Joe El-Khoury
Research & Publications
Biography
News
Research Summary
I have three active areas of research interest: 1) Discovery of new biomarkers for the assessment of kidney function and kidney injury, 2) Development of new mass spectrometry-based methods for the measurement of biomarkers in biological fluids, and 3) reducing errors in the clinical laboratory. These active areas of research are detailed below.
Extensive Research Description
Creatinine has known limitations as a biomarker for the evaluation of kidney function and kidney injury. Over the years, improvements in the eGFR equations slightly improved the performance of this marker, however these equations do not account for many non-GFR factors that affect creatinine. An important analogy to remember is that the light-bulb was not invented by trying to improve the candle. Hence, my goal has been to evaluate other existing markers for kidney function and bring them forward into the clinical field. Symmetric dimethylarginine (SDMA) is an emerging marker of kidney function that does not suffer from the same limitations that impact creatinine (such as muscle mass). My group’s recent publication evaluated the performance of SDMA against all existing markers of kidney function in a small population of healthy and CKD adult patients and showed that SDMA is superior to creatinine. This work is crucial for improvement in diagnosis of patients with CKD worldwide. We are currently working on the development of a high-throughput clinical assay for SDMA to enable its adoption in clinical laboratories.
Mass spectrometry has historically been limited to research laboratories, but the advent of soft ionization techniques such as electrospray ionization (ESI) and matrix assisted laser desorption ionization (MALDI) in the late 1980s, for which the inventers were jointly awarded the 2002 Nobel prize in Chemistry, rendered liquid chromatography-tandem mass spectrometry (LC-MS/MS) an indispensable tool for analyses of small and macro-molecules in biological fluids. Recent improvements in sensitivity and affordability have encouraged the adoption of this technology for routine applications in the clinical laboratory. Initially, clinical labs focused on its utilisation on drugs of abuse confirmation, newborn screening, and steroid analysis. Today, clinical applications of mass spectrometry are being used in almost all areas of laboratory medicine, including microbiology, anatomic pathology, genetic disorders and pharmacogenetics, immunology, endocrinology and toxicology. My goal is to adopt this technology for our patients here and to develop non-existent assays.
In a recent report, researchers from Johns Hopkins University School of Medicine in Baltimore made headlines when they estimated that medical error is the third leading cause of death in the US. While patient safety remains a struggle in many areas of healthcare, laboratory medicine has been a leader in reducing error, with an estimated total error rate of 0.33%, the lowest in diagnostic medicine. Major advancements in automation and analytical instrumentation have helped reduce laboratory-associated errors over the last decade, but with pre-analytical errors currently accounting for up to 75% of all mistakes, laboratory medicine professionals must keep expanding their focus to what is happening outside of the lab. My goal is to raise awareness regarding this issue and to develop quality indicators to help monitor and detect pre-analytical errors.
Coauthors
Research Interests
Chemistry Techniques, Analytical; Chromatography; Pathology, Clinical; Mass Spectrometry; Clinical Laboratory Techniques; Clinical Chemistry Tests
Public Health Interests
Biomarkers; Cardiovascular Diseases
Selected Publications
- Hemolysis or wine? A case of red-wine-colored plasmaMalaeb H, Vera M, Figueroa Villalba C, El-Khoury J. Hemolysis or wine? A case of red-wine-colored plasma Clinica Chimica Acta 2023, 542: 117277. PMID: 36870523, DOI: 10.1016/j.cca.2023.117277.
- Seasonal Variation and Thyroid Function Testing: Source of Misdiagnosis and Levothyroxine Over-Prescription.El-Khoury J. Seasonal Variation and Thyroid Function Testing: Source of Misdiagnosis and Levothyroxine Over-Prescription. Clinical Chemistry 2023 PMID: 36857303, DOI: 10.1093/clinchem/hvad017.
- Vitamin D and Bone Fractures Revisited.Malaeb H, El-Khoury J. Vitamin D and Bone Fractures Revisited. Clinical Chemistry 2023, 69: 209. PMID: 36724482, DOI: 10.1093/clinchem/hvac196.
