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Adam V Wisnewski, PhD, D(ABMLI)

Senior Research Scientist in Medicine (Occupational Medicine)

Research & Publications
Biography
News

Coauthors

Selected Publications

Occupational Risk Factors for SARS-CoV-2 Seropositivity in Healthcare WorkersFazen L, Abad Q, Smith R, Santiago R, Liu J, Wisnewski A, Redlich C. Occupational Risk Factors for SARS-CoV-2 Seropositivity in Healthcare Workers. Journal Of Occupational And Environmental Medicine 2023, 65: 521-528. PMID: 36893070, PMCID: PMC10227858, DOI: 10.1097/jom.0000000000002831.
Plasmodium infection is associated with cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike proteinLapidus S, Liu F, Casanovas-Massana A, Dai Y, Huck J, Lucas C, Klein J, Filler R, Strine M, Sy M, Deme A, Badiane A, Dieye B, Ndiaye I, Diedhiou Y, Mbaye A, Diagne C, Vigan-Womas I, Mbengue A, Sadio B, Diagne M, Moore A, Mangou K, Diallo F, Sene S, Pouye M, Faye R, Diouf B, Nery N, Costa F, Reis M, Muenker M, Hodson D, Mbarga Y, Katz B, Andrews J, Campbell M, Srivathsan A, Kamath K, Baum-Jones E, Faye O, Sall A, Vélez J, Cappello M, Wilson M, Ben-Mamoun C, Tedder R, McClure M, Cherepanov P, Somé F, Dabiré R, Moukoko C, Ouédraogo J, Boum Y, Shon J, Ndiaye D, Wisnewski A, Parikh S, Iwasaki A, Wilen C, Ko A, Ring A, Bei A. Plasmodium infection is associated with cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein. Scientific Reports 2022, 12: 22175. PMID: 36550362, PMCID: PMC9778468, DOI: 10.1038/s41598-022-26709-7.
Case Study: Metabolism and Reactions of Alkylating Agents in Cancer TherapyNASSAR A, WISNEWSKI A, KING I. Case Study: Metabolism and Reactions of Alkylating Agents in Cancer Therapy. 2022, 893-922. DOI: 10.1002/9781119851042.ch26.
MIF is a Common Genetic Determinant of COVID-19 Symptomatic Infection and SeverityShin JJ, Fan W, Par-Young J, Piecychna M, Leng L, Israni-Winger K, Qing H, Gu J, Zhao H, Schulz WL, Unlu S, Kuster J, Young G, Liu J, Ko AI, Garcia A, Sauler M, Wisnewski AV, Young L, Orduña A, Wang A, Klementina O, Garcia AB, Hegyi P, Armstrong ME, Mitchell P, Ordiz DB, Garami A, Kang I, Bucala R. MIF is a Common Genetic Determinant of COVID-19 Symptomatic Infection and Severity. QJM 2022, 116: hcac234. PMID: 36222594, PMCID: PMC9620729, DOI: 10.1093/qjmed/hcac234.
Glutathione reactivity with aliphatic polyisocyanatesWisnewski AV, Liu J. Glutathione reactivity with aliphatic polyisocyanates. PLOS ONE 2022, 17: e0271471. PMID: 35839242, PMCID: PMC9286259, DOI: 10.1371/journal.pone.0271471.
Changes Over Time in COVID-19 Incidence, Vaccinations, Serum Spike IgG, and Viral Neutralizing Potential Among Individuals From a North American Gaming VenueWisnewski AV, Cantley L, Luna J, Liu J, Smith RF, Hager K, Redlich CA. Changes Over Time in COVID-19 Incidence, Vaccinations, Serum Spike IgG, and Viral Neutralizing Potential Among Individuals From a North American Gaming Venue. Journal Of Occupational And Environmental Medicine 2022, 64: 788-796. PMID: 36054278, PMCID: PMC9426317, DOI: 10.1097/jom.0000000000002617.
Development and utilization of a surrogate SARS-CoV-2 viral neutralization assay to assess mRNA vaccine responsesWisnewski AV, Liu J, Lucas C, Klein J, Iwasaki A, Cantley L, Fazen L, Luna J, Slade M, Redlich CA. Development and utilization of a surrogate SARS-CoV-2 viral neutralization assay to assess mRNA vaccine responses. PLOS ONE 2022, 17: e0262657. PMID: 35041700, PMCID: PMC8765639, DOI: 10.1371/journal.pone.0262657.
Severe asthma and death in a worker using methylene diphenyl diisocyanate MDI asthma deathWisnewski AV, Cooney R, Hodgson M, Giese K, Liu J, Redlich CA. Severe asthma and death in a worker using methylene diphenyl diisocyanate MDI asthma death. American Journal Of Industrial Medicine 2022, 65: 166-172. PMID: 35028957, PMCID: PMC8846433, DOI: 10.1002/ajim.23323.
Reply to letter to the editor concerning Gui et al. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factoryWisnewski AV, Redlich CA. Reply to letter to the editor concerning Gui et al. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory. American Journal Of Industrial Medicine 2021, 64: 1055-1056. PMID: 34647343, DOI: 10.1002/ajim.23299.
Immunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccinesWisnewski AV, Redlich CA, Liu J, Kamath K, Abad QA, Smith RF, Fazen L, Santiago R, Luna J, Martinez B, Baum-Jones E, Waitz R, Haynes WA, Shon JC. Immunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccines. PLOS ONE 2021, 16: e0252849. PMID: 34499652, PMCID: PMC8428655, DOI: 10.1371/journal.pone.0252849.
Associations of SARS-CoV-2 serum IgG with occupation and demographics of military personnelZell J, Wisnewski AV, Liu J, Klein J, Lucas C, Slade M, Iwasaki A, Redlich CA. Associations of SARS-CoV-2 serum IgG with occupation and demographics of military personnel. PLOS ONE 2021, 16: e0251114. PMID: 34460832, PMCID: PMC8405017, DOI: 10.1371/journal.pone.0251114.
Mechanisms, Genetics, and PathophysiologyMaestrelli P, Wisnewski A, Carlsten C, Munoz X, Tsui H, Vanoirbeek J, Malo J, Bernstein D. Mechanisms, Genetics, and Pathophysiology. 2021, 35-54. DOI: 10.1201/9781003000624-4.
Author Correction: Delayed production of neutralizing antibodies correlates with fatal COVID-19Lucas C, Klein J, Sundaram ME, Liu F, Wong P, Silva J, Mao T, Oh JE, Mohanty S, Huang J, Tokuyama M, Lu P, Venkataraman A, Park A, Israelow B, Vogels CBF, Muenker MC, Chang CH, Casanovas-Massana A, Moore AJ, Zell J, Fournier JB, Wyllie A, Campbell M, Lee A, Chun H, Grubaugh N, Schulz W, Farhadian S, Dela Cruz C, Ring A, Shaw A, Wisnewski A, Yildirim I, Ko A, Omer S, Iwasaki A. Author Correction: Delayed production of neutralizing antibodies correlates with fatal COVID-19. Nature Medicine 2021, 27: 1309-1309. PMID: 34145437, PMCID: PMC8212078, DOI: 10.1038/s41591-021-01416-4.
Human IgG and IgA responses to COVID-19 mRNA vaccinesWisnewski AV, Luna J, Redlich CA. Human IgG and IgA responses to COVID-19 mRNA vaccines. PLOS ONE 2021, 16: e0249499. PMID: 34133415, PMCID: PMC8208542, DOI: 10.1371/journal.pone.0249499.
Delayed production of neutralizing antibodies correlates with fatal COVID-19Lucas C, Klein J, Sundaram ME, Liu F, Wong P, Silva J, Mao T, Oh JE, Mohanty S, Huang J, Tokuyama M, Lu P, Venkataraman A, Park A, Israelow B, Vogels CBF, Muenker MC, Chang CH, Casanovas-Massana A, Moore AJ, Zell J, Fournier JB, Wyllie A, Campbell M, Lee A, Chun H, Grubaugh N, Schulz W, Farhadian S, Dela Cruz C, Ring A, Shaw A, Wisnewski A, Yildirim I, Ko A, Omer S, Iwasaki A. Delayed production of neutralizing antibodies correlates with fatal COVID-19. Nature Medicine 2021, 27: 1178-1186. PMID: 33953384, PMCID: PMC8785364, DOI: 10.1038/s41591-021-01355-0.
Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma PathologyWisnewski AV, Liu J, Redlich CA. Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology. American Journal Of Respiratory Cell And Molecular Biology 2020, 0: 25-35. PMID: 32101465, PMCID: PMC7328250, DOI: 10.1165/rcmb.2019-0400oc.
Molecular Characterization and Experimental Utility of Monoclonal Antibodies with Specificity for Aliphatic Di- and PolyisocyanatesWisnewski AV, Liu J. Molecular Characterization and Experimental Utility of Monoclonal Antibodies with Specificity for Aliphatic Di- and Polyisocyanates. Monoclonal Antibodies In Immunodiagnosis And Immunotherapy 2020, 39: 66-73. PMID: 32302507, PMCID: PMC7310211, DOI: 10.1089/mab.2020.0006.
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.Wisnewski AV, Liu J, Nassar AF. LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate. EC Pharmacology And Toxicology 2019, 7: 205-219. PMID: 31143884, PMCID: PMC6536005.
Dilysine-Methylene Diphenyl Diisocyanate (MDI), a Urine Biomarker of MDI Exposure?Wisnewski AV, Nassar AF, Liu J, Bello D. Dilysine-Methylene Diphenyl Diisocyanate (MDI), a Urine Biomarker of MDI Exposure? Chemical Research In Toxicology 2019, 32: 557-565. PMID: 30724074, PMCID: PMC6465083, DOI: 10.1021/acs.chemrestox.8b00262.
Development and Validation of LC–MS-MS Assay for the Determination of the Emerging Alkylating Agent Laromustine and Its Active Metabolite in Human PlasmaNassar AF, Wisnewski AV, Wu T, Lam TT, King I. Development and Validation of LC–MS-MS Assay for the Determination of the Emerging Alkylating Agent Laromustine and Its Active Metabolite in Human Plasma. Journal Of Chromatographic Science 2018, 57: 195-203. PMID: 30395213, DOI: 10.1093/chromsci/bmy100.
