David Glahn, PhD
Research & Publications
Biography
News
Research Summary
The primary aims of my laboratory are (1) to identify and characterize risk genes for psychotic and affective disorders and (2) to specify genetic influences on normal variation of in-vivo measures of brain structure and cognitive function. My work involves the characterization of the multi-scale influence of genetic variation on cognitive processes, basic physiology, brain networks, and on the complex clinical features observed in affective and psychotic disorders. Interpretation of such findings is predicated on a clear understanding of the genetic control of normal neuroanatomic, neurophysiologic and cognitive variation, particularly since genes influencing normal variation are often also associated with pathology. Therefore, a major component of my research focuses on determining the genetic aspects of individual differences. Additionally, as development, aging and comorbid substance use are important factors in psychopathology, my laboratory actively searchers for genetic factors influencing these factors. My research on schizophrenia, bipolar disorder and recurrent major depression, combined with methods development and a commitment to teaching, is designed to enhance our ability to identify, treat, and, potentially, prevent these debilitating disorders.
Coauthors
Research Interests
Aging; Bipolar Disorder; Child Development; Depressive Disorder, Major; Genetics; Genetics, Behavioral; Neuropsychology; Schizophrenia; Neuroimaging; Psychiatry and Psychology
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Selected Publications
- A genetic association study of circulating coagulation factor VIII and von Willebrand factor levelsde Vries P, Reventun P, Brown M, Heath A, Huffman J, Le N, Bebo A, Brody J, Temprano-Sagrera G, Raffield L, Ozel A, Thibord F, Jain D, Lewis J, Rodriguez B, Pankratz N, Taylor K, Polasek O, Chen M, Yanek L, Carrasquilla G, Marioni R, Kleber M, Trégouët D, Yao J, Li-Gao R, Joshi P, Trompet S, Martinez-Perez A, Ghanbari M, Howard T, Reiner A, Arvanitis M, Ryan K, Bartz T, Rudan I, Faraday N, Linneberg A, Ekunwe L, Davies G, Delgado G, Suchon P, Guo X, Rosendaal F, Klaric L, Noordam R, van Rooij F, Curran J, Wheeler M, Osburn W, O'Connell J, Boerwinkle E, Beswick A, Psaty B, Kolcic I, Souto J, Becker L, Hansen T, Doyle M, Harris S, Moissl A, Deleuze J, Rich S, van Hylckama Vlieg A, Campbell H, Stott D, Soria J, de Maat M, Almasy L, Brody L, Auer P, Mitchell B, Ben-Shlomo Y, Fornage M, Hayward C, Mathias R, Kilpeläinen T, Lange C, Cox S, März W, Morange P, Rotter J, Mook-Kanamori D, Wilson C, van der Harst P, Jukema J, Ikram M, Blangero J, Kooperberg C, Desch K, Johnson A, Sabater-Lleal M, Lowenstein C, Smith A, Morrison A, Abe N, Abecasis G, Aguet F, Albert C, Almasy L, Alonso A, Ament S, Anderson P, Anugu P, Applebaum-Bowden D, Ardlie K, Arking D, Arnett D, Ashley-Koch A, Aslibekyan S, Assimes T, Auer P, Avramopoulos D, Ayas N, Balasubramanian A, Barnard J, Barnes K, Barr R, Barron-Casella E, Barwick L, Beaty T, Beck G, Becker D, Becker L, Beer R, Beitelshees A, Benjamin E, Benos T, Bezerra M, Bielak L, Bis J, Blackwell T, Blangero J, Blue N, Boerwinkle E, Bowden D, Bowler R, Brody J, Broeckel U, Broome J, Brown