Rachel Beekman, MD
Research & Publications
Biography
News
Research Summary
The central goal of my research is the early classification of brain injury severity, identification of secondary brain injury risk profiles, individualized brain-centered resuscitation to minimize secondary brain injury, and neuroprognostication in patients with hypoxic ischemic brain injury.
Extensive Research Description
1. I am the site PI for the Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (ICECAP) trial, aimed at identifying the optimal duration of cooling to 33C in cardiac arrest patients.
2. I am the site PI for the Multimodal Outcome CHAracterization after cardiac arrest (MOCHA) study, a multi-site prospective observational trial aimed at improving multimodal prognostication in cardiac arrest survivors.
3. I am the PI on an investigator-initiated proposal to evaluate cerebral pressure autoregulation and individualized blood pressure goals after cardiac arrest, using near infrared spectroscopy.
4. I am the PI on an industry sponsored pilot grant to evaluate synaptic density in survivors of cardiac arrest, using SV2A PET.
Coauthors
Research Interests
Brain Death; Out-of-Hospital Cardiac Arrest; Post-Cardiac Arrest Syndrome
Selected Publications
- Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfaAmmar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.
- Future of Neurology & Technology: Neuroimaging Made Accessible Using Low-Field, Portable MRIParasuram N, Crawford A, Mazurek M, Chavva I, Beekman R, Gilmore E, Petersen N, Payabvash S, Sze G, Iglesias J, Omay S, Matouk C, Longbrake E, de Havenon A, Schiff S, Rosen M, Kimberly W, Sheth K. Future of Neurology & Technology: Neuroimaging Made Accessible Using Low-Field, Portable MRI Neurology 2023, 10.1212/wnl.0000000000207074. PMID: 36720639, DOI: 10.1212/wnl.0000000000207074.
- Abstract 159: Time-course Of Left Ventricular Systolic Dysfunction Recovery After Cardiac ArrestBeekman R, Kim N, Faridi K, Aneni E, Chang T, Arakaki A, Kitlen E, Miller E, Khosla A, Wira C, Greer D, gilmore E. Abstract 159: Time-course Of Left Ventricular Systolic Dysfunction Recovery After Cardiac Arrest Circulation 2022, 146: a159-a159. DOI: 10.1161/circ.146.suppl_1.159.
- Abstract 156: Clinical Significance Of Left Ventricular Systolic Dysfunction After Cardiac ArrestBeekman R, Kim N, Faridi K, Aneni E, Chang T, Arakaki A, Kitlen E, Miller E, Khosla A, Wira C, Greer D, gilmore E. Abstract 156: Clinical Significance Of Left Ventricular Systolic Dysfunction After Cardiac Arrest Circulation 2022, 146: a156-a156. DOI: 10.1161/circ.146.suppl_1.156.
- Abstract 176: Development Of A Novel Score To Predict Brain Death After Out Of Hospital Cardiac ArrestKitlen E, Kim N, Rubenstein A, Keenan C, Greer D, gilmore E, Beekman R. Abstract 176: Development Of A Novel Score To Predict Brain Death After Out Of Hospital Cardiac Arrest Circulation 2022, 146: a176-a176. DOI: 10.1161/circ.146.suppl_1.176.
- Emergency department initiated resuscitative endovascular balloon occlusion of the aorta (REBOA) for out‐of‐hospital cardiac arrest is feasible and associated with improvements in end‐tidal carbon dioxideDaley J, Buckley R, Kisken KC, Barber D, Ayyagari R, Wira C, Aydin A, Latich I, Lozada JCP, Joseph D, Marino A, Mojibian H, Pollak J, Chaar CO, Bonz J, Belsky J, Coughlin R, Liu R, Sather J, Van Tonder R, Beekman R, Fults E, Johnson A, Moore C. Emergency department initiated resuscitative endovascular balloon occlusion of the aorta (REBOA) for out‐of‐hospital cardiac arrest is feasible and associated with improvements in end‐tidal carbon dioxide Journal Of The American College Of Emergency Physicians Open 2022, 3: e12791. PMID: 36176506, PMCID: PMC9463569, DOI: 10.1002/emp2.12791.
