Benjamin Bunney, MD
Research & Publications
Biography
News
Research Summary
Neuronal systems in the brain that use dopamine as their chemical messenger have been implicated in the pathogenesis of a variety of neurological and mental disorders, including Parkinson's disease and schizophrenia. Most of the pharmacological treatments for these disorders alter dopamine system functioning. We have been studying the site and mechanism of action of these drugs, as well as fundamental aspects of central dopamine system functioning and its control, both intra- and extracellular.
Our current approaches include the use of variety of electrophysiological, electrochemical, and anatomical techniques applied both in vivo and in vitro. Because of a strong interest in neurological and mental disorders related to presumed dopaminergic system malfunctioning, consideration of the potential relevance of all research findings to these disorders is an important aspect of the training received in this laboratory.
Coauthors
Selected Publications
- A model for the assessment, care, and treatment of suicidal risk within the military intelligence communityVan Dillen T, Kane R, Bunney B, Feuerstein S, Hopkins C, Raimo J, Stubbs T, Jobes D. A model for the assessment, care, and treatment of suicidal risk within the military intelligence community. Military Psychology 2021, 34: 345-351. PMID: 38536342, PMCID: PMC10013476, DOI: 10.1080/08995605.2021.1962185.
- Bursting as a source of non‐linear determinism in the firing patterns of nigral dopamine neuronsJeong J, Shi W, Hoffman R, Oh J, Gore JC, Bunney BS, Peterson BS. Bursting as a source of non‐linear determinism in the firing patterns of nigral dopamine neurons. European Journal Of Neuroscience 2012, 36: 3214-3223. PMID: 22831464, PMCID: PMC3490015, DOI: 10.1111/j.1460-9568.2012.08238.x.
- The Neuroscience Research Program at the Connecticut Mental Health CenterHeninger G, Krystal J, Duman R, Bunney B, Bowers M, Aghajanian G. The Neuroscience Research Program at the Connecticut Mental Health Center. 2007, 77-95. DOI: 10.1002/9780470994580.ch4.
- Oscillatory firing of dopamine neurons: Differences between cells in the substantia nigra and ventral tegmental areaZhang D, Yang S, Jin G, Bunney B, Shi W. Oscillatory firing of dopamine neurons: Differences between cells in the substantia nigra and ventral tegmental area. Synapse 2007, 62: 169-175. PMID: 18081182, DOI: 10.1002/syn.20479.
- Functional Coupling between the Prefrontal Cortex and Dopamine Neurons in the Ventral Tegmental AreaGao M, Liu C, Yang S, Jin G, Bunney B, Shi W. Functional Coupling between the Prefrontal Cortex and Dopamine Neurons in the Ventral Tegmental Area. Journal Of Neuroscience 2007, 27: 5414-5421. PMID: 17507563, PMCID: PMC6672349, DOI: 10.1523/jneurosci.5347-06.2007.
- Clozapine Blocks D-Amphetamine-Induced Excitation of Dopamine Neurons in the Ventral Tegmental AreaShi W, Zhang X, Pun C, Bunney B. Clozapine Blocks D-Amphetamine-Induced Excitation of Dopamine Neurons in the Ventral Tegmental Area. Neuropsychopharmacology 2007, 32: 1922-1928. PMID: 17299514, DOI: 10.1038/sj.npp.1301334.
- Patricia Goldman-Rakic, 1937–2003Aghajanian G, Bunney B, Holzman P. Patricia Goldman-Rakic, 1937–2003. Neuropsychopharmacology 2003, 28: 2218-2220. DOI: 10.1038/sj.npp.1300325.
- Enhancement of NMDA‐induced current by the putative NR2B selective antagonist ifenprodilZhang X, Bunney B, Shi W. Enhancement of NMDA‐induced current by the putative NR2B selective antagonist ifenprodil. Synapse 2000, 37: 56-63. PMID: 10842351, DOI: 10.1002/(sici)1098-2396(200007)37:1<56::aid-syn6>3.0.co;2-d.
- Dual Effects of d-Amphetamine on Dopamine Neurons Mediated by Dopamine and Nondopamine ReceptorsShi W, Pun C, Zhang X, Jones M, Bunney B. Dual Effects of d-Amphetamine on Dopamine Neurons Mediated by Dopamine and Nondopamine Receptors. Journal Of Neuroscience 2000, 20: 3504-3511. PMID: 10777813, PMCID: PMC6773133, DOI: 10.1523/jneurosci.20-09-03504.2000.
- Anatomic basis of sequence‐dependent predictability exhibited by nigral dopamine neuron firing patternsHoffman R, Shi W, Bunney B. Anatomic basis of sequence‐dependent predictability exhibited by nigral dopamine neuron firing patterns. Synapse 2000, 39: 133-138. PMID: 11180500, DOI: 10.1002/1098-2396(200102)39:2<133::aid-syn4>3.0.co;2-k.
- Endogenous DA‐mediated feedback inhibition of DA neurons: Involvement of both D1‐ and D2‐like receptorsShi W, Pun C, Smith P, Bunney B. Endogenous DA‐mediated feedback inhibition of DA neurons: Involvement of both D1‐ and D2‐like receptors. Synapse 1999, 35: 111-119. PMID: 10611636, DOI: 10.1002/(sici)1098-2396(200002)35:2<111::aid-syn3>3.0.co;2-7.