D, Bunting K, Burchard E, Bustamante C, Buth E, Cade B, Cardwell J, Carey V, Carrier J, Carson A, Carty C, Casaburi R, Romero J, Casella J, Castaldi P, Chaffin M, Chang C, Chang Y, Chasman D, Chavan S, Chen B, Chen W, Chen Y, Cho M, Choi S, Chuang L, Chung M, Chung R, Clish C, Comhair S, Conomos M, Cornell E, Correa A, Crandall C, Crapo J, Cupples L, Curran J, Curtis J, Custer B, Damcott C, Darbar D, David S, Davis C, Daya M, de Andrade M, de las Fuentes L, de Vries P, DeBaun M, Deka R, DeMeo D, Devine S, Dinh H, Doddapaneni H, Duan Q, Dugan-Perez S, Duggirala R, Durda J, Dutcher S, Eaton C, Ekunwe L, Boueiz A, Ellinor P, Emery L, Erzurum S, Farber C, Farek J, Fingerlin T, Flickinger M, Fornage M, Franceschini N, Frazar C, Fu M, Fullerton S, Fulton L, Gabriel S, Gan W, Gao S, Gao Y, Gass M, Geiger H, Gelb B, Geraci M, Germer S, Gerszten R, Ghosh A, Gibbs R, Gignoux C, Gladwin M, Glahn D, Gogarten S, Gong D, Goring H, Graw S, Gray K, Grine D, Gross C, Gu C, Guan Y, Guo X, Gupta N, Haessler J, Hall M, Han Y, Hanly P, Harris D, Hawley N, He J, Heavner B, Heckbert S, Hernandez R, Herrington D, Hersh C, Hidalgo B, Hixson J, Hobbs B, Hokanson J, Hong E, Hoth K, Hsiung C, Hu J, Hung Y, Huston H, Hwu C, Irvin M, Jackson R, Jain D, Jaquish C, Johnsen J, Johnson C, Johnson A, Johnston R, Jones K, Kang H, Kaplan R, Kardia S, Kelly S, Kenny E, Kessler M, Khan A, Khan Z, Kim W, Kimoff J, Kinney G, Konkle B, Kooperberg C, Kramer H, Lange E, Lange L, Lange L, Laurie C, Laurie C, LeBoff M, Lee J, Lee S, Lee W, LeFaive J, Levine D, Levy D, Lewis J, Li X, Li Y, Lin H, Lin H, Lin X, Liu S, Liu Y, Liu Y, Loos R, Lubitz S, Lunetta K, Luo J, Magalang U, Mahaney M, Make B, Manichaikul A, Manning A, Manson J, Martin L, Marton M, Mathai S, Mathias R, May S, McArdle P, McDonald M, McFarland S, McGarvey S, McGoldrick D, McHugh C, McNeil B, Mei H, Meigs J, Menon V, Mestroni L, Metcalf G, Meyers D, Mignot E, Mikulla J, Min N, Minear M, Minster R, Mitchell B, Moll M, Momin Z, Montasser M, Montgomery C, Muzny D, Mychaleckyj J, Nadkarni G, Naik R, Naseri T, Natarajan P, Nekhai S, Nelson S, Neltner B, Nessner C, Nickerson D, Nkechinyere O, North K, O'Connell J, O'Connor T, Ochs-Balcom H, Okwuonu G, Pack A, Paik D, Palmer N, Pankow J, Papanicolaou G, Parker C, Peloso G, Peralta J, Perez M, Perry J, Peters U, Peyser P, Phillips L, Pleiness J, Pollin T, Post W, Becker J, Boorgula M, Preuss M, Psaty B, Qasba P, Qiao D, Qin Z, Rafaels N, Raffield L, Rajendran M, Ramachandran V, Rao D, Rasmussen-Torvik L, Ratan A, Redline S, Reed R, Reeves C, Regan E, Reiner A, Reupena M, Rice K, Rich S, Robillard R, Robine N, Roden D, Roselli C, Rotter J, Ruczinski I, Runnels A, Russell P, Ruuska S, Ryan K, Sabino E, Saleheen D, Salimi S, Salvi S, Salzberg S, Sandow K, Sankaran V, Santibanez J, Schwander K, Schwartz D, Sciurba F, Seidman C, Seidman J, Sériès F, Sheehan V, Sherman S, Shetty A, Shetty A, Sheu W, Shoemaker M, Silver B, Silverman E, Skomro R, Smith J, Smith J, Smith N, Smith T, Smith E, Smoller S, Snively B, Snyder M, Sofer T, Sotoodehnia N, Stilp A, Storm G, Streeten E, Su J, Sung Y, Sylvia J, Szpiro A, Taliun D, Tang H, Taub M, Taylor K, Taylor M, Taylor S, Telen M, Thornton T, Threlkeld M, Tinker L, Tirschwell D, Tishkoff S, Tiwari H, Tong C, Tracy R, Tsai