Liza Konnikova, MD/PhD
Research & Publications
Biography
News
Research Summary
Dr. Konnikova is a Neonatologist who focuses on the development of neonatal immunity at barrier sites such as the GI tract and the maternal-fetal interface and how this is regulated by the microbiome and the associated metabolome. Her group further studies the pathogenesis of diverse diseases such as sepsis, preterm labor, necrotizing enterocolitis (NEC), very early onset (VEO) and pediatric IBD.
Extensive Research Description
Dr. Konnikova is an Attending Neonatologist, Mucosal Immunologist, and an Assistant Professor in Pediatrics and Obstetrics, Gynecology, and Reproductive Sciences. She is also a member of the Human and Translational Immunology Program and Program in Translational Biomedicine at the Yale School of Medicine. Her focus is on developing immunity at mucosal surfaces and its role in the pathogenesis of diverse diseases such as necrotizing enterocolitis (NEC), pediatric inflammatory bowel disease (IBD), sepsis, and preterm labor.
Using a systems biology approach and cutting-edge techniques such as imaging and suspension mass cytometry and single cell RNA sequencing, her group is currently focused on improving our understanding of how mucosal immunity develops at barrier sites such as the GI tract and the maternal-fetal interface and what goes awry to cause disease. To this end, she has established a large biorepository (over 5,000 samples) of control and disease cryopreserved intestinal and placental tissue. Using tissue from her biobank, her group have been able to study the development of human fetal intestinal immunity (Stras et al., Developmental Cell, 2019). In their pursuit to understand the source of antigens priming in utero T cells, the have established numeroud collaborations to study fetal intestinal microbiome and metabolome and were the first to show that human fetal intestinal tissue contains abundant and diverse bacterial metabolites in the absence of a detectable microbiome (Li and Toothaker et al, JCI Insight, 2020). Her group is also studying the development of enterocytes (Ergozi et al., Nature Medicine, 2021) where they have recently identified insulin-secreting enteroendocrine cells in the small fetal intestine with broad implications for gut development, immune regulation, and diabetes treatment.
Additionally, using a large cohort of over 100 patients with IBD, she has been able to characterize immune signatures differentiating ulcerative colitis and Crohn's disease (Mitsialis et al., Gastroenterology, 2020). Moreover, her group has identified unique immune populations in NEC (Olaloye et al., JEM, 2021). Finally, in the pursuit to better understand the contribution of fetal immunity to placental homeostasis, using a non-human primate model, her group has shown that fetal cells contribute to intra-amniotic inflammation (Toothaker et al., Frontiers, 2020). Similarly, her group has characterized the diverse immune-landscape of second trimester human placentas including fetal memory T cells (Development, 2022).
Coauthors
Research Interests
Infant Nutrition Disorders; Infant, Premature; Placenta; Inflammatory Bowel Diseases; Immunity, Mucosal; Enterocolitis, Necrotizing; Gastrointestinal Microbiome
Selected Publications
- Single cell analysis via mass cytometry of spontaneous intestinal perforation reveals alterations in small intestinal innate and adaptive mucosal immunityOlaloye O, Eke C, Jolteus A, Konnikova L. Single cell analysis via mass cytometry of spontaneous intestinal perforation reveals alterations in small intestinal innate and adaptive mucosal immunity Frontiers In Immunology 2023, 14: 995558. PMID: 36825028, PMCID: PMC9941693, DOI: 10.3389/fimmu.2023.995558.
- Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studiesKennedy K, de Goffau M, Perez-Muñoz M, Arrieta M, Bäckhed F, Bork P, Braun T, Bushman F, Dore J, de Vos W, Earl A, Eisen J, Elovitz M, Ganal-Vonarburg S, Gänzle M, Garrett W, Hall L, Hornef M, Huttenhower C, Konnikova L, Lebeer S, Macpherson A, Massey R, McHardy A, Koren O, Lawley T, Ley R, O’Mahony L, O’Toole P, Pamer E, Parkhill J, Raes J, Rattei T, Salonen A, Segal E, Segata N, Shanahan F, Sloboda D, Smith G, Sokol H, Spector T, Surette M, Tannock G, Walker A, Yassour M, Walter J. Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies Nature 2023, 613: 639-649. PMID: 36697862, DOI: 10.1038/s41586-022-05546-8.