- A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid useChoucair I, Villalba C, Vera M, Cassella-Mclane G, Durant T, El-Khoury J. A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use Clinical Biochemistry 2022, 112: 6-10. PMID: 36535386, DOI: 10.1016/j.clinbiochem.2022.12.009.
- Detecting Exogenous Contamination of Clinical Blood Samples with Crystalloid Solutions: A Data Driven Approach to Derive and Validate Delta ChecksChoucair I, Vera M, Lee E, El-Khoury J, Durant T. Detecting Exogenous Contamination of Clinical Blood Samples with Crystalloid Solutions: A Data Driven Approach to Derive and Validate Delta Checks American Journal Of Clinical Pathology 2022, 158: s3-s3. DOI: 10.1093/ajcp/aqac126.004.
- Compliance or Abuse? Detectable hydromorphone in patients taking oxycodoneVillalba C, Choucair I, El-Khoury J. Compliance or Abuse? Detectable hydromorphone in patients taking oxycodone American Journal Of Clinical Pathology 2022, 158: s5-s6. DOI: 10.1093/ajcp/aqac126.008.
- Low haptoglobin in pregnancy: physiological or intravascular hemolysis?Villalba C, Choucair I, Vera M, Lee E, El-Khoury J. Low haptoglobin in pregnancy: physiological or intravascular hemolysis? American Journal Of Clinical Pathology 2022, 158: s6-s6. DOI: 10.1093/ajcp/aqac126.009.
- Rising to the Challenge: Shortages in Laboratory Medicine.Knezevic CE, Das B, El-Khoury JM, Jannetto PJ, Lacbawan F, Winter WE. Rising to the Challenge: Shortages in Laboratory Medicine. Clinical Chemistry 2022, 68: 1486-1492. PMID: 36301321, DOI: 10.1093/clinchem/hvac179.
- Contamination of clinical blood samples with crystalloid solutions: An experimental approach to derive multianalyte delta checksChoucair I, Lee ES, Vera MA, Drongmebaro C, El-Khoury JM, Durant TJS. Contamination of clinical blood samples with crystalloid solutions: An experimental approach to derive multianalyte delta checks Clinica Chimica Acta 2022, 538: 22-28. PMID: 36309069, DOI: 10.1016/j.cca.2022.10.011.
- An Unusual Case of High 6-Monoacetylmorphine and Low Morphine in Urine: Heroin Abuse or Analytical Error?Choucair I, Cassella-Mclane G, Rogers K, Durant T, El-Khoury J. An Unusual Case of High 6-Monoacetylmorphine and Low Morphine in Urine: Heroin Abuse or Analytical Error? Clinical Chemistry 2022, 68: 1344-1345. DOI: 10.1093/clinchem/hvac110.
- A case of spuriously low serum creatinine concentrations in a patient with acetaminophen poisoningVerma A, Figueroa Villalba C, Choucair I, El-Khoury JM. A case of spuriously low serum creatinine concentrations in a patient with acetaminophen poisoning Clinica Chimica Acta 2022, 535: 195-196. PMID: 36075459, DOI: 10.1016/j.cca.2022.09.001.
- Resolving Icteric Interference by a Novel Photoisomerization Device: BiliboxVera MA, Koch CD, El-Khoury JM. Resolving Icteric Interference by a Novel Photoisomerization Device: Bilibox Clinical Biochemistry 2022 PMID: 35882276, DOI: 10.1016/j.clinbiochem.2022.07.004.
- Public Misinformation and Science Communication in Times of Public Health CrisesVera MA, El-Khoury JM, Thorp H, Tofel RJ, Ross JS, Mandavilli A, Topol E. Public Misinformation and Science Communication in Times of Public Health Crises Clinical Chemistry 2022, 68: hvac088-. PMID: 35675305, DOI: 10.1093/clinchem/hvac088.
