David Glahn, PhD
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Professor of Psychology
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Psychiatry
40 Temple Street, Suite 6E
New Haven, CT 06511
United States
About
Titles
Professor Adjunct of Psychiatry
Professor of PsychologyBiography
Dr. David Glahn joined Yale’s Department of Psychiatry and the Olin Neuropsychiatry Research Center in 2008. He received his doctorate in clinical psychology from the University of Pennsylvania in 2000 and completed a post-doctoral fellowship at the University of California at Los Angeles. From 2002 to 2008, Glahn was faculty at the University of Texas Health Science Center San Antonio, where he created a psychiatric genetics and imaging research program.
The primary aim of Glahn’s laboratory is to discover genes that predispose affective and psychotic disorders like major depression, bipolar disorder and schizophrenia. To achieve this aim, he develops and applies neuroanatomic, functional neuroimaging, and neurocognitive endophenotypes in large-scale family-based studies. Glahn co-direct the Neurocognition, Neurocomputation and Neurogenetics (n3) Division of the Department of Psychiatry at Yale University Medical School, and the Affective Disorders and Psychosis (ADAPTING) laboratory at the Olin Neuropsychiatric Research Center. In this capacity, he supervises an 11-strong research team comprised of junior faculty, postdoctoral fellows and research assistants. Glahn collaborates with investigators locally at Yale/Olin, nationally and internationally in connection to neuroimaging, neurocognition and genomic research.
Education & Training
- MA
- Yale University, Privatim (2015)
- Post-Doctoral Fellow
- University of California Los Angeles (2002)
- PhD
- University of Pennsylvania, Psychology (2000)
- MA
- University of Pennsylvania, Psychology (1997)
- BS
- Drexel University, Psychology (1993)
Research
Overview
Medical Subject Headings (MeSH)
Aging; Bipolar Disorder; Child Development; Depressive Disorder, Major; Genetics; Genetics, Behavioral; Neuroimaging; Neuropsychology; Psychiatry and Psychology; Schizophrenia
ORCID
0000-0002-4749-6977
Research at a Glance
Yale Co-Authors
Frequent collaborators of David Glahn's published research.
Publications Timeline
A big-picture view of David Glahn's research output by year.
Research Interests
Research topics David Glahn is interested in exploring.
Godfrey Pearlson, MA, MBBS
Kevin Sheth, MD
Alecia Dager, PhD
Nicola Hawley, PhD
15Publications
4Citations
Publications
Brain‐age prediction: Systematic evaluation of site effects, and sample age range and size
Yu Y, Cui H, Haas S, New F, Sanford N, Yu K, Zhan D, Yang G, Gao J, Wei D, Qiu J, Banaj N, Boomsma D, Breier A, Brodaty H, Buckner R, Buitelaar J, Cannon D, Caseras X, Clark V, Conrod P, Crivello F, Crone E, Dannlowski U, Davey C, de Haan L, de Zubicaray G, Di Giorgio A, Fisch L, Fisher S, Franke B, Glahn D, Grotegerd D, Gruber O, Gur R, Gur R, Hahn T, Harrison B, Hatton S, Hickie I, Pol H, Jamieson A, Jernigan T, Jiang J, Kalnin A, Kang S, Kochan N, Kraus A, Lagopoulos J, Lazaro L, McDonald B, McDonald C, McMahon K, Mwangi B, Piras F, Rodriguez‐Cruces R, Royer J, Sachdev P, Satterthwaite T, Saykin A, Schumann G, Sevaggi P, Smoller J, Soares J, Spalletta G, Tamnes C, Trollor J, Ent D, Vecchio D, Walter H, Wang Y, Weber B, Wen W, Wierenga L, Williams S, Wu M, Zunta‐Soares G, Bernhardt B, Thompson P, Frangou S, Ge R, Group E. Brain‐age prediction: Systematic evaluation of site effects, and sample age range and size. Human Brain Mapping 2024, 45: e26768. PMID: 38949537, PMCID: PMC11215839, DOI: 10.1002/hbm.26768.