- Opposite modulation of cortical N-methyl-d-aspartate receptor-mediated responses by low and high concentrations of dopamineZheng P, Zhang X, Bunney B, Shi W. Opposite modulation of cortical N-methyl-d-aspartate receptor-mediated responses by low and high concentrations of dopamine. Neuroscience 1999, 91: 527-535. PMID: 10366010, DOI: 10.1016/s0306-4522(98)00604-6.
- D1–D2 Interaction in Feedback Control of Midbrain Dopamine NeuronsShi W, Smith P, Pun C, Millet B, Bunney B. D1–D2 Interaction in Feedback Control of Midbrain Dopamine Neurons. Journal Of Neuroscience 1997, 17: 7988-7994. PMID: 9315916, PMCID: PMC6793911, DOI: 10.1523/jneurosci.17-20-07988.1997.
- Characterization of dopamine‐induced depolarization of prefrontal cortical neuronsShi W, Zheng P, Liang X, Bunney B. Characterization of dopamine‐induced depolarization of prefrontal cortical neurons. Synapse 1997, 26: 415-422. PMID: 9215600, DOI: 10.1002/(sici)1098-2396(199708)26:4<415::aid-syn9>3.0.co;2-9.
- Managed Care, Health Care Reform, and Academic PsychiatryJacobs S, Hoge M, Sledge W, Bunney B. Managed Care, Health Care Reform, and Academic Psychiatry. Academic Psychiatry 1997, 21: 72-85. PMID: 24442844, DOI: 10.1007/bf03341902.
- Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugsGrace A, Bunney B, Moore H, Todd C. Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs. Trends In Neurosciences 1997, 20: 31-37. PMID: 9004417, DOI: 10.1016/s0166-2236(96)10064-3.
- Effects of Lesions in the Medial Prefrontal Cortex on the Activity of Midbrain Dopamine NeuronsShim S, Bunney B, Shi W. Effects of Lesions in the Medial Prefrontal Cortex on the Activity of Midbrain Dopamine Neurons. Neuropsychopharmacology 1996, 15: 437-441. PMID: 8914116, DOI: 10.1016/s0893-133x(96)00052-8.
- Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons.Sklair-Tavron L, Shi W, Lane S, Harris H, Bunney B, Nestler E. Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 11202-11207. PMID: 8855333, PMCID: PMC38308, DOI: 10.1073/pnas.93.20.11202.
- Role of the Amygdala in the Coordination of Behavioral, Neuroendocrine, and Prefrontal Cortical Monoamine Responses to Psychological Stress in the RatGoldstein L, Rasmusson A, Bunney B, Roth R. Role of the Amygdala in the Coordination of Behavioral, Neuroendocrine, and Prefrontal Cortical Monoamine Responses to Psychological Stress in the Rat. Journal Of Neuroscience 1996, 16: 4787-4798. PMID: 8764665, PMCID: PMC6579011, DOI: 10.1523/jneurosci.16-15-04787.1996.
- Psychiatric status after human fetal mesencephalic tissue transplantation in Parkinson's diseasePrice L, Spencer D, Marek K, Robbins R, Leranth C, Farhi A, Naftolin F, Roth R, Bunney B, Hoffer P, Makuch R, Redmond D. Psychiatric status after human fetal mesencephalic tissue transplantation in Parkinson's disease. Biological Psychiatry 1995, 38: 498-505. PMID: 8562661, DOI: 10.1016/0006-3223(95)00129-5.
- Ritanserin, a 5-HT2A/2C antagonist, reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons.Shi W, Nathaniel P, Bunney B. Ritanserin, a 5-HT2A/2C antagonist, reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons. Journal Of Pharmacology And Experimental Therapeutics 1995, 274: 735-40. PMID: 7636736.
- Nonlinear sequence-dependent structure of nigral dopamine neuron interspike interval firing patternsHoffman R, Shi W, Bunney B. Nonlinear sequence-dependent structure of nigral dopamine neuron interspike interval firing patterns. Biophysical Journal 1995, 69: 128-137. PMID: 7669889, PMCID: PMC1236231, DOI: 10.1016/s0006-3495(95)79882-4.
- General Cognitive Ability Following Unilateral and Bilateral Fetal Ventral Mesencephalic Tissue Transplantation for Treatment of Parkinson's DiseaseSass K, Buchanan C, Westerveld M, Marek K, Farhi A, Robbins R, Naftolin F, Vollmer T, Leranth C, Roth R, Price L, Bunney B, Elsworth J, Hoffer P, Redmond D, Spencer D. General Cognitive Ability Following Unilateral and Bilateral Fetal Ventral Mesencephalic Tissue Transplantation for Treatment of Parkinson's Disease. JAMA Neurology 1995, 52: 680-686. PMID: 7619024, DOI: 10.1001/archneur.1995.00540310050016.
- 5‐HT1a agonist ±‐ 8‐OH‐DPAT modulates basal and stress‐induced changes in medial prefrontal cortical dopamineRasmusson A, Goldstein L, Deutch A, Bunney B, Roth R. 5‐HT1a agonist ±‐ 8‐OH‐DPAT modulates basal and stress‐induced changes in medial prefrontal cortical dopamine. Synapse 1994, 18: 218-224. PMID: 7855734, DOI: 10.1002/syn.890180307.
