John Elsworth, PhD
Research & Publications
Biography
News
Research Summary
Dysfunction of brain dopamine neurons is critically involved in the pathology of several neurologic and psychiatric disorders. Dr Elsworth’s research encompasses the “development, dysfunction, and demise” of dopamine neurons. The goal is to understand the mechanisms underlying the particular susceptibility of midbrain dopamine neurons to damage, and devising strategies for protecting, repairing or replacing these cells. As the population of midbrain dopamine neurons exhibits a profound loss during aging, they provide a model system for studying aging mechanisms and repair in other CNS neuronal populations.
Specialized Terms: Dopamine neurons; Aging; Oxidative stress; Mitochondrial dysfunction; Uncoupling proteins; Neurotrophic factors; Development; Parkinson’s disease; Striatum; Prefrontal cortex; Schizophrenia.
Extensive Research Description
Midbrain dopamine neurons exhibits an exaggerated loss during aging compared with other neuronal populations and consequently, they provide a model system for studying aging mechanisms and repair strategies that is relevant to other CNS neuronal populations.
Specific dysfunction of dopamine neurons is implicated in several neurological and psychiatric disorders, notably Parkinson’s disease and schizophrenia. During the prenatal period the fetal brain undergoes dramatic changes, as structures and connections form according to strict spatial and temporal criteria. It follows then that during development environmental insults have greater potential to exert profound and permanent changes than at other times during life and may affect the risk of the offspring succumbing to CNS disorders. A major focus of investigations is our finding of varying susceptibility of primate dopamine neurons to damage at different periods of development. Our research has identified prenatal phases when primate dopamine neurons are especially vulnerable to oxidative stress or endocrine disruptors and a postnatal period when they are remarkably resistant to such damage. We are particularly intrigued by neuroprotective factors that are preferentially expressed during the window of resistance to damage (‘juvenile protective factors”) and our recent work has focused on paraoxonase-2, a mitochondrial enzyme which if pharmacologically re-activated later in life could preserve and protect neurons vulnerable to age-dependent deficits.
Another field of research is the regulation of dopamine neurons innervating the prefrontal cortex, as our research has indicated that this input appears to determine alteration of dendrites and synapses on prefrontal pyramidal neurons, which are critical to the executive function of this brain region. Experimental restoration of normal dopamine transmission in the prefrontal cortex would enable treatment of cognitive deficits that are characteristic of Parkinson’s disease and schizophrenia.
Other research is focused on repair or maintenance of the vulnerable neuronal system, using strategies such as implants of modified stem cells and neurotrophic factor gene therapy.
Coauthors
Research Interests
Age Factors; Dopamine; Mitochondria; Parkinson Disease; Schizophrenia; Prefrontal Cortex; Oxidative Stress; Stem Cell Transplantation
Selected Publications
- Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brainJamwal S, Blackburn J, Elsworth J. Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain. Biology Of Sex Differences 2023, 14: 65. PMID: 37770961, PMCID: PMC10540392, DOI: 10.1186/s13293-023-00551-6.
- Expression of PON2 isoforms varies among brain regions in male and female African green monkeysJamwal S, Blackburn JK, Elsworth JD. Expression of PON2 isoforms varies among brain regions in male and female African green monkeys. Free Radical Biology And Medicine 2021, 178: 215-218. PMID: 34890766, PMCID: PMC8760629, DOI: 10.1016/j.freeradbiomed.2021.12.005.
- Pioglitazone transiently stimulates paraoxonase-2 expression in male nonhuman primate brain: Implications for sex-specific therapeutics in neurodegenerative disordersBlackburn JK, Jamwal S, Wang W, Elsworth JD. Pioglitazone transiently stimulates paraoxonase-2 expression in male nonhuman primate brain: Implications for sex-specific therapeutics in neurodegenerative disorders. Neurochemistry International 2021, 152: 105222. PMID: 34767873, PMCID: PMC8712400, DOI: 10.1016/j.neuint.2021.105222.
- Sex-based disparity in paraoxonase-2 expression in the brains of African green monkeysJamwal S, Blackburn JK, Elsworth JD. Sex-based disparity in paraoxonase-2 expression in the brains of African green monkeys. Free Radical Biology And Medicine 2021, 167: 201-204. PMID: 33722626, PMCID: PMC8096713, DOI: 10.1016/j.freeradbiomed.2021.03.003.
- PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disordersJamwal S, Blackburn J, Elsworth JD. PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders. Pharmacology & Therapeutics 2020, 219: 107705. PMID: 33039420, PMCID: PMC7887032, DOI: 10.1016/j.pharmthera.2020.107705.
- Generation of Pluripotent Stem Cells Using Somatic Cell Nuclear Transfer and Induced Pluripotent Somatic Cells from African Green MonkeysChung YG, Seay M, Elsworth J, Redmond D. Generation of Pluripotent Stem Cells Using Somatic Cell Nuclear Transfer and Induced Pluripotent Somatic Cells from African Green Monkeys. Stem Cells And Development 2020, 29: 1294-1307. PMID: 32715987, DOI: 10.1089/scd.2020.0059.
- Gene therapy and immunotherapy as promising strategies to combat Huntington’s disease-associated neurodegeneration: emphasis on recent updates and future perspectivesJamwal S, Elsworth JD, Rahi V, Kumar P. Gene therapy and immunotherapy as promising strategies to combat Huntington’s disease-associated neurodegeneration: emphasis on recent updates and future perspectives. Expert Review Of Neurotherapeutics 2020, 20: 1123-1141. PMID: 32720531, DOI: 10.1080/14737175.2020.1801424.
- Parkinson’s disease treatment: past, present, and futureElsworth JD. Parkinson’s disease treatment: past, present, and future. Journal Of Neural Transmission 2020, 127: 785-791. PMID: 32172471, PMCID: PMC8330829, DOI: 10.1007/s00702-020-02167-1.
- Pioglitazone activates paraoxonase-2 in the brain: A novel neuroprotective mechanismBlackburn JK, Curry DW, Thomsen AN, Roth RH, Elsworth JD. Pioglitazone activates paraoxonase-2 in the brain: A novel neuroprotective mechanism. Experimental Neurology 2020, 327: 113234. PMID: 32044330, PMCID: PMC7089823, DOI: 10.1016/j.expneurol.2020.113234.
- Human–Monkey Chimeras for Modeling Human Disease: Opportunities and ChallengesDe Los Angeles A, Hyun I, Latham S, Elsworth J, Redmond D. Human–Monkey Chimeras for Modeling Human Disease: Opportunities and Challenges. Stem Cells And Development 2018, 27: 1599-1604. PMID: 30319057, PMCID: PMC7366261, DOI: 10.1089/scd.2018.0162.
- Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageingCamell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Dixit VD. Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature 2017, 550: 119-123. PMID: 28953873, PMCID: PMC5718149, DOI: 10.1038/nature24022.
- Animal models in regenerative medicineBubak A, Elsworth J, Sladek J. Animal models in regenerative medicine. 2015, 301-316. DOI: 10.1002/9781118846193.ch16.