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsBrain-aging modelBrain-age predictionBrain-ageDiscovery sampleBrain morphometric measuresStructural neuroimaging dataSamples of healthy individualsSample age rangeNeuroimaging metricsNeuroimaging dataHealthy individualsLongitudinal consistencyBrain developmentIndependent samplesAge varianceAge rangeBrainSample sizeAge binsMorphometry dataIndividualsHuman lifespanEmpirical examinationMeaningful measuresFindingsAdmixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos
Xia R, Jian X, Rodrigue A, Bressler J, Boerwinkle E, Cui B, Daviglus M, DeCarli C, Gallo L, Glahn D, Knowles E, Moon J, Mosley T, Satizabal C, Sofer T, Tarraf W, Testai F, Blangero J, Seshadri S, González H, Fornage M. Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos. Alzheimer's & Dementia 2024 PMID: 38946675, DOI: 10.1002/alz.14082.Peer-Reviewed Original ResearchAltmetricConceptsSingle nucleotide polymorphismsLatino adultsAssociated to cognitive functionAdmixture mappingHispanic Community Health Study/Study of LatinosCognitive functionHispanic Community Health Study/StudyPrioritized single nucleotide polymorphismsGenetic variantsGenome-wide association studiesNon-Hispanic whitesFine-mapping analysisLoci harboring genesSample of BlackHispanic/Latino adultsPhosphoinositide lipid metabolismNeurocognitive measuresIndependent replicationAdmixture signalsUnique haplotypesGenetic architectureChromosomal regionsHarboring genesAssociation studiesNucleotide polymorphismsA genetic association study of circulating coagulation factor VIII and von Willebrand factor levels
de Vries P, Reventun P, Brown M, Heath A, Huffman J, Le N, Bebo A, Brody J, Temprano-Sagrera G, Raffield L, Ozel A, Thibord F, Jain D, Lewis J, Rodriguez B, Pankratz N, Taylor K, Polasek O, Chen M, Yanek L, Carrasquilla G, Marioni R, Kleber M, Trégouët D, Yao J, Li-Gao R, Joshi P, Trompet S, Martinez-Perez A, Ghanbari M, Howard T, Reiner A, Arvanitis M, Ryan K, Bartz T, Rudan I, Faraday N, Linneberg A, Ekunwe L, Davies G, Delgado G, Suchon P, Guo X, Rosendaal F, Klaric L, Noordam R, van Rooij F, Curran J, Wheeler M, Osburn W, O'Connell J, Boerwinkle E, Beswick A, Psaty B, Kolcic I, Souto J, Becker L, Hansen T, Doyle M, Harris S, Moissl A, Deleuze J, Rich S, van Hylckama Vlieg A, Campbell H, Stott D, Soria J, de Maat M, Almasy L, Brody L, Auer P, Mitchell B, Ben-Shlomo Y, Fornage M, Hayward C, Mathias R, Kilpeläinen T, Lange C, Cox S, März W, Morange P, Rotter J, Mook-Kanamori D, Wilson C, van der Harst P, Jukema J, Ikram M, Blangero J, Kooperberg C, Desch K, Johnson A, Sabater-Lleal M, Lowenstein C, Smith A, Morrison A, Abe N, Abecasis G, Aguet F, Albert C, Almasy L, Alonso A, Ament S, Anderson P, Anugu P, Applebaum-Bowden D, Ardlie K, Arking D, Arnett D, Ashley-Koch A, Aslibekyan S, Assimes T, Auer P, Avramopoulos D, Ayas N, Balasubramanian A, Barnard J, Barnes K, Barr R, Barron-Casella E, Barwick L, Beaty T, Beck G, Becker D, Becker L, Beer R, Beitelshees A, Benjamin E, Benos T, Bezerra M, Bielak L, Bis J, Blackwell T, Blangero J, Blue N, Boerwinkle E, Bowden D, Bowler R, Brody J, Broeckel U, Broome J, Brown D, Bunting K, Burchard E, Bustamante C, Buth E, Cade B, Cardwell J, Carey V, Carrier J, Carson A, Carty C, Casaburi R, Romero J, Casella J, Castaldi