- Advances in Laboratory Detection of Acute Kidney InjuryEl-Khoury JM. Advances in Laboratory Detection of Acute Kidney Injury Practical Laboratory Medicine 2022, 31: e00287. PMID: 35965846, PMCID: PMC9363638, DOI: 10.1016/j.plabm.2022.e00287.
- Pandemic ReflectionsEl-Khoury J. Pandemic Reflections Clinical Chemistry 2022, 68: 742-743. DOI: 10.1093/clinchem/hvab209.
- Effects of Bovine Hemoglobin on Chemistry Testing: Pseudohemolysis or Real?Vera MA, Eid T, El-Khoury JM. Effects of Bovine Hemoglobin on Chemistry Testing: Pseudohemolysis or Real? Clinical Chemistry 2022, 68: 607-608. PMID: 36103316, DOI: 10.1093/clinchem/hvab222.
- Unexpectedly low hemoglobin A1c in a patient with chronic lymphocytic leukemiaJacobs JW, Gisriel SD, Iyer K, Hauser RG, El-Khoury JM. Unexpectedly low hemoglobin A1c in a patient with chronic lymphocytic leukemia Clinica Chimica Acta 2022, 531: 91-93. PMID: 35351433, DOI: 10.1016/j.cca.2022.03.012.
- Rapid serum clot tubes reduce haemolysis due to pneumatic tube transportKoch CD, Vera MA, El-Khoury JM. Rapid serum clot tubes reduce haemolysis due to pneumatic tube transport Journal Of Clinical Pathology 2022, 75: 643-645. PMID: 35273119, DOI: 10.1136/jclinpath-2021-208126.
- Association of renalase with clinical outcomes in hospitalized patients with COVID-19Safdar B, Wang M, Guo X, Cha C, Chun HJ, Deng Y, Dziura J, El-Khoury JM, Gorelick F, Ko AI, Lee AI, Safirstein R, Simonov M, Zhou B, Desir GV. Association of renalase with clinical outcomes in hospitalized patients with COVID-19 PLOS ONE 2022, 17: e0264178. PMID: 35259186, PMCID: PMC8903289, DOI: 10.1371/journal.pone.0264178.
- Resolving Pseudohyponatremia: Validation of Plasma Sodium on Radiometer ABL800 Blood Gas Analyzers for Immediate Reflex Testing.Vera MA, Sutphin A, Hansen L, El-Khoury JM. Resolving Pseudohyponatremia: Validation of Plasma Sodium on Radiometer ABL800 Blood Gas Analyzers for Immediate Reflex Testing. Lab Medicine 2022, 53: e105-e108. PMID: 35015890, DOI: 10.1093/labmed/lmab114.
- A Horseback Riding Lesson in LeadershipEl-Khoury JM. A Horseback Riding Lesson in Leadership The Journal Of Applied Laboratory Medicine 2022, 7: 629-631. PMID: 34993546, DOI: 10.1093/jalm/jfab160.
- Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in DiabetesChen T, Coca S, Thiessen-Philbrook H, Heerspink H, Obeid W, Ix J, Fried L, Bonventre J, El-Khoury J, Shlipak M, Parikh C. Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes American Journal Of Nephrology 2022, 53: 775-785. PMID: 36630924, PMCID: PMC10006337, DOI: 10.1159/000528918.
- The ALT upper reference interval debate: Blame it on the alcoholVera MA, Koch CD, Liapakis A, Lim JK, El-Khoury JM. The ALT upper reference interval debate: Blame it on the alcohol Clinica Chimica Acta 2021, 526: 62-65. PMID: 34973184, DOI: 10.1016/j.cca.2021.12.026.
- The Surprising Absence of a Laboratory Result StandardHauser RG, Gisriel S, El-Khoury J. The Surprising Absence of a Laboratory Result Standard American Journal Of Clinical Pathology 2021, 157: aqab198-. PMID: 34871342, DOI: 10.1093/ajcp/aqab198.