- P.3.d.019 Asenapine improves cognition and cortical serotonergic function in monkeys with phencyclidine-induced impairmentJentsch J, Elsworth J, Shahid M, Marston H, Roth R. P.3.d.019 Asenapine improves cognition and cortical serotonergic function in monkeys with phencyclidine-induced impairment. European Neuropsychopharmacology 2009, 19: s565. DOI: 10.1016/s0924-977x(09)70901-0.
- DopamineElsworth J, Roth R. Dopamine. 2009, 539-547. DOI: 10.1016/b978-008045046-9.00683-5.
- Corrigendum to “prenatal cocaine exposure enhances responsivity of locus coeruleus norepinephrine neurons: Role of autoreceptors” [Neuroscience 147 (2007) 419–427]Elsworth J, Morrow B, Nguyen V, Mitra J, Picciotto M, Roth R. Corrigendum to “prenatal cocaine exposure enhances responsivity of locus coeruleus norepinephrine neurons: Role of autoreceptors” [Neuroscience 147 (2007) 419–427]. Neuroscience 2008, 156: 800. DOI: 10.1016/j.neuroscience.2008.08.024.
- Neural Stem Cells Implanted into MPTP-Treated Monkeys Increase the Size of Endogenous Tyrosine Hydroxylase-Positive Cells Found in the Striatum: A Return to Control MeasuresBjugstad K, Redmond D, Teng Y, Elsworth J, Roth R, Blanchard B, Snyder E, Sladek J. Neural Stem Cells Implanted into MPTP-Treated Monkeys Increase the Size of Endogenous Tyrosine Hydroxylase-Positive Cells Found in the Striatum: A Return to Control Measures. Cell Transplantation 2005, 14: 183-192. PMID: 15929553, DOI: 10.3727/000000005783983098.
- Prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stressElsworth J, Morrow B, Roth R. Prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stress. Synapse 2001, 42: 80-83. PMID: 11574943, DOI: 10.1002/syn.1102.
- Prenatal exposure to cocaine reduces the number and enhances reactivity of A10 dopaminergic neurons to environmental stressMorrow B, Elsworth J, Roth R. Prenatal exposure to cocaine reduces the number and enhances reactivity of A10 dopaminergic neurons to environmental stress. Synapse 2001, 41: 337-344. PMID: 11494404, DOI: 10.1002/syn.1090.
- Nicotine Receptor Inactivation Decreases Sensitivity to CocaineZachariou V, Caldarone B, Weathers-Lowin A, George T, Elsworth J, Roth R, Changeux J, Picciotto M. Nicotine Receptor Inactivation Decreases Sensitivity to Cocaine. Neuropsychopharmacology 2001, 24: 576-589. PMID: 11282258, DOI: 10.1016/s0893-133x(00)00224-4.
- Glial Cell Line-Derived Neurotrophic Factor (GDNF) Gene Delivery Protects Dopaminergic Terminals from DegenerationConnor B, Kozlowski D, Unnerstall J, Elsworth J, Tillerson J, Schallert T, Bohn M. Glial Cell Line-Derived Neurotrophic Factor (GDNF) Gene Delivery Protects Dopaminergic Terminals from Degeneration. Experimental Neurology 2001, 169: 83-95. PMID: 11312561, DOI: 10.1006/exnr.2001.7638.
- Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and MemoryLeranth C, Roth R, Elsworth J, Naftolin F, Horvath T, Redmond D. Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory. Journal Of Neuroscience 2000, 20: 8604-8609. PMID: 11102464, PMCID: PMC6773080, DOI: 10.1523/jneurosci.20-23-08604.2000.
- TMT, a predator odor, elevates mesoprefrontal dopamine metabolic activity and disrupts short-term working memory in the ratMorrow B, Roth R, Elsworth J. TMT, a predator odor, elevates mesoprefrontal dopamine metabolic activity and disrupts short-term working memory in the rat. Brain Research Bulletin 2000, 52: 519-523. PMID: 10974491, DOI: 10.1016/s0361-9230(00)00290-2.
- The predator odor, TMT, displays a unique, stress-like pattern of dopaminergic and endocrinological activation in the ratMorrow B, Redmond A, Roth R, Elsworth J. The predator odor, TMT, displays a unique, stress-like pattern of dopaminergic and endocrinological activation in the rat. Brain Research 2000, 864: 146-151. PMID: 10793199, DOI: 10.1016/s0006-8993(00)02174-0.
- Divergent effects of putative anxiolytics on stress‐induced Fos expression in the mesoprefrontal system of the ratMorrow B, Elsworth J, Lee E, Roth R. Divergent effects of putative anxiolytics on stress‐induced Fos expression in the mesoprefrontal system of the rat. Synapse 2000, 36: 143-154. PMID: 10767061, DOI: 10.1002/(sici)1098-2396(200005)36:2<143::aid-syn7>3.0.co;2-h.
- Striatal dopaminergic correlates of stable parkinsonism and degree of recovery in old-world primates one year after MPTP treatmentElsworth J, Taylor J, Sladek J, Collier T, Redmond D, Roth R. Striatal dopaminergic correlates of stable parkinsonism and degree of recovery in old-world primates one year after MPTP treatment. Neuroscience 1999, 95: 399-408. PMID: 10658619, DOI: 10.1016/s0306-4522(99)00437-6.
- Spontaneous Blink Rates Correlate with Dopamine Levels in the Caudate Nucleus of MPTP-Treated MonkeysTaylor J, Elsworth J, Lawrence M, Sladek J, Roth R, Redmond D. Spontaneous Blink Rates Correlate with Dopamine Levels in the Caudate Nucleus of MPTP-Treated Monkeys. Experimental Neurology 1999, 158: 214-220. PMID: 10448434, DOI: 10.1006/exnr.1999.7093.
- An Antisense Oligonucleotide Reverses the Footshock-Induced Expression of Fos in the Rat Medial Prefrontal Cortex and the Subsequent Expression of Conditioned Fear-Induced ImmobilityMorrow B, Elsworth J, Inglis F, Roth R. An Antisense Oligonucleotide Reverses the Footshock-Induced Expression of Fos in the Rat Medial Prefrontal Cortex and the Subsequent Expression of Conditioned Fear-Induced Immobility. Journal Of Neuroscience 1999, 19: 5666-5673. PMID: 10377372, PMCID: PMC6782327, DOI: 10.1523/jneurosci.19-13-05666.1999.
- The role of mesoprefrontal dopamine neurons in the acquisition and expression of conditioned fear in the ratMorrow B, Elsworth J, Rasmusson A, Roth R. The role of mesoprefrontal dopamine neurons in the acquisition and expression of conditioned fear in the rat. Neuroscience 1999, 92: 553-564. PMID: 10408604, DOI: 10.1016/s0306-4522(99)00014-7.
- Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficitsJentsch J, Taylor J, Elsworth J, Redmond D, Roth R. Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits. Neuroscience 1999, 90: 823-832. PMID: 10218783, DOI: 10.1016/s0306-4522(98)00481-3.
