Thomas Bärnthaler
Assistant Professor AdjunctCards
About
Research
Publications
2025
GPR55 in the tumor microenvironment of pancreatic cancer controls tumorigenesis
Ristić D, Bärnthaler T, Gruden E, Kienzl M, Danner L, Herceg K, Sarsembayeva A, Kargl J, Schicho R. GPR55 in the tumor microenvironment of pancreatic cancer controls tumorigenesis. Frontiers In Immunology 2025, 15: 1513547. PMID: 39885986, PMCID: PMC11779727, DOI: 10.3389/fimmu.2024.1513547.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaModel of pancreatic ductal adenocarcinomaImmune tumor microenvironmentTumor microenvironmentT cellsKO miceEndocannabinoid systemWT miceTumor growthCD8<sup>+</sup> T cellsG protein-coupled receptor 55Suppress T cell functionCancer cellsMurine pancreatic ductal adenocarcinomaCD3<sup>+</sup> T cellsExpression of PDL1T cell influxImmune cell compositionT cell functionTumor microenvironment cellsMigration of T cellsReduced tumor weightImmune cell populationsT cell activationCell lines
2024
Low LCAT activity is linked to acute decompensated heart failure and mortality in patients with CKD
Stadler J, Bärnthaler T, Borenich A, Emrich I, Habisch H, Rani A, Holzer M, Madl T, Heine G, Marsche G. Low LCAT activity is linked to acute decompensated heart failure and mortality in patients with CKD. Journal Of Lipid Research 2024, 65: 100624. PMID: 39154733, PMCID: PMC11416249, DOI: 10.1016/j.jlr.2024.100624.Peer-Reviewed Original ResearchAcute decompensated heart failureChronic kidney diseaseLecithin-cholesterol acyltransferase activityDecompensated heart failureLecithin-cholesterol acyltransferaseLCAT activityHeart failureFollow-upNon-dialysis CKD patientsIncreased risk of cardiovascular mortalityChronic kidney disease patientsLow LCAT activityAssociated with all-cause mortalityRisk of adverse outcomesAssociated with risk of deathRisk of cardiovascular mortalityKidney function declineAll-cause mortalityHDL particle sizeAssociated with riskRisk of deathSerum LCAT activityAtherosclerotic cardiovascular eventsAssociated with decreased activityActivity of lecithin-cholesterol acyltransferaseThe disrupted molecular circadian clock of monocytes and macrophages in allergic inflammation
Teppan J, Schwanzer J, Rittchen S, Bärnthaler T, Lindemann J, Nayak B, Reiter B, Luschnig P, Farzi A, Heinemann A, Sturm E. The disrupted molecular circadian clock of monocytes and macrophages in allergic inflammation. Frontiers In Immunology 2024, 15: 1408772. PMID: 38863703, PMCID: PMC11165079, DOI: 10.3389/fimmu.2024.1408772.Peer-Reviewed Original ResearchPolarized macrophagesHuman peripheral blood monocytesPrecision cut lung slicesMacrophage inflammatory proteinPeripheral blood monocytesChronic pulmonary diseaseInflammatory lung diseasesLung-protective propertiesTissue-resident macrophagesM2-polarized macrophagesMolecular circadian clockHuman monocyte-derived macrophagesHouse dust mite modelMonocyte-derived macrophagesCircadian protein CLOCKAllergic asthmaticsAllergic inflammationBlood monocytesEffector functionsLung diseaseInflammatory disordersMacrophage dysfunctionProtein expression patternsAllergic donorsTherapeutic approachesProfibrotic Role of GPR87 in Pulmonary Fibrosis
Khoury J, Ahangari F, Manning E, Justet A, barnthaler T, Adams T, Necola F, Alysandratos K, Beermann M, Kotton D, Kaminski N. Profibrotic Role of GPR87 in Pulmonary Fibrosis. 2024, a5183-a5183. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5183.Peer-Reviewed Original ResearchDevelopmental changes in lung function of mice are independent of sex as a biological variable
Bärnthaler T, Ramachandra A, Ebanks S, Guerrera N, Sharma L, Dela Cruz C, Humphrey J, Manning E. Developmental changes in lung function of mice are independent of sex as a biological variable. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2024, 326: l627-l637. PMID: 38375577, PMCID: PMC11380952, DOI: 10.1152/ajplung.00120.2023.Peer-Reviewed Original ResearchPulmonary function testsWeeks of ageStatic complianceMale miceInspiratory capacityLung functionBody weight-basedHuman lung pathologiesLung function of miceFemale C57BL/6J miceLung function parametersSex-dependent changesFunction of miceMeasures of lung functionIndependent of sexPreclinical modelsFemale miceC57BL/6J miceLung pathologyFunction testsMiceWeight-basedLungLung disease researchWeeks
2023
HDL-Related Parameters and COVID-19 Mortality: The Importance of HDL Function
Stadler J, Habisch H, Prüller F, Mangge H, Bärnthaler T, Kargl J, Pammer A, Holzer M, Meissl S, Rani A, Madl T, Marsche G. HDL-Related Parameters and COVID-19 Mortality: The Importance of HDL Function. Antioxidants 2023, 12: 2009. PMID: 38001862, PMCID: PMC10669705, DOI: 10.3390/antiox12112009.Peer-Reviewed Original ResearchCholesterol efflux capacityCOVID-19 mortalityCOVID-19 infectionHigh-density lipoprotein cholesterol levelsSARS-CoV-2 enters cellsCOVID-19-infected patientsCOVID-19Global public health challengeSignificant global public health challengeLipoprotein cholesterol levelsCOVID-19 groupPublic health challengeInflammatory markersHDL cholesterolHDL functionalityLipoprotein levelsSARS-CoV-2 coronavirusPneumonia patientsHDL functionCholesterol levelsHDL parametersEfflux capacityHDL phospholipidControl groupHDL