M, Vaidya D, Van Den Berg D, VandeHaar P, Vrieze S, Walker T, Wallace R, Walts A, Wang F, Wang H, Wang J, Watson K, Watt J, Weeks D, Weinstock J, Weir B, Weiss S, Weng L, Wessel J, Willer C, Williams K, Williams L, Wilson J, Wilson J, Winterkorn L, Wong Q, Wu J, Xu H, Yanek L, Yang I, Yu K, Zekavat S, Zhang Y, Zhao S, Zhao W, Zhu X, Ziv E, Zody M, Zoellner S, Lindstrom S, Wang L, Smith N, Gordon W, van Hylckama Vlieg A, de Andrade M, Brody J, Pattee J, Haessler J, Brumpton B, Chasman D, Suchon P, Chen M, Turman C, Germain M, Wiggins K, MacDonald J, Braekkan S, Armasu S, Pankratz N, Jackson R, Nielsen J, Giulianini F, Puurunen M, Ibrahim M, Heckbert S, Bammler T, Frazer K, McCauley B, Taylor K, Pankow J, Reiner A, Gabrielsen M, Deleuze J, O'Donnell C, Kim J, McKnight B, Kraft P, Hansen J, Rosendaal F, Heit J, Psaty B, Tang W, Kooperberg C, Hveem K, Ridker P, Morange P, Johnson A, Kabrhel C, AlexandreTrégouët D, Smith N. A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels. Blood 2024, 143: 1845-1855. PMID: 38320121, DOI: 10.1182/blood.2023021452.
- 434. Improving Image Accuracy in Low-Field Magnetic Resonance Imaging to Make Accessible Biomarkers for Psychiatric DisordersCooper R, Hayes R, Corcoran M, Sheth K, Arnold T, Stein J, Glahn D, Jalbrzikowski M. 434. Improving Image Accuracy in Low-Field Magnetic Resonance Imaging to Make Accessible Biomarkers for Psychiatric Disorders. Biological Psychiatry 2024, 95: s277-s278. DOI: 10.1016/j.biopsych.2024.02.933.
- 409. Cortico-Thalamic Structural Co-Variation Networks are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA StudyLella A, Antonucci L, Weinberger D, Glahn D, Sim K, Gruber O, Chung Y, Sugranyes G, Clote E, Marcelis M, Kircher T, Van Rheenen T, Sponheim S, Dannlowski U, Iasevoli F, Pearlson G, Green M, Spalletta G, Lee T, Turner J, van Erp T, Thompson P, Bertolino A, Pergola G. 409. Cortico-Thalamic Structural Co-Variation Networks are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study. Biological Psychiatry 2024, 95: s267-s268. DOI: 10.1016/j.biopsych.2024.02.908.
- 417. Diagnostic Complexity, Symptomatology, and Functioning in Two Early-Onset Psychosis Family Studies: Epicenter and EpimexMollon J, Mathias S, Lanzagorta N, Rodrigue A, Knowles E, Deaso E, Cadavid L, Saavedra J, Phelps E, Polat N, Brownstein C, D’Angelo E, Deo A, Gonzalez-Heydrich J, Sarmiento E, Walsh C, Almasy L, Nicolini H, Glahn D. 417. Diagnostic Complexity, Symptomatology, and Functioning in Two Early-Onset Psychosis Family Studies: Epicenter and Epimex. Biological Psychiatry 2024, 95: s270-s271. DOI: 10.1016/j.biopsych.2024.02.916.
- 8. The Relationship Between Treatment, Symptom Severity, and Brain Connectivity in Bipolar Disorder: An International Study Across 16 Enigma-Bipolar SitesNabulsi L, Kang M, Jahanshad N, Haarman B, McDonald C, Stein D, Glahn D, Pomarol-Clotet E, Vieta E, Houenou J, Favre P, Polosan M, Brambilla P, Bellani M, Mitchell P, Dannlowski U, Wessa M, Phillips M, Kircher T, Thompson P, Andreassen O, Ching C, Cannon D, Group E. 8. The Relationship Between Treatment, Symptom Severity, and Brain Connectivity in Bipolar Disorder: An International Study Across 16 Enigma-Bipolar Sites. Biological Psychiatry 2024, 95: s76-s77. DOI: 10.1016/j.biopsych.2024.02.186.