- The NMDA glycine site antagonist (+)-HA-966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal cortical dopamine but not serotonin systems: a behavioral, neuroendocrine, and neurochemical study in the ratGoldstein L, Rasmusson A, Bunney B, Roth R. The NMDA glycine site antagonist (+)-HA-966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal cortical dopamine but not serotonin systems: a behavioral, neuroendocrine, and neurochemical study in the rat. Journal Of Neuroscience 1994, 14: 4937-4950. PMID: 8046462, PMCID: PMC6577203, DOI: 10.1523/jneurosci.14-08-04937.1994.
- Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatmentYoungren K, Moghaddam B, Bunney B, Roth R. Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment. Neuroscience Letters 1994, 165: 41-44. PMID: 8015734, DOI: 10.1016/0304-3940(94)90704-8.
- Depolarization inactivation of dopamine neurons: Terminal release characteristicsMoghaddam B, Bunney B. Depolarization inactivation of dopamine neurons: Terminal release characteristics. Synapse 1993, 14: 195-200. PMID: 8105547, DOI: 10.1002/syn.890140302.
- Unilateral Transplantation of Human Fetal Mesencephalic Tissue Into the Caudate Nucleus of Patients With Parkinson's DiseaseSPENCER D, ROBBINS R, NAFTOLIN F, MAREK K, VOLLMER T, LERANTH C, ROTH R, PRICE L, GJEDDE A, BUNNEY B, SASS K, ELSWORTH J, KIER E, MAKUCH R, HOFFER P, REDMOND D. Unilateral Transplantation of Human Fetal Mesencephalic Tissue Into the Caudate Nucleus of Patients With Parkinson's Disease. Obstetrical & Gynecological Survey 1993, 48: 413-415. DOI: 10.1097/00006254-199306000-00013.
- In vivo assessment of basal and drug‐induced dopamine release in cortical and subcortical regions of the anesthetized primateMoghaddam B, Berridge C, Goldman‐Rakic P, Bunney B, Roth R. In vivo assessment of basal and drug‐induced dopamine release in cortical and subcortical regions of the anesthetized primate. Synapse 1993, 13: 215-222. PMID: 8497807, DOI: 10.1002/syn.890130304.
- Cellular replacement of dopamine deficit in Parkinson's disease using human fetal mesencephalic tissue: preliminary results in four patients.Redmond D, Robbins R, Naftolin F, Marek K, Vollmer T, Leranth C, Roth R, Price L, Gjedde A, Bunney B. Cellular replacement of dopamine deficit in Parkinson's disease using human fetal mesencephalic tissue: preliminary results in four patients. Proceedings Of The Association For Research In Nervous And Mental Disease 1993, 71: 325-59. PMID: 8417471.
- Unilateral Transplantation of Human Fetal Mesencephalic Tissue into the Caudate Nucleus of Patients with Parkinson's DiseaseSpencer D, Robbins R, Naftolin F, Marek K, Vollmer T, Leranth C, Roth R, Price L, Gjedde A, Bunney B, Sass K, Elsworth J, Kier E, Makuch R, Hoffer P, Redmond D. Unilateral Transplantation of Human Fetal Mesencephalic Tissue into the Caudate Nucleus of Patients with Parkinson's Disease. New England Journal Of Medicine 1992, 327: 1541-1548. PMID: 1435880, DOI: 10.1056/nejm199211263272201.
- Actions of Neurotensin: A Review of the Electrophysiological StudiesaSHI W, BUNNEY B. Actions of Neurotensin: A Review of the Electrophysiological Studiesa. Annals Of The New York Academy Of Sciences 1992, 668: 129-145. PMID: 1463269, DOI: 10.1111/j.1749-6632.1992.tb27345.x.
- Roles of intracellular cAMP and protein kinase A in the actions of dopamine and neurotensin on midbrain dopamine neuronsShi W, Bunney B. Roles of intracellular cAMP and protein kinase A in the actions of dopamine and neurotensin on midbrain dopamine neurons. Journal Of Neuroscience 1992, 12: 2433-2438. PMID: 1318960, PMCID: PMC6575923, DOI: 10.1523/jneurosci.12-06-02433.1992.
- Clozapine: A Hypothesised Mechanism for its Unique Clinical ProfileBunney B. Clozapine: A Hypothesised Mechanism for its Unique Clinical Profile. The British Journal Of Psychiatry. Supplement 1992, 160: 17-21. PMID: 1418885, DOI: 10.1192/s0007125000296864.
- Biochemical and Immunohistochemical Characterization of Human Fetal Ventral MesencephalonKontur P, Leranth C, Robbins R, Spencer D, Naftolin F, Bunney B, Redmond D, Roth R. Biochemical and Immunohistochemical Characterization of Human Fetal Ventral Mesencephalon. Neural Plasticity 1992, 3: 321-321. PMCID: PMC2565240, DOI: 10.1155/np.1992.321.
- Unilateral caudate implantation of fetal substantia nigra in four patients with parkinsonismRedmond D, Spencer D, Robbins R, Leranth C, Roth R, Marek K, Vollmer T, Price L, Sass K, Bunney B, Kier E, Gjedde A. Unilateral caudate implantation of fetal substantia nigra in four patients with parkinsonism. Journal Of The Neurological Sciences 1991, 106: 121. DOI: 10.1016/0022-510x(91)90245-3.