- Increased Lipemia Index in a Dark Green Sample from a Patient after Heart Transplant.Li P, Koch CD, El-Khoury JM. Increased Lipemia Index in a Dark Green Sample from a Patient after Heart Transplant. Clinical Chemistry 2021, 67: 1575-1576. PMID: 36103299, DOI: 10.1093/clinchem/hvab080.
- Determination of 97.5th and 99th percentile upper reference limits for heart-type fatty acid-binding protein (H-FABP) in a US populationVera MA, Koch CD, Kavsak PA, El-Khoury JM. Determination of 97.5th and 99th percentile upper reference limits for heart-type fatty acid-binding protein (H-FABP) in a US population Clinica Chimica Acta 2021, 523: 397-401. PMID: 34666029, DOI: 10.1016/j.cca.2021.10.011.
- The 2021 PhD Board-Certified Clinical Chemist Compensation Survey.Patel K, El-Khoury JM, Kataria Y, Wheeler S, Hackenmueller S. The 2021 PhD Board-Certified Clinical Chemist Compensation Survey. The Journal Of Applied Laboratory Medicine 2021, 6: 1655-1659. PMID: 34427677, DOI: 10.1093/jalm/jfab105.
- Perimenopausal woman with elevated serum hCG and abdominal painLi P, Koch CD, El-Khoury JM. Perimenopausal woman with elevated serum hCG and abdominal pain Clinica Chimica Acta 2021, 522: 141-143. PMID: 34418366, DOI: 10.1016/j.cca.2021.08.018.
- CO-Oximetry Interference in a Patient with Dyspnea Refractory to Oxygen Therapy.Binns TC, Koch CD, Durant TJS, El-Khoury JM. CO-Oximetry Interference in a Patient with Dyspnea Refractory to Oxygen Therapy. The Journal Of Applied Laboratory Medicine 2021, 6: 1671-1676. PMID: 34383919, DOI: 10.1093/jalm/jfab071.
- Longitudinal Assessment of SARS-CoV-2 Anti-Nucleocapsid and anti-Spike-1-RBD Antibody Testing Following PCR-Detected SARS-CoV-2 InfectionEl-Khoury JM, Schulz WL, Durant TJS. Longitudinal Assessment of SARS-CoV-2 Anti-Nucleocapsid and anti-Spike-1-RBD Antibody Testing Following PCR-Detected SARS-CoV-2 Infection The Journal Of Applied Laboratory Medicine 2021, 6: jfab030-. PMID: 33822964, PMCID: PMC8083453, DOI: 10.1093/jalm/jfab030.
- Preventing pseudohyponatremia: Intralipid®-based lipemia cutoffs for sodium are inappropriateKoch CD, Vera MA, Messina J, Price N, Durant TJS, El-Khoury JM. Preventing pseudohyponatremia: Intralipid®-based lipemia cutoffs for sodium are inappropriate Clinica Chimica Acta 2021, 520: 63-66. PMID: 34077753, DOI: 10.1016/j.cca.2021.05.032.
- The Case of the HyponatremiasKoch CD, Vera MA, Paulson N, El-Khoury JM. The Case of the Hyponatremias Clinica Chimica Acta 2021, 520: 76-77. PMID: 34048733, DOI: 10.1016/j.cca.2021.05.023.
- Current Utility and Reliability of Biological VariabilityPatel K, El-Khoury JM, Aarsand AK, Badrick T, Jones GRD, Sikaris K, Parnas ML. Current Utility and Reliability of Biological Variability Clinical Chemistry 2021, 67: 1050-1055. PMID: 33993263, DOI: 10.1093/clinchem/hvab055.
- AACC Guidance Document on Laboratory Investigation of Acute Kidney InjuryEl-Khoury JM, Hoenig MP, Jones GRD, Lamb EJ, Parikh CR, Tolan NV, Wilson FP. AACC Guidance Document on Laboratory Investigation of Acute Kidney Injury The Journal Of Applied Laboratory Medicine 2021, 6: jfab020-. PMID: 33973621, DOI: 10.1093/jalm/jfab020.