- Biochemical and behavioral anxiolytic-like effects of R(+)HA-966 at the level of the ventral tegmental area in ratsMorrow B, Elsworth J, Zito C, Roth R. Biochemical and behavioral anxiolytic-like effects of R(+)HA-966 at the level of the ventral tegmental area in rats. Psychopharmacology 1999, 143: 227-234. PMID: 10353424, DOI: 10.1007/s002130050941.
- Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeysJentsch J, Taylor J, Redmond Jr D, Elsworth J, Youngren K, Roth R. Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys. Psychopharmacology 1999, 142: 78-84. PMID: 10102786, DOI: 10.1007/s002130050865.
- Chapter 12 Fetal Grafts in Parkinson's Disease Primate ModelsSladek J, Collier T, Elsworth J, Roth R, Taylor J, Redmond D. Chapter 12 Fetal Grafts in Parkinson's Disease Primate Models. 1999, 321-364. DOI: 10.1016/b978-012705070-6/50013-5.
- A comparison of the effects of clonidine and CNQX infusion into the locus coeruleus and the amygdala on naloxone-precipitated opiate withdrawal in the ratTaylor J, Punch L, Elsworth J. A comparison of the effects of clonidine and CNQX infusion into the locus coeruleus and the amygdala on naloxone-precipitated opiate withdrawal in the rat. Psychopharmacology 1998, 138: 133-142. PMID: 9718282, DOI: 10.1007/s002130050655.
- In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vectorDuring M, Samulski R, Elsworth J, Kaplitt M, Leone P, Xiao X, Li J, Freese A, Taylor J, Roth R, Sladek J, O’Malley K, Redmond D. In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector. Gene Therapy 1998, 5: 820-827. PMID: 9747462, DOI: 10.1038/sj.gt.3300650.
- Upregulation of striatal D2 receptors in the MPTP-treated vervet monkey is reversed by grafts of fetal ventral mesencephalon: an autoradiographic studyElsworth J, Brittan M, Taylor J, Sladek J, Redmond D, Innis R, Zea-Ponce Y, Roth R. Upregulation of striatal D2 receptors in the MPTP-treated vervet monkey is reversed by grafts of fetal ventral mesencephalon: an autoradiographic study. Brain Research 1998, 795: 55-62. PMID: 9622593, DOI: 10.1016/s0006-8993(98)00252-2.
- Pattern of synaptophysin immunoreactivity within mesencephalic grafts following transplantation in a parkinsonian primate modelSortwell C, Blanchard B, Collier T, Elsworth J, Taylor J, Roth R, Redmond D, Sladek J. Pattern of synaptophysin immunoreactivity within mesencephalic grafts following transplantation in a parkinsonian primate model. Brain Research 1998, 791: 117-124. PMID: 9593853, DOI: 10.1016/s0006-8993(98)00086-9.
- Intrastriatal Grafts From Multiple Donors Do Not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman PrimatesSladek J, Collier T, Elsworth J, Roth R, Taylor J, Redmond D. Intrastriatal Grafts From Multiple Donors Do Not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman Primates. Cell Transplantation 1998, 7: 87-96. PMID: 9588591, DOI: 10.1016/s0963-6897(98)00007-4.
- Intrastriatal Grafts from Multiple Donors do not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman PrimatesSladek J, Collier T, Elsworth J, Roth R, Taylor J, Redmond D. Intrastriatal Grafts from Multiple Donors do not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman Primates. Cell Transplantation 1998, 7: 87-96. DOI: 10.1177/096368979800700204.
- (S)-(-)-HA-966, a gamma-hydroxybutyrate-like agent, prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear and cocaine sensitization.Morrow B, Lee E, Taylor J, Elsworth J, Nye H, Roth R. (S)-(-)-HA-966, a gamma-hydroxybutyrate-like agent, prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear and cocaine sensitization. Journal Of Pharmacology And Experimental Therapeutics 1997, 283: 712-21. PMID: 9353390.
- Severe long-term 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the vervet monkey (Cercopithecus aethiops sabaeus)Taylor J, Elsworth J, Roth R, Sladek J, Redmond D. Severe long-term 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the vervet monkey (Cercopithecus aethiops sabaeus). Neuroscience 1997, 81: 745-755. PMID: 9316026, DOI: 10.1016/s0306-4522(97)00214-5.
- Enduring Cognitive Deficits and Cortical Dopamine Dysfunction in Monkeys After Long-Term Administration of PhencyclidineJentsch J, Redmond D, Elsworth J, Taylor J, Youngren K, Roth R. Enduring Cognitive Deficits and Cortical Dopamine Dysfunction in Monkeys After Long-Term Administration of Phencyclidine. Science 1997, 277: 953-955. PMID: 9252326, DOI: 10.1126/science.277.5328.953.
- Metabolic energy capacity of dopaminergic grafts and the implanted striatum in parkinsonian nonhuman primates as visualized with cytochrome oxidase histochemistryCollier T, Redmond D, Roth R, Elsworth J, Taylor J, Sladek J. Metabolic energy capacity of dopaminergic grafts and the implanted striatum in parkinsonian nonhuman primates as visualized with cytochrome oxidase histochemistry. Cell Transplantation 1997, 6: 135-140. PMID: 9142445, DOI: 10.1016/s0963-6897(97)00003-1.
- Down-regulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs.Lidow M, Elsworth J, Goldman-Rakic P. Down-regulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs. Journal Of Pharmacology And Experimental Therapeutics 1997, 281: 597-603. PMID: 9103549.
- Dopamine Synthesis, Uptake, Metabolism, and Receptors: Relevance to Gene Therapy of Parkinson's DiseaseElsworth J, Roth R. Dopamine Synthesis, Uptake, Metabolism, and Receptors: Relevance to Gene Therapy of Parkinson's Disease. Experimental Neurology 1997, 144: 4-9. PMID: 9126143, DOI: 10.1006/exnr.1996.6379.
- Phencyclidine Increases Forebrain Monoamine Metabolism in Rats and Monkeys: Modulation by the Isomers of HA966Jentsch J, Elsworth J, Redmond D, Roth R. Phencyclidine Increases Forebrain Monoamine Metabolism in Rats and Monkeys: Modulation by the Isomers of HA966. Journal Of Neuroscience 1997, 17: 1769-1775. PMID: 9030635, PMCID: PMC6573388, DOI: 10.1523/jneurosci.17-05-01769.1997.
- Metabolic Energy Capacity of Dopaminergic Grafts and the Implanted Striatum in Parkinsonian Nonhuman Primates as Visualized with Cytochrome Oxidase HistochemistryCollier T, Redmond D, Roth R, Elsworth J, Taylor J, Sladek J. Metabolic Energy Capacity of Dopaminergic Grafts and the Implanted Striatum in Parkinsonian Nonhuman Primates as Visualized with Cytochrome Oxidase Histochemistry. Cell Transplantation 1997, 6: 135-140. DOI: 10.1177/096368979700600207.