- Oxygen Supplementation and Hyperoxia in Critically Ill Cardiac Patients From Pathophysiology to Clinical PracticeThomas A, van Diepen S, Beekman R, Sinha SS, Brusca SB, Alviar CL, Jentzer J, Bohula EA, Katz JN, Shahu A, Barnett C, Morrow DA, Gilmore EJ, Solomon MA, Miller PE. Oxygen Supplementation and Hyperoxia in Critically Ill Cardiac Patients From Pathophysiology to Clinical Practice JACC Advances 2022, 1: 100065. PMID: 36238193, PMCID: PMC9555075, DOI: 10.1016/j.jacadv.2022.100065.
- Retroperitoneal Hematoma as a Complication of Anticoagulation Therapy with HeparinBeekman R, Powell T, Gobeske K, Jabbour G. Retroperitoneal Hematoma as a Complication of Anticoagulation Therapy with Heparin Panamerican Journal Of Trauma Critical Care & Emergency Surgery 2022, 11: 51-53. DOI: 10.5005/jp-journals-10030-1372.
- Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrestBeekman R, Crawford A, Mazurek MH, Prabhat AM, Chavva IR, Parasuram N, Kim N, Kim JA, Petersen N, de Havenon A, Khosla A, Honiden S, Miller PE, Wira C, Daley J, Payabvash S, Greer DM, Gilmore EJ, Kimberly W, Sheth KN. Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest Resuscitation 2022, 176: 150-158. PMID: 35562094, PMCID: PMC9746653, DOI: 10.1016/j.resuscitation.2022.05.002.
- Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic strokeYuen MM, Prabhat AM, Mazurek MH, Chavva IR, Crawford A, Cahn BA, Beekman R, Kim JA, Gobeske KT, Petersen NH, Falcone GJ, Gilmore EJ, Hwang DY, Jasne AS, Amin H, Sharma R, Matouk C, Ward A, Schindler J, Sansing L, de Havenon A, Aydin A, Wira C, Sze G, Rosen MS, Kimberly WT, Sheth KN. Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke Science Advances 2022, 8: eabm3952. PMID: 35442729, PMCID: PMC9020661, DOI: 10.1126/sciadv.abm3952.
- Survivorship from Cardiac Arrest: Outcomes Uncensored by Withdrawal of Life Sustaining TherapyBeekman R, Gilmore EJ. Survivorship from Cardiac Arrest: Outcomes Uncensored by Withdrawal of Life Sustaining Therapy Resuscitation 2022, 174: 102-103. PMID: 35318103, DOI: 10.1016/j.resuscitation.2022.03.008.
- Abstract 89: Nimodipine-induced Blood Pressure Reductions Below Personalized Limits Of Autoregulation Are Associated With Worse Outcomes After Subarachnoid HemorrhageBartolome D, Begunova Y, Prasad A, Soto A, Kobsa J, Top I, Quispe-Orozco D, Farooqui M, Zevallos C, Kim J, Gilmore E, Beekman R, de Havenon A, Matouk C, Sheth K, Ortega-Gutierrez S, Petersen N. Abstract 89: Nimodipine-induced Blood Pressure Reductions Below Personalized Limits Of Autoregulation Are Associated With Worse Outcomes After Subarachnoid Hemorrhage Stroke 2022, 53: a89-a89. DOI: 10.1161/str.53.suppl_1.89.
- Outcomes of Endovascular Therapy in Patients With Prestroke Mobility ImpairmentBeekman R, Sun JL, Alhanti B, Schwamm LH, Smith EE, Bhatt DL, Xian Y, Shah S, Lytle BL, Fonarow GC, Sheth KN. Outcomes of Endovascular Therapy in Patients With Prestroke Mobility Impairment Stroke 2021, 52: e725-e728. PMID: 34517771, DOI: 10.1161/strokeaha.121.034464.
- Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhageMazurek MH, Cahn BA, Yuen MM, Prabhat AM, Chavva IR, Shah JT, Crawford AL, Welch EB, Rothberg J, Sacolick L, Poole M, Wira C, Matouk CC, Ward A, Timario N, Leasure A, Beekman R, Peng TJ, Witsch J, Antonios JP, Falcone GJ, Gobeske KT, Petersen N, Schindler J, Sansing L, Gilmore EJ, Hwang DY, Kim JA, Malhotra A, Sze G, Rosen MS, Kimberly WT, Sheth KN. Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage Nature Communications 2021, 12: 5119. PMID: 34433813, PMCID: PMC8387402, DOI: 10.1038/s41467-021-25441-6.
- Early head CT in post-cardiac arrest patients: A helpful tool or contributor to self-fulfilling prophecy?Beekman R, Maciel CB, Ormseth CH, Zhou SE, Galluzzo D, Miyares LC, Torres-Lopez VM, Payabvash S, Mak A, Greer DM, Gilmore EJ. Early head CT in post-cardiac arrest patients: A helpful tool or contributor to self-fulfilling prophecy? Resuscitation 2021, 165: 68-76. PMID: 34147572, DOI: 10.1016/j.resuscitation.2021.06.004.
- Neuromonitoring After Cardiac Arrest Can Twenty-First Century Medicine Personalize Post Cardiac Arrest Care?Beekman R, Maciel CB, Balu R, Greer DM, Gilmore EJ. Neuromonitoring After Cardiac Arrest Can Twenty-First Century Medicine Personalize Post Cardiac Arrest Care? Neurologic Clinics 2021, 39: 273-292. PMID: 33896519, DOI: 10.1016/j.ncl.2021.01.002.
- Abstract P384: Outcomes of Endovascular Therapy in Patients With Pre-Stroke Mobility ImpairmentBeekman R, Sun J, Alhanti B, Schwamm L, Smith E, Bhatt D, Xian Y, Shah S, Lytle B, Fonarow G, Sheth K. Abstract P384: Outcomes of Endovascular Therapy in Patients With Pre-Stroke Mobility Impairment Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p384.
- Pearls and Pitfalls of Introducing Ketogenic Diet in Adult Status Epilepticus: A Practical Guide for the IntensivistKatz JB, Owusu K, Nussbaum I, Beekman R, DeFilippo NA, Gilmore EJ, Hirsch LJ, Cervenka MC, Maciel CB. Pearls and Pitfalls of Introducing Ketogenic Diet in Adult Status Epilepticus: A Practical Guide for the Intensivist Journal Of Clinical Medicine 2021, 10: 881. PMID: 33671485, PMCID: PMC7926931, DOI: 10.3390/jcm10040881.
- Video quality using outpatient smartphone videos in epilepsy: Results from the OSmartViE studyTatum WO, Hirsch LJ, Gelfand MA, Acton EK, LaFrance WC, Duckrow RB, Chen D, Blum AS, Hixson J, Drazkowski J, Benbadis S, Cascino GD, Beekman R, Carvalho D, Marin Collazo I, Coonan E, Kleen J, Lopez A, Okazaki E, Ranpura A, Villarino L, Yuan S. Video quality using outpatient smartphone videos in epilepsy: Results from the OSmartViE study European Journal Of Neurology 2021, 28: 1453-1462. PMID: 33465822, DOI: 10.1111/ene.14744.
- Abstract 57: Deployment of Portable, Bedside, Low-Field Magnetic Resonance Imaging for Evaluation of Stroke PatientsCahn B, Shah J, Dyvorne H, O'Halloran R, Poole M, Yuen M, Mazurek M, Ward A, Payabvash S, Beekman R, Brown S, Falcone G, Gobeske K, Petersen N, Jasne A, Sharma R, Schindler J, Sansing L, Gilmore E, Wira C, Matouk C, Sze G, Rosen M, Kimberly W, Sheth K. Abstract 57: Deployment of Portable, Bedside, Low-Field Magnetic Resonance Imaging for Evaluation of Stroke Patients Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.57.