- Effects of neurotensin on midbrain dopamine neurons: Are they mediated by formation of a neurotensin—dopamine complex?Shi W, Bunney B. Effects of neurotensin on midbrain dopamine neurons: Are they mediated by formation of a neurotensin—dopamine complex? Synapse 1991, 9: 157-164. PMID: 1776128, DOI: 10.1002/syn.890090302.
- Midbrain dopamine system electrophysiological functioning: A review and new hypothesisBunney B, Chiodo L, Grace A. Midbrain dopamine system electrophysiological functioning: A review and new hypothesis. Synapse 1991, 9: 79-94. PMID: 1821487, DOI: 10.1002/syn.890090202.
- Repetitive firing properties of putative dopamine-containing neurons in vitro: regulation by an apamin-sensitive Ca2+-activated K+ conductanceShepard P, Bunney B. Repetitive firing properties of putative dopamine-containing neurons in vitro: regulation by an apamin-sensitive Ca2+-activated K+ conductance. Experimental Brain Research 1991, 86: 141-150. PMID: 1756785, DOI: 10.1007/bf00231048.
- Mechanisms of action of atypical antipsychotic drugs Implications for novel therapeutic strategies for schizophreniaDeutch A, Moghaddam B, Innis R, Krystal J, Aghajanian G, Bunney B, Charney D. Mechanisms of action of atypical antipsychotic drugs Implications for novel therapeutic strategies for schizophrenia. Schizophrenia Research 1991, 4: 121-156. PMID: 1674882, DOI: 10.1016/0920-9964(91)90030-u.
- Neurotensin modulates autoreceptor mediated dopamine effects on midbrain dopamine cell activityShi W, Bunney B. Neurotensin modulates autoreceptor mediated dopamine effects on midbrain dopamine cell activity. Brain Research 1991, 543: 315-321. PMID: 1676331, DOI: 10.1016/0006-8993(91)90043-u.
- A small volume chamber for electrical recording from submerged brain slices and a pulse-free medium supply system using a peristalic pumpShi W, Bunney B. A small volume chamber for electrical recording from submerged brain slices and a pulse-free medium supply system using a peristalic pump. Journal Of Neuroscience Methods 1990, 35: 235-240. PMID: 2084393, DOI: 10.1016/0165-0270(90)90129-4.
- Neurotensin attenuates dopamine D2 agonist quinpirole-induced inhibition of midbrain dopamine neuronsShi W, Bunney B. Neurotensin attenuates dopamine D2 agonist quinpirole-induced inhibition of midbrain dopamine neurons. Neuropharmacology 1990, 29: 1095-1097. PMID: 1982340, DOI: 10.1016/0028-3908(90)90119-c.
- A simple and effective method for preventing the formation of salt bridges between barrels of a multibarrel microiontophoresis electrodeShi W, Bunney B. A simple and effective method for preventing the formation of salt bridges between barrels of a multibarrel microiontophoresis electrode. Journal Of Neuroscience Methods 1990, 35: 89-91. PMID: 2277537, DOI: 10.1016/0165-0270(90)90098-z.
- Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studiesMoghaddam B, Gruen R, Roth R, Bunney B, Adams R. Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies. Brain Research 1990, 518: 55-60. PMID: 1975217, DOI: 10.1016/0006-8993(90)90953-9.
- Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis StudyMoghaddam B, Bunney B. Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study. Journal Of Neurochemistry 1990, 54: 1755-1760. PMID: 1969939, DOI: 10.1111/j.1471-4159.1990.tb01230.x.
- Characterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: Comparison to the striatumMoghaddam B, Roth R, Bunney B. Characterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: Comparison to the striatum. Neuroscience 1990, 36: 669-676. PMID: 2234405, DOI: 10.1016/0306-4522(90)90009-s.
- Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugsMoghaddam B, Bunney B. Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1990, 14: s51-s57. PMID: 2097674, DOI: 10.1016/0278-5846(90)90086-v.
- Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract‐tracing study with Phaseolus vulgaris leucoagglutininSesack S, Deutch A, Roth R, Bunney B. Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract‐tracing study with Phaseolus vulgaris leucoagglutinin. The Journal Of Comparative Neurology 1989, 290: 213-242. PMID: 2592611, DOI: 10.1002/cne.902900205.
- Ionic Composition of Microdialysis Perfusing Solution Alters the Pharmacological Responsiveness and Basal Outflow of Striatal DopamineMoghaddam B, Bunney B. Ionic Composition of Microdialysis Perfusing Solution Alters the Pharmacological Responsiveness and Basal Outflow of Striatal Dopamine. Journal Of Neurochemistry 1989, 53: 652-654. PMID: 2568406, DOI: 10.1111/j.1471-4159.1989.tb07383.x.
- Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study.Sesack S, Bunney B. Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study. Journal Of Pharmacology And Experimental Therapeutics 1989, 248: 1323-33. PMID: 2564893.
- The effect of acute and chronic treatment with SCH 23390 on the spontaneous activity of midbrain dopamine neuronsEsposito E, Bunney B. The effect of acute and chronic treatment with SCH 23390 on the spontaneous activity of midbrain dopamine neurons. European Journal Of Pharmacology 1989, 162: 109-113. PMID: 2656273, DOI: 10.1016/0014-2999(89)90609-2.
