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INFORMATION FOR

Emily J. Gilmore

MD, FNCS, FACNS
Associate Professor; Director, Neurosciences Intensive Care Unit, Neurology; Co-director, Neuorotrauma, Neurology & Neurosurgery

Contact Information

Emily J. Gilmore, MD, FNCS, FACNS

Mailing Address

  • Neurology

    PO Box 208018

    New Haven, CT 06520-8018

    United States

Research Summary

Our group and collaborations to date have focused on the use of continuous EEG (cEEG) monitoring in patients with severe brain injury, either secondary to a primary brain process or as a manifestions of systemic disease. We have several ongoing projects in the following areas: 1) the role of cEEG and cerebral oximetry (NIRS) monitoring in understanding cerebral perfusion and autoregulation in severe sepsis; 2) the impact of potentially harmful EEG patterns on management and outcome in critical illness; 3) novel approaches to invasive multimodality brain monitoring; and 4) the prognostic role of various EEG signatures in post-anoxic brain injury. In addition to being the site-PI for several trials, I have also authored chapters on neuromonitoring and have experience with multimodalty monitoring, which involves using information from probes placed in the acutely injured brain of comatose patients to guide medical management.


Coauthors

Research Interests

Brain Injuries; Cerebral Hemorrhage; Cerebrovascular Disorders; Critical Care; Delirium; Education; Electroencephalography; Neurosciences; Status Epilepticus; Subarachnoid Hemorrhage; Treatment Outcome; Stroke

