Our group and collaborations to date have focused on the use of continuous EEG (cEEG) monitoring in patients with severe brain injury, either secondary to a primary brain process or as a manifestions of systemic disease. We have several ongoing projects in the following areas: 1) the role of cEEG and cerebral oximetry (NIRS) monitoring in understanding cerebral perfusion and autoregulation in severe sepsis; 2) the impact of potentially harmful EEG patterns on management and outcome in critical illness; 3) novel approaches to invasive multimodality brain monitoring; and 4) the prognostic role of various EEG signatures in post-anoxic brain injury. In addition to being the site-PI for several trials, I have also authored chapters on neuromonitoring and have experience with multimodalty monitoring, which involves using information from probes placed in the acutely injured brain of comatose patients to guide medical management.
Brain Injuries; Cerebral Hemorrhage; Cerebrovascular Disorders; Critical Care; Delirium; Education; Electroencephalography; Neurosciences; Status Epilepticus; Subarachnoid Hemorrhage; Treatment Outcome; Stroke
Conditions | Study Title |
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Diseases of the Cardiovascular System | Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH) |
Diseases of the Nervous System | Brain Oxygen Optimization in Severe TBI, Phase 3 (BOOST3) |
Diseases of the Cardiovascular System; Diseases of the Nervous System | Anticoagulation for Stroke Prevention and Recovery After ICH (ASPIRE) |
Diseases of the Nervous System | Multi-arm Optimization of Stroke Thrombolysis (MOST) |
Diseases of the Nervous System | Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction (CHARM) |
Diseases of the Nervous System | Transforming Acute Stroke Detection through Real Time Neurological Monitoring |
Diseases of the Cardiovascular System | Multimodal Outcome CHAracterization (MOCHA) in comatose cardiac arrest patients |