Jay Humphrey, PhD

2026

• Postnatal pulmonary artery development from transcript to tissue

  Schwarz E, Ramachandra A, Yeung N, Manning E, Weiss D, Humphrey J. Postnatal pulmonary artery development from transcript to tissue. Journal Of The Royal Society Interface 2026, 23: 20250962. PMID: 42303255, DOI: 10.1098/rsif.2025.0962.

  Peer-Reviewed Original Research

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• A continuum model for collective cell migration in tissues and biomaterials in response to chemo-mechanical stimuli

  Shirani M, Humphrey J. A continuum model for collective cell migration in tissues and biomaterials in response to chemo-mechanical stimuli. International Journal Of Engineering Science 2026, 223: 104502. DOI: 10.1016/j.ijengsci.2026.104502.

  Peer-Reviewed Original Research

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• Growth arrest of thoracic aortic aneurysms in aging Marfan mice

  Means C, Mays G, Yeung N, Cavinato C, Manning E, Lam T, Humphrey J, Weiss D. Growth arrest of thoracic aortic aneurysms in aging Marfan mice. AJP Heart And Circulatory Physiology 2026, 331: h115-h129. PMID: 42222959, DOI: 10.1152/ajpheart.00007.2026.

  Peer-Reviewed Original Research

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• A multiscale computational model of ascending thoracic aortic aneurysm development in Marfan syndrome for in silico trials

  Jansen L, Maes L, Verbrugghe P, Segers P, Sips P, Humphrey J, Famaey N. A multiscale computational model of ascending thoracic aortic aneurysm development in Marfan syndrome for in silico trials. Biomechanics And Modeling In Mechanobiology 2026, 25: 49. PMID: 42207208, DOI: 10.1007/s10237-026-02057-7.

  Peer-Reviewed Original Research

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• Hypertension drives thoracic aortic aneurysm and dissection in male, but not female, Marfan mice

  Mays G, Humphrey J. Hypertension drives thoracic aortic aneurysm and dissection in male, but not female, Marfan mice. Journal Of The Mechanical Behavior Of Biomedical Materials 2026, 180: 107473. PMID: 42214182, PMCID: PMC13270476, DOI: 10.1016/j.jmbbm.2026.107473.

  Peer-Reviewed Original Research

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• The aorta in Marfan syndrome: from molecular mechanisms to mechanobiological dysfunction

  Humphrey J, Milewicz D. The aorta in Marfan syndrome: from molecular mechanisms to mechanobiological dysfunction. Cardiovascular Research 2026, cvag114. PMID: 42140666, DOI: 10.1093/cvr/cvag114.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

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• Mechanisms driving thoracic aortic aneurysm instability

  Schwarz E, Li D, Means C, Assi R, Humphrey J. Mechanisms driving thoracic aortic aneurysm instability. Biomechanics And Modeling In Mechanobiology 2026, 25: 43. PMID: 42113285, DOI: 10.1007/s10237-026-02054-w.

  Peer-Reviewed Original Research

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• Physics-Informed Machine Learning in Biomedical Science and Engineering.

  Ahmadi N, Cao Q, Humphrey J, Karniadakis G. Physics-Informed Machine Learning in Biomedical Science and Engineering. Annual Review Of Biomedical Engineering 2026, 28: 309-336. PMID: 42067517, DOI: 10.1146/annurev-bioeng-110824-124907.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

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• The role of vascular smooth muscle cell plasticity in arterial remodelling and biomechanical failure: a numerical approach

  Abdel-Raouf Y, Maes L, Maga L, De Backer J, Sips P, Peirlinck M, Famaey N, Humphrey J, Segers P. The role of vascular smooth muscle cell plasticity in arterial remodelling and biomechanical failure: a numerical approach. Proceedings Of The Royal Society A 2026, 482: 20250787. DOI: 10.1098/rspa.2025.0787.

  Peer-Reviewed Original Research

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• A systematic comparison of membrane, shell, and 3D solid formulations for nonlinear vascular biomechanics

  Kim T, Ortigosa R, Nama N, Aguirre M, Gil A, Humphrey J, Figueroa C. A systematic comparison of membrane, shell, and 3D solid formulations for nonlinear vascular biomechanics. Journal Of The Mechanical Behavior Of Biomedical Materials 2026, 179: 107423. PMID: 41946235, DOI: 10.1016/j.jmbbm.2026.107423.

  Peer-Reviewed Original Research

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