- RIPK1 mutations causing infantile-onset IBD with inflammatory and fistulizing featuresSultan M, Adawi M, Kol N, McCourt B, Adawi I, Baram L, Tal N, Werner L, Lev A, Snapper S, Barel O, Konnikova L, Somech R, Shouval D. RIPK1 mutations causing infantile-onset IBD with inflammatory and fistulizing features Frontiers In Immunology 2022, 13: 1041315. PMID: 36466854, PMCID: PMC9716469, DOI: 10.3389/fimmu.2022.1041315.
- Insulin is expressed by enteroendocrine cells during human fetal developmentA E, D L, BT M, K B, L F, X A, F W, K C, L K, S I. Insulin is expressed by enteroendocrine cells during human fetal development 2022 DOI: 10.1530/ey.19.10.8.
- 524: PATHOGENIC RIPK1 MUTATIONS CAUSE INFANTILE-ONSET IBD WITH INFLAMMATORY AND FISTULIZING FEATURESSultan M, Wilschanski M, Millman P, McCourt B, Kol N, Lev A, Matar M, Barel O, Shamir R, Konnikova L, Somech R, Shouval D. 524: PATHOGENIC RIPK1 MUTATIONS CAUSE INFANTILE-ONSET IBD WITH INFLAMMATORY AND FISTULIZING FEATURES Gastroenterology 2022, 162: s-121-s-122. DOI: 10.1016/s0016-5085(22)60296-8.
- Renalase and its receptor, PMCA4b, are expressed in the placenta throughout the human gestationWang M, Silva T, Toothaker JM, McCourt BT, Shugrue C, Desir G, Gorelick F, Konnikova L. Renalase and its receptor, PMCA4b, are expressed in the placenta throughout the human gestation Scientific Reports 2022, 12: 4953. PMID: 35322081, PMCID: PMC8943056, DOI: 10.1038/s41598-022-08817-6.
- Insights into the Role of Commensal-Specific T Cells in Intestinal InflammationGehlhaar A, Inala A, Llivichuzhca-Loja D, Silva TN, Adegboye CY, O’Connell A, Konnikova L. Insights into the Role of Commensal-Specific T Cells in Intestinal Inflammation Journal Of Inflammation Research 2022, 15: 1873-1887. PMID: 35342295, PMCID: PMC8943607, DOI: 10.2147/jir.s288288.
- Immune landscape of human placental villi using single-cell analysisToothaker JM, Olaloye O, McCourt BT, McCourt CC, Silva TN, Case RM, Liu P, Yimlamai D, Tseng G, Konnikova L. Immune landscape of human placental villi using single-cell analysis Development 2022, 149 PMID: 35050308, PMCID: PMC8935213, DOI: 10.1242/dev.200013.
- DOP64 Pathogenic RIPK1 Mutations Cause Infantile-onset IBD with Inflammatory and Fistulizing FeaturesSultan M, Millman P, McCourt B, Kol N, Lev A, Matar M, Barel O, Shamir R, Wilschanski M, Konnikova L, Somech R, Shouval D. DOP64 Pathogenic RIPK1 Mutations Cause Infantile-onset IBD with Inflammatory and Fistulizing Features Journal Of Crohn's And Colitis 2022, 16: i109-i109. DOI: 10.1093/ecco-jcc/jjab232.103.
- CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infantsOlaloye OO, Liu P, Toothaker JM, McCourt BT, McCourt CC, Xiao J, Prochaska E, Shaffer S, Werner L, , , Gringauz J, Good M, Goldsmith JD, An X, Wang F, Snapper SB, Shouval D, Chen K, Tseng G, Konnikova L. CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants Journal Of Experimental Medicine 2021, 218: e20200344. PMID: 34269788, PMCID: PMC8289692, DOI: 10.1084/jem.20200344.