- The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum.Bean A, Shepard P, Bunney B, Nestler E, Roth R. The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum. Molecular Pharmacology 1988, 34: 715-8. PMID: 2974120.
- Effects of apamin on the discharge properties of putative dopamine-containing neurons in vitroShepard P, Bunney B. Effects of apamin on the discharge properties of putative dopamine-containing neurons in vitro. Brain Research 1988, 463: 380-384. PMID: 3196925, DOI: 10.1016/0006-8993(88)90414-3.
- Effects of Acute and Chronic Neuroleptic Treatment on the Activity of Mid brain Dopamine NeuronsaBUNNEY B. Effects of Acute and Chronic Neuroleptic Treatment on the Activity of Mid brain Dopamine Neuronsa. Annals Of The New York Academy Of Sciences 1988, 537: 77-85. PMID: 2904786, DOI: 10.1111/j.1749-6632.1988.tb42097.x.
- Pharmacology of Dopamine‐Induced Electrophysiological Responses in the Rat Prefrontal Cortex: D1‐ or D2‐Mediated?SESACK S, BUNNEY B. Pharmacology of Dopamine‐Induced Electrophysiological Responses in the Rat Prefrontal Cortex: D1‐ or D2‐Mediated? Annals Of The New York Academy Of Sciences 1988, 537: 529-530. DOI: 10.1111/j.1749-6632.1988.tb42149.x.
- Excitability properties of medial forebrain bundle axons of A9 and A10 dopamine cellsYeomans J, Maidment N, Bunney B. Excitability properties of medial forebrain bundle axons of A9 and A10 dopamine cells. Brain Research 1988, 450: 86-93. PMID: 3261193, DOI: 10.1016/0006-8993(88)91547-8.
- Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamineSilva N, Bunney B. Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine. European Journal Of Pharmacology 1988, 149: 307-315. PMID: 3409955, DOI: 10.1016/0014-2999(88)90661-9.
- Central dopamine-peptide interactions: Electrophysiological studiesBunney B. Central dopamine-peptide interactions: Electrophysiological studies. Neuropharmacology 1987, 26: 1003-1009. PMID: 3309707, DOI: 10.1016/0028-3908(87)90079-7.
- Electrophysiological studies on the specificity of the cholecystokinin antagonist proglumideChiodo L, Freeman A, Bunney B. Electrophysiological studies on the specificity of the cholecystokinin antagonist proglumide. Brain Research 1987, 410: 205-211. PMID: 3036308, DOI: 10.1016/0006-8993(87)90317-9.
- Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokininFreeman A, Bunney B. Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin. Brain Research 1987, 405: 46-55. PMID: 3032350, DOI: 10.1016/0006-8993(87)90988-7.
- Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic neuronal influencesChiodo L, Bunney B. Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic neuronal influences. Journal Of Neuroscience 1987, 7: 629-633. PMID: 2881987, PMCID: PMC6569064, DOI: 10.1523/jneurosci.07-03-00629.1987.
- Chronic Neuroleptic Effects on Dopamine Neuron Activity: A Model for Predicting Therapeutic Efficacy and Side Effects?Freeman A, Bunney B. Chronic Neuroleptic Effects on Dopamine Neuron Activity: A Model for Predicting Therapeutic Efficacy and Side Effects? 1987, 3: 225-235. PMID: 2881290, DOI: 10.1007/978-3-642-71288-3_26.
- The Electrophysiological and Biochemical Pharmacology of the Mesolimbic and Mesocortical Dopamine NeuronsBannon M, Freeman A, Chiodo L, Bunney B, Roth R. The Electrophysiological and Biochemical Pharmacology of the Mesolimbic and Mesocortical Dopamine Neurons. 1987, 329-374. DOI: 10.1007/978-1-4613-1819-4_5.
- Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording.Grace A, Bunney B. Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording. Journal Of Pharmacology And Experimental Therapeutics 1986, 238: 1092-100. PMID: 3746660.
- Does the cholecystokinin antagonist proglumide possess antipsychotic activity?Innis R, Bunney B, Charney D, Price L, Glazer W, Sternberg D, Rubin A, Heninger G. Does the cholecystokinin antagonist proglumide possess antipsychotic activity? Psychiatry Research 1986, 18: 1-7. PMID: 3737785, DOI: 10.1016/0165-1781(86)90056-9.
- Midbrain Dopamine Neurons: Electrophysiological Studies on the Acute Effects of EstrogenChiodo L, Glazer W, Bunney B. Midbrain Dopamine Neurons: Electrophysiological Studies on the Acute Effects of Estrogen. 1986, 303-311. DOI: 10.1007/978-1-349-07431-0_21.
- The treatment of tardive dyskinesia with baclofenGlazer W, Moore D, Bowers M, Bunney B, Roffman M. The treatment of tardive dyskinesia with baclofen. Psychopharmacology 1985, 87: 480-483. PMID: 3936106, DOI: 10.1007/bf00432517.
- Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neuronsChiodo L, Bunney B. Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons. Journal Of Neuroscience 1985, 5: 2539-2544. PMID: 2863337, PMCID: PMC6565310, DOI: 10.1523/jneurosci.05-09-02539.1985.
- Further Studies on the Specificity of Proglumide as a Selective Cholecystokinin Antagonist in the Central Nervous SystemaBUNNEY B, CHIODO L, FREEMAN A. Further Studies on the Specificity of Proglumide as a Selective Cholecystokinin Antagonist in the Central Nervous Systema. Annals Of The New York Academy Of Sciences 1985, 448: 345-351. PMID: 2862828, DOI: 10.1111/j.1749-6632.1985.tb29929.x.