Polymerization of hexamethylene diisocyanate in solution and a 260.23 m/z [M+H]+ ion in exposed human cellsWisnewski AV, Liu J, Redlich CA, Nassar AF. Polymerization of hexamethylene diisocyanate in solution and a 260.23 m/z [M+H]+ ion in exposed human cells. Analytical Biochemistry 2017, 543: 21-29. PMID: 29175138, PMCID: PMC5826792, DOI: 10.1016/j.ab.2017.11.017.
Mass spectrometry-based analysis of murine bronchoalveolar lavage fluid following respiratory exposure to 4,4'-methylene diphenyl diisocyanate aerosolHettick JM, Law BF, Lin CC, Wisnewski AV, Siegel PD. Mass spectrometry-based analysis of murine bronchoalveolar lavage fluid following respiratory exposure to 4,4'-methylene diphenyl diisocyanate aerosol. Xenobiotica 2017, 48: 626-636. PMID: 28629263, PMCID: PMC5864557, DOI: 10.1080/00498254.2017.1344791.
Reaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomyWisnewski AV, Kanyo J, Asher J, Goodrich JA, Barnett G, Patrylak L, Liu J, Redlich CA, Nassar AF. Reaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy. Xenobiotica 2017, 48: 488-497. PMID: 28489470, PMCID: PMC5863241, DOI: 10.1080/00498254.2017.1329569.
Automation of sample preparation for mass cytometry barcoding in support of clinical research: protocol optimizationNassar AF, Wisnewski AV, Raddassi K. Automation of sample preparation for mass cytometry barcoding in support of clinical research: protocol optimization. Analytical And Bioanalytical Chemistry 2017, 409: 2363-2372. PMID: 28124752, PMCID: PMC5863240, DOI: 10.1007/s00216-017-0182-4.
Single-Cell Metabolomics by Mass Spectrometry for Drug Discovery: Moving ForwardK R, T W, SF N, AV W. Single-Cell Metabolomics by Mass Spectrometry for Drug Discovery: Moving Forward. Drug Designing Open Access 2017, 6: 1-5. DOI: 10.4172/2169-0138.1000149.
UPLC–MS for metabolomics: a giant step forward in support of pharmaceutical researchNassar AF, Wu T, Nassar SF, Wisnewski AV. UPLC–MS for metabolomics: a giant step forward in support of pharmaceutical research. Drug Discovery Today 2016, 22: 463-470. PMID: 27919805, PMCID: PMC5721520, DOI: 10.1016/j.drudis.2016.11.020.
Corrigendum to “Identification of novel reaction products of methylene-biS-phenylisocyanate (“MDI”) with oxidized glutathione in aqueous solution and also during incubation of MDI with a murine hepatic S9 fraction” [Toxicol. In vitro (2016) 97–104]Wisnewski AV, Liu J, Nassar AF. Corrigendum to “Identification of novel reaction products of methylene-biS-phenylisocyanate (“MDI”) with oxidized glutathione in aqueous solution and also during incubation of MDI with a murine hepatic S9 fraction” [Toxicol. In vitro (2016) 97–104]. Toxicology In Vitro 2016, 38: 193. PMID: 27784537, DOI: 10.1016/j.tiv.2016.10.008.
The influence of diisocyanate antigen preparation methodology on monoclonal and serum antibody recognitionHagerman LM, Law BF, Bledsoe TA, Hettick JM, Kashon ML, Lemons AR, Wisnewski AV, Siegel PD. The influence of diisocyanate antigen preparation methodology on monoclonal and serum antibody recognition. Journal Of Occupational And Environmental Hygiene 2016, 13: 829-839. PMID: 27124286, PMCID: PMC5016257, DOI: 10.1080/15459624.2016.1183013.
Identification of novel reaction products of methylene-bis-phenylisocyanate (“MDI”) with oxidized glutathione in aqueous solution and also during incubation of MDI with a murine hepatic S9 fractionWisnewski AV, Liu J, Nassar AF. Identification of novel reaction products of methylene-bis-phenylisocyanate (“MDI”) with oxidized glutathione in aqueous solution and also during incubation of MDI with a murine hepatic S9 fraction. Toxicology In Vitro 2016, 36: 97-104. PMID: 27453132, PMCID: PMC5010927, DOI: 10.1016/j.tiv.2016.07.011.
Population pharmacokinetic (PK) analysis of laromustine, an emerging alkylating agent, in cancer patientsNassar AF, Wisnewski AV, King I. Population pharmacokinetic (PK) analysis of laromustine, an emerging alkylating agent, in cancer patients. Xenobiotica 2016, 47: 394-407. PMID: 27440490, DOI: 10.1080/00498254.2016.1201703.
Progress in automation of mass cytometry barcoding for drug developmentNassar AF, Wisnewski AV, Raddassi K. Progress in automation of mass cytometry barcoding for drug development. Bioanalysis 2016, 8: 1429-1435. PMID: 27323800, DOI: 10.4155/bio-2016-0135.
Biotransformation and Rearrangement of LaromustineNassar AE, Wisnewski AV, King I. Biotransformation and Rearrangement of Laromustine. Drug Metabolism And Disposition 2016, 44: 1349-1363. PMID: 27278961, DOI: 10.1124/dmd.116.069823.