- Is It Time to Move On? Reexamining Race in Glomerular Filtration Rate EquationsModerators:, El-Khoury JM, Ovalle AA, Cervinski MA, Experts:, Levey AS, Jones G, Eneanya ND, Lieske JC, Jha V. Is It Time to Move On? Reexamining Race in Glomerular Filtration Rate Equations Clinical Chemistry 2021, 67: hvaa333-. PMID: 33686430, DOI: 10.1093/clinchem/hvaa333.
- Evolution of Blood Sample Transportation and Monitoring TechnologiesPatel K, El-Khoury JM, Simundic AM, Farnsworth CW, Broell F, Genzen JR, Amukele TK. Evolution of Blood Sample Transportation and Monitoring Technologies Clinical Chemistry 2021, 67: 812-819. PMID: 33615326, DOI: 10.1093/clinchem/hvab001.
- The Dimethylarginines (Asymmetric and Symmetric): A Deadly Combination in Sepsis.El-Khoury JM. The Dimethylarginines (Asymmetric and Symmetric): A Deadly Combination in Sepsis. The Journal Of Applied Laboratory Medicine 2021, 6: 577-579. PMID: 33544823, DOI: 10.1093/jalm/jfaa241.
- Elevated Lipemia Index in Dark-Brown Plasma from a Bronze Baby.Koch CD, Paulson N, Vera MA, Loza A, El-Khoury JM. Elevated Lipemia Index in Dark-Brown Plasma from a Bronze Baby. Clinical Chemistry 2020, 67: 447-448. PMID: 33523217, DOI: 10.1093/clinchem/hvaa146.
- First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population.Bunch DR, Firmender K, Harb R, El-Khoury JM. First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population. American Journal Of Clinical Pathology 2020, 155: 776-780. PMID: 33210132, DOI: 10.1093/ajcp/aqaa165.
- Nephrocheck®: Checkmate or reality check?El-Khoury JM. Nephrocheck®: Checkmate or reality check? Annals Of Clinical Biochemistry International Journal Of Laboratory Medicine 2020, 58: 3-5. PMID: 33016084, DOI: 10.1177/0004563220967581.
- Urinary cannabinoid mass spectrometry profiles differentiate dronabinol from cannabis useKoch CD, Xu L, Curtis SA, Roberts JD, Bunch DR, El-Khoury JM. Urinary cannabinoid mass spectrometry profiles differentiate dronabinol from cannabis use Clinica Chimica Acta 2020, 510: 515-521. PMID: 32795544, DOI: 10.1016/j.cca.2020.08.014.
- New Sampson Low-Density Lipoprotein Equation: Better Than Friedewald and Martin-Hopkins.Koch CD, El-Khoury JM. New Sampson Low-Density Lipoprotein Equation: Better Than Friedewald and Martin-Hopkins. Clinical Chemistry 2020, 66: 1120-1121. PMID: 32746460, DOI: 10.1093/clinchem/hvaa126.
- Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes.Mansour SG, Liu C, Jia Y, Reese PP, Hall IE, El-Achkar TM, LaFavers KA, Obeid W, Rosenberg AZ, Daneshpajouhnejad P, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, El-Khoury JM, Weng FL, Thiessen-Philbrook HR, Parikh CR. Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes. Transplantation 2020, 105: 876-885. PMID: 32769629, PMCID: PMC8805736, DOI: 10.1097/tp.0000000000003299.
- Investigating Interference with Lamotrigine Quantification by Liquid Chromatography-Tandem Mass Spectrometry.Hultgren C, Rogers K, Bunch DR, El-Khoury JM. Investigating Interference with Lamotrigine Quantification by Liquid Chromatography-Tandem Mass Spectrometry. The Journal Of Applied Laboratory Medicine 2020, 5: 609-611. PMID: 32445366, DOI: 10.1093/jalm/jfaa007.