Selected Publications

  • Abstract 89: Nimodipine-induced Blood Pressure Reductions Below Personalized Limits Of Autoregulation Are Associated With Worse Outcomes After Subarachnoid HemorrhageBartolome D, Begunova Y, Prasad A, Soto A, Kobsa J, Top I, Quispe-Orozco D, Farooqui M, Zevallos C, Kim J, Gilmore E, Beekman R, de Havenon A, Matouk C, Sheth K, Ortega-Gutierrez S, Petersen N. Abstract 89: Nimodipine-induced Blood Pressure Reductions Below Personalized Limits Of Autoregulation Are Associated With Worse Outcomes After Subarachnoid Hemorrhage Stroke 2022, 53: a89-a89. DOI: 10.1161/str.53.suppl_1.89.
  • The Significance of LRDA With Bilateral Involvement Compared With GRDA on EEG in Critically Ill PatientsFong M, Jadav R, Alzawahmah M, Hussein O, Gilmore E, Hirsch L. The Significance of LRDA With Bilateral Involvement Compared With GRDA on EEG in Critically Ill Patients Journal Of Clinical Neurophysiology 2021, Publish Ahead of Print DOI: 10.1097/wnp.0000000000000897.
  • Abstract P41: Integrating Demographics, TCD and EEG Diagnostic Modalities Improves Delayed Cerebral Ischemia Prediction After Subarachnoid HemorrhageChen H, Elmer J, Ghanta M, Valdery-Moura J, Zahar S, Rosenthal E, Gilmore E, Hirsch L, Zaveri H, Sheth K, Petersen N, Westover M, Kim J. Abstract P41: Integrating Demographics, TCD and EEG Diagnostic Modalities Improves Delayed Cerebral Ischemia Prediction After Subarachnoid Hemorrhage Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p41.
  • Abstract P27: Safety and Efficacy of Alteplase in Ischemic Stroke Patients > 80 Years of Age in the Extended Time WindowStretz C, Mac Grory B, Fakhri N, Boyanpally A, Asad S, Modak J, Effendi M, Kucher O, Owusu K, Yaghi S, Nouh A, Reznik M, Burton T, Cutting S, Sacchetti D, El JAMAL S, Madsen T, Falcone G, Petersen N, Furie K, gilmore E. Abstract P27: Safety and Efficacy of Alteplase in Ischemic Stroke Patients > 80 Years of Age in the Extended Time Window Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p27.
  • Abstract 117: Fixed Compared to Autoregulation-oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic StrokePetersen N, Silverman A, Strander S, Kodali S, Wang A, Sansing L, Schindler J, Falcone G, Gilmore E, Jasne A, Cord B, Hebert R, Johnson M, Matouk C, Sheth K. Abstract 117: Fixed Compared to Autoregulation-oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.117.
  • Abstract 57: Deployment of Portable, Bedside, Low-Field Magnetic Resonance Imaging for Evaluation of Stroke PatientsCahn B, Shah J, Dyvorne H, O'Halloran R, Poole M, Yuen M, Mazurek M, Ward A, Payabvash S, Beekman R, Brown S, Falcone G, Gobeske K, Petersen N, Jasne A, Sharma R, Schindler J, Sansing L, Gilmore E, Wira C, Matouk C, Sze G, Rosen M, Kimberly W, Sheth K. Abstract 57: Deployment of Portable, Bedside, Low-Field Magnetic Resonance Imaging for Evaluation of Stroke Patients Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.57.
  • Abstract TMP89: Impaired Cerebral Autoregulation Increases Risk of Worse Outcome After Endovascular Thrombectomy in Stroke Patients With High Blood Pressure VariabilityNguyen C, Silverman A, Wang A, Kodali S, Strander S, Kimmel A, Peshwe K, De Havenon A, Gilmore E, Matouk C, Sansing L, Schindler J, Sheth K, Petersen N. Abstract TMP89: Impaired Cerebral Autoregulation Increases Risk of Worse Outcome After Endovascular Thrombectomy in Stroke Patients With High Blood Pressure Variability Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.tmp89.
  • Abstract WP413: Portable, Bedside, Point of Care Magnetic Resonance Imaging in an Intensive Care Setting for Intracranial HemorrhageCahn B, Shah J, By S, Welch E, Sacolick L, Yuen M, Mazurek M, Wira C, Leasure A, Matouk C, Ward A, Payabvash S, Beekman R, Brown S, Falcone G, Gobeske K, Petersen N, Jasne A, Sharma R, Schindler J, Sansing L, Gilmore E, Sze G, Rosen M, Kimberly W, Sheth K. Abstract WP413: Portable, Bedside, Point of Care Magnetic Resonance Imaging in an Intensive Care Setting for Intracranial Hemorrhage Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.wp413.
  • Deviation from Dynamic and Personalized Optimal Blood Pressure Targets is Associated With Worse Functional Outcomes After Aneurysmal Subarachnoid HemorrhageSilverman A, Kodali S, Strander S, Gilmore E, Kimmel A, Wang A, Cord B, Falcone G, Hebert R, Matouk C, Sheth K, Petersen N. Deviation from Dynamic and Personalized Optimal Blood Pressure Targets is Associated With Worse Functional Outcomes After Aneurysmal Subarachnoid Hemorrhage Neurosurgery 2019, 66: 310-186. DOI: 10.1093/neuros/nyz310_186.
  • Abstract WP223: Ischemic and Hemorrhagic Stroke in Native AmericansKing Z, Beekman R, Chu S, Leasure A, Orgrass H, Gilmore E, Sansing L, Matouk C, Sheth K, Falcone G. Abstract WP223: Ischemic and Hemorrhagic Stroke in Native Americans Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.wp223.
  • Abstract 147: Individualized Blood Pressure Management After Subarachnoid Hemorrhage Using Real-time Autoregulation Monitoring: A Pilot Study Using NIRS and ICP-derived Limits of AutoregulationSilverman A, Wang A, Kodali S, Strander S, Cord B, Hebert R, Matouk C, Gilmore E, Sheth K, Petersen N. Abstract 147: Individualized Blood Pressure Management After Subarachnoid Hemorrhage Using Real-time Autoregulation Monitoring: A Pilot Study Using NIRS and ICP-derived Limits of Autoregulation Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.147.
  • Abstract 95: Exceeding Personalized Blood Pressure Targets After Endovascular Stroke Therapy is Associated With Hemorrhagic Transformation and Worse Functional OutcomePetersen N, Wang A, Strander S, Kodali S, Silverman A, Gilmore E, Sansing L, Schindler J, Hebert R, Cord B, Matouk C, Sheth K. Abstract 95: Exceeding Personalized Blood Pressure Targets After Endovascular Stroke Therapy is Associated With Hemorrhagic Transformation and Worse Functional Outcome Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.95.
