 2023Yan L, Streja E, Li Y, Rajeevan N, Rowneki M, Berry K, Hynes D, Cunningham F, Huang G, Aslan M, Ioannou G, Bajema K. Anti–SARS-CoV-2 Pharmacotherapies Among Nonhospitalized US Veterans, January 2022 to January 2023. JAMA Network Open 2023, 6: e2331249. PMID: 37651140, PMCID: PMC10472184, DOI: 10.1001/jamanetworkopen.2023.31249.
Effectiveness of COVID-19 Treatment With Nirmatrelvir–Ritonavir or Molnupiravir Among U.S. Veterans: Target Trial Emulation Studies With One-Month and Six-Month OutcomesBajema K, Berry K, Streja E, Rajeevan N, Li Y, Mutalik P, Yan L, Cunningham F, Hynes D, Rowneki M, Bohnert A, Boyko E, Iwashyna T, Maciejewski M, Osborne T, Viglianti E, Aslan M, Huang G, Ioannou G. Effectiveness of COVID-19 Treatment With Nirmatrelvir–Ritonavir or Molnupiravir Among U.S. Veterans: Target Trial Emulation Studies With One-Month and Six-Month Outcomes. Annals Of Internal Medicine 2023, 176: m22-3565. PMID: 37276589, PMCID: PMC10243488, DOI: 10.7326/m22-3565.
Modeling the longitudinal changes of ancestry diversity in the Million Veteran ProgramWendt F, Pathak G, Vahey J, Qin X, Koller D, Cabrera-Mendoza B, Haeny A, Harrington K, Rajeevan N, Duong L, Levey D, De Angelis F, De Lillo A, Bigdeli T, Pyarajan S, Gaziano J, Gelernter J, Aslan M, Provenzale D, Helmer D, Hauser E, Polimanti R. Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program. Human Genomics 2023, 17: 46. PMID: 37268996, PMCID: PMC10239111, DOI: 10.1186/s40246-023-00487-3.
561. Lifetime Consequences and Correlates of Anticholinergic Medication Burden in the VA Healthcare SystemBigdeli T, Joshi Y, Li Y, Rajeevan N, Sayward F, Przygodszki R, Huang G, Pyarajan S, Muralidhar S, Gaziano J, Braff D, Light G, Aslan M, Roussos P, Harvey P. 561. Lifetime Consequences and Correlates of Anticholinergic Medication Burden in the VA Healthcare System. Biological Psychiatry 2023, 93: s321. DOI: 10.1016/j.biopsych.2023.02.801.
Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military VeteransKimbrel N, Ashley-Koch A, Qin X, Lindquist J, Garrett M, Dennis M, Hair L, Huffman J, Jacobson D, Madduri R, Trafton J, Coon H, Docherty A, Mullins N, Ruderfer D, Harvey P, McMahon B, Oslin D, Beckham J, Hauser E, Hauser M, Agarwal K, Ashley-Koch A, Aslan M, Beckham J, Begoli E, Bhattacharya T, Brown B, Calhoun P, Cheung K, Choudhury S, Cliff A, Cohn J, Crivelli S, Cuellar-Hengartner L, Deangelis H, Dennis M, Dhaubhadel S, Finley P, Ganguly K, Garvin M, Gelernter J, Hair L, Harvey P, Hauser E, Hauser M, Hengartner N, Jacobson D, Jones P, Kainer D, Kaplan A, Katz I, Kember R, Kimbrel N, Kirby A, Ko J, Kolade B, Lagergren J, Lane M, Levey D, Levin D, Lindquist J, Liu X, Madduri R, Manore C, Martins S, McCarthy J, McDevitt-Cashman M, McMahon B, Miller I, Morrow D, Oslin D, Pavicic-Venegas M, Pestian J, Pyarajan S, Qin X, Rajeevan N, Ramsey C, Ribeiro R, Rodriguez A, Romero J, Santel D, Schaefferkoetter N, Shi Y, Stein M, Sullivan K, Sun N, Tamang S, Townsend A, Trafton J, Walker A, Wang X, Wangia-Anderson V, Yang R, Yoon H, Yoo S, Zamora-Resendiz R, Zhao H, Docherty A, Mullins N, Coleman J, Shabalin A, Kang J, Murnyak B, Wendt F, Adams M, Campos A, DiBlasi E, Fullerton J, Kranzler H, Bakian A, Monson E, Rentería M, Andreassen O, Bulik C, Edenberg H, Kessler R, Mann J, Nurnberger J, Pistis G, Streit F, Ursano R, Awasthi S, Bergen A, Berrettini W, Bohus M, Brandt H, Chang X, Chen H, Chen W, Christensen E, Crawford S, Crow S, Duriez P, Edwards A, Fernández-Aranda F, Fichter M, Galfalvy H, Gallinger S, Gandal M, Gorwood P, Guo Y, Hafferty J, Hakonarson H, Halmi K, Hishimoto A, Jain S, Jamain S, Jiménez-Murcia S, Johnson