- Dysregulation of Mesoprefrontal Dopamine Neurons Induced by Acute and Repeated Phencyclidine Administration in the Nonhuman Primate: Implications for SchizophreniaJentsch J, Elsworth J, Taylor J, Redmond D, Roth R. Dysregulation of Mesoprefrontal Dopamine Neurons Induced by Acute and Repeated Phencyclidine Administration in the Nonhuman Primate: Implications for Schizophrenia. 1997, 42: 810-814. PMID: 9328021, DOI: 10.1016/s1054-3589(08)60870-4.
- Identification of Novel Variants oftrkC mRNA Transcripts in Brain of African Green MonkeysTam S, Elsworth J, Sladek J, Redmond D, Roth R. Identification of Novel Variants oftrkC mRNA Transcripts in Brain of African Green Monkeys. Experimental Neurology 1997, 143: 172-176. PMID: 9000456, DOI: 10.1006/exnr.1996.6338.
- Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposureHorger B, Taylor J, Elsworth J, Jatlow P, Roth R. Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure. Brain Research 1996, 733: 133-137. PMID: 8891259, DOI: 10.1016/0006-8993(96)00783-4.
- Alcohol plus cocaine: the whole is more than the sum of its parts.Jatlow P, McCance E, Bradberry C, Elsworth J, Taylor J, Roth R. Alcohol plus cocaine: the whole is more than the sum of its parts. Therapeutic Drug Monitoring 1996, 18: 460-4. PMID: 8857569, DOI: 10.1097/00007691-199608000-00026.
- Effects of D2 dopamine receptor antagonists on fos protein expression in the striatal complex and entorhinal cortex of the nonhuman primateDeutch A, Lewis D, Whitehead R, Elsworth J, Iadarola M, Redmond D, Roth R. Effects of D2 dopamine receptor antagonists on fos protein expression in the striatal complex and entorhinal cortex of the nonhuman primate. Synapse 1996, 23: 182-191. PMID: 8807746, DOI: 10.1002/(sici)1098-2396(199607)23:3<182::aid-syn7>3.0.co;2-4.
- Blockade of FG 7142‐Induced Increased Dopamine Utilization by the Glycine/NMDA Receptor Antagonist (+)‐HA 966Horger B, Elsworth J, Roth R. Blockade of FG 7142‐Induced Increased Dopamine Utilization by the Glycine/NMDA Receptor Antagonist (+)‐HA 966. Journal Of Neurochemistry 1996, 66: 1959-1962. PMID: 8780023, DOI: 10.1046/j.1471-4159.1996.66051959.x.
- Early gestational mesencephalon grafts, but not later gestational mesencephalon, cerebellum or sham grafts, increase dopamine in caudate nucleus of MPTP-treated monkeysElsworth J, Sladek J, Taylor J, Collier T, Redmond D, Roth R. Early gestational mesencephalon grafts, but not later gestational mesencephalon, cerebellum or sham grafts, increase dopamine in caudate nucleus of MPTP-treated monkeys. Neuroscience 1996, 72: 477-484. PMID: 8737417, DOI: 10.1016/0306-4522(95)00564-1.
- Restoration of dopamine transporter density in the striatum of fetal ventral mesencephalon-grafted, but not sham-grafted, MPTP-treated parkinsonian monkeysElsworth J, Brittan M, Taylor J, Sladek J, Al-Tikriti M, Zea-Ponce Y, Innis R, Redmond D, Roth R. Restoration of dopamine transporter density in the striatum of fetal ventral mesencephalon-grafted, but not sham-grafted, MPTP-treated parkinsonian monkeys. Cell Transplantation 1996, 5: 315-325. PMID: 8689042, DOI: 10.1016/0963-6897(95)02034-9.
- Restoration of Dopamine Transporter Density in the Striatum of Fetal Ventral Mesencephalon-Grafted, but not Sham-Grafted, Mptp-Treated Parkinsonian MonkeysElsworth J, Brittan M, Taylor J, Sladek J, Al-Tikriti M, Zea-Ponce Y, Innis R, Redmond D, Roth R. Restoration of Dopamine Transporter Density in the Striatum of Fetal Ventral Mesencephalon-Grafted, but not Sham-Grafted, Mptp-Treated Parkinsonian Monkeys. Cell Transplantation 1996, 5: 315-325. DOI: 10.1177/096368979600500220.
- Tyrosine enhances behavioral and mesocorticolimbic dopaminergic responses to aversive conditioningMorrow B, Elsworth J, Roth R. Tyrosine enhances behavioral and mesocorticolimbic dopaminergic responses to aversive conditioning. Synapse 1996, 22: 100-105. PMID: 8787125, DOI: 10.1002/(sici)1098-2396(199602)22:2<100::aid-syn2>3.0.co;2-h.
- Selective Increase in Dopamine Utilization in the Shell Subdivision of the Nucleus Accumbens by the Benzodiazepine Inverse Agonist FG 7142Horger B, Elsworth J, Roth R. Selective Increase in Dopamine Utilization in the Shell Subdivision of the Nucleus Accumbens by the Benzodiazepine Inverse Agonist FG 7142. Journal Of Neurochemistry 1995, 65: 770-774. PMID: 7616234, DOI: 10.1046/j.1471-4159.1995.65020770.x.
- General Cognitive Ability Following Unilateral and Bilateral Fetal Ventral Mesencephalic Tissue Transplantation for Treatment of Parkinson's DiseaseSass K, Buchanan C, Westerveld M, Marek K, Farhi A, Robbins R, Naftolin F, Vollmer T, Leranth C, Roth R, Price L, Bunney B, Elsworth J, Hoffer P, Redmond D, Spencer D. General Cognitive Ability Following Unilateral and Bilateral Fetal Ventral Mesencephalic Tissue Transplantation for Treatment of Parkinson's Disease. JAMA Neurology 1995, 52: 680-686. PMID: 7619024, DOI: 10.1001/archneur.1995.00540310050016.
- Co-Grafts in Dopamine-Depleted Primates: Preliminary Results and Theoretical Issues Related to Human Applications for Parkinson’s DiseaseSladek J, Elsworth J, Roth R, Blanchard B, Taylor J, Collier T, Redmond D. Co-Grafts in Dopamine-Depleted Primates: Preliminary Results and Theoretical Issues Related to Human Applications for Parkinson’s Disease. 1995, 219-230. DOI: 10.1007/978-1-4615-1929-4_18.
- Sham surgery does not ameliorate MPTP-induced behavioral deficits in monkeysTaylor J, Elsworth J, Sladek J, Collier T, Roth R, Redmond D. Sham surgery does not ameliorate MPTP-induced behavioral deficits in monkeys. Cell Transplantation 1995, 4: 13-26. PMID: 7728327, DOI: 10.1016/0963-6897(94)00035-i.
- Sham Surgery does not Ameliorate MPTP-Induced Behavioral Deficits in MonkeysTaylor J, Elsworth J, Sladek J, Collier T, Roth R, Redmond D. Sham Surgery does not Ameliorate MPTP-Induced Behavioral Deficits in Monkeys. Cell Transplantation 1995, 4: 13-26. DOI: 10.1177/096368979500400105.