- 752: EVALUATION OF SCHEDULED INTERMITTENT 23.4% HYPERTONIC SALINE FOR ELEVATED INTRACRANIAL PRESSUREOwusu K, DeFilippo N, Beekman R. 752: EVALUATION OF SCHEDULED INTERMITTENT 23.4% HYPERTONIC SALINE FOR ELEVATED INTRACRANIAL PRESSURE Critical Care Medicine 2020, 48: 356-356. DOI: 10.1097/01.ccm.0000626748.85986.f1.
- Cerebrovascular DiseaseGreer D, Beekman R, Johnson M, Huttner A. Cerebrovascular Disease 2019, 167-285. DOI: 10.1007/978-3-030-03283-8_5.
- Differential outcomes following successful resuscitation in cardiac arrest due to drug overdoseOrmseth CH, Maciel CB, Zhou SE, Barden MM, Miyares LC, Beekman RB, Gilmore EJ, Greer DM. Differential outcomes following successful resuscitation in cardiac arrest due to drug overdose Resuscitation 2019, 139: 9-16. PMID: 30965094, DOI: 10.1016/j.resuscitation.2019.04.004.
- Distinct predictive values of current neuroprognostic guidelines in post-cardiac arrest patientsZhou SE, Maciel CB, Ormseth CH, Beekman R, Gilmore EJ, Greer DM. Distinct predictive values of current neuroprognostic guidelines in post-cardiac arrest patients Resuscitation 2019, 139: 343-350. PMID: 30951843, PMCID: PMC6589093, DOI: 10.1016/j.resuscitation.2019.03.035.
- Abstract WP223: Ischemic and Hemorrhagic Stroke in Native AmericansKing Z, Beekman R, Chu S, Leasure A, Orgrass H, Gilmore E, Sansing L, Matouk C, Sheth K, Falcone G. Abstract WP223: Ischemic and Hemorrhagic Stroke in Native Americans Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.wp223.
- Author responseBeekman R, Greer DM, Brooks DC, Maciel CB. Author response Neurology 2018, 91: 103. PMID: 29987180, DOI: 10.1212/wnl.0000000000005770.
- Spontaneous Intracerebral Hemorrhage in the Elderly PopulationSommaruga S, Beekman R, Chu S, King Z, Matouk C, Hwang D, Sheth K, Falcone G. Spontaneous Intracerebral Hemorrhage in the Elderly Population Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660768.
- Clinical ReasoningBeekman RB, Greer DM, Brooks DC, Maciel CB. Clinical Reasoning Neurology 2017, 89: e239-e244. PMID: 29133614, DOI: 10.1212/wnl.0000000000004649.
- Poor neurologic outcomes after cardiac arrest; a spectrum with individual implicationsBeekman R, Greer DM, Maciel CB. Poor neurologic outcomes after cardiac arrest; a spectrum with individual implications Epilepsy & Behavior Reports 2017, 8: 85-86. PMID: 29159067, PMCID: PMC5678751, DOI: 10.1016/j.ebcr.2017.08.002.
Clinical Trials
Conditions | Study Title |
---|---|
Diseases of the Nervous System | Brain Oxygen Optimization in Severe TBI, Phase 3 (BOOST3) |
Diseases of the Cardiovascular System; Diseases of the Nervous System | Anticoagulation for Stroke Prevention and Recovery After ICH (ASPIRE) |
Diseases of the Nervous System | Multi-arm Optimization of Stroke Thrombolysis (MOST) |
Diseases of the Cardiovascular System | Multimodal Outcome CHAracterization (MOCHA) in comatose cardiac arrest patients |