- The 2018 AACC/SYCL PhD Clinical Chemist Compensation Survey.Bunch DR, El-Khoury JM, Colby J, Colon-Franco J, Hackenmueller SA, Olson KN, Cotten SW, Kampfrath T, Chittiprol S, Suh-Lailam B, French D, Isbell TS, Nerenz RD, Parnas ML, Tolan NV. The 2018 AACC/SYCL PhD Clinical Chemist Compensation Survey. The Journal Of Applied Laboratory Medicine 2020, 5: 377-387. PMID: 32445390, DOI: 10.1093/jalm/jfaa001.
- Perspectives on the Changing Landscape of Measuring Cardiovascular Risk Related to LDLEl-Khoury JM, Remaley AT, Nordestgaard BG, Kaufman HW, Mora S, Cao J, Meeusen JW. Perspectives on the Changing Landscape of Measuring Cardiovascular Risk Related to LDL Clinical Chemistry 2019, 65: 1487-1492. PMID: 31699699, DOI: 10.1373/clinchem.2019.307306.
- Practical Approach to Eliminate Bilirubin Interference in Icteric Samples for Creatinine Measurement.Charifa A, Bunch DR, El-Khoury JM. Practical Approach to Eliminate Bilirubin Interference in Icteric Samples for Creatinine Measurement. The Journal Of Applied Laboratory Medicine 2019, 4: 477-479. PMID: 31659092, DOI: 10.1373/jalm.2019.030247.
- Unusual Drug Test Results for a Patient on Buprenorphine and Naloxone.Gall B, El-Khoury JM. Unusual Drug Test Results for a Patient on Buprenorphine and Naloxone. Clinical Chemistry 2019, 65: 1332-1333. PMID: 31570415, DOI: 10.1373/clinchem.2019.309484.
- The Role of Volume Regulation and Thermoregulation in AKI during Marathon RunningMansour SG, Martin TG, Obeid W, Pata RW, Myrick KM, Kukova L, Jia Y, Bjornstad P, El-Khoury JM, Parikh CR. The Role of Volume Regulation and Thermoregulation in AKI during Marathon Running Clinical Journal Of The American Society Of Nephrology 2019, 14: 1297-1305. PMID: 31413064, PMCID: PMC6730516, DOI: 10.2215/cjn.01400219.
- Hyperhomocysteinemia in a Gammopathy Patient: Malnutrition or Interference?Charifa A, El-Khoury JM. Hyperhomocysteinemia in a Gammopathy Patient: Malnutrition or Interference? Clinical Chemistry 2019, 65: 1063-1064. PMID: 31358504, DOI: 10.1373/clinchem.2019.302752.
- Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients.Kukova LZ, Mansour SG, Coca SG, de Fontnouvelle CA, Thiessen-Philbrook HR, Shlipak MG, El-Khoury JM, Parikh CR. Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients. The Journal Of Applied Laboratory Medicine 2019, 4: 331-342. PMID: 31659071, DOI: 10.1373/jalm.2018.028621.
- Erratic Serum Creatinine Concentrations in a Cardiac Patient.Charifa A, Bunch DR, El-Khoury JM. Erratic Serum Creatinine Concentrations in a Cardiac Patient. Clinical Chemistry 2018, 64: 1543-1544. PMID: 30266720, DOI: 10.1373/clinchem.2017.285858.
- Emerging Biomarker of Kidney Disease: suPAR or Subpar?Bunch DR, El-Khoury JM. Emerging Biomarker of Kidney Disease: suPAR or Subpar? Clinical Chemistry 2018, 64: 1545-1547. PMID: 32100860, DOI: 10.1373/clinchem.2018.293167.
- CommentaryEl-Khoury JM. Commentary Clinical Chemistry 2018, 64: 445-445. PMID: 29490996, DOI: 10.1373/clinchem.2017.273714.
- Networking and the Career Opportunities It Affords in Clinical Chemistry.El-Khoury JM. Networking and the Career Opportunities It Affords in Clinical Chemistry. The Journal Of Applied Laboratory Medicine 2017, 2: 284-285. PMID: 32630974, DOI: 10.1373/jalm.2016.022210.