C, Kaplan A, Kaye W, Keel P, Kennedy J, Kim M, Klump K, Levey D, Li D, Liao S, Lieb K, Lilenfeld L, Lori A, Magistretti P, Marshall C, Mitchell J, Myers R, Okazaki S, Otsuka I, Pinto D, Powers A, Ramoz N, Ripke S, Roepke S, Rozanov V, Scherer S, Schmahl C, Sokolowski M, Starnawska A, Strober M, Su M, Thornton L, Treasure J, Ware E, Watson H, Witt S, Woodside D, Yilmaz Z, Zillich L, Agerbo E, Børglum A, Breen G, Demontis D, Erlangsen A, Esko T, Gelernter J, Glatt S, Hougaard D, Hwu H, Kuo P, Lewis C, Li Q, Liu C, Martin N, McIntosh A, Medland S, Mors O, Nordentoft M, Nurnberger J, Olsen C, Porteous D, Smith D, Stahl E, Stein M, Wasserman D, Werge T, Whiteman D, Willour V, Coon H, Ruderfer D, Dedert E, Elbogen E, Fairbank J, Hurley R, Kilts J, Martindale S, Marx C, McDonald S, Moore S, Morey R, Naylor J, Rowland J, Shura R, Swinkels C, Tupler L, Van Voorhees E, Yoash-Gantz R, Gaziano J, Muralidhar S, Ramoni R, Chang K, O’Donnell C, Tsao P, Breeling J, Hauser E, Sun Y, Huang G, Casas J, Moser J, Whitbourne S, Brewer J, Conner T, Argyres D, Stephens B, Brophy M, Humphries D, Selva L, Do N, Shayan S, Cho K, Churby L, Wilson P, McArdle R, Dellitalia L, Mattocks K, Harley J, Whittle J, Jacono F, Wells J, Gutierrez S, Gibson G, Hammer K, Kaminsky L, Villareal G, Kinlay S, Xu J, Hamner M, Mathew R, Bhushan S, Iruvanti P, Godschalk M, Ballas Z, Ivins D, Mastorides S, Moorman J, Gappy S, Klein J, Ratcliffe N, Florez H, Okusaga O, Murdoch M, Sriram P, Yeh S, Tandon N, Jhala D, Liangpunsakul S, Oursler K, Whooley M, Ahuja S, Constans J, Meyer P, Greco J, Rauchman M, Servatius R, Gaddy M, Wallbom A, Morgan T, Stapley T, Sherman S, Ross G, Strollo P, Boyko E, Meyer L, Gupta S, Huq M, Fayad J, Hung A, Lichy J, Hurley R, Robey B, Striker R. Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans. JAMA Psychiatry 2023, 80: 135-145. PMID: 36515925, PMCID: PMC9857322, DOI: 10.1001/jamapsychiatry.2022.3896.
Dome1–JAK–STAT signaling between parasite and host integrates vector immunity and developmentRana V, Kitsou C, Dutta S, Ronzetti M, Zhang M, Bernard Q, Smith A, Tomás-Cortázar J, Yang X, Wu M, Kepple O, Li W, Dwyer J, Matias J, Baljinnyam B, Oliver J, Rajeevan N, Pedra J, Narasimhan S, Wang Y, Munderloh U, Fikrig E, Simeonov A, Anguita J, Pal U. Dome1–JAK–STAT signaling between parasite and host integrates vector immunity and development. Science 2023, 379: eabl3837. PMID: 36634189, PMCID: PMC10122270, DOI: 10.1126/science.abl3837.
A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or MortalityVerma A, Minnier J, Wan ES, Huffman JE, Gao L, Joseph J, Ho YL, Wu WC, Cho K, Gorman BR, Rajeevan N, Pyarajan S, Garcon H, Meigs JB, Sun YV, Reaven PD, McGeary JE, Suzuki A, Gelernter J, Lynch JA, Petersen JM, Zekavat SM, Natarajan P, Dalal S, Jhala DN, Arjomandi M, Gatsby E, Lynch KE, Bonomo RA, Freiberg M, Pathak GA, Zhou JJ, Donskey CJ, Madduri RK, Wells QS, Huang R, Polimanti R, Chang KM, Liao KP, Tsao PS, Wilson PWF, Hung A, O’Donnell C, Gaziano JM, Hauger RL, Iyengar S, Luoh SW, Initiative T. A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 1220-1229. PMID: 35771531, PMCID: PMC9746845, DOI: 10.1164/rccm.202109-2166oc.
Tick transmission of Borrelia burgdorferi to the murine host is not influenced by environmentally acquired midgut microbiotaNarasimhan S, Rajeevan N, Graham M, Wu MJ, DePonte K, Marion S, Masson O, O’Neal A, Pedra JHF, Sonenshine DE, Fikrig E. Tick transmission of Borrelia burgdorferi to the murine host is not influenced by environmentally acquired midgut microbiota. Microbiome 2022, 10: 173. PMID: 36253842, PMCID: PMC9575305, DOI: 10.1186/s40168-022-01378-w.
Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use DisorderDeak JD, Levey DF, Wendt FR, Zhou H, Galimberti M, Kranzler HR, Gaziano JM, Stein MB, Polimanti R, Gelernter J, Muralidhar S, Moser J, Deen J, Gaziano J, Beckham J, Chang K, Tsao P, Luoh S, Casas J, Churby L, Whitbourne S, Brewer J, Brophy M, Selva L, Shayan S, Cho K, Pyarajan S, DuVall S, Connor T, Argyres D, Aslan M, Stephens B, Concato J, Gelernter J, Gleason T, Huang G, Koenen K, Marx C, Radhakrishnan K, Schork N, Stein M, Zhao H, Kaufman J, Nunez Y, Pietrzak R, Beck D, Cissell S, Crutchfield P, Lance W, Cheung K, Li Y, Sun N, Chen Q, Rajeevan N, Sayward F, Gagnon D, Harrington K, Quaden R, O'Leary T, Ramoni R. Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder. JAMA Network Open 2022, 5: e2238880. PMID: 36301540, PMCID: PMC9614582, DOI: 10.1001/jamanetworkopen.2022.38880.
Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care SystemBigdeli TB, Voloudakis G, Barr PB, Gorman BR, Genovese G, Peterson RE, Burstein DE, Velicu VI, Li Y, Gupta R, Mattheisen M, Tomasi S, Rajeevan N, Sayward F, Radhakrishnan K, Natarajan S, Malhotra AK, Shi Y, Zhao H, Kosten TR, Concato J, O’Leary T, Przygodzki R, Gleason T, Pyarajan S, Brophy M, Huang GD, Muralidhar S, Gaziano JM, Aslan M, Fanous AH, Harvey PD, Roussos P, Aslan M, Antonelli M, de Asis M, Bauer M, Brophy M, Concato J, Cunningham F, Freedman R, Gaziano M, Gleason T, Harvey P, Huang G, Kelsoe J, Kosten T, Lehner T, Lohr J, Marder S, Miller P, O Leary T, Patterson T, Peduzzi P, Przygodski R, Siever L, Sklar P, Strakowski S, Zhao H, Fanous A, Farwell W, Malhorta A, Mane S, Palacios P, Bigdeli T, Corsey M, Zaluda L, Johnson J, Sueiro M, Cavaliere D, Jeanpaul V, Maffucci A, Mancini L, Deen J, Muldoon G, Whitbourne S, Canive J, Adamson L, Calais L, Fuldauer G, Kushner R, Toney G, Lackey M, Mank A, Mahdavi N, Villarreal G, Muly E, Amin F, Dent M, Wold J, Fischer B, Elliott A, Felix C, Gill G, Parker P, Logan C, McAlpine J, DeLisi L, Reece S, Hammer M, Agbor-Tabie D, Goodson W, Aslam M, Grainger M, Richtand N, Rybalsky A, Al Jurdi R, Boeckman E, Natividad T, Smith D, Stewart M, Torres S, Zhao Z, Mayeda A, Green A, Hofstetter J, Ngombu S, Scott M, Strasburger A, Sumner J, Paschall G, Mucciarelli J, Owen R, Theus S, Tompkins D, Potkin S, Reist C, Novin M, Khalaghizadeh S, Douyon R, Kumar N, Martinez B, Sponheim S, Bender T, Lucas H, Lyon A, Marggraf M, Sorensen L, Surerus C, Sison C, Amato J, Johnson D, Pagan-Howard N, Adler L, Alerpin S, Leon T, Mattocks K, Araeva N, Sullivan J, Suppes T, Bratcher K, Drag L, Fischer E, Fujitani L, Gill S, Grimm D, Hoblyn J, Nguyen T, Nikolaev E, Shere L, Relova R, Vicencio A, Yip M, Hurford I, Acheampong S, Carfagno G, Haas G, Appelt C, Brown E, Chakraborty B, Kelly E, Klima G, Steinhauer S, Hurley R, Belle R, Eknoyan D, Johnson K, Lamotte J, Granholm E, Bradshaw K, Holden J, Jones R, Le T, Molina I, Peyton M, Ruiz I, Sally L, Tapp A, Devroy S, Jain V, Kilzieh N, Maus L, Miller K, Pope H, Wood A, Meyer E, Givens P, Hicks P, Justice S, McNair K, Pena J, Tharp D, Davis L, Ban M, Cheatum L, Darr P, Grayson W, Munford J, Whitfield B, Wilson E, Melnikoff S, Schwartz B, Tureson M, D Souza D, Forselius K, Ranganathan M, Rispoli L, Sather M, Colling C, Haakenson C, Kruegar D, Muralidhar S, Ramoni R, Breeling J, Chang K, O Donnell C, Tsao P, Moser J, Brewer J, Warren S, Argyres D, Stevens B, Humphries D, Do N, Shayan S, Nguyen X, Pyarajan S, Cho K, Hauser E, Sun Y, Wilson P, McArdle R, Dellitalia L, Harley J, Whittle J. Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System. JAMA Psychiatry 2022, 79: 1092-1101. PMID: 36103194, PMCID: PMC9475441, DOI: 10.1001/jamapsychiatry.2022.2742.
Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell TraitVerma A, Huffman JE, Gao L, Minnier J, Wu WC, Cho K, Ho YL, Gorman BR, Pyarajan S, Rajeevan N, Garcon H, Joseph J, McGeary JE, Suzuki A, Reaven PD, Wan ES, Lynch JA, Petersen JM, Meigs JB, Freiberg MS, Gatsby E, Lynch KE, Zekavat SM, Natarajan P, Dalal S, Jhala DN, Arjomandi M, Bonomo RA, Thompson TK, Pathak GA, Zhou JJ, Donskey CJ, Madduri RK, Wells QS, Gelernter J, Huang RDL, Polimanti R, Chang KM, Liao KP, Tsao PS, Sun YV, Wilson PWF, O’Donnell C, Hung AM, Gaziano JM, Hauger RL, Iyengar SK, Luoh SW, Muralidhar S, Beckham J, Moser J, Thomann L, Garcon H, Kosik N, Damrauer S, Assimes T, Roussos P, Striker R, Tuteja S, DuVall S, Lynch K, Gatsby E, Ramoni R, Breeling J, Huang G, Whitbourne S, Brewer J, Aslan M, Connor T, Argyres D, Stephens B, Brophy M, Humphries D, Selva L, Do N, Shayan S, Churby L, Hauser E, Zhao H, Wilson P, McArdle R, Dellitalia L, Mattocks K, Harley J, Whittle J, Jacono F, Wells J, Gutierrez S, Gibson G, Hammer K, Kaminsky L, Villareal G, Kinlay S, Xu J, Hamner M, Mathew R, Bhushan S, Iruvanti P, Godschalk M, Ballas Z, Ivins D, Mastorides S, Moorman J, Gappy S, Klein J, Ratcliffe N, Florez H, Okusaga O, Murdoch M, Sriram P, Yeh S, Tandon N, Jhala D, Aguayo S, Cohen D, Sharma S, Liangpunsakul S, Oursler K, Whooley M, Ahuja S, Constans J, Meyer P, Greco J, Rauchman M, Servatius R, Gaddy M, Wallbom A, Morgan T, Stapley T, Sherman S, Ross G, Tsao P, Strollo P, Boyko E, Meyer L, Gupta S, Huq M, Fayad J, Hung A, Lichy J, Hurley R, Robey B. Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait. JAMA Internal Medicine 2022, 182: 796-804. PMID: 35759254, PMCID: PMC9237798, DOI: 10.1001/jamainternmed.2022.2141.
P515. Genomic Analyses of Schizophrenia and Bipolar Disorder Patients With Very Poor OutcomesHarvey P, Bigdeli T, Fanous A, Rajeevan N, Gorman B, Genovese G, Li Y, Sayward F, Pyarajan S, Aslan M. P515. Genomic Analyses of Schizophrenia and Bipolar Disorder Patients With Very Poor Outcomes. Biological Psychiatry 2022, 91: s297. DOI: 10.1016/j.biopsych.2022.02.752.
TU72. GENOMIC ANALYSES OF SCHIZOPHRENIA AND BIPOLAR PATIENTS WITH VERY POOR OUTCOMESHarvey P, Bigdeli T, Li Y, Rajeevan N, Gorman B, Pyarajan S, Gaziano M, Genovese G, Fanous A, O'Leary T, Gleason T, Przygodzki R, Huang G, Muralidhar S, Group M. TU72. GENOMIC ANALYSES OF SCHIZOPHRENIA AND BIPOLAR PATIENTS WITH VERY POOR OUTCOMES. European Neuropsychopharmacology 2021, 51: e134-e135. DOI: 10.1016/j.euroneuro.2021.08.074.
Polygenic Breast Cancer Risk for Women Veterans in the Million Veteran ProgramMinnier J, Rajeevan N, Gao L, Park B, Pyarajan S, Spellman P, Haskell SG, Brandt CA, Luoh SW. Polygenic Breast Cancer Risk for Women Veterans in the Million Veteran Program. JCO Precision Oncology 2021, 5: 1178-1191. PMID: 34381935, PMCID: PMC8345920, DOI: 10.1200/po.20.00541.
Cooperative studies Program (CSP) #572: A study of serious mental illness in veterans as a pathway to personalized medicine in schizophrenia and bipolar illnessHarvey PD, Bigdeli TB, Fanous AH, Li Y, Rajeevan N, Sayward F, Radhakrishnan K, Huang G, Aslan M. Cooperative studies Program (CSP) #572: A study of serious mental illness in veterans as a pathway to personalized medicine in schizophrenia and bipolar illness. Personalized Medicine In Psychiatry 2021, 27: 100078. PMID: 34222732, PMCID: PMC8247126, DOI: 10.1016/j.pmip.2021.100078.
Genomic and Phenomic Correlates of Suicidality Among US Veterans With Schizophrenia or Bipolar DisorderBigdeli T, Peterson R, Khankari N, Rajeevan N, Swann A, Sayward F, Meyers J, Li Y, Nielsen D, Wilkinson A, Graham D, O'Leary T, Zhao H, Cheung K, Mane S, Miller P, Brophy M, Program M, Przygodszki R, Siever L, Pyarajan S, Gleason T, Muralidhar S, Gaziano J, Concato J, Huang G, Fanous A, Aslan M, Kosten T, Harvey P. Genomic and Phenomic Correlates of Suicidality Among US Veterans With Schizophrenia or Bipolar Disorder. Biological Psychiatry 2021, 89: s237-s238. DOI: 10.1016/j.biopsych.2021.02.596.