- Expression Of A Novel TRK C Receptor Isoform With Truncated Extracellular Domain In Fetal And Adult Monkey BrainsTam S, Elsworth J, Redmond D, Roth R. Expression Of A Novel TRK C Receptor Isoform With Truncated Extracellular Domain In Fetal And Adult Monkey Brains. Neuropsychopharmacology 1994, 11: 286-286. DOI: 10.1038/sj.npp.1380219.
- Preexposure to, but Not Cotreatment with, the Neurotensin Antagonist SR 48692 Delays the Development of Cocaine SensitizationHorger B, Taylor J, Elsworth J, Roth R. Preexposure to, but Not Cotreatment with, the Neurotensin Antagonist SR 48692 Delays the Development of Cocaine Sensitization. Neuropsychopharmacology 1994, 11: 215-222. PMID: 7865101, DOI: 10.1038/sj.npp.1380108.
- Peripheral nerve-dopamine neuron co-grafts in mptp-treated monkeys: Augmentation of tyrosine hydroxylase-positive fiber staining and dopamine content in host systemsCollier T, Elsworth J, Taylor J, Sladek J, Roth R, Redmond D. Peripheral nerve-dopamine neuron co-grafts in mptp-treated monkeys: Augmentation of tyrosine hydroxylase-positive fiber staining and dopamine content in host systems. Neuroscience 1994, 61: 875-889. PMID: 7838385, DOI: 10.1016/0306-4522(94)90410-3.
- Novel Radioligands for the Dopamine Transporter Demonstrate the Presence of Intrastriatal Nigral Grafts in the MPTP-Treated Monkey: Correlation with Improved Behavioral FunctionElsworth J, Al-Tikriti M, Sladek J, Taylor J, Innis R, Redmond D, Roth R. Novel Radioligands for the Dopamine Transporter Demonstrate the Presence of Intrastriatal Nigral Grafts in the MPTP-Treated Monkey: Correlation with Improved Behavioral Function. Experimental Neurology 1994, 126: 299-304. PMID: 7925828, DOI: 10.1006/exnr.1994.1068.
- Behavioral Effects of MPTP Administration in the Vervet MonkeyTaylor J, Elsworth J, Roth R, Sladek J, Redmond D. Behavioral Effects of MPTP Administration in the Vervet Monkey. 1994, 139-174. DOI: 10.1007/978-1-4899-1447-7_6.
- Can Graft-Derived Neurotrophic Activity Be Used to Direct Axonal Outgrowth of Grafted Dopamine Neurons for Circuit Reconstruction in Primates?Sladek J, Collier T, Elsworth J, Taylor J, Roth R, Redmond D. Can Graft-Derived Neurotrophic Activity Be Used to Direct Axonal Outgrowth of Grafted Dopamine Neurons for Circuit Reconstruction in Primates? Experimental Neurology 1993, 124: 134-139. PMID: 8282070, DOI: 10.1006/exnr.1993.1184.
- Serotonin involvement in cocaine sensitization: Clues from studies with cocaine analogsElsworth J, Taylor J, Jatlow P, Roth R. Serotonin involvement in cocaine sensitization: Clues from studies with cocaine analogs. Drug Development Research 1993, 30: 189-200. DOI: 10.1002/ddr.430300311.
- Neural Transplantation for Neurodegenerative Diseases: Past, Present, and FutureaREDMOND D, ROTH R, SPENCER D, NAFTOLIN F, LERANTH C, ROBBINS R, MAREK K, ELSWORTH J, SASS K, TAYLOR J, SLADEK J. Neural Transplantation for Neurodegenerative Diseases: Past, Present, and Futurea. Annals Of The New York Academy Of Sciences 1993, 695: 258-266. PMID: 8239293, DOI: 10.1111/j.1749-6632.1993.tb23064.x.
- Cocaine-sensitive and -insensitive dopamine uptake in prefrontal cortex, nucleus accumbens and striatumElsworth J, Taylor J, Berger P, Roth R. Cocaine-sensitive and -insensitive dopamine uptake in prefrontal cortex, nucleus accumbens and striatum. Neurochemistry International 1993, 23: 61-69. PMID: 8369733, DOI: 10.1016/0197-0186(93)90144-t.
- Fetal Dopamine Cell Survival after Transplantation Is Dramatically Improved at a Critical Donor Gestational Age in Nonhuman PrimatesSladek J, Elsworth J, Roth R, Evans L, Collier T, Cooper S, Taylor J, Redmond D. Fetal Dopamine Cell Survival after Transplantation Is Dramatically Improved at a Critical Donor Gestational Age in Nonhuman Primates. Experimental Neurology 1993, 122: 16-27. PMID: 8101820, DOI: 10.1006/exnr.1993.1103.
- Unilateral Transplantation of Human Fetal Mesencephalic Tissue Into the Caudate Nucleus of Patients With Parkinson's DiseaseSPENCER D, ROBBINS R, NAFTOLIN F, MAREK K, VOLLMER T, LERANTH C, ROTH R, PRICE L, GJEDDE A, BUNNEY B, SASS K, ELSWORTH J, KIER E, MAKUCH R, HOFFER P, REDMOND D. Unilateral Transplantation of Human Fetal Mesencephalic Tissue Into the Caudate Nucleus of Patients With Parkinson's Disease. Obstetrical & Gynecological Survey 1993, 48: 413-415. DOI: 10.1097/00006254-199306000-00013.
- Cocaine and Cocaethylene: Microdialysis Comparison of Brain Drug Levels and Effects on Dopamine and SerotoninBradberry C, Nobiletti J, Elsworth J, Murphy B, Jatlow P, Roth R. Cocaine and Cocaethylene: Microdialysis Comparison of Brain Drug Levels and Effects on Dopamine and Serotonin. Journal Of Neurochemistry 1993, 60: 1429-1435. PMID: 8455033, DOI: 10.1111/j.1471-4159.1993.tb03305.x.
- Deprenyl: Pharmacological aspects of its clinical effectsElsworth JD, Roth RH. Deprenyl: Pharmacological aspects of its clinical effects Biogenic Amines. 9: 381-394.
- Unilateral Transplantation of Human Fetal Mesencephalic Tissue into the Caudate Nucleus of Patients with Parkinson's DiseaseSpencer D, Robbins R, Naftolin F, Marek K, Vollmer T, Leranth C, Roth R, Price L, Gjedde A, Bunney B, Sass K, Elsworth J, Kier E, Makuch R, Hoffer P, Redmond D. Unilateral Transplantation of Human Fetal Mesencephalic Tissue into the Caudate Nucleus of Patients with Parkinson's Disease. New England Journal Of Medicine 1992, 327: 1541-1548. PMID: 1435880, DOI: 10.1056/nejm199211263272201.