- Urinalysis findings and urinary kidney injury biomarker concentrationsNadkarni GN, Coca SG, Meisner A, Patel S, Kerr KF, Patel UD, Koyner JL, Garg AX, Philbrook HT, Edelstein CL, Shlipak M, El-Khoury J, Parikh CR, on behalf of the TRIBE-AKI Consortium Investigators. Urinalysis findings and urinary kidney injury biomarker concentrations BMC Nephrology 2017, 18: 218. PMID: 28683730, PMCID: PMC5499057, DOI: 10.1186/s12882-017-0629-z.
- Moving Averages: Real-Time Data Monitoring in the Clinical Chemistry Laboratory.Durant T, Schulz W, El-Khoury J. Moving Averages: Real-Time Data Monitoring in the Clinical Chemistry Laboratory. American Journal Of Clinical Pathology 2017 PMID: 28340007, DOI: 10.1093/ajcp/aqw191.032.
- A tumor specific antibody to aid breast cancer screening in women with dense breast tissueRoy LD, Dillon LM, Zhou R, Moore LJ, Livasy C, El-Khoury JM, Puri R, Mukherjee P. A tumor specific antibody to aid breast cancer screening in women with dense breast tissue Genes & Cancer 2017, 8: 536-549. PMID: 28680538, PMCID: PMC5489651, DOI: 10.18632/genesandcancer.134.
- Moving Averages: Real-Time Data Monitoring in the Clinical Chemistry LaboratoryDurant T, Schulz W, El-Khoury J. Moving Averages: Real-Time Data Monitoring in the Clinical Chemistry Laboratory American Journal Of Clinical Pathology 2017, 147: s163-s164. DOI: 10.1093/ajcp/aqw191.026.
- Comparison of symmetric dimethylarginine with creatinine, cystatin C and their eGFR equations as markers of kidney functionEl-Khoury JM, Bunch DR, Hu B, Payto D, Reineks EZ, Wang S. Comparison of symmetric dimethylarginine with creatinine, cystatin C and their eGFR equations as markers of kidney function Clinical Biochemistry 2016, 49: 1140-1143. PMID: 27452178, DOI: 10.1016/j.clinbiochem.2016.07.009.
- High-throughput measurement of 25-hydroxyvitamin D by LC–MS/MS with separation of the C3-epimer interference for pediatric populationsYang Y, Rogers K, Wardle R, El-Khoury JM. High-throughput measurement of 25-hydroxyvitamin D by LC–MS/MS with separation of the C3-epimer interference for pediatric populations Clinica Chimica Acta 2016, 454: 102-106. PMID: 26772722, DOI: 10.1016/j.cca.2016.01.004.
- 1. Angiotensin converting enzymeEl-Khoury J, Reineks E, Wang S. 1. Angiotensin converting enzyme 2014, 1-18. DOI: 10.1515/9783110227802.1.
- 3. AldolaseReineks E, El-Khoury J, Wang S. 3. Aldolase 2014, 41-56. DOI: 10.1515/9783110227802.41.
- 5. Aspartate aminotransferase and alanine aminotransferaseEl-Khoury J, Wang S. 5. Aspartate aminotransferase and alanine aminotransferase 2014, 81-104. DOI: 10.1515/9783110227802.81.
- 9. Pancreatic lipaseZhang W, Reineks E, El-Khoury J, Wang S. 9. Pancreatic lipase 2014, 153-180. DOI: 10.1515/9783110227802.153.
- Screen-Only Tests for Anti-Nuclear Antibodies Lead to Inappropriate Follow-Up in Majority of CasesAnsari M, El-Khoury J, Daly T. Screen-Only Tests for Anti-Nuclear Antibodies Lead to Inappropriate Follow-Up in Majority of Cases American Journal Of Clinical Pathology 2014, 142: a032-a032. DOI: 10.1093/ajcp/142.suppl1.032.
- Recent advances in MS methods for nicotine and metabolite analysis in human matrices: clinical perspectivesEl-Khoury JM, Wang S. Recent advances in MS methods for nicotine and metabolite analysis in human matrices: clinical perspectives Bioanalysis 2014, 6: 2171-2183. PMID: 25331861, DOI: 10.4155/bio.14.176.