- Serum Analyte Profiles Associated With Crohn’s Disease and Disease LocationBoucher G, Paradis A, Chabot-Roy G, Coderre L, Hillhouse E, Bitton A, Des Rosiers C, Levings M, Schumm L, Lazarev M, Brant S, Duerr R, McGovern D, Silverberg M, Cho J, Lesage S, Rioux J, Bitton A, Boucher G, Charron G, Des Rosiers C, Forest A, Goyette P, Ivinson S, Joseph L, Kohen R, Lachaine J, Lesage S, Levings M, Rioux J, Thompson-Legault J, Vachon L, Veilleux S, White-Guay B, Bajpai M, Birch S, Bitton A, Borowski K, Botwin G, Boucher G, Brant S, Chen W, Cho J, Cordero R, Côté-Daigneault J, Daly M, Datta L, Duerr R, Filice M, Fleshner P, Gettler K, Giri M, Goyette P, Hao K, Haritunians T, Itan Y, Johnston E, Konnikova L, Landers C, Lazarev M, Li D, McGovern D, Mengesha E, Merad M, Miladinova V, Nayeri S, Proksell S, Raquel M, Rioux J, Rymaszewski K, Sabic K, Sands B, Schumm L, Schwartz M, Silverberg M, Simpson C, Stempak J, Stevens C, Targan S, Xavier R. Serum Analyte Profiles Associated With Crohn’s Disease and Disease Location Inflammatory Bowel Diseases 2021, 28: 9-20. PMID: 34106269, PMCID: PMC8730700, DOI: 10.1093/ibd/izab123.
- Genetic Signatures From RNA Sequencing of Pediatric Localized Scleroderma SkinMirizio E, Liu C, Yan Q, Waltermire J, Mandel R, Schollaert KL, Konnikova L, Wang X, Chen W, Torok KS. Genetic Signatures From RNA Sequencing of Pediatric Localized Scleroderma Skin Frontiers In Pediatrics 2021, 9: 669116. PMID: 34164359, PMCID: PMC8215272, DOI: 10.3389/fped.2021.669116.
- Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interfaceLu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Team Y, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface Med 2021, 2: 591-610.e10. PMID: 33969332, PMCID: PMC8084634, DOI: 10.1016/j.medj.2021.04.016.
- Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemiaKonnikova L, Robinson TO, Owings AH, Shirley JF, Davis E, Tang Y, Wall S, Li J, Hasan MH, Gharaibeh RZ, Mendoza Alvarez LB, Ryan LK, Doty A, Chovanec JF, O'Connell MP, Grunes DE, Daley WP, Mayer E, Chang L, Liu J, Snapper SB, Milner JD, Glover SC, Lyons JJ. Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemia Journal Of Allergy And Clinical Immunology 2021, 148: 813-821.e7. PMID: 33865872, PMCID: PMC9017395, DOI: 10.1016/j.jaci.2021.04.004.
- Gestational Age-Specific Complete Blood Count Signatures in Necrotizing EnterocolitisPantalone JM, Liu S, Olaloye OO, Prochaska EC, Yanowitz T, Riley MM, Buland JR, Brozanski BS, Good M, Konnikova L. Gestational Age-Specific Complete Blood Count Signatures in Necrotizing Enterocolitis Frontiers In Pediatrics 2021, 9: 604899. PMID: 33718296, PMCID: PMC7952609, DOI: 10.3389/fped.2021.604899.
- SARS-CoV-2 infection in pregnancy is associated with robust inflammatory response at the maternal-fetal interface.Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. SARS-CoV-2 infection in pregnancy is associated with robust inflammatory response at the maternal-fetal interface. MedRxiv : The Preprint Server For Health Sciences 2021 PMID: 33532791, PMCID: PMC7852242, DOI: 10.1101/2021.01.25.21250452.
- In utero human intestine harbors unique metabolomic features including bacterial metabolitesLi Y, Toothaker JM, Ben-Simon S, Ozeri L, Schweitzer R, McCourt BT, McCourt CC, Werner L, Snapper SB, Shouval DS, Khatib S, Koren O, Agnihorti S, Tseng G, Konnikova L. In utero human intestine harbors unique metabolomic features including bacterial metabolites JCI Insight 2020, 5: e138751. PMID: 33001863, PMCID: PMC7710283, DOI: 10.1172/jci.insight.138751.