- An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine systemClark D, Engberg G, Pileblad E, Svensson T, Carlsson A, Freeman A, Bunney B. An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system. Naunyn-Schmiedeberg's Archives Of Pharmacology 1985, 329: 344-354. PMID: 4033804, DOI: 10.1007/bf00496366.
- Firing properties of substantia nigra dopaminergic neurons in freely moving ratsFreeman A, Meltzer L, Bunney B. Firing properties of substantia nigra dopaminergic neurons in freely moving rats. Life Sciences 1985, 36: 1983-1994. PMID: 3990520, DOI: 10.1016/0024-3205(85)90448-5.
- Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiologyGrace A, Bunney B. Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology. Brain Research 1985, 333: 285-298. PMID: 3995296, DOI: 10.1016/0006-8993(85)91582-3.
- Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activityGrace A, Bunney B. Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity. Brain Research 1985, 333: 271-284. PMID: 2986775, DOI: 10.1016/0006-8993(85)91581-1.
- DopamineGrace A, Bunney B. Dopamine. 1985, 285-319. DOI: 10.1007/978-1-4684-4961-7_9.
- The control of firing pattern in nigral dopamine neurons: single spike firingGrace A, Bunney B. The control of firing pattern in nigral dopamine neurons: single spike firing. Journal Of Neuroscience 1984, 4: 2866-2876. PMID: 6150070, PMCID: PMC6564731, DOI: 10.1523/jneurosci.04-11-02866.1984.
- The control of firing pattern in nigral dopamine neurons: burst firingGrace A, Bunney B. The control of firing pattern in nigral dopamine neurons: burst firing. Journal Of Neuroscience 1984, 4: 2877-2890. PMID: 6150071, PMCID: PMC6564720, DOI: 10.1523/jneurosci.04-11-02877.1984.
- The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activityFreeman A, Bunney B. The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity. European Journal Of Pharmacology 1984, 104: 287-293. PMID: 6094217, DOI: 10.1016/0014-2999(84)90404-7.
- THE EFFECTS OF NOVEL DOPAMINERGIC AGONISTS ON THE NIGROSTRIATAL DOPAMINE SYSTEM.Clark D, Engberg G, Pileblad E, Svensson T, Carisson A, Freeman A, Bunney B. THE EFFECTS OF NOVEL DOPAMINERGIC AGONISTS ON THE NIGROSTRIATAL DOPAMINE SYSTEM. Clinical Neuropharmacology 1984, 7: s45. DOI: 10.1097/00002826-198406001-00044.
- Antipsychotic drug effects on the electrical activity of dopaminergic neuronsBunney B. Antipsychotic drug effects on the electrical activity of dopaminergic neurons. Trends In Neurosciences 1984, 7: 212-215. DOI: 10.1016/s0166-2236(84)80013-2.
- Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neuronsChiodo L, Bannon M, Grace A, Roth R, Bunney B. Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons. Neuroscience 1984, 12: 1-16. PMID: 6462443, DOI: 10.1016/0306-4522(84)90133-7.
- Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—2. Action potential generating mechanisms and morphological correlatesGrace A, Bunney B. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—2. Action potential generating mechanisms and morphological correlates. Neuroscience 1983, 10: 317-331. PMID: 6633864, DOI: 10.1016/0306-4522(83)90136-7.
- Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterizationGrace A, Bunney B. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization. Neuroscience 1983, 10: 301-315. PMID: 6633863, DOI: 10.1016/0306-4522(83)90135-5.
- Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neuronsChiodo L, Bunney B. Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons. Journal Of Neuroscience 1983, 3: 1607-1619. PMID: 6135762, PMCID: PMC6564520, DOI: 10.1523/jneurosci.03-08-01607.1983.
- A modification of the rapid glyoxylic acid technique permits visualization of serotonergic and hypothalamic dopaminergic neuronsRassmussen S, Bunney B. A modification of the rapid glyoxylic acid technique permits visualization of serotonergic and hypothalamic dopaminergic neurons. Journal Of Neuroscience Methods 1982, 6: 139-144. PMID: 6750255, DOI: 10.1016/0165-0270(82)90024-3.
- Effect of cholecystokinin of the activity of midbrain dopaminergic neurons.Bunney B, Grace A, Hommer D, Skirboll L. Effect of cholecystokinin of the activity of midbrain dopaminergic neurons. Advances In Biochemical Psychopharmacology 1982, 33: 429-36. PMID: 7124507.
- Peptide-monoamine coexistence: Studies of the actions of cholecystokinin-like peptide on the electrical activity of midbrain dopamine neuronsSkirboll L, Grace A, Hommer D, Rehfeld J, Goldstein M, Hökfelt T, Bunney B. Peptide-monoamine coexistence: Studies of the actions of cholecystokinin-like peptide on the electrical activity of midbrain dopamine neurons. Neuroscience 1981, 6: 2111-2124. PMID: 6120481, DOI: 10.1016/0306-4522(81)90002-6.
