Fada Guan, PhD
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Appointments
Therapeutic Radiology
Primary
Contact Info
About
Titles
Assistant Professor of Therapeutic Radiology
Appointments
Therapeutic Radiology
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- PhD
- Texas A&M University, Nuclear Engineering (2012)
- MS
- Texas A&M University, Health Physics (2009)
- BE
- Tsinghua University, Nuclear Engineering (2005)
Board Certifications
Therapeutic Medical Physics
- Certification Organization
- American Board of Radiology
- Original Certification Date
- 2024
Research
Overview
Radiation Therapy; Medical Physics; Radiation Biology; Monte Carlo Simulations; Proton and Particle Therapy; Microdosimetry; X-ray Bragg Diffraction; Space Radiation
Medical Subject Headings (MeSH)
Radiation
ORCID
0000-0001-8477-7391
Research at a Glance
Yale Co-Authors
Frequent collaborators of Fada Guan's published research.
Publications Timeline
A big-picture view of Fada Guan's research output by year.
Zhe Jay Chen, PhD, FAAPM
Christopher J. Tien, PhD, DABR, FAAPM
Dae Yup Han, PhD, DABR
David J. Carlson, PhD, DABR, FASTRO, FAAPM
79Publications
799Citations
Publications
2024
Impact of setup errors on the robustness of linac‐based single‐isocenter coplanar and non‐coplanar VMAT plans for multiple brain metastases
Sun X, Guan F, Yun Q, Jennings M, Biggs S, Wang Z, Wang W, Zhang T, Shi M, Zhao L. Impact of setup errors on the robustness of linac‐based single‐isocenter coplanar and non‐coplanar VMAT plans for multiple brain metastases. Journal Of Applied Clinical Medical Physics 2024, 25: e14317. PMID: 38439583, PMCID: PMC11244668, DOI: 10.1002/acm2.14317.Peer-Reviewed Original ResearchConceptsNon-coplanar plansPlanning target volumeGross tumor volumePatient setup errorsPlan evaluation metricsSetup errorsMultiple brain metastasesImpact of setup errorsNon-coplanar VMAT plansDose delivery accuracyGamma passing ratesRobust treatment plansModified plansSingle-isocenterVMAT plansGamma analysisRotation errorBrain metastasesDose coverageLinac-basedTreatment planningDelivery accuracyTarget volumePrescribed doseNon-coplanarMulti-omics approaches for biomarker discovery in predicting the response of esophageal cancer to neoadjuvant therapy: A multidimensional perspective
Yang Z, Guan F, Bronk L, Zhao L. Multi-omics approaches for biomarker discovery in predicting the response of esophageal cancer to neoadjuvant therapy: A multidimensional perspective. Pharmacology & Therapeutics 2024, 254: 108591. PMID: 38286161, DOI: 10.1016/j.pharmthera.2024.108591.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPathological complete responseNeoadjuvant chemoradiotherapyEsophageal cancerLocally advanced esophageal cancerPathological complete response patientsAdvanced esophageal cancerStandard treatment strategyPredicting treatment responsePredicting nCRT responseMulti-omics dataMulti-omicsComplete responseNeoadjuvant therapyChemoradiation responseNCRT responsePredictive biomarkersSurvival outcomesActive surveillanceTreatment responsePlanned surgeryEC patientsTreatment strategiesMulti-omics approachImproved biomarkersOrgan preservationEditorial: Advances in the biological effects of ionizing radiation
Guan F, Zhao L, Bronk J, Maletic-Savatic M, Grosshans D, Carlson D. Editorial: Advances in the biological effects of ionizing radiation. Frontiers In Oncology 2024, 13: 1352771. PMID: 38234403, PMCID: PMC10793655, DOI: 10.3389/fonc.2023.1352771.Peer-Reviewed Original ResearchAltmetric
2023
Editorial: Innovations, advances, and challenges in precision radiation oncology physics
Guan F, Bronk L, Yue J, Mohan R, Chen Z. Editorial: Innovations, advances, and challenges in precision radiation oncology physics. Precision Radiation Oncology 2023, 7: 222-224. DOI: 10.1002/pro6.1216.Peer-Reviewed Original ResearchCase Report: MR-LINAC-guided adaptive radiotherapy for gastric cancer
Song Y, Zhang Y, Wang H, Zhao M, Guan F, Li Z, Yue J. Case Report: MR-LINAC-guided adaptive radiotherapy for gastric cancer. Frontiers In Oncology 2023, 13: 1159197. PMID: 37746250, PMCID: PMC10514477, DOI: 10.3389/fonc.2023.1159197.Peer-Reviewed Original ResearchAltmetricConceptsGastric cancerUpper abdomenGastric cancer patientsCourse of treatmentGastric cancer biopsiesDaily MR imageAdaptive radiotherapyMR-linacAdaptive treatment plansCT simulation imagesBlack stoolCancer patientsCase reportGastroscopy resultsInoperable tumorsPancreatic cancerImage-guided radiotherapyPatientsCancer biopsiesClinical experienceRadiotherapyTreatment planApparent causeCancerStomachPO61 Can Current Monotherapy High-Dose-Rate Prostate Brachytherapy Prescriptions Overcome Intrafractional DNA Damage Repair and 192Ir Source Decay?