Abstract PS7-07: Predicting breast cancer risk for women veteransLuoh S, Brandt C, Haskell S, Gao L, Park B, Spellman P, Pyarajan S, Program M, Rajeevan N, Minnier J. Abstract PS7-07: Predicting breast cancer risk for women veterans. Cancer Research 2021, 81: ps7-07-ps7-07. DOI: 10.1158/1538-7445.sabcs20-ps7-07.
Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US VeteransBigdeli TB, Fanous AH, Li Y, Rajeevan N, Sayward F, Genovese G, Gupta R, Radhakrishnan K, Malhotra AK, Sun N, Lu Q, Hu Y, Li B, Chen Q, Mane S, Miller P, Cheung KH, Gur RE, Greenwood TA, Braff DL, on the Genetics of Schizophrenia C, Achtyes ED, Buckley PF, Escamilla MA, Lehrer D, Malaspina DP, McCarroll SA, Rapaport MH, Vawter P, Pato MT, Pato CN, Investigators G, Zhao H, Kosten TR, Brophy M, Pyarajan S, Shi Y, O’Leary T, Gleason T, Przygodzki R, Muralidhar S, Gaziano JM, Program M, Huang GD, Concato J, Siever LJ, Aslan M, Harvey PD. Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans. Schizophrenia Bulletin 2020, 47: sbaa133-. PMID: 33169155, PMCID: PMC7965063, DOI: 10.1093/schbul/sbaa133.
S173. GENOME-WIDE ASSOCIATION STUDIES OF SCHIZOPHRENIA AND BIPOLAR DISORDER IN A DIVERSE COHORT OF US VETERANSBigdeli T, Fanous A, Rajeevan N, Sayward F, Li Y, Brophy M, Pyarajan S, Gleason T, Przygodszki R, Gaziano M, O’Leary T, Muralidhar S, , Huang G, Concato J, Siever L, Aslan M, Harvey P. S173. GENOME-WIDE ASSOCIATION STUDIES OF SCHIZOPHRENIA AND BIPOLAR DISORDER IN A DIVERSE COHORT OF US VETERANS. Schizophrenia Bulletin 2020, 46: s103-s103. PMCID: PMC7234483, DOI: 10.1093/schbul/sbaa031.239.
Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US VeteransBigdeli T, Fanous A, Li Y, Rajeevan N, Sayward F, Investigators G, Zhao H, Brophy M, Pyarajan S, O'Leary T, Gleason T, Przygodszki R, Muralidhar S, Gaziano J, Program M, Concato J, Siever L, Aslan M, Harvey P. Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans. Biological Psychiatry 2020, 87: s178. DOI: 10.1016/j.biopsych.2020.02.468.
Suicidal ideation, behavior, and mortality in male and female US veterans with severe mental illnessAslan M, Radhakrishnan K, Rajeevan N, Sueiro M, Goulet JL, Li Y, Depp C, Concato J, Harvey PD. Suicidal ideation, behavior, and mortality in male and female US veterans with severe mental illness. Journal Of Affective Disorders 2020, 267: 144-152. PMID: 32063566, DOI: 10.1016/j.jad.2020.02.022.
Genome‐wide association study of cognitive performance in U.S. veterans with schizophrenia or bipolar disorderHarvey PD, Sun N, Bigdeli TB, Fanous AH, Aslan M, Malhotra AK, Lu Q, Hu Y, Li B, Chen Q, Mane S, Miller P, Rajeevan N, Sayward F, Cheung K, Li Y, Greenwood TA, Gur RE, Braff DL, on the Genetics of Schizophrenia C, Brophy M, Pyarajan S, O'Leary TJ, Gleason T, Przygodszki R, Muralidhar S, Gaziano JM, Concato J, Zhao H, Siever LJ. Genome‐wide association study of cognitive performance in U.S. veterans with schizophrenia or bipolar disorder. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2019, 183: 181-194. PMID: 31872970, DOI: 10.1002/ajmg.b.32775.
Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veteransGelernter J, Sun N, Polimanti R, Pietrzak R, Levey DF, Bryois J, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Pyarajan S, Sullivan PF, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Concato J, Zhao H, Stein MB. Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans. Nature Neuroscience 2019, 22: 1394-1401. PMID: 31358989, PMCID: PMC6953633, DOI: 10.1038/s41593-019-0447-7.
Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk LociGelernter J, Sun N, Polimanti R, Pietrzak RH, Levey DF, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Honerlaw J, Pyarajan S, Lencz T, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Kranzler HR, Concato J, Zhao H, Stein MB, Program D, Program M. Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci. Biological Psychiatry 2019, 86: 365-376. PMID: 31151762, PMCID: PMC6919570, DOI: 10.1016/j.biopsych.2019.03.984.