P, Chaffin M, Chang C, Chang Y, Chasman D, Chavan S, Chen B, Chen W, Chen Y, Cho M, Choi S, Chuang L, Chung M, Chung R, Clish C, Comhair S, Conomos M, Cornell E, Correa A, Crandall C, Crapo J, Cupples L, Curran J, Curtis J, Custer B, Damcott C, Darbar D, David S, Davis C, Daya M, de Andrade M, de las Fuentes L, de Vries P, DeBaun M, Deka R, DeMeo D, Devine S, Dinh H, Doddapaneni H, Duan Q, Dugan-Perez S, Duggirala R, Durda J, Dutcher S, Eaton C, Ekunwe L, Boueiz A, Ellinor P, Emery L, Erzurum S, Farber C, Farek J, Fingerlin T, Flickinger M, Fornage M, Franceschini N, Frazar C, Fu M, Fullerton S, Fulton L, Gabriel S, Gan W, Gao S, Gao Y, Gass M, Geiger H, Gelb B, Geraci M, Germer S, Gerszten R, Ghosh A, Gibbs R, Gignoux C, Gladwin M, Glahn D, Gogarten S, Gong D, Goring H, Graw S, Gray K, Grine D, Gross C, Gu C, Guan Y, Guo X, Gupta N, Haessler J, Hall M, Han Y, Hanly P, Harris D, Hawley N, He J, Heavner B, Heckbert S, Hernandez R, Herrington D, Hersh C, Hidalgo B, Hixson J, Hobbs B, Hokanson J, Hong E, Hoth K, Hsiung C, Hu J, Hung Y, Huston H, Hwu C, Irvin M, Jackson R, Jain D, Jaquish C, Johnsen J, Johnson C, Johnson A, Johnston R, Jones K, Kang H, Kaplan R, Kardia S, Kelly S, Kenny E, Kessler M, Khan A, Khan Z, Kim W, Kimoff J, Kinney G, Konkle B, Kooperberg C, Kramer H, Lange E, Lange L, Lange L, Laurie C, Laurie C, LeBoff M, Lee J, Lee S, Lee W, LeFaive J, Levine D, Levy D, Lewis J, Li X, Li Y, Lin H, Lin H, Lin X, Liu S, Liu Y, Liu Y, Loos R, Lubitz S, Lunetta K, Luo J, Magalang U, Mahaney M, Make B, Manichaikul A, Manning A, Manson J, Martin L, Marton M, Mathai S, Mathias R, May S, McArdle P, McDonald M, McFarland S, McGarvey S, McGoldrick D, McHugh C, McNeil B, Mei H, Meigs J, Menon V, Mestroni L, Metcalf G, Meyers D, Mignot E, Mikulla J, Min N, Minear M, Minster R, Mitchell B, Moll M, Momin Z, Montasser M, Montgomery C, Muzny D, Mychaleckyj J, Nadkarni G, Naik R, Naseri T, Natarajan P, Nekhai S, Nelson S, Neltner B, Nessner C, Nickerson D, Nkechinyere O, North K, O'Connell J, O'Connor T, Ochs-Balcom H, Okwuonu G, Pack A, Paik D, Palmer N, Pankow J, Papanicolaou G, Parker C, Peloso G, Peralta J, Perez M, Perry J, Peters U, Peyser P, Phillips L, Pleiness J, Pollin T, Post W, Becker J, Boorgula M, Preuss M, Psaty B, Qasba P, Qiao D, Qin Z, Rafaels N, Raffield L, Rajendran M, Ramachandran V, Rao D, Rasmussen-Torvik L, Ratan A, Redline S, Reed R, Reeves C, Regan E, Reiner A, Reupena M, Rice K, Rich S, Robillard R, Robine N, Roden D, Roselli C, Rotter J, Ruczinski I, Runnels A, Russell P, Ruuska S, Ryan K, Sabino E, Saleheen D, Salimi S, Salvi S, Salzberg S, Sandow K, Sankaran V, Santibanez J, Schwander K, Schwartz D, Sciurba F, Seidman C, Seidman J, Sériès F, Sheehan V, Sherman S, Shetty A, Shetty A, Sheu W, Shoemaker M, Silver B, Silverman E, Skomro R, Smith J, Smith J, Smith N, Smith T, Smith E, Smoller S, Snively B, Snyder M, Sofer T, Sotoodehnia N, Stilp A, Storm G, Streeten E, Su J, Sung Y, Sylvia J, Szpiro A, Taliun D, Tang H, Taub M, Taylor K, Taylor M, Taylor S, Telen M, Thornton T, Threlkeld M, Tinker L, Tirschwell D, Tishkoff S, Tiwari H, Tong C, Tracy R, Tsai M, Vaidya D, Van Den Berg D, VandeHaar P, Vrieze S, Walker T, Wallace R, Walts A, Wang F, Wang H, Wang J, Watson K, Watt J, Weeks D, Weinstock J, Weir B, Weiss S, Weng L, Wessel J, Willer C, Williams K, Williams L, Wilson J, Wilson J, Winterkorn L, Wong Q, Wu J, Xu H, Yanek L, Yang I, Yu K, Zekavat S, Zhang Y, Zhao S, Zhao W, Zhu X, Ziv E, Zody