Mass cytometry moving forward in support of clinical research: advantages and considerationsNassar AF, Wisnewski AV, Raddassi K. Mass cytometry moving forward in support of clinical research: advantages and considerations. Bioanalysis 2016, 8: 255-257. PMID: 26847541, DOI: 10.4155/bio.15.257.
In vitro cleavage of diisocyanate-glutathione conjugates by human gamma-glutamyl transpeptidase-1Wisnewski AV, Liu J, Nassar AF. In vitro cleavage of diisocyanate-glutathione conjugates by human gamma-glutamyl transpeptidase-1. Xenobiotica 2015, 46: 726-732. PMID: 26678254, PMCID: PMC4848134, DOI: 10.3109/00498254.2015.1118576.
Immunochemical detection of the occupational allergen, methylene diphenyl diisocyanate (MDI), in situWisnewski AV, Liu J. Immunochemical detection of the occupational allergen, methylene diphenyl diisocyanate (MDI), in situ. Journal Of Immunological Methods 2015, 429: 60-65. PMID: 26690039, PMCID: PMC4753098, DOI: 10.1016/j.jim.2015.12.008.
Impact of recent innovations in the use of mass cytometry in support of drug developmentNassar AF, Ogura H, Wisnewski AV. Impact of recent innovations in the use of mass cytometry in support of drug development. Drug Discovery Today 2015, 20: 1169-1175. PMID: 26092491, PMCID: PMC4668584, DOI: 10.1016/j.drudis.2015.06.001.
Metabolic disposition of the anti-cancer agent [14C]laromustine in male ratsNassar AF, Wisnewski A, King I. Metabolic disposition of the anti-cancer agent [14C]laromustine in male rats. Xenobiotica 2015, 45: 711-721. PMID: 25798740, PMCID: PMC4681490, DOI: 10.3109/00498254.2015.1016475.
Glutathione Reaction Products with a Chemical Allergen, Methylene-diphenyl Diisocyanate, Stimulate Alternative Macrophage Activation and Eosinophilic Airway InflammationWisnewski AV, Liu J, Colangelo CM. Glutathione Reaction Products with a Chemical Allergen, Methylene-diphenyl Diisocyanate, Stimulate Alternative Macrophage Activation and Eosinophilic Airway Inflammation. Chemical Research In Toxicology 2015, 28: 729-737. PMID: 25635619, PMCID: PMC4667722, DOI: 10.1021/tx5005002.
Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐upGui W, Wisnewski AV, Neamtiu I, Gurzau E, Sparer JA, Stowe MH, Liu J, Slade MD, Rusu OA, Redlich CA. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up. American Journal Of Industrial Medicine 2014, 57: 1207-1215. PMID: 25266741, PMCID: PMC4198484, DOI: 10.1002/ajim.22385.
Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposureWisnewski AV, Liu J, Redlich CA. Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure. Chemico-Biological Interactions 2013, 205: 38-45. PMID: 23791970, PMCID: PMC3767171, DOI: 10.1016/j.cbi.2013.06.005.
Mechanisms, genetics and pathophysiologyMaestrelli P, Yucesoy B, Park H, Wisnewski A. Mechanisms, genetics and pathophysiology. 2013, 40-56. DOI: 10.1201/b15116-5.
Polyisocyanates and their prepolymersWisnewski A, Redlich C, Mapp C. Polyisocyanates and their prepolymers. 2013, 262-275. DOI: 10.1201/b15116-20.
Polyisocyanates and their prepolymersWisnewski A, Redlich C. Polyisocyanates and their prepolymers. 2013, 276-289. DOI: 10.1201/b15116-24.
Mechanisms, genetics, and pathophysiologyMaestrelli P, Yucesoy B, Park H, Wisnewski A. Mechanisms, genetics, and pathophysiology. 2013, 40-56. DOI: 10.3109/9781841849256.004.
Polyisocyanates and their prepolymersWisnewski A, Redlich C, Mapp C, I. Bernstein D. Polyisocyanates and their prepolymers. 2013, 262-275. DOI: 10.3109/9781841849256.018.
Molecular determinants of humoral immune specificity for the occupational allergen, methylene diphenyl diisocyanateWisnewski AV, Liu J. Molecular determinants of humoral immune specificity for the occupational allergen, methylene diphenyl diisocyanate. Molecular Immunology 2013, 54: 233-237. PMID: 23295252, PMCID: PMC3563841, DOI: 10.1016/j.molimm.2012.11.017.
Hexamethylene diisocyanate (HDI) vapor reactivity with glutathione and subsequent transfer to human albuminWisnewski AV, Mhike M, Hettick JM, Liu J, Siegel PD. Hexamethylene diisocyanate (HDI) vapor reactivity with glutathione and subsequent transfer to human albumin. Toxicology In Vitro 2012, 27: 662-671. PMID: 23178851, PMCID: PMC3587365, DOI: 10.1016/j.tiv.2012.11.013.
Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based On Serum Levels Of HDI-Specific IgGWisnewski A, Stowe M, DeCamp D, Kleinsmith C, Redlich C. Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based On Serum Levels Of HDI-Specific IgG. 2012, a3221-a3221. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3221.
Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgGWisnewski AV, Stowe MH, Nerlinger A, Opare-addo P, Decamp D, Kleinsmith CR, Redlich CA. Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgG. Annals Of Work Exposures And Health 2012, 56: 901-910. PMID: 22449630, PMCID: PMC3471419, DOI: 10.1093/annhyg/mes024.
Vapor conjugation of toluene diisocyanate to specific lysines of human albuminHettick JM, Siegel PD, Green BJ, Liu J, Wisnewski AV. Vapor conjugation of toluene diisocyanate to specific lysines of human albumin. Analytical Biochemistry 2011, 421: 706-711. PMID: 22206939, PMCID: PMC3324820, DOI: 10.1016/j.ab.2011.12.013.
Pathogenesis and Disease Mechanisms of Occupational AsthmaLummus ZL, Wisnewski AV, Bernstein DI. Pathogenesis and Disease Mechanisms of Occupational Asthma. Immunology And Allergy Clinics Of North America 2011, 31: 699-716. PMID: 21978852, PMCID: PMC4683932, DOI: 10.1016/j.iac.2011.07.008.
Toluene Diisocyanate Reactivity with Glutathione Across a Vapor/Liquid Interface and Subsequent Transcarbamoylation of Human AlbuminWisnewski AV, Hettick JM, Siegel PD. Toluene Diisocyanate Reactivity with Glutathione Across a Vapor/Liquid Interface and Subsequent Transcarbamoylation of Human Albumin. Chemical Research In Toxicology 2011, 24: 1686-1693. PMID: 21806041, PMCID: PMC3321232, DOI: 10.1021/tx2002433.
Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responsesWisnewski AV, Xu L, Robinson E, Liu J, Redlich CA, Herrick CA. Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses. Journal Of Occupational Medicine And Toxicology 2011, 6: 6. PMID: 21414210, PMCID: PMC3068988, DOI: 10.1186/1745-6673-6-6.
Pro/Con debate: is occupational asthma induced by isocyanates an immunoglobulin E‐mediated disease?Wisnewski AV, Jones M. Pro/Con debate: is occupational asthma induced by isocyanates an immunoglobulin E‐mediated disease? Clinical & Experimental Allergy 2010, 40: 1155-1162. PMID: 20545707, PMCID: PMC3121887, DOI: 10.1111/j.1365-2222.2010.03550.x.
The 24-bp CHIT1 Exon 10 Polymorphism Is Associated With Airway Hyperresponsiveness In A Population Of Autobody Shop WorkersOng P, Wisnewski A, Stowe M, Holm C, He X, Zheng W, Zhang C, Zhao H, Redlich C, Chupp G. The 24-bp CHIT1 Exon 10 Polymorphism Is Associated With Airway Hyperresponsiveness In A Population Of Autobody Shop Workers. 2010, a4002-a4002. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4002.
Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanateWisnewski AV, Liu J, Redlich CA. Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate. Analytical Biochemistry 2010, 400: 251-258. PMID: 20123080, PMCID: PMC3106273, DOI: 10.1016/j.ab.2010.01.037.
Immune Responses Triggered by Skin Exposure to the Occupational Allergen, Methylene-Diphenyl Diisocyanate (MDI).Wisnewski A, Liu J, Herrick C, Redlich C. Immune Responses Triggered by Skin Exposure to the Occupational Allergen, Methylene-Diphenyl Diisocyanate (MDI). 2009, a1645. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1645.
IgG Responses to Isocyanate in Auto Body Shop Workers: Associations with Skin and Respiratory Exposures.Redlich C, Stowe M, Wang S, Liu J, Gore R, Liu Y, Woskie, Wisnewski A. IgG Responses to Isocyanate in Auto Body Shop Workers: Associations with Skin and Respiratory Exposures. 2009, a3670. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3670.
Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI–albumin conjugatesWisnewski AV, Liu Q, Liu J, Redlich CA. Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI–albumin conjugates. Clinical & Experimental Allergy 2008, 38: 957-967. PMID: 18498542, PMCID: PMC3131007, DOI: 10.1111/j.1365-2222.2008.02982.x.
Respiratory Symptoms, Sensitization, and Exposure–Response Relationships in Spray Painters Exposed to IsocyanatesPronk A, Preller L, Raulf-Heimsoth M, Jonkers IC, Lammers JW, Wouters IM, Doekes G, Wisnewski AV, Heederik D. Respiratory Symptoms, Sensitization, and Exposure–Response Relationships in Spray Painters Exposed to Isocyanates. American Journal Of Respiratory And Critical Care Medicine 2007, 176: 1090-1097. PMID: 17656675, PMCID: PMC2176099, DOI: 10.1164/rccm.200702-215oc.
Diisocyanate conjugate and immunoassay characteristics influence detection of specific antibodies in HDI‐exposed workersCampo P, Wisnewski AV, Lummus Z, Cartier A, Malo J, Boulet LP, Bernstein DI. Diisocyanate conjugate and immunoassay characteristics influence detection of specific antibodies in HDI‐exposed workers. Clinical & Experimental Allergy 2007, 37: 1095-1102. PMID: 17581205, DOI: 10.1111/j.1365-2222.2007.02745.x.
Reply to PilsczekBarry M, Inouye S, Wisnewski A, Vinetz J. Reply to Pilsczek. Clinical Infectious Diseases 2007, 44: 1012-1012. PMID: 17342661, DOI: 10.1086/512376.