M25 GENETICS OF COGNITIVE FUNCTION IN SCHIZOPHRENIA AND BIPOLAR DISORDERHarvey P, Sun N, Lu Q, Hu Y, Li B, Chen Q, Aslan M, Radhakrishnan K, Cheung K, Li Y, Sayward F, Rajeevan N, Zhao H, Gaziano M, Concato J. M25 GENETICS OF COGNITIVE FUNCTION IN SCHIZOPHRENIA AND BIPOLAR DISORDER. European Neuropsychopharmacology 2019, 29: s967-s968. DOI: 10.1016/j.euroneuro.2017.08.332.
Suicidal ideation and behavior in US veterans with schizophrenia or bipolar disorderHarvey PD, Posner K, Rajeevan N, Yershova KV, Aslan M, Concato J. Suicidal ideation and behavior in US veterans with schizophrenia or bipolar disorder. Journal Of Psychiatric Research 2018, 102: 216-222. PMID: 29698922, DOI: 10.1016/j.jpsychires.2018.04.014.
Effect of the Tool to Reduce Inappropriate Medications on Medication Communication and DeprescribingFried TR, Niehoff KM, Street RL, Charpentier PA, Rajeevan N, Miller PL, Goldstein MK, O'Leary JR, Fenton BT. Effect of the Tool to Reduce Inappropriate Medications on Medication Communication and Deprescribing. Journal Of The American Geriatrics Society 2017, 65: 2265-2271. PMID: 28804870, PMCID: PMC5641237, DOI: 10.1111/jgs.15042.
Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonizationNarasimhan S, Schuijt TJ, Abraham NM, Rajeevan N, Coumou J, Graham M, Robson A, Wu MJ, Daffre S, Hovius JW, Fikrig E. Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization. Nature Communications 2017, 8: 184. PMID: 28775250, PMCID: PMC5543126, DOI: 10.1038/s41467-017-00208-0.
Utilizing patient data from the veterans administration electronic health record to support web-based clinical decision support: informatics challenges and issues from three clinical domainsRajeevan N, Niehoff KM, Charpentier P, Levin FL, Justice A, Brandt CA, Fried TR, Miller PL. Utilizing patient data from the veterans administration electronic health record to support web-based clinical decision support: informatics challenges and issues from three clinical domains. BMC Medical Informatics And Decision Making 2017, 17: 111. PMID: 28724368, PMCID: PMC5517800, DOI: 10.1186/s12911-017-0501-x.
Impact of genotyping errors on statistical power of association tests in genomic analyses: A case studyHou L, Sun N, Mane S, Sayward F, Rajeevan N, Cheung K, Cho K, Pyarajan S, Aslan M, Miller P, Harvey PD, Gaziano JM, Concato J, Zhao H. Impact of genotyping errors on statistical power of association tests in genomic analyses: A case study. Genetic Epidemiology 2016, 41: 152-162. PMID: 28019059, PMCID: PMC5604789, DOI: 10.1002/gepi.22027.
Development of the Tool to Reduce Inappropriate Medications (TRIM): A Clinical Decision Support System to Improve Medication Prescribing for Older AdultsNiehoff KM, Rajeevan N, Charpentier PA, Miller PL, Goldstein MK, Fried TR. Development of the Tool to Reduce Inappropriate Medications (TRIM): A Clinical Decision Support System to Improve Medication Prescribing for Older Adults. Pharmacotherapy The Journal Of Human Pharmacology And Drug Therapy 2016, 36: 694-701. PMID: 27041466, PMCID: PMC4919149, DOI: 10.1002/phar.1751.
Gut Microbiota of the Tick Vector Ixodes scapularis Modulate Colonization of the Lyme Disease SpirocheteNarasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, DePonte K, Fish D, Fikrig E. Gut Microbiota of the Tick Vector Ixodes scapularis Modulate Colonization of the Lyme Disease Spirochete. Cell Host & Microbe 2014, 15: 58-71. PMID: 24439898, PMCID: PMC3905459, DOI: 10.1016/j.chom.2013.12.001.
Exploring a Clinically Friendly Web-Based Approach to Clinical Decision Support Linked to the Electronic Health Record: Design Philosophy, Prototype Implementation, and Framework for AssessmentMiller P, Phipps M, Chatterjee S, Rajeevan N, Levin F, Frawley S, Tokuno H. Exploring a Clinically Friendly Web-Based Approach to Clinical Decision Support Linked to the Electronic Health Record: Design Philosophy, Prototype Implementation, and Framework for Assessment. JMIR Medical Informatics 2014, 2: e20. PMID: 25580426, PMCID: PMC4288105, DOI: 10.2196/medinform.3586.
Diffusion Tensor Imaging in Autism Spectrum Disorders: Preliminary Evidence of Abnormal Neural ConnectivityJou RJ, Jackowski AP, Papademetris X, Rajeevan N, Staib LH, Volkmar FR. Diffusion Tensor Imaging in Autism Spectrum Disorders: Preliminary Evidence of Abnormal Neural Connectivity. Australian & New Zealand Journal Of Psychiatry 2011, 45: 153-162. PMID: 21128874, PMCID: PMC3123660, DOI: 10.3109/00048674.2010.534069.
Testing Predictions From Personality NeuroscienceDeYoung CG, Hirsh JB, Shane MS, Papademetris X, Rajeevan N, Gray JR. Testing Predictions From Personality Neuroscience. Psychological Science 2010, 21: 820-828. PMID: 20435951, PMCID: PMC3049165, DOI: 10.1177/0956797610370159.