  • 777Heck C, Owusu K, Ammar A, Alimi O, Gilmore E. 777 Critical Care Medicine 2019, 47: 367. DOI: 10.1097/01.ccm.0000551526.29723.6c.
  • History of Intracranial Hemorrhage Is Associated with In-Hospital Mortality in Ischemic Stroke Patients Treated with Intravenous ThrombolyticsSommaruga S, Chu S, Hwang D, Dearborn J, Sansing L, Cord B, Santarosa C, Samarth G, Petersen N, Gilmore E, Schindler J, Bijlenga P, Schaller K, Matouk C, Sheth K, Falcone G. History of Intracranial Hemorrhage Is Associated with In-Hospital Mortality in Ischemic Stroke Patients Treated with Intravenous Thrombolytics Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660745.
  • F80. Seizures and hyperexcitable EEG patterns in spontaneous deep intraparenchymal hemorrhageSheikh Z, Stretz C, Maciel C, Dhakar M, Hirsch L, Gilmore E. F80. Seizures and hyperexcitable EEG patterns in spontaneous deep intraparenchymal hemorrhage Clinical Neurophysiology 2018, 129: e96-e97. DOI: 10.1016/j.clinph.2018.04.243.
  • S18. Hypotension after ketamine administration for refractory status epilepticus in patients at risk of shockSheikh Z, Owusu K, Ammar A, Landreneau M, Heck C, Gilmore E. S18. Hypotension after ketamine administration for refractory status epilepticus in patients at risk of shock Clinical Neurophysiology 2018, 129: e149. DOI: 10.1016/j.clinph.2018.04.378.
  • T62. Bilateral independent periodic discharges are associated with electrographic seizures and poor outcome: A case-control studyOsman G, Rahangdale R, Britton J, Gilmore E, Haider H, Hantus S, Herlopian A, Hocker S, Lee J, Legros B, Punia V, Rampal N, Szaflarski J, Wallace A, Westover M, Hirsch L, Gaspard N. T62. Bilateral independent periodic discharges are associated with electrographic seizures and poor outcome: A case-control study Clinical Neurophysiology 2018, 129: e25-e26. DOI: 10.1016/j.clinph.2018.04.063.
  • S96. EEG reactivity testing practices for cardiac arrest coma prognostication in North AmericaAmorim E, Gaspard N, Gilmore E, Hahn C, Abend N, Herman S, Hirsch L, Lee J, Cash S, Westover M. S96. EEG reactivity testing practices for cardiac arrest coma prognostication in North America Clinical Neurophysiology 2018, 129: e178. DOI: 10.1016/j.clinph.2018.04.456.
  • EEG Monitoring in the Medical ICUDhakar M, Hantus S, Gilmore E. EEG Monitoring in the Medical ICU 2018 DOI: 10.1891/9780826168627.0014.
  • Abstract TMP14: Thrombolysis in Ischemic Stroke Patients with Prior History of Intracranial HemorrhageChu S, Sommaruga S, Hwang D, Dearborn J, Sansing L, Matouk C, Samarth G, Petersen N, Gilmore E, Schindler J, Sheth K, Falcone G. Abstract TMP14: Thrombolysis in Ischemic Stroke Patients with Prior History of Intracranial Hemorrhage Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.tmp14.
  • Abstract TP277: The Neurointensivists’ Role in Management of Cerebral Venous Sinus ThrombosisStretz C, Ghoshal S, Marcolini E, Hwang D, Petersen N, Schindler J, Sheth K, Falcone G, Gilmore E. Abstract TP277: The Neurointensivists’ Role in Management of Cerebral Venous Sinus Thrombosis Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.tp277.
  • Abstract TP331: Plasma IL-6 Levels are Independently Associated With Functional Outcome and Markers of Secondary Injury in Spontaneous Intracerebral HemorrhageLeasure A, Steinschneider A, Falcone G, Gilmore E, Sansing L, Sheth K. Abstract TP331: Plasma IL-6 Levels are Independently Associated With Functional Outcome and Markers of Secondary Injury in Spontaneous Intracerebral Hemorrhage Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.tp331.
  • Abstract 35: Hyperexcitability and Seizures in Primary Intraventricular HemorrhageStretz C, Sheikh Z, Maciel C, Sheth K, Hirsch L, Gilmore E. Abstract 35: Hyperexcitability and Seizures in Primary Intraventricular Hemorrhage Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.35.
  • 775Effendi M, Kucher O, Stretz C, Owusu K, Petersen N, Gilmore E. 775 Critical Care Medicine 2018, 46: 374. DOI: 10.1097/01.ccm.0000528789.23433.2c.
  • 49 Management of Postoperative SeizuresGrory B, Hirsch L, Gilmore E, Sheth K. 49 Management of Postoperative Seizures 2018, 497-507. DOI: 10.1016/b978-0-323-32106-8.00049-2.
  • Seizures and Status EpilepticusHarris C, Gilmore E. Seizures and Status Epilepticus 2017, 201-221. DOI: 10.1007/978-3-319-48669-7_12.
  • Abstract TP338: Differences Between the Modified Rankin Scale and Barthel Index in Measuring Intracerebral Hemorrhage Recovery at 12 MonthsSreekrishnan A, Leasure A, Zhou S, Amin H, Petersen N, Hwang D, Schindler J, Gilmore E, Sansing L, Greer D, Sheth K. Abstract TP338: Differences Between the Modified Rankin Scale and Barthel Index in Measuring Intracerebral Hemorrhage Recovery at 12 Months Stroke 2017, 48 DOI: 10.1161/str.48.suppl_1.tp338.
  • Status EpilepticusGilmore E, Nourollahzadeh E. Status Epilepticus 2016, 23-33. DOI: 10.1007/978-3-319-33341-0_3.
  • Electroencephalogram Monitoring of VasospasmGilmore E, Gaspard N, Hirsch L. Electroencephalogram Monitoring of Vasospasm 2015, 62-62. DOI: 10.5005/jp/books/12423_10.
  • Medical Management of VasospasmMarcolini E, Gilmore E. Medical Management of Vasospasm 2015, 55-55. DOI: 10.5005/jp/books/12423_9.
  • O23: Uncoupling between heart rate and EEG in sepsisAdmiraal M, Gilmore E, Hirsch L, Zaveri H, Gaspard N. O23: Uncoupling between heart rate and EEG in sepsis Clinical Neurophysiology 2014, 125: s35. DOI: 10.1016/s1388-2457(14)50128-9.

Clinical Trials