Developments in laboratory diagnostics for isocyanate asthmaWisnewski AV. Developments in laboratory diagnostics for isocyanate asthma. Current Opinion In Allergy And Clinical Immunology 2007, 7: 138-145. PMID: 17351466, PMCID: PMC3131002, DOI: 10.1097/aci.0b013e3280895d22.
Beta 2-Adrenergic Receptor Gene 46 A>G Polymorphism May Confer Specific IgE Sensitization In Toluene Diisocyanate-Exposed WorkersYe Y, Park H, Kim S, Kang Y, Kim C, Kim H, Hong C, Jang A, Park C, Wisnewski A, Redlich C. Beta 2-Adrenergic Receptor Gene 46 A>G Polymorphism May Confer Specific IgE Sensitization In Toluene Diisocyanate-Exposed Workers. Journal Of Allergy And Clinical Immunology 2007, 119: s237. DOI: 10.1016/j.jaci.2006.12.297.
Suburban Leptospirosis: Atypical Lymphocytosis and γ-δ T Cell ResponseBarry M, Wisnewski AV, Matthias MA, Inouye SK, Vinetz JM. Suburban Leptospirosis: Atypical Lymphocytosis and γ-δ T Cell Response. Clinical Infectious Diseases 2006, 43: 1304-1307. PMID: 17051497, DOI: 10.1086/508537.
Biophysical determinants of toluene diisocyanate antigenicity associated with exposure and asthmaYe YM, Kim CW, Kim HR, Kim HM, Suh CH, Nahm DH, Park HS, Redlich CA, Wisnewski AV. Biophysical determinants of toluene diisocyanate antigenicity associated with exposure and asthma. Journal Of Allergy And Clinical Immunology 2006, 118: 885-891. PMID: 17030242, DOI: 10.1016/j.jaci.2006.06.026.
Polyisocyanates and Their PrepolymersWisnewski A, Redlich C, Mapp C. Polyisocyanates and Their Prepolymers. 2006, 481-504. DOI: 10.3109/9780849374531-22.
Immunologic Changes in Human Albumin Exposed to Toluene Diisocyanate (TDI) Vapor: Differences Compared with Liquid TDI Exposure and Association with IgE/IgG Binding and TDI AsthmaYe Y, Kim S, Lee S, Park H, Redlich C, Wisnewski A. Immunologic Changes in Human Albumin Exposed to Toluene Diisocyanate (TDI) Vapor: Differences Compared with Liquid TDI Exposure and Association with IgE/IgG Binding and TDI Asthma. Journal Of Allergy And Clinical Immunology 2006, 117: s267. DOI: 10.1016/j.jaci.2005.12.1057.
Glutathione protects human airway proteins and epithelial cells from isocyanatesWisnewski AV, Liu Q, Liu J, Redlich CA. Glutathione protects human airway proteins and epithelial cells from isocyanates. Clinical & Experimental Allergy 2005, 35: 352-357. PMID: 15784115, DOI: 10.1111/j.1365-2222.2005.02185.x.
Predictive value of a specific IgG assay for diisocyanate asthma (DA) is strongly influenced by chemical-protein antigen characteristicsCampo P, Wisnewski A, Cartier A, Lummus Z, Malo J, Boulet L, Bernstein D. Predictive value of a specific IgG assay for diisocyanate asthma (DA) is strongly influenced by chemical-protein antigen characteristics. Journal Of Allergy And Clinical Immunology 2005, 115: s27. DOI: 10.1016/j.jaci.2004.12.122.
Isocyanate vapor-induced antigenicity of human albuminWisnewski AV, Stowe MH, Cartier A, Liu Q, Liu J, Chen L, Redlich CA. Isocyanate vapor-induced antigenicity of human albumin. Journal Of Allergy And Clinical Immunology 2004, 113: 1178-1184. PMID: 15208602, DOI: 10.1016/j.jaci.2004.03.009.
Human γ/δ T-cell proliferation and IFN-γ production induced by hexamethylene diisocyanateWisnewski AV, Herrick CA, Liu Q, Chen L, Bottomly K, Redlich CA. Human γ/δ T-cell proliferation and IFN-γ production induced by hexamethylene diisocyanate. Journal Of Allergy And Clinical Immunology 2003, 112: 538-546. PMID: 13679813, DOI: 10.1016/s0091-6749(03)01865-7.
Differential roles for CD4 and CD8 T cells after diisocyanate sensitization: Genetic control of TH2-induced lung inflammationHerrick CA, Das J, Xu L, Wisnewski AV, Redlich CA, Bottomly K. Differential roles for CD4 and CD8 T cells after diisocyanate sensitization: Genetic control of TH2-induced lung inflammation. Journal Of Allergy And Clinical Immunology 2003, 111: 1087-1094. PMID: 12743574, DOI: 10.1067/mai.2003.1413.
Recent developments in diisocyanate asthmaLiu Q, Wisnewski AV. Recent developments in diisocyanate asthma. Annals Of Allergy Asthma & Immunology 2003, 90: 35-41. PMID: 12772950, DOI: 10.1016/s1081-1206(10)61647-x.