- Amphetamine‐stimulated dopamine release competes in vivo for [123I]IBZM binding to the D2 receptor in nonhuman primatesInnis R, Malison R, Al‐Tikriti M, Hoffer P, Sybirska E, Seibyl J, Zoghbi S, Baldwin R, Laruelle M, Smith E, Charney D, Heninger G, Elsworth J, Roth R. Amphetamine‐stimulated dopamine release competes in vivo for [123I]IBZM binding to the D2 receptor in nonhuman primates. Synapse 1992, 10: 177-184. PMID: 1532675, DOI: 10.1002/syn.890100302.
- Biochemical Changes Induced by Embryonic Substantia Nigra Transplanted to the Striatum of Parkinsonian MonkeysElsworth J, Sladek Jr. J, Redmond Jr. D, Taylor J, Collier T, Roth R. Biochemical Changes Induced by Embryonic Substantia Nigra Transplanted to the Striatum of Parkinsonian Monkeys. Neural Plasticity 1992, 3: 216-217. PMCID: PMC2565213, DOI: 10.1155/np.1992.216.
- Quantitative Behavioral Assessment Methods for the Analysis of Graft-Induced Motor and Cognitive Function in the MPTP-Treated Parkinsonian MonkeyTaylor J, Elsworth J, Roth R, Sladek, Jr. J, Collier T, Redmond, Jr. D. Quantitative Behavioral Assessment Methods for the Analysis of Graft-Induced Motor and Cognitive Function in the MPTP-Treated Parkinsonian Monkey. Neural Plasticity 1992, 3: 227-228. PMCID: PMC2565157, DOI: 10.1155/np.1992.227.
- D1 and D2 dopamine receptors independently regulate spontaneous blink rate in the vervet monkey.Elsworth J, Lawrence M, Roth R, Taylor J, Mailman R, Nichols D, Lewis M, Redmond D. D1 and D2 dopamine receptors independently regulate spontaneous blink rate in the vervet monkey. Journal Of Pharmacology And Experimental Therapeutics 1991, 259: 595-600. PMID: 1682479.
- Dihydrexidine, a full dopamine D1 agonist, reduces MPTP-ioduced parkinsonism in monkeysTaylor J, Lawrence M, Redmond D, Elsworth J, Roth R, Nichols D, Mailman R. Dihydrexidine, a full dopamine D1 agonist, reduces MPTP-ioduced parkinsonism in monkeys. European Journal Of Pharmacology 1991, 199: 389-391. PMID: 1680717, DOI: 10.1016/0014-2999(91)90508-n.
- Anxiogenic β-carboline FG 7142 produces activation of noradrenergic neurons in specific brain regions of ratsIda Y, Elsworth J, Roth R. Anxiogenic β-carboline FG 7142 produces activation of noradrenergic neurons in specific brain regions of rats. Pharmacology Biochemistry And Behavior 1991, 39: 791-793. PMID: 1784607, DOI: 10.1016/0091-3057(91)90166-y.
- Grafting of fetal substantia nigra to striatum reverses behavioral deficits induced by MPTP in primates: a comparison with other types of grafts as controlsTaylor J, Elsworth J, Roth R, Sladek J, Collier T, Redmond D. Grafting of fetal substantia nigra to striatum reverses behavioral deficits induced by MPTP in primates: a comparison with other types of grafts as controls. Experimental Brain Research 1991, 85: 335-348. PMID: 1893983, DOI: 10.1007/bf00229411.
- Yohimbine co-treatment during chronic morphine administration attenuates naloxone-precipitated withdrawal without diminishing tail-flick analgesia in ratsTaylor J, Lewis V, Elsworth J, Pivirotto P, Roth R, Redmond D. Yohimbine co-treatment during chronic morphine administration attenuates naloxone-precipitated withdrawal without diminishing tail-flick analgesia in rats. Psychopharmacology 1991, 103: 407-414. PMID: 2057541, DOI: 10.1007/bf02244297.
- The D1 receptor antagonist, SCH 23390, induces signs of parkinsonism in African green monkeysLawrence M, Redmond D, Elsworth J, Taylor J, Roth R. The D1 receptor antagonist, SCH 23390, induces signs of parkinsonism in African green monkeys. Life Sciences 1991, 49: pl229-pl234. PMID: 1836030, DOI: 10.1016/0024-3205(91)90299-q.
- 3-Acetylpyridine results in degeneration of the extrapyramidal and cerebellar motor systems: loss of the dorsolateral striatal dopamine innervationDeutsch A, Elsworth J, Roth R, Menek G. 3-Acetylpyridine results in degeneration of the extrapyramidal and cerebellar motor systems: loss of the dorsolateral striatal dopamine innervation. Brain Research 1990, 527: 96-102. PMID: 2126479, DOI: 10.1016/0006-8993(90)91065-o.
- MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primateElsworth J, Deutch A, Redmond D, Sladek J, Roth R. MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate. Neuroscience Letters 1990, 114: 316-322. PMID: 2402341, DOI: 10.1016/0304-3940(90)90583-u.
- Mesocortical dopamine neurons: High basal firing frequency predicts tyrosine dependence of dopamine synthesisTam S, Elsworth J, Bradberry C, Roth R. Mesocortical dopamine neurons: High basal firing frequency predicts tyrosine dependence of dopamine synthesis. Journal Of Neural Transmission 1990, 81: 97-110. PMID: 2363911, DOI: 10.1007/bf01245830.
- Regionally specific alterations in the low-affinity GABAA receptor following perinatal exposure to diazepamGruen R, Elsworth J, Roth R. Regionally specific alterations in the low-affinity GABAA receptor following perinatal exposure to diazepam. Brain Research 1990, 514: 151-154. PMID: 2162709, DOI: 10.1016/0006-8993(90)90449-l.
- MPTP-induced parkinsonism: relative changes in dopamine concentration in subregions of substantia nigra, ventral tegmental area and retrorubral field of symptomatic and asymptomatic vervet monkeysElsworth J, Deutch A, Redmond D, Sladek J, Roth R. MPTP-induced parkinsonism: relative changes in dopamine concentration in subregions of substantia nigra, ventral tegmental area and retrorubral field of symptomatic and asymptomatic vervet monkeys. Brain Research 1990, 513: 320-324. PMID: 2350702, DOI: 10.1016/0006-8993(90)90474-p.
- Complex interaction of cocaine with the dopamine uptake carrierBerger P, Elsworth J, Reith M, Tanen D, Roth R. Complex interaction of cocaine with the dopamine uptake carrier. European Journal Of Pharmacology 1990, 176: 251-252. PMID: 2311671, DOI: 10.1016/0014-2999(90)90540-m.
- Interaction of [3H]GBR 12935 and GBR 12909 with the dopamine uptake complex in nucleus accumbensBerger P, Elsworth J, Arroyo J, Roth R. Interaction of [3H]GBR 12935 and GBR 12909 with the dopamine uptake complex in nucleus accumbens. European Journal Of Pharmacology 1990, 177: 91-94. PMID: 1967129, DOI: 10.1016/0014-2999(90)90554-j.