Guan F, Draeger E, Carlson D, Chen Z, Tien C. PO61 Can Current Monotherapy High-Dose-Rate Prostate Brachytherapy Prescriptions Overcome Intrafractional DNA Damage Repair and 192Ir Source Decay? Brachytherapy 2023, 22: s97-s98. DOI: 10.1016/j.brachy.2023.06.162.Peer-Reviewed Original ResearchPO83 Utilization of a Virtual Clinical Trial to Characterize Sensitivity of the Linear-Quadratic Model
Tien C, Draeger E, Guan F, Carlson D, Chen Z. PO83 Utilization of a Virtual Clinical Trial to Characterize Sensitivity of the Linear-Quadratic Model. Brachytherapy 2023, 22: s110. DOI: 10.1016/j.brachy.2023.06.184.Peer-Reviewed Original ResearchConceptsTumor control probabilityClinical trialsLinear-quadratic modelNumber of patientsPatient cohort sizeTCP curvesRadiobiological parametersVirtual clinical trialsGy-1Cohort sizeRange of dosesPatient outcomesReference cohortPatientsHeterogeneous cohortVirtual patientsNew trialsRadiobiological parameter valuesClonogenic populationPatient ordersControl probabilityGyInput model parametersTrialsCohortCharacterization of GafchromicTM EBT4 film with clinical kV/MV photons and MeV electrons
Guan F, Chen H, Draeger E, Li Y, Aydin R, Tien C, Chen Z. Characterization of GafchromicTM EBT4 film with clinical kV/MV photons and MeV electrons. Precision Radiation Oncology 2023, 7: 84-91. DOI: 10.1002/pro6.1204.Peer-Reviewed Original ResearchCitationsConceptsX-ray beamMeV electron beamMV photon beamElectron beamMV photonsBeam energyMeV electronsPhoton beamsEnergy dependenceKilovoltage x-ray beamsMinimal energy dependenceClinical photonPhotonsBeamRadiation typesMeVElectronsDependence experimentsFilmsDose-response dependenceResponse dependenceDependenceEnergyNoise ratioEBT3Evaluating bone marrow dosimetry with the addition of bone marrow structures to the medical internal radiation dose phantom
Ferrone K, Willis C, Guan F, Ma J, Peterson L, Kry S. Evaluating bone marrow dosimetry with the addition of bone marrow structures to the medical internal radiation dose phantom. Precision Radiation Oncology 2023, 7: 27-35. DOI: 10.1002/pro6.1189.Peer-Reviewed Original ResearchCitationsConceptsBone marrow doseBone marrowBone marrow structureMarrow doseMedical Internal Radiation Dose (MIRD) methodMarrow structureRadiation-induced cancerRadiation exposure scenariosBone marrow dosimetryAverage doseDoseSoft tissueMarrowMarrow dosimetryRadiation doseDose methodExposure scenariosDose estimationDosimetric response of Gafchromic™ EBT‐XD film to therapeutic protons
Guan F, Wang X, Yang M, Draeger E, Han D, Iga K, Guo F, Perles L, Li Y, Sahoo N, Mohan R, Chen Z. Dosimetric response of Gafchromic™ EBT‐XD film to therapeutic protons. Precision Radiation Oncology 2023, 7: 15-26. PMID: 37868341, PMCID: PMC10586355, DOI: 10.1002/pro6.1187.Peer-Reviewed Original ResearchCitationsConceptsLinear energy transferEBT-XD filmsTherapeutic protonsFilm calibrationProton linear energy transferUltra-high Dose Rate FLASH RadiotherapyDynamic dose rangeMV photon beamDose-averaged LET valuesDose rate dependenceProton beamlineProton beamPhoton beamsFLASH beamSpot scanning proton beamsDosimetric responseLET dependenceFLASH radiotherapyHigh-dose applicationFilm responseLET valuesEnergy transferBeamProtonsGafchromic
Academic Achievements and Community Involvement
activity Editorial Board Member
Journal ServicePhysics in Medicine and BiologyDetails02/01/2024 - Presentactivity Guest
Public ServiceAmerican Association of Physicists in MedicineDetails2024 - PresentDescriptionGuest member, Work Group on Particle Beams (WGPB)activity Associate Editor
Journal ServicePhysica Medica (European Journal of Medical Physics)Details2023 - Presentactivity Guest Editor
Journal ServiceFrontiers in OncologyDetails09/07/2022 - Presentactivity Associate Editor
Journal ServicePhysical and Engineering Sciences in MedicineDetails2022 - Present
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