- Serum IgG4 Subclass Deficiency Defines a Distinct, Commonly Encountered, Severe Inflammatory Bowel Disease SubtypeKoutroumpakis F, Phillips AE, Yadav D, Machicado JD, Ahsan M, Rivers C, Tan X, Schwartz M, Proksell S, Johnston E, Dueker J, Hashash JG, Barrie A, Harrison J, Dunn MA, Konnikova L, Hartman DJ, Din H, Babichenko D, Tang G, Binion DG. Serum IgG4 Subclass Deficiency Defines a Distinct, Commonly Encountered, Severe Inflammatory Bowel Disease Subtype Inflammatory Bowel Diseases 2020, 27: 855-863. PMID: 32879976, DOI: 10.1093/ibd/izaa230.
- An RTEL1 Mutation Links to Infantile-Onset Ulcerative Colitis and Severe ImmunodeficiencyZiv A, Werner L, Konnikova L, Awad A, Jeske T, Hastreiter M, Mitsialis V, Stauber T, Wall S, Kotlarz D, Klein C, Snapper SB, Tzfati Y, Weiss B, Somech R, Shouval DS. An RTEL1 Mutation Links to Infantile-Onset Ulcerative Colitis and Severe Immunodeficiency Journal Of Clinical Immunology 2020, 40: 1010-1019. PMID: 32710398, DOI: 10.1007/s10875-020-00829-z.
- Artificial-cell-type aware cell-type classification in CITE-seqLian Q, Xin H, Ma J, Konnikova L, Chen W, Gu J, Chen K. Artificial-cell-type aware cell-type classification in CITE-seq Bioinformatics 2020, 36: i542-i550. PMID: 32657383, PMCID: PMC7355304, DOI: 10.1093/bioinformatics/btaa467.
- Immune Cells in the Placental Villi Contribute to Intra-amniotic InflammationToothaker JM, Presicce P, Cappelletti M, Stras SF, McCourt CC, Chougnet CA, Kallapur SG, Konnikova L. Immune Cells in the Placental Villi Contribute to Intra-amniotic Inflammation Frontiers In Immunology 2020, 11: 866. PMID: 32528468, PMCID: PMC7256198, DOI: 10.3389/fimmu.2020.00866.
- The Protective Effects of Calcineurin on Pancreatitis in Mice Depend on the Cellular SourceWen L, Javed TA, Dobbs AK, Brown R, Niu M, Li L, Khalid A, Barakat M, Xiao X, Yimlamai D, Konnikova L, Yu M, Byersdorfer CA, Husain SZ. The Protective Effects of Calcineurin on Pancreatitis in Mice Depend on the Cellular Source Gastroenterology 2020, 159: 1036-1050.e8. PMID: 32445858, PMCID: PMC7502475, DOI: 10.1053/j.gastro.2020.05.051.
- Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn’s DiseaseMitsialis V, Wall S, Liu P, Ordovas-Montanes J, Parmet T, Vukovic M, Spencer D, Field M, McCourt C, Toothaker J, Bousvaros A, Center B, Ballal S, Bonilla S, Fawaz R, Fishman L, Flores A, Fox V, Grover A, Higuchi L, Huh S, Kahn S, Lee C, Mobassaleh M, Ouahed J, Pleskow R, Regan B, Rufo P, Sabharwal S, Silverstein J, Verhave M, Wolf A, Zimmerman L, Zitomersky N, Center B, Allegretti J, De Silva P, Friedman S, Hamilton M, Korzenik J, Makrauer F, Norton B, Winter R, Shalek A, Kean L, Horwitz B, Goldsmith J, Tseng G, Snapper S, Konnikova L. Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn’s Disease Gastroenterology 2020, 159: 591-608.e10. PMID: 32428507, PMCID: PMC8166295, DOI: 10.1053/j.gastro.2020.04.074.
- Role of Nutrition in Prevention of Neonatal Spontaneous Intestinal Perforation and Its Complications: A Systematic ReviewOlaloye O, Swatski M, Konnikova L. Role of Nutrition in Prevention of Neonatal Spontaneous Intestinal Perforation and Its Complications: A Systematic Review Nutrients 2020, 12: 1347. PMID: 32397283, PMCID: PMC7284579, DOI: 10.3390/nu12051347.