M, Zoellner S, Lindstrom S, Wang L, Smith N, Gordon W, van Hylckama Vlieg A, de Andrade M, Brody J, Pattee J, Haessler J, Brumpton B, Chasman D, Suchon P, Chen M, Turman C, Germain M, Wiggins K, MacDonald J, Braekkan S, Armasu S, Pankratz N, Jackson R, Nielsen J, Giulianini F, Puurunen M, Ibrahim M, Heckbert S, Bammler T, Frazer K, McCauley B, Taylor K, Pankow J, Reiner A, Gabrielsen M, Deleuze J, O'Donnell C, Kim J, McKnight B, Kraft P, Hansen J, Rosendaal F, Heit J, Psaty B, Tang W, Kooperberg C, Hveem K, Ridker P, Morange P, Johnson A, Kabrhel C, AlexandreTrégouët D, Smith N. A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels. Blood 2024, 143: 1845-1855. PMID: 38320121, DOI: 10.1182/blood.2023021452.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMendelian randomizationGene-based aggregation testingImputation of genotypesGene-based analysisMulti-phenotype analysisAssociations of factor VIIIGenetic association studiesHuman umbilical vein endothelial cellsCausal genesTrans-OmicsAssociation studiesB3GNT2Genetic associationVon Willebrand factorProtein von Willebrand factorLociIdentified associationsPDIA3Umbilical vein endothelial cellsIncreased riskMeta-analysisCarrier protein von Willebrand factorVein endothelial cellsPrecision medicineEndothelial cells434. Improving Image Accuracy in Low-Field Magnetic Resonance Imaging to Make Accessible Biomarkers for Psychiatric Disorders
Cooper R, Hayes R, Corcoran M, Sheth K, Arnold T, Stein J, Glahn D, Jalbrzikowski M. 434. Improving Image Accuracy in Low-Field Magnetic Resonance Imaging to Make Accessible Biomarkers for Psychiatric Disorders. Biological Psychiatry 2024, 95: s277-s278. DOI: 10.1016/j.biopsych.2024.02.933.Peer-Reviewed Original Research409. Cortico-Thalamic Structural Co-Variation Networks are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study
Lella A, Antonucci L, Weinberger D, Glahn D, Sim K, Gruber O, Chung Y, Sugranyes G, Clote E, Marcelis M, Kircher T, Van Rheenen T, Sponheim S, Dannlowski U, Iasevoli F, Pearlson G, Green M, Spalletta G, Lee T, Turner J, van Erp T, Thompson P, Bertolino A, Pergola G. 409. Cortico-Thalamic Structural Co-Variation Networks are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study. Biological Psychiatry 2024, 95: s267-s268. DOI: 10.1016/j.biopsych.2024.02.908.Peer-Reviewed Original ResearchAltmetric417. Diagnostic Complexity, Symptomatology, and Functioning in Two Early-Onset Psychosis Family Studies: Epicenter and Epimex
Mollon J, Mathias S, Lanzagorta N, Rodrigue A, Knowles E, Deaso E, Cadavid L, Saavedra J, Phelps E, Polat N, Brownstein C, D’Angelo E, Deo A, Gonzalez-Heydrich J, Sarmiento E, Walsh C, Almasy L, Nicolini H, Glahn D. 417. Diagnostic Complexity, Symptomatology, and Functioning in Two Early-Onset Psychosis Family Studies: Epicenter and Epimex. Biological Psychiatry 2024, 95: s270-s271. DOI: 10.1016/j.biopsych.2024.02.916.Peer-Reviewed Original ResearchAltmetric8. The Relationship Between Treatment, Symptom Severity, and Brain Connectivity in Bipolar Disorder: An International Study Across 16 Enigma-Bipolar Sites
Nabulsi L, Kang M, Jahanshad N, Haarman B, McDonald C, Stein D, Glahn D, Pomarol-Clotet E, Vieta E, Houenou J, Favre P, Polosan M, Brambilla P, Bellani M, Mitchell P, Dannlowski U, Wessa M, Phillips M, Kircher T, Thompson P, Andreassen O, Ching C, Cannon D, Group E. 8. The Relationship Between Treatment, Symptom Severity, and Brain Connectivity in Bipolar Disorder: An International Study Across 16 Enigma-Bipolar Sites. Biological Psychiatry 2024, 95: s76-s77. DOI: 10.1016/j.biopsych.2024.02.186.Peer-Reviewed Original ResearchAltmetric295. Rare Variant Genetic Architecture of the Human Cortical MRI Phenotypes in General Population