Variation in orbitofrontal cortex volume: relation to sex, emotion regulation and affectWelborn BL, Papademetris X, Reis DL, Rajeevan N, Bloise SM, Gray JR. Variation in orbitofrontal cortex volume: relation to sex, emotion regulation and affect. Social Cognitive And Affective Neuroscience 2009, 4: 328-339. PMID: 20019072, PMCID: PMC2799952, DOI: 10.1093/scan/nsp028.
Arterial transit time effects in pulsed arterial spin labeling CBF mapping: Insight from a PET and MR study in normal human subjectsQiu M, Maguire R, Arora J, Planeta‐Wilson B, Weinzimmer D, Wang J, Wang Y, Kim H, Rajeevan N, Huang Y, Carson RE, Constable RT. Arterial transit time effects in pulsed arterial spin labeling CBF mapping: Insight from a PET and MR study in normal human subjects. Magnetic Resonance In Medicine 2009, 63: 374-384. PMID: 19953506, PMCID: PMC2867043, DOI: 10.1002/mrm.22218.
Functional connectivity and alterations in baseline brain state in humansMartuzzi R, Ramani R, Qiu M, Rajeevan N, Constable RT. Functional connectivity and alterations in baseline brain state in humans. NeuroImage 2009, 49: 823-834. PMID: 19631277, PMCID: PMC2764802, DOI: 10.1016/j.neuroimage.2009.07.028.
Release of Adaptation and Isolation of a Pure Cognitive Effect in MMN Reveals Evidence for Serial PredictionLaufer I, Negishi M, Rajeevan N, Lacadie C, Constable. Release of Adaptation and Isolation of a Pure Cognitive Effect in MMN Reveals Evidence for Serial Prediction. NeuroImage 2009, 47: s42. DOI: 10.1016/s1053-8119(09)70007-2.
Brain Connectivity Changes Induced by Sevoflurane as Assessed using Intrinsic Connectivity ContrastMartuzzi R, Rajeevan N, Qiu M, Ramani R, Constable. Brain Connectivity Changes Induced by Sevoflurane as Assessed using Intrinsic Connectivity Contrast. NeuroImage 2009, 47: s82. DOI: 10.1016/s1053-8119(09)70591-9.
Alterations in neural connectivity in preterm children at school ageGozzo Y, Vohr B, Lacadie C, Hampson M, Katz KH, Maller-Kesselman J, Schneider KC, Peterson BS, Rajeevan N, Makuch RW, Constable RT, Ment LR. Alterations in neural connectivity in preterm children at school age. NeuroImage 2009, 48: 458-463. PMID: 19560547, PMCID: PMC2775072, DOI: 10.1016/j.neuroimage.2009.06.046.
Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjectsQiu M, Ramani R, Swetye M, Rajeevan N, Constable RT. Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects. Magnetic Resonance In Medicine 2008, 60: 987-996. PMID: 18816821, PMCID: PMC2716171, DOI: 10.1002/mrm.21759.
More accurate Talairach coordinates for neuroimaging using non-linear registrationLacadie CM, Fulbright RK, Rajeevan N, Constable RT, Papademetris X. More accurate Talairach coordinates for neuroimaging using non-linear registration. NeuroImage 2008, 42: 717-725. PMID: 18572418, PMCID: PMC2603575, DOI: 10.1016/j.neuroimage.2008.04.240.
Sensory and cognitive mechanisms of change detection in the context of speechLaufer I, Negishi M, Rajeevan N, Lacadie CM, Constable RT. Sensory and cognitive mechanisms of change detection in the context of speech. Brain Structure And Function 2008, 212: 427-442. PMID: 18193453, PMCID: PMC2248604, DOI: 10.1007/s00429-007-0167-8.
BioImage Suite: An integrated medical image analysis suite: An update.Papademetris X, Jackowski MP, Rajeevan N, DiStasio M, Okuda H, Constable RT, Staib LH. BioImage Suite: An integrated medical image analysis suite: An update. Insight Journal 2006, 2006: 209. PMID: 25364771, PMCID: PMC4213804, DOI: 10.54294/2g80r4.
Disturbed Coupling of rCBF, BOLD and CMRO2 in the Presence of Stimuli During Anesthesia As Revealed by Simultaneous BOLD and CBF Functional Magnetic Resonance ImagingQiu M, Ramani R, Shulman R, Hyder F, Rajeevan N, Constable R. Disturbed Coupling of rCBF, BOLD and CMRO2 in the Presence of Stimuli During Anesthesia As Revealed by Simultaneous BOLD and CBF Functional Magnetic Resonance Imaging. Journal Of Neurosurgical Anesthesiology 2005, 17: 224-225. DOI: 10.1097/01.ana.0000187715.47773.67.
BioImage Suite: An integrated medical image analysis suitePapademetris X, Jackowski M, Rajeevan N, Constable R, Staib L. BioImage Suite: An integrated medical image analysis suite. Insight Journal 2005 DOI: 10.54294/vb5z20.