- 295. Rare Variant Genetic Architecture of the Human Cortical MRI Phenotypes in General PopulationKumar K, Kazem S, Liao Z, Kopal J, Huguet G, Renne T, Jean-Louis M, Xie Z, Saci Z, Almasy L, Glahn D, Paus T, Dumas G, Bearden C, Thompson P, Bethlehem R, Warrier V, Jacquemont S. 295. Rare Variant Genetic Architecture of the Human Cortical MRI Phenotypes in General Population. Biological Psychiatry 2024, 95: s220-s221. DOI: 10.1016/j.biopsych.2024.02.794.
- Role of Neurocellular Endoplasmic Reticulum Stress Response in Alzheimer’s Disease and Related Dementias RiskAceves M, Granados J, Leandro A, Peralta J, Glahn D, Williams-Blangero S, Curran J, Blangero J, Kumar S. Role of Neurocellular Endoplasmic Reticulum Stress Response in Alzheimer’s Disease and Related Dementias Risk. Genes 2024, 15: 569. PMID: 38790197, PMCID: PMC11121587, DOI: 10.3390/genes15050569.
- When virtual reality becomes psychoneuroendocrine reality: A stress(or) reviewFinseth T, Smith B, Van Steenis A, Glahn D, Johnson M, Ruttle P, Shirtcliff B, Shirtcliff E. When virtual reality becomes psychoneuroendocrine reality: A stress(or) review. Psychoneuroendocrinology 2024, 166: 107061. PMID: 38701607, DOI: 10.1016/j.psyneuen.2024.107061.
- Author Correction: Using rare genetic mutations to revisit structural brain asymmetryKopal J, Kumar K, Shafighi K, Saltoun K, Modenato C, Moreau C, Huguet G, Jean-Louis M, Martin C, Saci Z, Younis N, Douard E, Jizi K, Beauchamp-Chatel A, Kushan L, Silva A, van den Bree M, Linden D, Owen M, Hall J, Lippé S, Draganski B, Sønderby I, Andreassen O, Glahn D, Thompson P, Bearden C, Zatorre R, Jacquemont S, Bzdok D. Author Correction: Using rare genetic mutations to revisit structural brain asymmetry. Nature Communications 2024, 15: 3098. PMID: 38600109, PMCID: PMC11006936, DOI: 10.1038/s41467-024-47545-5.
- Relating depressive and manic symptomatology to 1H-MRS spectraChoquette A, Dager A, Marjańska M, Zatony M, Pearlson G, Glahn D, Knowles E. Relating depressive and manic symptomatology to 1H-MRS spectra. Journal Of Affective Disorders Reports 2024, 16: 100774. DOI: 10.1016/j.jadr.2024.100774.
- Using rare genetic mutations to revisit structural brain asymmetryKopal J, Kumar K, Shafighi K, Saltoun K, Modenato C, Moreau C, Huguet G, Jean-Louis M, Martin C, Saci Z, Younis N, Douard E, Jizi K, Beauchamp-Chatel A, Kushan L, Silva A, van den Bree M, Linden D, Owen M, Hall J, Lippé S, Draganski B, Sønderby I, Andreassen O, Glahn D, Thompson P, Bearden C, Zatorre R, Jacquemont S, Bzdok D. Using rare genetic mutations to revisit structural brain asymmetry. Nature Communications 2024, 15: 2639. PMID: 38531844, PMCID: PMC10966068, DOI: 10.1038/s41467-024-46784-w.
- Bridging the gap: improving correspondence between low-field and high-field magnetic resonance images in young peopleCooper R, Hayes R, Corcoran M, Sheth K, Arnold T, Stein J, Glahn D, Jalbrzikowski M. Bridging the gap: improving correspondence between low-field and high-field magnetic resonance images in young people. Frontiers In Neurology 2024, 15: 1339223. PMID: 38585353, PMCID: PMC10995930, DOI: 10.3389/fneur.2024.1339223.
- Riemannian frameworks for the harmonization of resting-state functional MRI scansHonnorat N, Seshadri S, Killiany R, Blangero J, Glahn D, Fox P, Habes M. Riemannian frameworks for the harmonization of resting-state functional MRI scans. Medical Image Analysis 2023, 91: 103043. PMID: 38029722, PMCID: PMC11157681, DOI: 10.1016/j.media.2023.103043.
Clinical Trials
Conditions | Study Title |
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Diseases of the Nervous System; Mental Health & Behavioral Research | Teen Brain and Behavior Study |