Diisocyanate‐exposed auto body shop workers: A one‐year follow‐upRedlich CA, Stowe MH, Coren BA, Wisnewski AV, Holm CT, Cullen MR. Diisocyanate‐exposed auto body shop workers: A one‐year follow‐up. American Journal Of Industrial Medicine 2002, 42: 511-518. PMID: 12439874, DOI: 10.1002/ajim.10143.
Mouse Models of Diisocyanate AsthmaRedlich CA, Wisnewski AV, Gordon T. Mouse Models of Diisocyanate Asthma. American Journal Of Respiratory Cell And Molecular Biology 2002, 27: 385-390. PMID: 12356570, DOI: 10.1165/rcmb.f249.
Effects of hexamethylene diisocyanate exposure on human airway epithelial cells: in vitro cellular and molecular studies.Wisnewski AV, Liu Q, Miller JJ, Magoski N, Redlich CA. Effects of hexamethylene diisocyanate exposure on human airway epithelial cells: in vitro cellular and molecular studies. Environmental Health Perspectives 2002, 110: 901-907. PMID: 12204825, PMCID: PMC1240990, DOI: 10.1289/ehp.02110901.
A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challengeHerrick CA, Xu L, Wisnewski AV, Das J, Redlich CA, Bottomly K. A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge. Journal Of Allergy And Clinical Immunology 2002, 109: 873-878. PMID: 11994714, DOI: 10.1067/mai.2002.123533.
Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure.Lemus R, Lukinskeine L, Bier ME, Wisnewski AV, Redlich CA, Karol MH. Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure. Environmental Health Perspectives 2001, 109: 1103-1108. PMID: 11712993, PMCID: PMC1240469, DOI: 10.1289/ehp.011091103.
Subclinical immunologic and physiologic responses in hexamethylene diisocyanate‐exposed auto body shop workersRedlich C, Stowe M, Wisnewski A, Eisen E, Karol M, Lemus R, Holm C, Chung J, Sparer J, Liu Y, Woskie S, Appiah‐Pippim J, Gore R, Cullen M. Subclinical immunologic and physiologic responses in hexamethylene diisocyanate‐exposed auto body shop workers. American Journal Of Industrial Medicine 2001, 39: 587-597. PMID: 11385643, DOI: 10.1002/ajim.1058.
Recent developments in diisocyanate asthmaWisnewski A, Redlich C. Recent developments in diisocyanate asthma. Current Opinion In Allergy And Clinical Immunology 2001, 1: 169. DOI: 10.1097/01.all.0000011003.36723.d8.
Recent developments in diisocyanate asthmaWisnewski A, Redlich C. Recent developments in diisocyanate asthma. Current Opinion In Allergy And Clinical Immunology 2001, 1: 169. PMID: 11964686, DOI: 10.1097/00130832-200104000-00009.
Human γ / δ T-Cell Lines Derived from Airway BiopsiesWisnewski A, Cain H, Magoski N, Wang H, Holm C, Redlich C. Human γ / δ T-Cell Lines Derived from Airway Biopsies. American Journal Of Respiratory Cell And Molecular Biology 2001, 24: 332-338. PMID: 11245633, DOI: 10.1165/ajrcmb.24.3.4325.
Identification of Human Lung and Skin Proteins Conjugated with Hexamethylene DiisocyanateIn Vitro and In VivoWISNEWSKI A, SRIVASTAVA R, HERICK C, XU L, LEMUS R, CAIN H, MAGOSKI N, KAROL M, BOTTOMLY K, REDLICH C. Identification of Human Lung and Skin Proteins Conjugated with Hexamethylene DiisocyanateIn Vitro and In Vivo. American Journal Of Respiratory And Critical Care Medicine 2000, 162: 2330-2336. PMID: 11112159, DOI: 10.1164/ajrccm.162.6.2002086.
A Human Anti-HIV Autoantibody Enhances EBV Transformation and HIV InfectionCavacini L, Wisnewski A, Peterson J, Montefiori D, Emes C, Duval M, Kingsbury G, Wang A, Scadden D, Posner M. A Human Anti-HIV Autoantibody Enhances EBV Transformation and HIV Infection. Clinical Immunology 1999, 93: 263-273. PMID: 10600338, DOI: 10.1006/clim.1999.4790.
The Immunology and Prevention of Isocyanate Asthma: A Model for Low Molecular Weight AsthmaRedlich C, Cain H, Wisnewski A. The Immunology and Prevention of Isocyanate Asthma: A Model for Low Molecular Weight Asthma. Seminars In Respiratory And Critical Care Medicine 1999, 20: 591-599. DOI: 10.1055/s-2007-1009478.
Isocyanate-conjugated human lung epithelial cell proteins: A link between exposure and asthma?Wisnewski A, Lemus R, Karol M, Redlich C. Isocyanate-conjugated human lung epithelial cell proteins: A link between exposure and asthma? Journal Of Allergy And Clinical Immunology 1999, 104: 341-347. PMID: 10452755, DOI: 10.1016/s0091-6749(99)70377-5.