- Chapter 62 Improvements in MPTP-induced object retrieval deficits and behavioral deficits after fetal nigral grafting in monkeysTaylor J, Elsworth J, Roth R, Collier T, Sladek J, Redmond D. Chapter 62 Improvements in MPTP-induced object retrieval deficits and behavioral deficits after fetal nigral grafting in monkeys. 1990, 82: 543-559. PMID: 2290957, DOI: 10.1016/s0079-6123(08)62645-x.
- Cognitive and motor deficits in the acquisition of an object retrieval/detour task in MPTP-treated monkeys.Taylor J, Elsworth J, Roth R, Sladek J, Redmond D. Cognitive and motor deficits in the acquisition of an object retrieval/detour task in MPTP-treated monkeys. Brain 1990, 113 ( Pt 3): 617-37. PMID: 2364263, DOI: 10.1093/brain/113.3.617.
- Cocaethylene inhibits uptake of dopamine and can reach high plasma concentrations following combined cocaine and ethanol use.Jatlow P, Hearn W, Elsworth J, Roth R, Bradberry C, Taylor J. Cocaethylene inhibits uptake of dopamine and can reach high plasma concentrations following combined cocaine and ethanol use. NIDA Research Monograph 1990, 105: 572-3. PMID: 1876124.
- Symptomatic and asymptomatic 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridinetreated primates: Biochemical changes in striatal regionsElsworth J, Deutch A, Redmond D, Taylor J, Sladek J, Roth R. Symptomatic and asymptomatic 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridinetreated primates: Biochemical changes in striatal regions. Neuroscience 1989, 33: 323-331. PMID: 2622529, DOI: 10.1016/0306-4522(89)90212-1.
- Transplantation advances in parkinson's diseaseSladek J, Redmond D, Collier T, Elsworth J, Roth R. Transplantation advances in parkinson's disease. Movement Disorders 1989, 4: s120-s125. PMID: 2786143, DOI: 10.1002/mds.870040513.
- Biochemical analysis of caudate nucleus biopsy samples from parkinsonian patientsGoldstein M, Lieberman A, Helmer E, Koslow M, Ransohoff J, Elsworth J, Roth R, Deutch A. Biochemical analysis of caudate nucleus biopsy samples from parkinsonian patients. Annals Of Neurology 1988, 24: 685-688. PMID: 2904793, DOI: 10.1002/ana.410240517.
- Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawalTaylor J, Elsworth J, Garcia E, Grant S, Roth R, Redmond D. Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal. Psychopharmacology 1988, 96: 121-134. PMID: 3147472, DOI: 10.1007/bf02431544.
- Reversal of Experimental Parkinsonism in African Green Monkeys Following Fetal Dopamine Neuron TransplantationCollier T, Redmond D, Roth R, Elsworth J, Sladek J. Reversal of Experimental Parkinsonism in African Green Monkeys Following Fetal Dopamine Neuron Transplantation. 1988, 211-218. DOI: 10.1007/978-1-4613-0759-4_27.
- Chapter 64 Fetal dopamine neural grafts: extended reversal of methylphenyltetrahydropyridine-induced parkinsonism in monkeysSladek J, Redmond D, Collier T, Blount J, Elsworth J, Taylor J, Roth R. Chapter 64 Fetal dopamine neural grafts: extended reversal of methylphenyltetrahydropyridine-induced parkinsonism in monkeys. 1988, 78: 497-506. PMID: 3266802, DOI: 10.1016/s0079-6123(08)60323-4.
- Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSFElsworth J, Deutch A, Redmond D, Sladek J, Roth R. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF. Brain Research 1987, 415: 293-299. PMID: 3496938, DOI: 10.1016/0006-8993(87)90211-3.
- Reversal of Parkinsonism by Fetal Nerve Cell Transplants in Primate BrainaSLADEK J, COLLIER T, HABER S, DEUTCH A, ELSWORTH J, ROTH R, REDMOND D. Reversal of Parkinsonism by Fetal Nerve Cell Transplants in Primate Braina. Annals Of The New York Academy Of Sciences 1987, 495: 641-657. PMID: 2886092, DOI: 10.1111/j.1749-6632.1987.tb23706.x.
- Homovanillic acid concentrations in brain, CSF and plasma as indicators of central dopamine function in primatesElsworth J, Leahy D, Roth R, Redmond D. Homovanillic acid concentrations in brain, CSF and plasma as indicators of central dopamine function in primates. Journal Of Neural Transmission 1987, 68: 51-62. PMID: 3806086, DOI: 10.1007/bf01244639.
- Chapter 25 Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonismSladek J, Redmond D, Collier T, Haber S, Elsworth J, Deutch A, Roth R. Chapter 25 Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism. 1987, 71: 309-323. PMID: 3495818, DOI: 10.1016/s0079-6123(08)61833-6.
- Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatumElsworth J, Deutch A, Redmond D, Sladek J, Roth R. Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum. Life Sciences 1987, 40: 193-202. PMID: 3491946, DOI: 10.1016/0024-3205(87)90359-6.
- Effect of morphine treatment and withdrawal on endogenous methionine- and leucine-enkephalin levels in primate brainElsworth J, Redmond D, Roth R. Effect of morphine treatment and withdrawal on endogenous methionine- and leucine-enkephalin levels in primate brain. Biochemical Pharmacology 1986, 35: 3415-3417. PMID: 3768031, DOI: 10.1016/0006-2952(86)90447-8.
- Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineDeutch A, Elsworth J, Goldstein M, Fuxe K, Redmond D, Sladek J, Roth R. Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neuroscience Letters 1986, 68: 51-56. PMID: 3487756, DOI: 10.1016/0304-3940(86)90228-4.
- Equol and other compounds from bovine urine as monoamine oxidase inhibitorsDewar D, Glover V, Elsworth J, Sandler M. Equol and other compounds from bovine urine as monoamine oxidase inhibitors. Journal Of Neural Transmission 1986, 65: 147-150. PMID: 3009710, DOI: 10.1007/bf01256490.
- Purification and characterization of tribulin, an endogenous inhibitor of monoamine oxidase and of benzodiazepine receptor bindingElsworth J, Dewar D, Glover V, Goodwin B, Clow A, Sandler M. Purification and characterization of tribulin, an endogenous inhibitor of monoamine oxidase and of benzodiazepine receptor binding. Journal Of Neural Transmission 1986, 67: 45-56. PMID: 3023548, DOI: 10.1007/bf01243358.
- Phenylacetic acid production in dominant and non-dominant vervet monkeysElsworth J, Redmond D, Ruthven C, Sandler M. Phenylacetic acid production in dominant and non-dominant vervet monkeys. Life Sciences 1985, 37: 1727-1730. PMID: 4058249, DOI: 10.1016/0024-3205(85)90301-7.
- Tribulin: an endogenous monoamine oxidase inhibitor/benzodiazepine receptor ligand.Sandler M, Glover V, Clow A, Elsworth J. Tribulin: an endogenous monoamine oxidase inhibitor/benzodiazepine receptor ligand. Progress In Clinical And Biological Research 1985, 192: 359-62. PMID: 3001762.