- Su1867 BIG DATA ANALYTICS DEMONSTRATE A NOVEL, UNEXPECTED ASSOCIATION OF LOW SERUM IGG4 ANTIBODIES WITH INCREASED DISEASE SEVERITY IN 20% OF IBD PATIENTSKoutroumpakis F, Phillips A, Yadav D, Ahsan M, Rivers C, Machicado J, Tan X, Proksell S, Johnston E, Dueker J, Din H, Jana H, Tang G, Babichenko D, Barrie A, Hartman D, Konnikova L, Dunn M, Binion D. Su1867 BIG DATA ANALYTICS DEMONSTRATE A NOVEL, UNEXPECTED ASSOCIATION OF LOW SERUM IGG4 ANTIBODIES WITH INCREASED DISEASE SEVERITY IN 20% OF IBD PATIENTS Gastroenterology 2020, 158: s-681-s-682. DOI: 10.1016/s0016-5085(20)32394-5.
- 317 CYTOF ANALYSIS OF HUMAN COLON AND BLOOD REVEALS DISTINCT IMMUNE SIGNATURES OF ULCERATIVE COLITIS AND CROHN'S DISEASEMitsialis V, Wall S, Liu P, Ordovas-Montanes J, Parmet T, Field M, McCourt C, Toothaker J, Goldsmith J, Kean L, Shalek A, Tseng G, Konnikova L, Snapper S. 317 CYTOF ANALYSIS OF HUMAN COLON AND BLOOD REVEALS DISTINCT IMMUNE SIGNATURES OF ULCERATIVE COLITIS AND CROHN'S DISEASE Gastroenterology 2020, 158: s-57. DOI: 10.1016/s0016-5085(20)30824-6.
- Recent Advances in Computer-Assisted Algorithms for Cell Subtype Identification of Cytometry DataLiu P, Liu S, Fang Y, Xue X, Zou J, Tseng G, Konnikova L. Recent Advances in Computer-Assisted Algorithms for Cell Subtype Identification of Cytometry Data Frontiers In Cell And Developmental Biology 2020, 8: 234. PMID: 32411698, PMCID: PMC7198724, DOI: 10.3389/fcell.2020.00234.
- Maturation of the Human Intestinal Immune System Occurs Early in Fetal DevelopmentStras SF, Werner L, Toothaker JM, Olaloye OO, Oldham AL, McCourt CC, Lee YN, Rechavi E, Shouval DS, Konnikova L. Maturation of the Human Intestinal Immune System Occurs Early in Fetal Development Developmental Cell 2019, 51: 357-373.e5. PMID: 31607651, DOI: 10.1016/j.devcel.2019.09.008.
- 1240 Increased Mucosal Innate Immune Activation in Hereditary Alpha Trytpasemia Subjects Is Predictive of Clinical Response to Tofacitanib TherapyGlover S, Davis E, Shirley J, Konnikova L. 1240 Increased Mucosal Innate Immune Activation in Hereditary Alpha Trytpasemia Subjects Is Predictive of Clinical Response to Tofacitanib Therapy The American Journal Of Gastroenterology 2019, 114: s691-s692. DOI: 10.14309/01.ajg.0000594488.99132.5d.
- A Unique Presentation of Infantile-Onset Colitis and Eosinophilic Disease without Recurrent Infections Resulting from a Novel Homozygous CARMIL2 VariantKurolap A, Eshach Adiv O, Konnikova L, Werner L, Gonzaga-Jauregui C, Steinberg M, Mitsialis V, Mory A, Nunberg MY, Wall S, Shaoul R, Overton JD, Shuldiner A, Zohar Y, Paperna T, Snapper S, Shouval D, Baris Feldman H. A Unique Presentation of Infantile-Onset Colitis and Eosinophilic Disease without Recurrent Infections Resulting from a Novel Homozygous CARMIL2 Variant Journal Of Clinical Immunology 2019, 39: 430-439. PMID: 31079270, DOI: 10.1007/s10875-019-00631-6.
- Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse ModelGoettel JA, Kotlarz D, Emani R, Canavan JB, Konnikova L, Illig D, Frei SM, Field M, Kowalik M, Peng K, Gringauz J, Mitsialis V, Wall SM, Tsou A, Griffith AE, Huang Y, Friedman JR, Towne JE, Plevy SE, Hall A, Snapper SB. Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model Cellular And Molecular Gastroenterology And Hepatology 2019, 8: 193-195. PMID: 31078723, PMCID: PMC6661391, DOI: 10.1016/j.jcmgh.2019.05.001.