Functional and Molecular Characterization of Human Monoclonal Antibody Reactive with the Immunodominant Region of HIV Type 1 Glycoprotein 41Cavacini L, Emes C, Wisnewski A, Power J, Lewis G, Montefiori D, Posner M. Functional and Molecular Characterization of Human Monoclonal Antibody Reactive with the Immunodominant Region of HIV Type 1 Glycoprotein 41. AIDS Research And Human Retroviruses 1998, 14: 1271-1280. PMID: 9764911, DOI: 10.1089/aid.1998.14.1271.
Phase I Study of a Human Monoclonal Antibody Directed against the CD4-Binding Site of HIV Type 1 Glycoprotein 120Cavacini LA, Samore MH, Gambertoglio J, Jackson B, Duval M, Wisnewski A, Hammer S, Koziel C, Trapnell C, Posner MR. Phase I Study of a Human Monoclonal Antibody Directed against the CD4-Binding Site of HIV Type 1 Glycoprotein 120. AIDS Research And Human Retroviruses 1998, 14: 545-550. PMID: 9591708, DOI: 10.1089/aid.1998.14.545.
In vitro inhibition of Cryptosporidium parvum infection by human monoclonal antibodies.Elliot BC, Wisnewski AV, Johnson J, Fenwick-Smith D, Wiest P, Hamer D, Kresina T, Flanigan TP. In vitro inhibition of Cryptosporidium parvum infection by human monoclonal antibodies. Infection And Immunity 1997, 65: 3933-5. PMID: 9284173, PMCID: PMC175560, DOI: 10.1128/iai.65.9.3933-3935.1997.
Function and expression of a human idiotypic network in Schistosomiasis japonicaWISNEWSKI A, OLDS G, JOHNSON J, RAMIREZ B, KRESINA T. Function and expression of a human idiotypic network in Schistosomiasis japonica. Parasite Immunology 1996, 18: 439-447. PMID: 9226679, DOI: 10.1111/j.1365-3024.1996.tb01027.x.
Human antibody variable region gene usage in HIV-1 infection.Wisnewski A, Cavacini L, Posner M. Human antibody variable region gene usage in HIV-1 infection. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1996, 11: 31-8. PMID: 8528730, DOI: 10.1097/00042560-199601010-00004.
Induction of protective immunity to schistosomiasis with immunologically cross-reactive Lumbricus moleculesWisnewski AV, Kresina TF. Induction of protective immunity to schistosomiasis with immunologically cross-reactive Lumbricus molecules. International Journal For Parasitology 1995, 25: 503-510. PMID: 7543459, DOI: 10.1016/0020-7519(94)00132-8.
Induction of hepatic pathology in SCID-Hu mice engrafted with peripheral blood lymphocytes of patients with Schistosomiasis japonica.Kresina TF, Wisnewski A, Love-Homan L, Ramirez B, Neil GA. Induction of hepatic pathology in SCID-Hu mice engrafted with peripheral blood lymphocytes of patients with Schistosomiasis japonica. The Journal Of Infectious Diseases 1994, 170: 733-6. PMID: 8077739, DOI: 10.1093/infdis/170.3.733.
Human monoclonal antibodies heterogeneously express a human cross-reactive idiotype associated with immune function in Schistosoma japonicum infection.Wisnewski AV, Olds GR, Kresina TF. Human monoclonal antibodies heterogeneously express a human cross-reactive idiotype associated with immune function in Schistosoma japonicum infection. Human Antibodies 1994, 5: 178-82. PMID: 7756581.
Human monoclonal antibodies against Cryptosporidium parvum generated by hypo-osmolar electrofusion.Flanigan TP, Wisnewski A, Wiest PM, Johnson J, Tzipori S, Hamer D, Lam N, Kresina TF. Human monoclonal antibodies against Cryptosporidium parvum generated by hypo-osmolar electrofusion. Proceedings Of The Association Of American Physicians 1993, 106: 86-90. PMID: 8036749.
Human Hybridoma Generation by Hypo-Osmolar Electrofusion: Characterization of Human Monoclonal Antibodies to Schistosoma mansoni Parasite AntigensKlock G, Wisnewski AV, el-Bassiouni EA, Ramadan MI, Gessner P, Zimmermann U, Kresina TF. Human Hybridoma Generation by Hypo-Osmolar Electrofusion: Characterization of Human Monoclonal Antibodies to Schistosoma mansoni Parasite Antigens. Monoclonal Antibodies In Immunodiagnosis And Immunotherapy 1992, 11: 469-481. PMID: 1398684, DOI: 10.1089/hyb.1992.11.469.
Screening of murine monoclonal antibodies against living schistosomula of Schistosoma mansoni by radioimmunoassayWiest P, Wisnewski A, Johnson J, Ramirez B, Kresina T, Olds G. Screening of murine monoclonal antibodies against living schistosomula of Schistosoma mansoni by radioimmunoassay. International Journal For Parasitology 1991, 21: 449-454. PMID: 1917285, DOI: 10.1016/0020-7519(91)90102-d.
An immunoregulatory human monoclonal antibody in schistosomiasis japonicaKresina T, Guan X, Posner M, Wisnewski A, Olds G. An immunoregulatory human monoclonal antibody in schistosomiasis japonica. Human Antibodies 1991, 2: 42-45. PMID: 1651785, DOI: 10.3233/hab-1991-2107.

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Adam V Wisnewski, PhD, D(ABMLI)

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