- TRIBULIN IN ANXIETY AND PANIC.Glover V, Clow A, Elsworth J, Sandler M. TRIBULIN IN ANXIETY AND PANIC. Clinical Neuropharmacology 1984, 7: s94. DOI: 10.1097/00002826-198406001-00089.
- Endogenous substrates and inhibitors of monoamine oxidaseSandler M, Glover V, Elsworth J. Endogenous substrates and inhibitors of monoamine oxidase. 1984, 187-192. DOI: 10.1007/978-1-349-86029-6_28.
- Ethanol and endogenous ligands in humans.Sandler M, Glover V, Elsworth J, Clow A. Ethanol and endogenous ligands in humans. Psychopharmacology Bulletin 1984, 20: 485-6. PMID: 6089251.
- Panic-induced elevation of plasma MHPG levels in phobic-anxious patients. Effects of clonidine and imipramineKo G, Elsworth J, Roth R, Rifkin B, Leigh H, Redmond E. Panic-induced elevation of plasma MHPG levels in phobic-anxious patients. Effects of clonidine and imipramine. Journal Of Clinical Psychopharmacology 1983, 3: 328. DOI: 10.1097/00004714-198310000-00029.
- Relative Importance of 3‐Methoxy‐4‐Hydroxyphenylglycol and 3,4‐Dihydroxyphenylglycol as Norepinephrine Metabolites in Rat, Monkey, and HumansElsworth J, Roth R, Redmond D. Relative Importance of 3‐Methoxy‐4‐Hydroxyphenylglycol and 3,4‐Dihydroxyphenylglycol as Norepinephrine Metabolites in Rat, Monkey, and Humans. Journal Of Neurochemistry 1983, 41: 786-793. PMID: 6875564, DOI: 10.1111/j.1471-4159.1983.tb04809.x.
- Panic-Induced Elevation of Plasma MHPG Levels in Phobic-Anxious Patients: Effects of Clonidine and ImipramineKo G, Elsworth J, Roth R, Rifkin B, Leigh H, Redmond D. Panic-Induced Elevation of Plasma MHPG Levels in Phobic-Anxious Patients: Effects of Clonidine and Imipramine. JAMA Psychiatry 1983, 40: 425-430. PMID: 6838322, DOI: 10.1001/archpsyc.1983.01790040079011.
- Brain catecholamine metabolites and behavior in morphine withdrawalSwann A, Elsworth J, Charney D, Jablons D, Roth R, Redmond D, Maas J. Brain catecholamine metabolites and behavior in morphine withdrawal. European Journal Of Pharmacology 1982, 86: 167-175. PMID: 6297931, DOI: 10.1016/0014-2999(82)90314-4.
- Clonidine suppression of noradrenergic hyperactivity during morphine withdrawal by clonidine: biochemical studies in rodents and primates.Roth R, Elsworth J, Redmond D. Clonidine suppression of noradrenergic hyperactivity during morphine withdrawal by clonidine: biochemical studies in rodents and primates. The Journal Of Clinical Psychiatry 1982, 43: 42-6. PMID: 6806253.
- Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primatesElsworth J, Redmond D, Roth R. Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates. Brain Research 1982, 235: 115-124. PMID: 7188317, DOI: 10.1016/0006-8993(82)90200-1.
- The contribution of amphetamine metabolites of (−)-deprenyl to its antiparkinsonian propertiesElsworth J, Sandler M, Lees A, Ward C, Stern G. The contribution of amphetamine metabolites of (−)-deprenyl to its antiparkinsonian properties. Journal Of Neural Transmission 1982, 54: 105-110. PMID: 6809891, DOI: 10.1007/bf01249283.
- The effect of deprenyl, a selective monoamine oxidase B inhibitor, on sleep and mood in manThornton C, Doré C, Elsworth J, Herbert M, Stern G. The effect of deprenyl, a selective monoamine oxidase B inhibitor, on sleep and mood in man. Psychopharmacology 1980, 70: 163-166. PMID: 6776576, DOI: 10.1007/bf00435308.
- Tele-methylhistamine is a specific MAO B substrate in manElsworth J, Glover V, Sandler M. Tele-methylhistamine is a specific MAO B substrate in man. Psychopharmacology 1980, 69: 287-290. PMID: 6774369, DOI: 10.1007/bf00433097.
- Dopamine Oxidation and Its Inhibition by (—)-Deprenyl in ManGlover V, Elsworth J, Sandler M. Dopamine Oxidation and Its Inhibition by (—)-Deprenyl in Man. 1980, 163-172. DOI: 10.1007/978-3-7091-8582-7_18.
- Dopamine Oxidation and Its Inhibition by (—)-Deprenyl in ManGlover V, Elsworth J, Sandler M. Dopamine Oxidation and Its Inhibition by (—)-Deprenyl in Man. 1980, 163-172. PMID: 6776235, DOI: 10.1007/978-3-7091-8582-7_18.
- DOPAMINE OXIDATION AND ITS INHIBITION BY (−)-DEPRENYL IN HUMAN BRAIN AND TISSUESGlover V, Elsworth J, Sandler M. DOPAMINE OXIDATION AND ITS INHIBITION BY (−)-DEPRENYL IN HUMAN BRAIN AND TISSUES. 1979, 201-203. DOI: 10.1016/b978-1-4832-8363-0.50063-x.
- SELECTIVE MAO INHIBITION: A NEW STRATEGY IN THE TREATMENT OF PARKINSON'S DISEASEElsworth J, Glover V, Sandler M. SELECTIVE MAO INHIBITION: A NEW STRATEGY IN THE TREATMENT OF PARKINSON'S DISEASE. 1979, 1575-1577. DOI: 10.1016/b978-1-4832-8363-0.50482-1.
- Deprenyl is metabolized to methamphetamine and amphetamine in man.Reynolds G, Elsworth J, Blau K, Sandler M, Lees A, Stern G. Deprenyl is metabolized to methamphetamine and amphetamine in man. British Journal Of Clinical Pharmacology 1978, 6: 542-544. PMID: 728327, PMCID: PMC1429688, DOI: 10.1111/j.1365-2125.1978.tb00883.x.
- Deprenyl administration in man: A selective monoamine oxidase B inhibitor without the ‘cheese effect’Elsworth J, Glover V, Reynolds G, Sandler M, Lees A, Phuapradit P, Shaw K, Stern G, Kumar P. Deprenyl administration in man: A selective monoamine oxidase B inhibitor without the ‘cheese effect’. Psychopharmacology 1978, 57: 33-38. PMID: 96466, DOI: 10.1007/bf00426954.
- DEPRENYL IN PARKINSON'S DISEASELees A, Kohout L, Shaw K, Stern G, Elsworth J, Sandler M, Youdim M. DEPRENYL IN PARKINSON'S DISEASE. The Lancet 1977, 310: 791-795. PMID: 71602, DOI: 10.1016/s0140-6736(77)90725-5.
- For other publications (from over 150), see PubMed.For other publications (from over 150), see PubMed.