- Tu1845 – Identification of a Unique Population of Gi Mast Cells in a Subset of Patients with Mast Cell Activation SyndromeHamilton M, Konnikova L, Pozdnyakova O, Lyons J, Milner J, Shirley J, Ryan L, Tang Y, Snapper S, Glover S. Tu1845 – Identification of a Unique Population of Gi Mast Cells in a Subset of Patients with Mast Cell Activation Syndrome Gastroenterology 2019, 156: s-1146. DOI: 10.1016/s0016-5085(19)39831-2.
- 947 – Priming and Maturation of the Human Fetal Immunity Occurs Early in Fetal DevelopmentStras S, Werner L, Toothaker J, Shouval D, Konnikova L. 947 – Priming and Maturation of the Human Fetal Immunity Occurs Early in Fetal Development Gastroenterology 2019, 156: s-202. DOI: 10.1016/s0016-5085(19)37297-x.
- Su1885 – Analysis of Human Colonic Tissue and Peripheral Blood by Mass Cytometry Reveals Immune Signatures Differentiating Inflammatory States in Uc, Cd, and ControlsMitsialis V, Wall S, Parmet T, Bousvaros A, Korzenik J, Snapper S, Konnikova L. Su1885 – Analysis of Human Colonic Tissue and Peripheral Blood by Mass Cytometry Reveals Immune Signatures Differentiating Inflammatory States in Uc, Cd, and Controls Gastroenterology 2019, 156: s-648-s-649. DOI: 10.1016/s0016-5085(19)38522-1.
- Su1884 – Combined Rnaseq and Cytof Analysis of Pbmcs Reveal Unique Profiles Between Il10 Receptor Deficiency and IBD Patients and Non-Ibd ControlsLiu P, Mitsialis V, Wall S, Shouval D, Gordon W, Snapper S, Konnikova L. Su1884 – Combined Rnaseq and Cytof Analysis of Pbmcs Reveal Unique Profiles Between Il10 Receptor Deficiency and IBD Patients and Non-Ibd Controls Gastroenterology 2019, 156: s-648. DOI: 10.1016/s0016-5085(19)38521-x.
- High-dimensional immune atlas of second trimester human intestinal immunityKonnikova L, Stras S, Werner L, Toothaker J, Oldham A, Shouval D. High-dimensional immune atlas of second trimester human intestinal immunity The Journal Of Immunology 2019, 202: 67.12-67.12. DOI: 10.4049/jimmunol.202.supp.67.12.
- CD117+ Exosomes and Mast Cells From Hereditary Alpha Tryptasemia Patients Reveal Unique Phosphorylation, Lipidomics, and Proteomics Profiles: Category Award (Small Intestine): Presidential Poster AwardAlli A, Konnikova L, Tuna K, Denslow N, Nouri M, Koh J, Li J, Tang Y, Shirley F, Ryan L, Lyons J, Milner J, Snapper S, Glover S. CD117+ Exosomes and Mast Cells From Hereditary Alpha Tryptasemia Patients Reveal Unique Phosphorylation, Lipidomics, and Proteomics Profiles: Category Award (Small Intestine): Presidential Poster Award The American Journal Of Gastroenterology 2018, 113: s668. DOI: 10.14309/00000434-201810001-01173.
- High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissueKonnikova L, Boschetti G, Rahman A, Mitsialis V, Lord J, Richmond C, Tomov VT, Gordon W, Jelinsky S, Canavan J, Liss A, Wall S, Field M, Zhou F, Goldsmith JD, Bewtra M, Breault DT, Merad M, Snapper SB. High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue Mucosal Immunology 2018, 11: 1684-1693. PMID: 30111863, PMCID: PMC6512331, DOI: 10.1038/s41385-018-0047-y.
- WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasisBiswas A, Shouval DS, Griffith A, Goettel JA, Field M, Kang YH, Konnikova L, Janssen E, Redhu NS, Thrasher AJ, Chatila T, Kuchroo VK, Geha RS, Notarangelo LD, Pai SY, Horwitz BH, Snapper SB. WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis Nature Communications 2018, 9: 1779. PMID: 29725003, PMCID: PMC5934380, DOI: 10.1038/s41467-018-03670-6.
