Alia Bazzy-Asaad, MD
Research & Publications
Biography
News
Research Summary
Our research interests have focused on trying to understand the role of respiratory muscle fatigue in the development of respiratory failure in children. In particular, studying sites along the neuromuscular axis that could potentially fail and lead to impaired performance of the respiratory muscles. Examples of these include phrenic neural activation, neuromuscular transmission and utilization of energy substrate by the muscle. We have determined that neuromuscular transmission failure plays an important in the development of muscle fatigue in the newborn diaphragm, and that this relates to impaired release of neurotransmitter from the nerve terminals. Because of the important role of calcium in neurotransmitter release, we are focusing on the differences between presynaptic calcium channels subtypes in newborn and mature neuromuscular junction.
A second research interest has been childhood asthma. We currently have 2 areas that are being developed in the laboratory. One is to try to understand the mechanisms underlying the development of chronic asthma in childhood, and in particular how airway inflammation might modulate airway smooth muscle function. We will be examining the effect of chronic exposure to several cytokines on ion channel activity in airway smooth muscle, and how this affects the contractile properties of the muscle. We are also interested in performing clinical studies to determine whether the increase in exhaled nitric oxide (NO) that is observed in children with asthma is secondary to increased production or decreased absorption of NO in the lungs. This has implications on understanding the pathogenesis of the inflammatory process in asthma.
Specialized Terms: Respiratory Muscle Fatigue in Children; Development of Chronic Asthma in Children; Pathogenesis of Inflammatory Process in Asthma
Coauthors
Research Interests
Asthma; England; Pediatrics; Respiration Disorders; Respiratory Muscles
Selected Publications
- Pediatric unilobar resection in primary ciliary dyskinesiaSENDON C, COWLES R, WORHUNSKY D, HODSON D, MOROTTI R, BAZZY-ASAAD A, ESQUIBIES A. Pediatric unilobar resection in primary ciliary dyskinesia Minerva Pediatrica 2022, 74 DOI: 10.23736/s2724-5276.20.05802-8.
- Opportunities on the road to value‐based payment for children with chronic respiratory diseaseKevill KA, Bazzy‐Asaad A, Pati S. Opportunities on the road to value‐based payment for children with chronic respiratory disease Pediatric Pulmonology 2018, 54: 105-116. PMID: 30561848, DOI: 10.1002/ppul.24175.
- Family‐based study reveals decreased abundance of sputum Granulicatella in asthmaticsWang L, Solá D, Mao Y, Bielecki P, Zhu Y, Sun Z, Shan L, Flavell R, Bazzy‐Asaad A, DeWan A. Family‐based study reveals decreased abundance of sputum Granulicatella in asthmatics Allergy 2018, 73: 1918-1921. PMID: 29862523, PMCID: PMC6586473, DOI: 10.1111/all.13493.
- Official American Thoracic Society Clinical Practice Guidelines: Diagnostic Evaluation of Infants with Recurrent or Persistent WheezingRen CL, Esther CR, Debley JS, Sockrider M, Yilmaz O, Amin N, Bazzy-Asaad A, Davis SD, Durand M, Ewig JM, Yuksel H, Lombardi E, Noah TL, Radford P, Ranganathan S, Teper A, Weinberger M, Brozek J, Wilson KC. Official American Thoracic Society Clinical Practice Guidelines: Diagnostic Evaluation of Infants with Recurrent or Persistent Wheezing American Journal Of Respiratory And Critical Care Medicine 2016, 194: 356-373. PMID: 27479061, DOI: 10.1164/rccm.201604-0694st.
- Biochemical Screening for Pulmonary Hypertension in Preterm Infants with Bronchopulmonary DysplasiaMontgomery AM, Bazzy-Asaad A, Asnes JD, Bizzarro MJ, Ehrenkranz RA, Weismann CG. Biochemical Screening for Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia Neonatology 2016, 109: 190-194. PMID: 26780635, DOI: 10.1159/000442043.
