Edward Manning, MD, PhD
Assistant Professor of Medicine (Pulmonary)Cards
About
Research
Publications
2026
Oxygen Delivery in the Adult Intensive Care Unit with a Focus on Hyperoxic Acute Lung Injury Pathogenesis and Clinical Manifestations.
Harris Z, Manning E. Oxygen Delivery in the Adult Intensive Care Unit with a Focus on Hyperoxic Acute Lung Injury Pathogenesis and Clinical Manifestations. Journal Of Intensive Care Medicine 2026, 8850666261481468. PMID: 42658476, DOI: 10.1177/08850666261481468.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsModified RNA Extraction Methods to Eliminate Agarose Impurities in Human Precision-Cut Lung Slices
Rangel R, Anderson S, DeIuliis G, Manning E, Ahangari F, Pandit A, Kaminski N, Marti-Munoz J. Modified RNA Extraction Methods to Eliminate Agarose Impurities in Human Precision-Cut Lung Slices. American Journal Of Respiratory Cell And Molecular Biology 2026, aanag164. PMID: 42606537, DOI: 10.1093/ajrcmb/aanag164.Peer-Reviewed Original ResearchTargeting mTOR to Mitigate Sequelae of Chronic Hypoxia on the Carotid Artery and Cerebral Circulation
Choi R, Mihailovic J, Sharma P, Nikola F, Bluestein S, Doddaballapur P, Guerrera N, Abu Hussein N, Cavinato C, Adams T, Yan X, Hyder F, Herman P, Humphrey J, Manning E. Targeting mTOR to Mitigate Sequelae of Chronic Hypoxia on the Carotid Artery and Cerebral Circulation. Comprehensive Physiology 2026, 16: e70240. PMID: 42609627, PMCID: PMC13478350, DOI: 10.1002/cph4.70240.Peer-Reviewed Original ResearchPolymerized Z-α-1 antitrypsin leads to lung injury in a murine model of emphysema
Serrano M, Khodayari N, Bowers W, Manning E, Liu X, Lee J, Flagg T, Oshins R, Griffin A, Patel S, Lascano J, Chandra D, Majka S, Petrache I, Brantly M, Serban K. Polymerized Z-α-1 antitrypsin leads to lung injury in a murine model of emphysema. JCI Insight 2026, 11: e199029. PMID: 42579796, PMCID: PMC13463610, DOI: 10.1172/jci.insight.199029.Peer-Reviewed Original ResearchPhysiologic Changes in the Aging Lung
Manning E. Physiologic Changes in the Aging Lung. Respiratory Medicine 2026, 3-31. DOI: 10.1007/978-3-032-29861-4_1.ChaptersPostnatal pulmonary artery development from transcript to tissue
Schwarz E, Ramachandra A, Yeung N, Manning E, Weiss D, Humphrey J. Postnatal pulmonary artery development from transcript to tissue. Journal Of The Royal Society Interface 2026, 23: 20250962. PMID: 42303255, PMCID: PMC13475744, DOI: 10.1098/rsif.2025.0962.Peer-Reviewed Original ResearchA Brief Overview of Biomechanics and Mechanobiology of the Pulmonary Circulation
Ramachandra A, Manning E. A Brief Overview of Biomechanics and Mechanobiology of the Pulmonary Circulation. Advances In Experimental Medicine And Biology 2026, 1512: 127-140. PMID: 42420706, DOI: 10.1007/978-3-032-22285-5_6.ChaptersGrowth arrest of thoracic aortic aneurysms in aging Marfan mice
Means C, Mays G, Yeung N, Cavinato C, Manning E, Lam T, Humphrey J, Weiss D. Growth arrest of thoracic aortic aneurysms in aging Marfan mice. AJP Heart And Circulatory Physiology 2026, 331: h115-h129. PMID: 42222959, PMCID: PMC13471068, DOI: 10.1152/ajpheart.00007.2026.Peer-Reviewed Original ResearchThe interplay of airway epithelium and biomechanical stress in pulmonary fibrosis
Lin L, Khoury J, Zhang G, Szafron J, Manning E, Ahangari F. The interplay of airway epithelium and biomechanical stress in pulmonary fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2026, 74: 1016-1031. PMID: 42089315, DOI: 10.1093/ajrcmb/aanag066.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEpidermal growth factor receptor regulates Beclin-1 in hyperoxic acute lung injury
Harris Z, Korde A, Khoury J, Manning E, Stanley G, Shin Y, Mitchell K, von der Schulenburg A, Sun Y, Hu B, Shin H, Joerns J, Clark B, Placek L, Unutmaz D, Moldobaeva A, Sharma L, Sauler M, Rajagopalan G, Zhang X, Wang H, Ghaedi M, Kang M, Koff J. Epidermal growth factor receptor regulates Beclin-1 in hyperoxic acute lung injury. BMJ Open Respiratory Research 2026, 13: e003323. PMID: 41592865, PMCID: PMC12853440, DOI: 10.1136/bmjresp-2025-003323.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Clinical Care
Overview
Edward Manning, MD, PhD, is a specialist in pulmonary and critical care medicine who treats people with lung diseases and breathing challenges. He diagnoses and manages conditions such as persistent shortness of breath and chronic lung disorders, using a range of approaches to improve patients’ well-being.
As an assistant professor of medicine (pulmonary) at Yale School of Medicine, Dr. Manning studies how prolonged low oxygen levels and aging can alter the blood vessels of the lungs and affect heart function. His work aims to develop strategies that support long-term cardiopulmonary health.
Dr. Manning pursued his medical training at Albert Einstein College of Medicine, completed a residency at the Hospital of the University of Pennsylvania, and gained further expertise through a fellowship in pulmonary and critical care medicine at Yale School of Medicine.
Clinical Specialties
Board Certifications
Adult Echocardiography
- Certification Organization
- National Board of Echocardiography
- Original Certification Date
- 2021
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