Kumar K, Kazem S, Liao Z, Kopal J, Huguet G, Renne T, Jean-Louis M, Xie Z, Saci Z, Almasy L, Glahn D, Paus T, Dumas G, Bearden C, Thompson P, Bethlehem R, Warrier V, Jacquemont S. 295. Rare Variant Genetic Architecture of the Human Cortical MRI Phenotypes in General Population. Biological Psychiatry 2024, 95: s220-s221. DOI: 10.1016/j.biopsych.2024.02.794.Peer-Reviewed Original ResearchRole of Neurocellular Endoplasmic Reticulum Stress Response in Alzheimer’s Disease and Related Dementias Risk
Aceves M, Granados J, Leandro A, Peralta J, Glahn D, Williams-Blangero S, Curran J, Blangero J, Kumar S. Role of Neurocellular Endoplasmic Reticulum Stress Response in Alzheimer’s Disease and Related Dementias Risk. Genes 2024, 15: 569. PMID: 38790197, PMCID: PMC11121587, DOI: 10.3390/genes15050569.Peer-Reviewed Original ResearchAltmetricConceptsTranscriptional response to ER stressProtein kinase RNA-like ER kinaseActivating transcription factor 6Inositol-requiring enzyme-1ER stress responseUnfolded protein responseElevated endoplasmic reticulumAlzheimer's diseaseResponse to ER stressSarco/endoplasmic reticulum Ca2+-ATPaseNeural stem cellsRNA-like ER kinaseStress responseAnalysis of DE genesG1/S phase cell cycle arrestEndoplasmic reticulum stress responseInduced G1/S-phase cell cycle arrestPostmortem AD brainsGene network analysisTranscription factor 6E2F transcription factor 1Animal models of ADCell cycle arrestModel of ADBinding protein 1When virtual reality becomes psychoneuroendocrine reality: A stress(or) review
Finseth T, Smith B, Van Steenis A, Glahn D, Johnson M, Ruttle P, Shirtcliff B, Shirtcliff E. When virtual reality becomes psychoneuroendocrine reality: A stress(or) review. Psychoneuroendocrinology 2024, 166: 107061. PMID: 38701607, DOI: 10.1016/j.psyneuen.2024.107061.Peer-Reviewed Original ResearchAltmetric
Clinical Trials
Current Trials
Teen Brain and Behavior Study
HIC ID1111009332RoleSub InvestigatorPrimary Completion Date12/21/2022Recruiting ParticipantsGenderBothAge13 years - 17 years
Academic Achievements and Community Involvement
activity Member
CommitteesYale Scholar Awards CommitteeDetails05/03/2015 - PresentDescriptionMemberactivity Member
CommitteesYale Center for Clinical InvestigationDetails04/30/2015 - PresentDescriptionRevieweractivity Member
CommitteesBurlingame Award Selection CommitteeDetails04/30/2000 - PresentDescriptionMemberactivity Member
CommitteesMonash Biomedical Imaging Center, Monash UniversityDetails04/30/2012 - PresentDescriptionMember, External Advisory Boardactivity Member
Public ServiceHuman Brain Mapping (Journal)Details04/30/2015 - PresentDescriptionEditorial Board
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News
- June 05, 2024
Four Faculty Invited to Speak at Cold Spring Harbor's 2024 Schizophrenia and Related Disorders Course
- July 11, 2017
Glahn serves as vice chair of Gordon Research Conference in Hong Kong
- December 14, 2016
Yale faculty, researchers contribute chapter to book about Computational Psychiatry
- December 05, 2016
Glahn given the ACNP Joel Elkes Research Award
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Mailing Address
Psychiatry
40 Temple Street, Suite 6E
New Haven, CT 06511
United States