- Vascular endothelial growth factor (VEGF) isoform attenuates hyperoxic injury of embryonic lung via a Flk1–neuropilin (Nrp)-1–protein kinase C (PKC) dependent pathwayEsquibies A, Karihaloo A, Bazzy-Asaad A, Cantley L. Vascular endothelial growth factor (VEGF) isoform attenuates hyperoxic injury of embryonic lung via a Flk1–neuropilin (Nrp)-1–protein kinase C (PKC) dependent pathway Paediatric Respiratory Reviews 2013, 14: s79-s80. DOI: 10.1016/s1526-0542(13)70141-6.
- Sleep Problems in Children with Sickle Cell DiseaseKhatwa U, Bazzy-Asaad A, Kothare S. Sleep Problems in Children with Sickle Cell Disease 2012, 323-336. DOI: 10.1007/978-1-60761-725-9_24.
- Instituting A Standardized Model Of Care Improves Care And Length Of Stay For Infants With Bronchopulmonary Dysplasia (BPD): Results Of A Quality Improvement (QI) InitiativeTolomeo C, Szondy V, Zrenda K, Lyons L, Major N, Bazzy-Asaad A. Instituting A Standardized Model Of Care Improves Care And Length Of Stay For Infants With Bronchopulmonary Dysplasia (BPD): Results Of A Quality Improvement (QI) Initiative 2012, a5151-a5151. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5151.
- Unusual pulmonary findings in mucolipidosis IIIshak M, Zambrano EV, Bazzy‐Asaad A, Esquibies AE. Unusual pulmonary findings in mucolipidosis II Pediatric Pulmonology 2011, 47: 719-721. PMID: 22162509, DOI: 10.1002/ppul.21599.
- Effect Of Vitamin D Binding Protein (DBP) Genotype On The Development Of Asthma In Young ChildrenNavas-Nazario A, Fangyong L, Northrup V, Weiss P, Cole D, Carpenter T, Bazzy-Asaad A. Effect Of Vitamin D Binding Protein (DBP) Genotype On The Development Of Asthma In Young Children 2011, a1358-a1358. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1358.
- Vascular Endothelial Growth Factor (VEGF) Attenuates Hyperoxia Via Neuropilin-1 (nrp)-Protein Kinase C (pkc) Dependent Pathway In Explanted Embryonic LungEsquibies A, Bazzy-Asaad A, Cantley L. Vascular Endothelial Growth Factor (VEGF) Attenuates Hyperoxia Via Neuropilin-1 (nrp)-Protein Kinase C (pkc) Dependent Pathway In Explanted Embryonic Lung 2011, a2100-a2100. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2100.
- Lack of Identification of Asthmatic Players in a Youth Soccer LeagueWeiss P, Bazzy-Asaad A, Tolomeo C. Lack of Identification of Asthmatic Players in a Youth Soccer League Journal Of Asthma & Allergy Educators 2010, 1: 117-121. DOI: 10.1177/2150129710370703.
- Utilization of a second caregiver in the care of a child with a tracheostomy in the homecare settingTolomeo C, Bazzy‐Asaad A. Utilization of a second caregiver in the care of a child with a tracheostomy in the homecare setting Pediatric Pulmonology 2010, 45: 656-660. PMID: 20578067, DOI: 10.1002/ppul.21233.
- Pulmonary squamous cell carcinoma associated with repaired congenital tracheoesophageal fistula and esophageal atresiaEsquibies AE, Zambrano E, Ziai J, Kesebir D, Touloukian RJ, Egan ME, Reyes‐Múgica M, Bazzy‐Asaad A. Pulmonary squamous cell carcinoma associated with repaired congenital tracheoesophageal fistula and esophageal atresia Pediatric Pulmonology 2010, 45: 202-204. PMID: 20054858, DOI: 10.1002/ppul.21148.
- Predictors of Asthma-related Pediatric Emergency Department Visits and HospitalizationsTolomeo C, Savrin C, Heinzer M, Bazzy-Asaad A. Predictors of Asthma-related Pediatric Emergency Department Visits and Hospitalizations Journal Of Asthma 2009, 46: 829-834. DOI: 10.1080/02770900903162753.
- Longitudinal follow up of elevated pulmonary artery pressures in children with sickle cell diseasePashankar FD, Carbonella J, Bazzy‐Asaad A, Friedman A. Longitudinal follow up of elevated pulmonary artery pressures in children with sickle cell disease British Journal Of Haematology 2008, 144: 736-741. PMID: 19055665, DOI: 10.1111/j.1365-2141.2008.07501.x.