- Nigral Dopamine Neurons: Intracellular Recording and Identification with L-Dopa Injection and HistofluorescenceGrace A, Bunney B. Nigral Dopamine Neurons: Intracellular Recording and Identification with L-Dopa Injection and Histofluorescence. Science 1980, 210: 654-656. PMID: 7433992, DOI: 10.1126/science.7433992.
- Response: Dopamine Auto- and Postsynaptic Receptors: Possible Interference by GallamineGrace A, Skirboll L, Bunney B. Response: Dopamine Auto- and Postsynaptic Receptors: Possible Interference by Gallamine. Science 1980, 209: 721-722. PMID: 17821195, DOI: 10.1126/science.209.4457.721-a.
- Effect of sensory stimuli on the activity of dopaminergic neurons: Involvement of non-dopaminergic nigral neurons and striato-nigral pathwaysHommer D, Bunney B. Effect of sensory stimuli on the activity of dopaminergic neurons: Involvement of non-dopaminergic nigral neurons and striato-nigral pathways. Life Sciences 1980, 27: 377-386. PMID: 7412480, DOI: 10.1016/0024-3205(80)90185-x.
- Changing Concepts of Nigral Dopamine System Function Within the Basal Ganglia: Relevance to Extrapyramidal DisordersBunney B, Grace A, Hommer D. Changing Concepts of Nigral Dopamine System Function Within the Basal Ganglia: Relevance to Extrapyramidal Disorders. 1980, 17-23. PMID: 6107330, DOI: 10.1007/978-3-7091-8582-7_3.
- Acute and chronic haloperidol treatment: effects on nigrostriatal dopaminergic system activity.Bunney B, Skirboll L, Grace A. Acute and chronic haloperidol treatment: effects on nigrostriatal dopaminergic system activity. Advances In Biochemical Psychopharmacology 1980, 24: 267-73. PMID: 7405666.
- Effects of baclofen on nigral dopaminergic cell activity following acute and chronic haloperidol treatmentGrace A, Bunney B. Effects of baclofen on nigral dopaminergic cell activity following acute and chronic haloperidol treatment. Brain Research Bulletin 1980, 5: 537-543. DOI: 10.1016/0361-9230(80)90087-8.
- Peripheral and striatal influences on nigral dopamine cells: Mediation by reticulata neuronsGrace A, Hommer D, Bunney B. Peripheral and striatal influences on nigral dopamine cells: Mediation by reticulata neurons. Brain Research Bulletin 1980, 5: 105-109. DOI: 10.1016/0361-9230(80)90017-9.
- Localization of dopamine-sensitive adenylate cyclase activity within laminae of the rat prefrontal cortexKrieger N, Bunney B, Greengard P. Localization of dopamine-sensitive adenylate cyclase activity within laminae of the rat prefrontal cortex. Brain Research 1979, 179: 171-175. PMID: 509228, DOI: 10.1016/0006-8993(79)90502-x.
- Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neuronsGrace A, Bunney B. Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons. European Journal Of Pharmacology 1979, 59: 211-218. PMID: 527646, DOI: 10.1016/0014-2999(79)90283-8.
- Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine AgonistsSkirboll L, Grace A, Bunney B. Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists. Science 1979, 206: 80-82. PMID: 482929, DOI: 10.1126/science.482929.
- The effects of acute and chronic haloperidol treatment on spontaneously firing neurons in the caudate nucleus of the ratSkirboll L, Bunney B. The effects of acute and chronic haloperidol treatment on spontaneously firing neurons in the caudate nucleus of the rat. Life Sciences 1979, 25: 1419-1433. PMID: 522610, DOI: 10.1016/0024-3205(79)90420-x.
- EFFECTS OF CHRONIC HALOPERIDOL TREATMENT ON NIGRAL DOPAMINERGIC CELL ACTIVITYBunney B, Grace A. EFFECTS OF CHRONIC HALOPERIDOL TREATMENT ON NIGRAL DOPAMINERGIC CELL ACTIVITY. 1979, 666-668. DOI: 10.1016/b978-1-4832-8363-0.50202-0.
- Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activityBunney B, Grace A. Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity. Life Sciences 1978, 23: 1715-1727. PMID: 31529, DOI: 10.1016/0024-3205(78)90471-x.
- d-Amphetamine-induced depression of central dopamine neurons: Evidence for mediation by both autoreceptors and a striato-nigral feedback pathwayBunney B, Aghajanian G. d-Amphetamine-induced depression of central dopamine neurons: Evidence for mediation by both autoreceptors and a striato-nigral feedback pathway. Naunyn-Schmiedeberg's Archives Of Pharmacology 1978, 304: 255-261. PMID: 714182, DOI: 10.1007/bf00507966.
- 498 EFFECTS OF CHRONIC HALOPERIDOL ON SPONTANEOUSLY FIRING CAUDATE NEURONSSkirboll L, Bunney B. 498 EFFECTS OF CHRONIC HALOPERIDOL ON SPONTANEOUSLY FIRING CAUDATE NEURONS. 1978, 191. DOI: 10.1016/b978-0-08-023768-8.50504-1.
- Dopamine “Autoreceptors”: Pharmacological characterization by microiontophoretic single cell recording studiesAghajanian G, Bunney B. Dopamine “Autoreceptors”: Pharmacological characterization by microiontophoretic single cell recording studies. Naunyn-Schmiedeberg's Archives Of Pharmacology 1977, 297: 1-7. PMID: 193046, DOI: 10.1007/bf00508803.
