Research & Publications
Our areas of expertise include drug metabolism, bioanalytical chemistry and mass spectrometry. Mass spectrometry makes it possible to identify hundreds or even thousands of different proteins in a mixture of molecules. We used several mass spec tools to study the ADME-Tox properties of new molecules. Also, we applied single-cell resolution capabilities of proteomics and metabolomics to seek deeper understanding of biology and cellular heterogeneity. Such studies should help facilitate new target and biomarker discovery in drug development and translational research.
Extensive Research Description
Our research focuses on understanding how structure modification can improve the ADME-Tox profile for new chemical entities as they advance toward clinical candidacy. Our recent efforts use Mass Cytometry & MALDI-IHC as novel tools for Cancer Research. With their capacity for tremendous detail, these techniques produce enhanced investigative power for analyses involving simultaneous cellular profiling of multiple cell populations. Our latest endeavors are focused on an advance in single cell analysis using a hybrid mass spectrometry-flow cytometry instrument to identify and characterize rare cell types in clinical samples. Another emphasis is the development of mass spectrometric and proteomic methods for application in biological and clinical contexts to identify and quantify proteins with greater depth and coverage in a single cell.
Metabolism; Pharmacology; Mass Spectrometry; Proteomics; Metabolomics; Single-Cell Analysis
Public Health Interests
- Metabolite Characterization- One Key to Success in Drug DiscoveryPharmaTech. 2004; :46-51.
- Atmospheric Pressure Chemical Ionization/Mass Spectrometry and Capillary Electrophoresis for the Analysis of Chemical Warfare Agent Degradation ProductsIn: Scamehorn JF, editor. In Surfactant-Based Separations: Recent Advances USA: ACS Symposium Series, Vol. 740; 1999. Chapter 20; p.329–350.
- Indirect Spectrometric Determination of Phosphate by Atomic Absorption. Int. J. BioChemPhys.
- Effect of Coagulants and Extent of Color Removal from Textile Effluents. Int. J. BioChemPhys