Michelle Hampson, PhD
Research & Publications
Biography
News
Research Summary
We work on the development and application of new functional brain imaging paradigms with a current focus on real-time fMRI neurofeedback. This technique has great potential as a clinical treatment for mental and neurological disorders and is also a powerful perturb-and-measure tool for studying human brain function.
Extensive Research Description
1. We use neurofeedback of real-time fMRI data to train patients with tic disorders, OCD, PTSD, and borderline personality disorder to control clinically relevant brain activity patterns. An important question is whether this training can improve their symptoms.
2. We evaluate changes in resting state functional connectivity between brain areas before and after neurofeedback. This allows us to investigate how neurofeedback alters brain networks. Also, by correlating changes in brain connectivity with symptom changes, we can gain insight into the neural circuitry that gives rise to symptoms.
Coauthors
Research Interests
Magnetic Resonance Imaging; Neurosciences; Obsessive-Compulsive Disorder; Stress Disorders, Post-Traumatic; Video Games; Neurofeedback; Psychiatry and Psychology
Research Image
rt-fMRI_nfdbk
Selected Publications
- fMRI NeurofeedbackHampson, M., editor. fMRI Neurofeedback. Published in 2021 by Academic Press, Elsevier, Inc., London, United Kingdom.
- Neurofeedback for obsessive compulsive disorder: A randomized, double-blind trialRance M, Zhao Z, Zaboski B, Kichuk S, Romaker E, Koller W, Walsh C, Harris-Starling C, Wasylink S, Adams T, Gruner P, Pittenger C, Hampson M. Neurofeedback for obsessive compulsive disorder: A randomized, double-blind trial. Psychiatry Research 2023, 328: 115458. PMID: 37722238, DOI: 10.1016/j.psychres.2023.115458.
- Protocol description for a randomized controlled trial of fMRI neurofeedback for tics in adolescents with Tourette SyndromeAwasthi J, Harris-Starling C, Kalvin C, Pittman B, Park H, Bloch M, Fernandez T, Sukhodolsky D, Hampson M. Protocol description for a randomized controlled trial of fMRI neurofeedback for tics in adolescents with Tourette Syndrome. Psychiatry Research Neuroimaging 2023, 111692. PMID: 37673711, DOI: 10.1016/j.pscychresns.2023.111692.
- Amygdala downregulation training using fMRI neurofeedback in post-traumatic stress disorder: a randomized, double-blind trialZhao Z, Duek O, Seidemann R, Gordon C, Walsh C, Romaker E, Koller W, Horvath M, Awasthi J, Wang Y, O’Brien E, Fichtenholtz H, Hampson M, Harpaz-Rotem I. Amygdala downregulation training using fMRI neurofeedback in post-traumatic stress disorder: a randomized, double-blind trial. Translational Psychiatry 2023, 13: 177. PMID: 37230984, PMCID: PMC10209552, DOI: 10.1038/s41398-023-02467-6.
- HALO: A software tool for real‐time head alignment in the MR scannerZhao Z, Galiana G, Zillo C, Camarro T, Qiu M, Papademetris X, Hampson M. HALO: A software tool for real‐time head alignment in the MR scanner. Magnetic Resonance In Medicine 2022, 89: 1506-1513. PMID: 36426774, DOI: 10.1002/mrm.29535.
- Chapter 3 Protocol design in fMRI neurofeedback studiesHampson M, Linden D. Chapter 3 Protocol design in fMRI neurofeedback studies. 2021, 57-79. DOI: 10.1016/b978-0-12-822421-2.00012-0.
- Chapter 14 Ethical considerations for fMRI neurofeedbackCherkaoui M, Rissman J, Lau H, Hampson M. Chapter 14 Ethical considerations for fMRI neurofeedback. 2021, 315-331. DOI: 10.1016/b978-0-12-822421-2.00007-7.
- Chapter 9 The treatment and study of psychiatric disorders with fMRI neurofeedback☆Zhao Z, Romaker E, Hampson M. Chapter 9 The treatment and study of psychiatric disorders with fMRI neurofeedback☆. 2021, 207-237. DOI: 10.1016/b978-0-12-822421-2.00016-8.
- Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette SyndromeSukhodolsky DG, Walsh C, Koller WN, Eilbott J, Rance M, Fulbright RK, Zhao Z, Bloch MH, King R, Leckman JF, Scheinost D, Pittman B, Hampson M. Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome. Biological Psychiatry 2019, 87: 1063-1070. PMID: 31668476, PMCID: PMC7015800, DOI: 10.1016/j.biopsych.2019.07.035.