- Measurement of GFR for children and an LC–MS/MS method for nonradioactive iothalamateEl-Khoury JM, Gabler J, Wang S. Measurement of GFR for children and an LC–MS/MS method for nonradioactive iothalamate Clinical Biochemistry 2014, 47: 749-750. PMID: 24858210, DOI: 10.1016/j.clinbiochem.2014.05.042.
- Stability of serum and plasma osmolality in common clinical laboratory storage conditionsAbbadi A, El-Khoury JM, Wang S. Stability of serum and plasma osmolality in common clinical laboratory storage conditions Clinical Biochemistry 2014, 47: 686-687. PMID: 24631174, DOI: 10.1016/j.clinbiochem.2014.02.024.
- Do deuterium labeled internal standards correct for matrix effects in LC-MS/MS assays? A case study using plasma free metanephrine and normetanephrineBunch DR, El-Khoury JM, Gabler J, Wang S. Do deuterium labeled internal standards correct for matrix effects in LC-MS/MS assays? A case study using plasma free metanephrine and normetanephrine Clinica Chimica Acta 2013, 429: 4-5. PMID: 24269502, DOI: 10.1016/j.cca.2013.11.013.
- Does Paricalcitol (Zemplar®) interfere with 1,25-dihydroxyvitamin D measurement by liquid chromatography–tandem mass spectrometry assays?El-Khoury JM, Bicer F, Bunch DR, Yuan C, Wang S. Does Paricalcitol (Zemplar®) interfere with 1,25-dihydroxyvitamin D measurement by liquid chromatography–tandem mass spectrometry assays? Clinica Chimica Acta 2012, 415: 230-232. PMID: 23142648, DOI: 10.1016/j.cca.2012.10.050.
- Highly sensitive and selective measurement of underivatized methylmalonic acid in serum and plasma by liquid chromatography-tandem mass spectrometryYuan C, Gabler J, El-Khoury JM, Spatholt R, Wang S. Highly sensitive and selective measurement of underivatized methylmalonic acid in serum and plasma by liquid chromatography-tandem mass spectrometry Analytical And Bioanalytical Chemistry 2012, 404: 133-140. PMID: 22618327, DOI: 10.1007/s00216-012-6099-z.
- Is the Effect of Hemolysis on Plasma Ammonia Measurement Overrated?El-Khoury JM, Bunch DR, Wang S. Is the Effect of Hemolysis on Plasma Ammonia Measurement Overrated? Archives Of Pathology & Laboratory Medicine 2012, 136: 471-2. PMID: 22540295, DOI: 10.5858/arpa.2011-0445-le.
- Stability of 1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 in human serumEl-Khoury JM, Wang S. Stability of 1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 in human serum Clinical Biochemistry 2012, 45: 707-708. PMID: 22465273, DOI: 10.1016/j.clinbiochem.2012.03.016.
- A simple and fast liquid chromatography–tandem mass spectrometry method for measurement of underivatized l-arginine, symmetric dimethylarginine, and asymmetric dimethylarginine and establishment of the reference rangesEl-Khoury JM, Bunch DR, Reineks E, Jackson R, Steinle R, Wang S. A simple and fast liquid chromatography–tandem mass spectrometry method for measurement of underivatized l-arginine, symmetric dimethylarginine, and asymmetric dimethylarginine and establishment of the reference ranges Analytical And Bioanalytical Chemistry 2011, 402: 771-779. PMID: 22124751, DOI: 10.1007/s00216-011-5462-9.
- Progress of liquid chromatography-mass spectrometry in measurement of vitamin D metabolites and analoguesEl-Khoury JM, Reineks EZ, Wang S. Progress of liquid chromatography-mass spectrometry in measurement of vitamin D metabolites and analogues Clinical Biochemistry 2010, 44: 66-76. PMID: 20493831, DOI: 10.1016/j.clinbiochem.2010.05.007.