- SCREENING FOR OBSTRUCTIVE SLEEP APNEA AND SLEEP-DISORDERED BREATHING IN CHILDREN: RESULTS OF A COMMUNITY SURVEYBhargava S, Bazzy-Asaad A. SCREENING FOR OBSTRUCTIVE SLEEP APNEA AND SLEEP-DISORDERED BREATHING IN CHILDREN: RESULTS OF A COMMUNITY SURVEY CHEST Journal 2008, 134: p141001-a-p141001-b. DOI: 10.1378/chest.134.4_meetingabstracts.p141001.
- Sleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway PressureNakra N, Bhargava S, Dzuira J, Caprio S, Bazzy-Asaad A. Sleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway Pressure Pediatrics 2008, 122: e634-e642. PMID: 18762497, PMCID: PMC5117807, DOI: 10.1542/peds.2008-0154.
- Prevalence and Risk Factors of Elevated Pulmonary Artery Pressures in Children With Sickle Cell DiseasePashankar FD, Carbonella J, Bazzy-Asaad A, Friedman A. Prevalence and Risk Factors of Elevated Pulmonary Artery Pressures in Children With Sickle Cell Disease Pediatrics 2008, 121: 777-782. PMID: 18381543, DOI: 10.1542/peds.2007-0730.
- A Role for Macrophage Migration Inhibitory Factor in the Neonatal Respiratory Distress SyndromeKevill KA, Bhandari V, Kettunen M, Leng L, Fan J, Mizue Y, Dzuira JD, Reyes-Mugica M, McDonald CL, Baugh JA, O’Connor C, Aghai ZH, Donnelly SC, Bazzy-Asaad A, Bucala RJ. A Role for Macrophage Migration Inhibitory Factor in the Neonatal Respiratory Distress Syndrome The Journal Of Immunology 2008, 180: 601-608. PMID: 18097062, DOI: 10.4049/jimmunol.180.1.601.
- δ‐, but not µ‐, opioid receptor stabilizes K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxiaChao D, Bazzy‐Asaad A, Balboni G, Xia Y. δ‐, but not µ‐, opioid receptor stabilizes K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia Journal Of Cellular Physiology 2007, 212: 60-67. PMID: 17373650, DOI: 10.1002/jcp.21000.
- PORTABLE SPIROMETRY DURING ACUTE EXACERBATIONS OF ASTHMA IN THE PEDIATRIC EMERGENCY DEPARTMENTLanghan M, Zonfrillo M, Bazzy-Asaad A, Spiro D. PORTABLE SPIROMETRY DURING ACUTE EXACERBATIONS OF ASTHMA IN THE PEDIATRIC EMERGENCY DEPARTMENT Pediatric Emergency Care 2006, 22: 685. DOI: 10.1097/00006565-200609000-00031.
- Safety of inhaled corticosteroids in children with asthmaBazzy-Asaad A. Safety of inhaled corticosteroids in children with asthma Current Opinion In Pediatrics 2001, 13: 523-527. PMID: 11753100, DOI: 10.1097/00008480-200112000-00005.
- Chronic hypoxia modulates diaphragm function in the developing ratKass LJ, Bazzy AR. Chronic hypoxia modulates diaphragm function in the developing rat Journal Of Applied Physiology 2001, 90: 2325-2329. PMID: 11356799, DOI: 10.1152/jappl.2001.90.6.2325.
- Effect of inspiratory training on mitochondrial DNA and cytochrome-c oxidase expression in the diaphragmAkiyama Y, Garcia RE, Bazzy AR. Effect of inspiratory training on mitochondrial DNA and cytochrome-c oxidase expression in the diaphragm American Journal Of Physiology 1996, 271: l320-l325. PMID: 8770071, DOI: 10.1152/ajplung.1996.271.2.l320.
- Failure to generate action potentials in newborn diaphragms following nerve stimulation.Bazzy AR, Donnelly DF. Failure to generate action potentials in newborn diaphragms following nerve stimulation. Brain Research 1993, 600: 349-52. PMID: 8382101.