- Time course of clinical change following neurofeedbackRance M, Walsh C, Sukhodolsky DG, Pittman B, Qiu M, Kichuk SA, Wasylink S, Koller WN, Bloch M, Gruner P, Scheinost D, Pittenger C, Hampson M. Time course of clinical change following neurofeedback. NeuroImage 2018, 181: 807-813. PMID: 29729393, PMCID: PMC6454268, DOI: 10.1016/j.neuroimage.2018.05.001.
- Neural Correlates of Success and Failure Signals During Neurofeedback LearningRadua J, Stoica T, Scheinost D, Pittenger C, Hampson M. Neural Correlates of Success and Failure Signals During Neurofeedback Learning. Neuroscience 2016, 378: 11-21. PMID: 27063101, PMCID: PMC5537049, DOI: 10.1016/j.neuroscience.2016.04.003.
- Resting state functional connectivity predicts neurofeedback responseScheinost D, Stoica T, Wasylink S, Gruner P, Saksa J, Pittenger C, Hampson M. Resting state functional connectivity predicts neurofeedback response. Frontiers In Behavioral Neuroscience 2014, 8: 338. PMID: 25309375, PMCID: PMC4173810, DOI: 10.3389/fnbeh.2014.00338.
- Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivityScheinost D, Stoica T, Saksa J, Papademetris X, Constable RT, Pittenger C, Hampson M. Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity. Translational Psychiatry 2013, 3: e250-e250. PMID: 23632454, PMCID: PMC3641411, DOI: 10.1038/tp.2013.24.
- Functional connectivity between task-positive and task-negative brain areas and its relation to working memory performanceHampson M, Driesen N, Roth JK, Gore JC, Constable RT. Functional connectivity between task-positive and task-negative brain areas and its relation to working memory performance. Magnetic Resonance Imaging 2010, 28: 1051-1057. PMID: 20409665, PMCID: PMC2936669, DOI: 10.1016/j.mri.2010.03.021.
- Brain Areas Coactivating with Motor Cortex During Chronic Motor Tics and Intentional MovementsHampson M, Tokoglu F, King RA, Constable RT, Leckman JF. Brain Areas Coactivating with Motor Cortex During Chronic Motor Tics and Intentional Movements. Biological Psychiatry 2008, 65: 594-599. PMID: 19111281, PMCID: PMC2679868, DOI: 10.1016/j.biopsych.2008.11.012.
- Brain Connectivity Related to Working Memory PerformanceHampson M, Driesen NR, Skudlarski P, Gore JC, Constable RT. Brain Connectivity Related to Working Memory Performance. Journal Of Neuroscience 2006, 26: 13338-13343. PMID: 17182784, PMCID: PMC2677699, DOI: 10.1523/jneurosci.3408-06.2006.
- Connectivity–behavior analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading abilityHampson M, Tokoglu F, Sun Z, Schafer RJ, Skudlarski P, Gore JC, Constable RT. Connectivity–behavior analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading ability. NeuroImage 2006, 31: 513-519. PMID: 16497520, DOI: 10.1016/j.neuroimage.2005.12.040.
- Detection of functional connectivity using temporal correlations in MR imagesHampson M, Peterson BS, Skudlarski P, Gatenby JC, Gore JC. Detection of functional connectivity using temporal correlations in MR images. Human Brain Mapping 2002, 15: 247-262. PMID: 11835612, PMCID: PMC6872035, DOI: 10.1002/hbm.10022.
Clinical Trials
Conditions | Study Title |
---|---|
Mental Health & Behavioral Research | Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD |
Child Development & Autism; Diseases of the Nervous System; Genetics - Adult; Genetics - Pediatric; Mental Health & Behavioral Research | Genetic and molecular studies of developmental neuropsychiatric disorders |
Diseases of the Nervous System; Mental Health & Behavioral Research | Neurofeedback of Amygdala Activity for Post-traumatic Stress Disorder (PTSD) |
Child Development & Autism; Children's Health; Mental Health & Behavioral Research | CBT for Anxiety in Children With Autism |
Diseases of the Nervous System; Mental Health & Behavioral Research | Biomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder |
Diseases of the Nervous System; Mental Health & Behavioral Research | Neurofeedback for Obsessive-Compulsive Disorder |
Mental Health & Behavioral Research | Studying the Adult Brain |