Test-retest reproducibility of extrastriatal dopamine D2 receptor imaging with [123I]epidepride SPECT in humans.Varrone A, Fujita M, Verhoeff NP, Zoghbi SS, Baldwin RM, Rajeevan N, Charney DS, Seibyl JP, Innis RB. Test-retest reproducibility of extrastriatal dopamine D2 receptor imaging with [123I]epidepride SPECT in humans. Journal Of Nuclear Medicine 2000, 41: 1343-51. PMID: 10945525.
Graphical analysis and simplified quantification of striatal and extrastriatal dopamine D2 receptor binding with [123I]epidepride SPECT.Ichise M, Fujita M, Seibyl JP, Verhoeff NP, Baldwin RM, Zoghbi SS, Rajeevan N, Charney DS, Innis RB. Graphical analysis and simplified quantification of striatal and extrastriatal dopamine D2 receptor binding with [123I]epidepride SPECT. Journal Of Nuclear Medicine 1999, 40: 1902-12. PMID: 10565788.
Kinetic and equilibrium analyses of [123I]epidepride binding to striatal and extrastriatal dopamine D2 receptorsFujita M, Seibyl J, Verhoeff N, Ichise M, Baldwin R, Zoghbi S, Burger C, Staley J, Rajeevan N, Charney D, Innis R. Kinetic and equilibrium analyses of [123I]epidepride binding to striatal and extrastriatal dopamine D2 receptors. Synapse 1999, 34: 290-304. PMID: 10529723, DOI: 10.1002/(sici)1098-2396(19991215)34:4<290::aid-syn5>3.0.co;2-b.
Effects of Vigabatrin on the GABAergic System as Determined by [123I]Iomazenil SPECT and GABA MRSVerhoeff N, Petroff O, Hyder F, Zoghbi S, Fujita M, Rajeevan N, Rothman D, Seibyl J, Mattson R, Innis R. Effects of Vigabatrin on the GABAergic System as Determined by [123I]Iomazenil SPECT and GABA MRS. Epilepsia 1999, 40: 1433-1438. PMID: 10528940, DOI: 10.1111/j.1528-1157.1999.tb02016.x.
[123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophreniaVerhoeff N, Soares J, D’Souza C, Gil R, Degen K, Abi-Dargham A, Zoghbi S, Fujita M, Rajeevan N, Seibyl J, Krystal J, van Dyck C, Charney D, Innis R. [123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia. Psychiatry Research 1999, 91: 163-173. PMID: 10641580, DOI: 10.1016/s0925-4927(99)00027-x.
Changes of benzodiazepine receptors during chronic benzodiazepine administration in humansFujita M, Woods S, Verhoeff N, Abi-Dargham A, Baldwin R, Zoghbi S, Soares J, Jatlow P, Krystal J, Rajeevan N, Charney D, Seibyl J, Innis R. Changes of benzodiazepine receptors during chronic benzodiazepine administration in humans. European Journal Of Pharmacology 1999, 368: 161-172. PMID: 10193652, DOI: 10.1016/s0014-2999(99)00013-8.
Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenilAbi-Dargham A, Krystal JH, Anjilvel S, Scanley BE, Zoghbi S, Baldwin RM, Rajeevan N, Ellis S, Petrakis IL, Seibyl JP, Charney DS, Laruelle M, Innis RB. Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenil. American Journal Of Psychiatry 1998, 155: 1550-1555. PMID: 9812116, DOI: 10.1176/ajp.155.11.1550.
Significance of nonuniform attenuation correction in quantitative brain SPECT imaging.Rajeevan N, Zubal IG, Ramsby SQ, Zoghbi SS, Seibyl J, Innis RB. Significance of nonuniform attenuation correction in quantitative brain SPECT imaging. Journal Of Nuclear Medicine 1998, 39: 1719-26. PMID: 9776276.
Comparison of Methods for Quantitative Measurement of Striatal and Extrastriatal Dopamine D2/3 Receptors with [123I]EpideprideFujita M, Seibyl J, Verhoeff N, Baldwin R, Zoghbi S, Burger C, Ichise M, Staley J, Rajeevan N, Charney D, Innis R. Comparison of Methods for Quantitative Measurement of Striatal and Extrastriatal Dopamine D2/3 Receptors with [123I]Epidepride. NeuroImage 1998, 7: a60. DOI: 10.1016/s1053-8119(18)31929-3.
Image processing and analysis for medical applicationsDuncan J, Amir A, Staib L, Rajeevan N, Rangarajan A, Tagaer H, Curwen R, Lee M, Meyer F, Robinson G, Chakraborty A, McEachen J, Shi P, Zhang L, Zubal I, Zrischlunas P, Meloling C. Image processing and analysis for medical applications. ACM SIGBIO Newsletter 1994, 14: 8-9. DOI: 10.1145/192602.953451.
Vector-extrapolated fast maximum likelihood estimation algorithms for emission tomography.Rajeevan N, Rajgopal K, Krishna G. Vector-extrapolated fast maximum likelihood estimation algorithms for emission tomography. IEEE Transactions On Medical Imaging 1992, 11: 9-20. PMID: 18218351, DOI: 10.1109/42.126905.

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