- Electrophysiological studies of dopamine- innervated cells in the frontal cortex.Bunney B, Aghajanian G. Electrophysiological studies of dopamine- innervated cells in the frontal cortex. Advances In Biochemical Psychopharmacology 1977, 16: 65-70. PMID: 329653.
- Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: Pharmacological differentiation using microiontophoretic techniquesBunney B, Aghajanian G. Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: Pharmacological differentiation using microiontophoretic techniques. Life Sciences 1976, 19: 1783-1792. PMID: 1004134, DOI: 10.1016/0024-3205(76)90087-4.
- The precise localization of nigral afferents in the rat as determined by a retrograde tracing techniqueBunney B, Aghajanian G. The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique. Brain Research 1976, 117: 423-435. PMID: 990939, DOI: 10.1016/0006-8993(76)90751-4.
- d-Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback PathwayBunney B, Achajanian G. d-Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback Pathway. Science 1976, 192: 391-393. PMID: 1257777, DOI: 10.1126/science.1257777.
- Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidineSvensson T, Bunney B, Aghajanian G. Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine. Brain Research 1975, 92: 291-306. PMID: 1174954, DOI: 10.1016/0006-8993(75)90276-0.
- D & L amphetamine stereoisomers: comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons.Bunney B, Walters J, Kuhar M, Roth R, Aghajanian G. D & L amphetamine stereoisomers: comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons. Psychopharmacology Communications 1975, 1: 177-90. PMID: 1223998.
- Effects of molindone on central dopaminergic neuronal activity and metabolism: similarity to other neuroleptics.Bunney B, Roth R, Aghajanian G. Effects of molindone on central dopaminergic neuronal activity and metabolism: similarity to other neuroleptics. Psychopharmacology Communications 1975, 1: 349-58. PMID: 1224004.
- A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neuronsBunney B, Aghajanian G. A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neurons. Life Sciences 1974, 15: 309-318. PMID: 4549921, DOI: 10.1016/0024-3205(74)90221-5.
- Central dopaminergic neurons: Neurophysiological identification and responses to drugsAghajanian G, Bunney B. Central dopaminergic neurons: Neurophysiological identification and responses to drugs. Biochemical Pharmacology 1974, 23: 523-528. DOI: 10.1016/0006-2952(74)90074-4.
- Electrophysiological effects of amphetamine on dopaminergic neuronsBunney B, Aghajanian G. Electrophysiological effects of amphetamine on dopaminergic neurons. Biochemical Pharmacology 1974, 23: 792-797. DOI: 10.1016/0006-2952(74)90134-8.
- Noradrenergic neurons: Morphine inhibition of spontaneous activityKorf J, Bunney B, Aghajanian G. Noradrenergic neurons: Morphine inhibition of spontaneous activity. European Journal Of Pharmacology 1974, 25: 165-169. PMID: 4435020, DOI: 10.1016/0014-2999(74)90045-4.
- Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic NeuronesBUNNEY B, AGHAJANIAN G, ROTH R. Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones. Nature 1973, 245: 123-125. PMID: 4518113, DOI: 10.1038/newbio245123a0.
- Central dopaminergic neurons: Neurophysiological identification and responses to drugsAghajanian G, Bunney B. Central dopaminergic neurons: Neurophysiological identification and responses to drugs. Life Sciences 1973, 13: i-ii. DOI: 10.1016/0024-3205(73)90234-8.
- Electrophysiological effects of amphetamine on dopaminergic neuronsBunney B, Aghajanian G. Electrophysiological effects of amphetamine on dopaminergic neurons. Life Sciences 1973, 13: xiii. DOI: 10.1016/0024-3205(73)90243-9.
- Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.Bunney B, Walters J, Roth R, Aghajanian G. Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity. Journal Of Pharmacology And Experimental Therapeutics 1973, 185: 560-71. PMID: 4576427.
- Use of Single Unit Recording in Correlating Transmitter Turnover with Impulse Flow in Monoamine NeuronsAghajanian G, Bunney B, Kuhar M. Use of Single Unit Recording in Correlating Transmitter Turnover with Impulse Flow in Monoamine Neurons. 1973, 115-134. DOI: 10.1007/978-1-4613-4574-9_7.
- CENTRAL DOPAMINERGIC NEURONS: NEUROPHYSIOLOGICAL IDENTIFICATION AND RESPONSES TO DRUGS**This research was supported by NIMH Grant MH-17871, USPHS Research Scientist Development Award MH-14459 (to G. K. A.), and the State of Connecticut.AGHAJANIAN G, BUNNEY B. CENTRAL DOPAMINERGIC NEURONS: NEUROPHYSIOLOGICAL IDENTIFICATION AND RESPONSES TO DRUGS**This research was supported by NIMH Grant MH-17871, USPHS Research Scientist Development Award MH-14459 (to G. K. A.), and the State of Connecticut. 1973, 643-648. DOI: 10.1016/b978-0-08-017922-3.50120-9.
- ELECTROPHYSIOLOGICAL EFFECTS OF AMPHETAMINE ON DOPAMINERGIC NEURONSBUNNEY B, AGHAJANIAN G. ELECTROPHYSIOLOGICAL EFFECTS OF AMPHETAMINE ON DOPAMINERGIC NEURONS. 1973, 957-962. DOI: 10.1016/b978-0-08-017922-3.50182-9.