- 382 - High Dimensional Immune Phenotyping Using Mass Cytometry Reveals Unique IL1B Signatures in Peripheral Blood and GI Tissue of Ulcerative Colitis, Crohn's Disease, and IL10R Deficient PatientsMitsialis V, Shouval D, Wall S, Snapper S, Konnikova L. 382 - High Dimensional Immune Phenotyping Using Mass Cytometry Reveals Unique IL1B Signatures in Peripheral Blood and GI Tissue of Ulcerative Colitis, Crohn's Disease, and IL10R Deficient Patients Gastroenterology 2018, 154: s-90-s-91. DOI: 10.1016/s0016-5085(18)30750-9.
- Tu1865 - High Dimensional Immune Phenotyping and Transcriptional Analysis Reveal Robust Recovery of Viable Human Immune and Epithelial Cells from Frozen Gastrointestinal TissueKonnikova L, Boschetti G, Rahman A, Lord J, Richmond C, Tomov V, Gordon W, Canavan J, Wall S, Field M, Zhou F, Bewtra M, Goldsmith J, Breault D, merad M, Snapper S. Tu1865 - High Dimensional Immune Phenotyping and Transcriptional Analysis Reveal Robust Recovery of Viable Human Immune and Epithelial Cells from Frozen Gastrointestinal Tissue Gastroenterology 2018, 154: s-1041-s-1042. DOI: 10.1016/s0016-5085(18)33491-7.
- Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathyKotlarz D, Marquardt B, Barøy T, Lee WS, Konnikova L, Hollizeck S, Magg T, Lehle AS, Walz C, Borggraefe I, Hauck F, Bufler P, Conca R, Wall SM, Schumacher EM, Misceo D, Frengen E, Bentsen BS, Uhlig HH, Hopfner KP, Muise AM, Snapper SB, Strømme P, Klein C. Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy Nature Genetics 2018, 50: 344-348. PMID: 29483653, PMCID: PMC6309869, DOI: 10.1038/s41588-018-0063-6.
- P045 HIGH DIMENSIONAL IMMUNE PHENOTYPING AND TRANSCRIPTIONAL ANALYSES REVEAL ROBUST RECOVERY OF VIABLE HUMAN IMMUNE AND EPITHELIAL CELLS FROM CRYOPRESERVED INTESTINAL TISSUEKonnikova L, Boschetti G, Rahman A, Lord J, Richmond C, Tomov V, Gordon W, Jelinsky S, Canavan J, Wall S, Field M, Zhou F, Goldsmith J, Bewtra M, Breault D, Merad M, Snapper S. P045 HIGH DIMENSIONAL IMMUNE PHENOTYPING AND TRANSCRIPTIONAL ANALYSES REVEAL ROBUST RECOVERY OF VIABLE HUMAN IMMUNE AND EPITHELIAL CELLS FROM CRYOPRESERVED INTESTINAL TISSUE Inflammatory Bowel Diseases 2018, 24: s16-s16. DOI: 10.1093/ibd/izy019.051.
- DOP010 Activating PIK3CD mutations cause severe intestinal lymphonodular hyperplasia and an IBD-like phenotypeFarachi S, Werner L, Konnikova L, Rea F, Vardi I, Romeo E, Barel O, De Angelis P, Dall’Oglio L, Rechavi G, Snapper S, Somech R, Weiss B, Cancrini C, Shouval D. DOP010 Activating PIK3CD mutations cause severe intestinal lymphonodular hyperplasia and an IBD-like phenotype Journal Of Crohn's And Colitis 2018, 12: s036-s037. DOI: 10.1093/ecco-jcc/jjx180.047.
- P045 HIGH DIMENSIONAL IMMUNE PHENOTYPING AND TRANSCRIPTIONAL ANALYSES REVEAL ROBUST RECOVERY OF VIABLE HUMAN IMMUNE AND EPITHELIAL CELLS FROM CRYOPRESERVED INTESTINAL TISSUEKonnikova L, Boschetti G, Rahman A, Lord J, Richmond C, Tomov V, Gordon W, Jelinsky S, Canavan J, Wall S, Field M, Zhou F, Goldsmith J, Bewtra M, Breault D, Merad M, Snapper S. P045 HIGH DIMENSIONAL IMMUNE PHENOTYPING AND TRANSCRIPTIONAL ANALYSES REVEAL ROBUST RECOVERY OF VIABLE HUMAN IMMUNE AND EPITHELIAL CELLS FROM CRYOPRESERVED INTESTINAL TISSUE Gastroenterology 2018, 154: s23-s24. DOI: 10.1053/j.gastro.2017.11.083.
