Research & Publications
The Lucas lab advances basic and translational immunology through discovery and mechanistic investigation of severe, human immunodeficiency and autoinflammatory disorders, often caused by single-gene defects. Starting with patients and extending to mouse models, our work aims to dive deeply into fundamental yet translationally relevant biology of adaptive and innate immune cells by combining genetic, cellular, molecular, and in-vivo approaches. We then aim to apply this knowledge not only to devise targeted therapies for rare disorders but also to more generally illuminate approaches to improve common diseases with shared features of underlying pathophysiology. Major current efforts in the lab focus on genetic errors of immunity from phosphoinositide 3-kinase (PI3K) mutations, ELF4 transcription factor mutations, and others in the research pipeline.
Immunologic Deficiency Syndromes; Immunoproliferative Disorders; Inflammation; T-Lymphocytes; Signal Transduction; Hereditary Autoinflammatory Diseases