Anirvan Nandy, PhD
Research & Publications
Biography
News
Research Summary
My lab investigates the neural mechanisms of perception, attention, and social cognition using a combination of cutting-edge tools in high-density electrophysiology, deep learning, machine vision, and computational modeling of neural and behavioral dynamics.
Extensive Research Description
Perception and cognition depend crucially on the ability of our sensory cortical systems to select behaviorally relevant stimuli for detailed inspection while ignoring distractors. Neurons in the neocortex are embedded in a layered (or laminar) structure, and there are stereotypical patterns of anatomical connectivity in this layered cortical architecture and these connectivity motifs are shared across sensory modalities, leading to the idea of a canonical information processing circuit. By studying the functional dynamics of these intricate layered circuits while animals are engaged in challenging visuo-spatial tasks and naturalistic social behaviors, we hope to discover fundamental principles of information flow through the cortex, and how this information flow is modulated by brain and behavioral state. These investigations will significantly advance our understanding of the mechanisms of cognition and ultimately help us understand disease conditions in which information flow is disrupted.
Coauthors
Research Interests
Attention; Macular Degeneration; Neurobiology; Neurons; Neurosciences; Visual Cortex; Prefrontal Cortex; Social Cognition
Selected Publications
- Laminar compartmentalization of attention modulation in area V4 aligns with the demands of visual processing hierarchy in the cortexWang X, Nandy A, Jadi M. Laminar compartmentalization of attention modulation in area V4 aligns with the demands of visual processing hierarchy in the cortex. Scientific Reports 2023, 13: 19558. PMID: 37945642, PMCID: PMC10636153, DOI: 10.1038/s41598-023-46722-8.
- Laminar mechanisms of saccadic suppression in primate visual cortexDenagamage S, Morton M, Hudson N, Reynolds J, Jadi M, Nandy A. Laminar mechanisms of saccadic suppression in primate visual cortex. Cell Reports 2023, 42: 112720. PMID: 37392385, PMCID: PMC10528056, DOI: 10.1016/j.celrep.2023.112720.
- The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviorsShi W, Meisner O, Blackmore S, Jadi M, Nandy A, Chang S. The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors. Neurobiology Of Learning And Memory 2023, 203: 107793. PMID: 37353191, PMCID: PMC10527225, DOI: 10.1016/j.nlm.2023.107793.
- Laminar Organization of Attentional Modulation in Macaque Visual Area V4Nandy AS, Nassi JJ, Reynolds JH. Laminar Organization of Attentional Modulation in Macaque Visual Area V4. Neuron 2016, 93: 235-246. PMID: 27989456, PMCID: PMC5217483, DOI: 10.1016/j.neuron.2016.11.029.
- Neurons in Macaque Area V4 Are Tuned for Complex Spatio-Temporal PatternsNandy AS, Mitchell JF, Jadi MP, Reynolds JH. Neurons in Macaque Area V4 Are Tuned for Complex Spatio-Temporal Patterns. Neuron 2016, 91: 920-930. PMID: 27499085, PMCID: PMC4990477, DOI: 10.1016/j.neuron.2016.07.026.
- Rapid and Persistent Adaptability of Human Oculomotor Control in Response to Simulated Central Vision LossKwon M, Nandy AS, Tjan BS. Rapid and Persistent Adaptability of Human Oculomotor Control in Response to Simulated Central Vision Loss. Current Biology 2013, 23: 1663-1669. PMID: 23954427, PMCID: PMC3773263, DOI: 10.1016/j.cub.2013.06.056.
- The Fine Structure of Shape Tuning in Area V4Nandy AS, Sharpee TO, Reynolds JH, Mitchell JF. The Fine Structure of Shape Tuning in Area V4. Neuron 2013, 78: 1102-1115. PMID: 23791199, PMCID: PMC3694358, DOI: 10.1016/j.neuron.2013.04.016.
- Saccade-confounded image statistics explain visual crowdingNandy AS, Tjan BS. Saccade-confounded image statistics explain visual crowding. Nature Neuroscience 2012, 15: 463-469. PMID: 22231425, PMCID: PMC3288353, DOI: 10.1038/nn.3021.
- The Angry Brain: Neural Correlates of Anger, Angry Rumination, and Aggressive PersonalityDenson T, Pedersen W, Ronquillo J, Nandy A. The Angry Brain: Neural Correlates of Anger, Angry Rumination, and Aggressive Personality. Journal Of Cognitive Neuroscience 2009, 21: 734-744. PMID: 18578600, DOI: 10.1162/jocn.2009.21051.