We use a combination of biochemistry, molecular biology, and bio-organic chemistry to explore different aspects of cell biology. Different projects include the development of novel small molecules to control intracellular processes such as protein homeostasis and signal transduction.
We develop novel reagents and methodologies, which will allow us to explore new areas in cell biology. This 'chemical genetic' approach uses biologically active small molecules to control various intracellular processes. For example we developed the PROTAC technology that decrease target protein levels within cells by inducing their proteolysis via the 26S proteasome. A goal of this research is to develop novel methodologies that would allow for small molecule control of the 'undruggable proteome'.
Biochemistry; Biology; Chemistry; Cell Biology; Neoplasms; Pharmacology; Drugs, Investigational; Proteasome Endopeptidase Complex; Proteasome Inhibitors