- An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learningSallis BF, Erkert L, Moñino-Romero S, Acar U, Wu R, Konnikova L, Lexmond WS, Hamilton MJ, Dunn WA, Szepfalusi Z, Vanderhoof JA, Snapper SB, Turner JR, Goldsmith JD, Spencer LA, Nurko S, Fiebiger E. An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning Journal Of Allergy And Clinical Immunology 2017, 141: 1354-1364.e9. PMID: 29273402, PMCID: PMC6425755, DOI: 10.1016/j.jaci.2017.11.027.
- Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBDShouval DS, Konnikova L, Griffith AE, Wall SM, Biswas A, Werner L, Nunberg M, Kammermeier J, Goettel JA, Anand R, Chen H, Weiss B, Li J, Loizides A, Yerushalmi B, Yanagi T, Beier R, Conklin LS, Ebens CL, Santos FGMS, Sherlock M, Goldsmith JD, Kotlarz D, Glover SC, Shah N, Bousvaros A, Uhlig HH, Muise AM, Klein C, Snapper SB. Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD Inflammatory Bowel Diseases 2017, 23: 1950-1961. PMID: 29023267, DOI: 10.1097/mib.0000000000001270.
- Impact of Antibiotics on Necrotizing Enterocolitis and Antibiotic-Associated DiarrheaSilverman MA, Konnikova L, Gerber JS. Impact of Antibiotics on Necrotizing Enterocolitis and Antibiotic-Associated Diarrhea Gastroenterology Clinics Of North America 2017, 46: 61-76. PMID: 28164853, PMCID: PMC5314436, DOI: 10.1016/j.gtc.2016.09.010.
- DOP082 Enhanced TH17 responses in patients with IL10 receptor deficiency and history of infantile-onset IBDShouval D, Konnikova L, Werner L, Nunberg M, Weiss B, Glover S, Snapper S. DOP082 Enhanced TH17 responses in patients with IL10 receptor deficiency and history of infantile-onset IBD Journal Of Crohn's And Colitis 2017, 11: s75-s75. DOI: 10.1093/ecco-jcc/jjx002.119.
- Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor DeficiencyShouval DS, Biswas A, Kang YH, Griffith AE, Konnikova L, Mascanfroni ID, Redhu NS, Frei SM, Field M, Doty AL, Goldsmith JD, Bhan AK, Loizides A, Weiss B, Yerushalmi B, Yanagi T, Lui X, Quintana FJ, Muise AM, Klein C, Horwitz BH, Glover SC, Bousvaros A, Snapper SB. Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency Gastroenterology 2016, 151: 1100-1104. PMID: 27693323, PMCID: PMC5124405, DOI: 10.1053/j.gastro.2016.08.055.
- Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cellsSefik E, Geva-Zatorsky N, Oh S, Konnikova L, Zemmour D, McGuire AM, Burzyn D, Ortiz-Lopez A, Lobera M, Yang J, Ghosh S, Earl A, Snapper SB, Jupp R, Kasper D, Mathis D, Benoist C. Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells Science 2015, 349: 993-997. PMID: 26272906, PMCID: PMC4700932, DOI: 10.1126/science.aaa9420.
- The Role of Nutrition in Health and Disease in Premature Infants: Current Knowledge Gaps and Defining the Research AgendaParker M, Konnikova L, Martin C. The Role of Nutrition in Health and Disease in Premature Infants: Current Knowledge Gaps and Defining the Research Agenda 2012, 111-133. DOI: 10.1007/978-1-62703-224-7_8.
- The Role of Pulmonary Follow-up in Reducing Health Care Utilization in Infants With Bronchopulmonary DysplasiaRhein LM, Konnikova L, McGeachey A, Pruchniewski M, Smith VC. The Role of Pulmonary Follow-up in Reducing Health Care Utilization in Infants With Bronchopulmonary Dysplasia Clinical Pediatrics 2012, 51: 645-650. PMID: 22492835, DOI: 10.1177/0009922812439242.